CD38 triggers cytotoxic responses in activated human natural killer cells

Blood

Volumn 94, Issue 11, 1999, Pages 3864-3871

  Sconocchia, Giuseppe ^b   Titus, Julie A ^b   Mazzoni, Alessandra ^b   Visintin, Alberto ^b   Pericle, Federica ^b   Hicks, Stuart W ^b   Malavasi, Fabio ^b   Segal, David M ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN;

ARTICLE; CALCIUM CELL LEVEL; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; ENZYME RELEASE; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN CROSS LINKING; T LYMPHOCYTE ACTIVATION;

EID: 0033485344     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.11.3864.423k14_3864_3871     Document Type: Article

References (49)

1. Leibson PJ: Signal transduction during natural killer cell activation: Inside the mind of a killer. Immunity 6:655, 1997
2. Lanier LL: Natural killer cells: From no receptors to too many. Immunity 6:371, 1997
3. Lanier LL: NK cell receptors. Annu Rev Immunol 16:359, 1998
4. Yokoyama WM: Natural killer cell receptors. Curr Opin Immunol 10:298, 1998
5. Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH: LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. Immunity 7:283, 1997
6. Daeron M: Fc receptor biology. Annu Rev Immunol 15:203, 1997
7. Lanier LL, Corliss BC, Wu J, Leong C, Phillips JH: Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells. Nature 391:703, 1998
8. Mason LH, Willette-Brown J, Anderson SK, Gosselin P, Shores EW, Love PE, Ortaldo JR, McVicar DW: Characterization of an associated 16-kDa tyrosine phosphoprotein required for Ly-49D signal transduction. J Immunol 160:4148, 1998
9. Segal DM, Bakacs T, Jost CR, Kurucz I, Sconocchia G, Titus JA: T cell-targeted cytotoxicity, in Fanger MW (ed): Bispecific Antibodies. Austin, TX, R.G. Landes, 1995, p 27
10. Segal DM, Vance BA, Sconocchia G: Bispecific antibodies, in Matzku S, Stahel RA (eds): Antibodies in Diagnosis and Therapy. Technologies, Mechanisms and Clinical Data. Amsterdam, The Netherlands, Harwood Academic, 1999, p 49
11. Siliciano RF, Pratt JC, Schmidt RE, Ritz J, Reinherz EL: Activation of cytotoxic T lymphocyte and natural killer cell function through the T11 sheep erythrocyte binding protein. Nature 317:428, 1985
12. Schmidt RE, Michon JM, Woronicz J, Schlossman SF, Reinherz EL, Ritz J: Enhancement of natural killer function through activation of the T11 E rosette receptor. J Clin Invest 79:305, 1987
13. Bolhuis RLH, Roozemond RC, van de Griend RJ: Induction and blocking of cytolysis in CD2+, CD3-NK and CD2+, CD3+ cytotoxic lymphocytes via CD2 50 KD sheep erythrocyte receptor. J Immunol 136:3939, 1986
14. Galandrini R, De Maria R, Piccoli M, Frati L, Santoni A: CD44 triggering enhances human NK cell cytotoxic functions. J Immunol 153:4399, 1994
15. Sconocchia G, Titus JA, Segal DM: CD44 is a cytotoxic triggering molecule in human peripheral blood NK cells. J Immunol 153:5473, 1994
16. Tan PH, Liu YF, Santos EB, Sandmaier BM: Mechanisms of enhancement of natural killer activity by an antibody to CD44: Increase conjugate formation and release of tumor necrosis factor α. Cell Immunol 164:255, 1995
17. Moretta A, Poggi A, Pende D, Tripodi G, Orengo AM, Pella N, Augugliaro R, Bottino C, Ciccone E, Moretta L: CD69-mediated pathway of lymphocyte activation: Anti-CD69 monoclonal antibodies trigger the cytolytic activity of different lymphoid effector cells with the exception of cytolytic T lymphocytes expressing T cell receptor α/β. J Exp Med 174:1393, 1991
18. Giorda R, Rudert WA, Vavassori C, Chambers WH, Hiserodt JC, Trucco M: NKR-P1, a signal transduction molecule on natural killer cells. Science 249:1298, 1990
19. Martin-Fontecha A, Assarsson E, Carbone E, Karre K, Ljunggren HG: Triggering of murine NK cells by CD40 and CD86 (B7-2). J Immunol 162:5910, 1999
20. Frey JL, Bino T, Kantor RR, Segal DM, Giardina SL, Roder J, Anderson S, Ortaldo JR: Mechanism of target cell recognition by natural killer cells: Characterization of a novel triggering molecule restricted to CD3-large granular lymphocytes. J Exp Med 174:1527, 1991
21. Mehta K, Shahid U, Malavasi F: Human CD38, a cell-surface protein with multiple functions. FASEB J 10:1408, 1996
22. Deaglio S, Morra M, Horenstein A, Mallone R, Ausiello CM, Prager E, Garbarino G, Dianzani U, Stockinger H, Malavasi F: Human CD38 (ADP-ribosyl cyclase) is a ligand of CD31, an Ig superfamily member. J Immunol 160:395, 1998
23. Shubinsky G, Schlesinger M: The CD38 lymphocyte differentiation marker: New insight into its ectoenzymatic activity and its role as a signal transducer. Immunity 7:315, 1997
24. Blom B, Res P, Noteboom E, Weijer K, Spits H: Prethymic CD34+ progenitors capable of developing into T cells are not committed to the T cell lineage. J Immunol 158:3571, 1997
25. Jaleco AC, Blom B, Res P, Weijer K, Lanier LL, Phillips JH, Spits H: Fetal liver contains committed NK progenitors, but is not a site for development of CD34+ cells into T cells. J Immunol 159:694, 1997
26. Zubiaur M, Izquierdo M, Terhorst C, Malavasi F, Sancho J: CD38 ligation results in activation of the Raf-1/mitogen-activated protein kinase and the CD3-zeta/zeta-associated protein-70 signaling pathways in Jurkat T lymphocytes. J Immunol 159:193, 1997
27. Morra M, Zubiaur M, Terhorst C, Sancho J, Malavasi F: CD38 is functionally dependent on TCR/CD3 complex in human T cells. FASEB J 12:581, 1998
28. Silvennoinen O, Nishigaki H, Kitanaka A, Kumagai M, Ito C, Malavasi F, Lin Q, Conley ME, Campana D: CD38 signal transduction in human B cell precursors. Rapid induction of tyrosine phosphorylation, activation of syk tyrosine kinase, and phosphorylation of phospholipase C-gamma and phosphatidylinositoi 3-kinase. J Immunol 156: 100, 1996
29. Kontani K, Kukimoto I, Nishina H, Hoshino S, Hazeki O, Kanaho Y, Katada T: Tyrosine phosphorylation of the c-cbl protooncogene product mediated by cell surface antigen CD38 in HL-60 cells. J Biol Chem 271:1534, 1996
30. Cesano A, Visonneau S, Deaglio S, Malavasi F, Santoli D: Role of CD38 and its ligand in the regulation of MHC-nonrestricted cytotoxic T cells. J Immunol 160:1106, 1998
31. Lund FE, Cockayne DA, Randall TD, Solvason N, Schuber F, Howard MC: CD38: A new paradigm in lymphocyte activation and signal transduction. Immunol Rev 161:79, 1998
32. Peola S, Borrione P, Matera L, Malavasi F, Pileri A, Massaia M: Selective induction of CD73 expression in human lymphocytes by CD38 ligation: A novel pathway linking signal transducers with ecto-enzyme activities. J Immunol 157:4354, 1996
33. Fleit HB, Wright SD, Unkeless JC: Human neutrophil Fc gamma receptor distribution and structure. Proc Natl Acad Sci USA 79:3275, 1982
34. Kung P, Goldstein G, Reinherz EL, Schlossman SF: Monoclonal antibodies denning distinctive human T cell surface antigens. Science 206:347, 1979
35. Barnstable CJ, Bodmer WF, Brown G, Galfre G, Milstein C, Williams AF, Ziegler A: Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens - New tools for genetic analysis. Cell 14:9, 1978
36. Funaro A, De Monte LB, Dianzani U, Forni M, Malavasi F: Human CD38 is associated to distinct molecules which mediate transmembrane signaling in different lineages. Eur J Immunol 23:2407, 1993
37. Garrido MA, Perez P, Titus JA, Valdayo MJ, Winkler DA, Barbieri SA, Wunderlich JR, Segal DM: Targeted cytotoxic cells in human peripheral blood lymphocytes. J Immunol 144:2891, 1990
38. Phillips JH, Warner NL, Lanier LL: Correlation of biophysical properties and cell surface antigenic profile of Percoll gradient-separated human natural killer cells. Nat Immun Cell Growth Regul 3:73, 1983
39. Wunderlich JR, Shearer GM: Induction and measurement of cytotoxic T lymphocyte activity, Unit 3.11, in Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W (eds): Current Protocols in Immunology, vol 1. New York, NY, Wiley, 1991, p 3.11.1
40. Segal DM: Measurement of intercellular conjugates by flow cytometry, in Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W (eds): Current Protocols in Immunology. New York, NY, Wiley, 1997, p 5.6.1
41. Taffs R, Sitkovsky MV: Granule enzyme exocytosis assay for cytotoxic T lymphocyte activation, in Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W (eds): Current Protocols in Immunology. New York, NY, Wiley, 1991, p 3.16.1
42. Vandenberghe PA, Ceuppens JL: Flow cytometric measurement of cytoplasmic free calcium in human peripheral blood T lymphocytes with fluo-3, a new fluorescent calcium indicator. J Immunol Methods 127:197, 1990
43. Zupo S, Rugari E, Dono M, Taborelli G, Malavasi F, Ferrarini M: CD38 signaling by agonistic monoclonal antibody prevents apoptosis of human germinal center B cells. Eur J Immunol 24:1218, 1994
44. Henkart PA: Lymphocyte-mediated cytotoxicity: Two pathways and multiple effector molecules. Immunity 1:343, 1994
45. Sconocchia G, Titus JA, Segal DM: Signaling pathways regulating CD44-dependent cytolysis in NK cells. Blood 90:716, 1997
46. Cassatella MA, Anegon I, Cuturi MC, Griskey P, Trinchieri G, Perussia B: Fc gamma R(CD16) interaction with ligand induces Ca2+ mobilization and phosphoinositide turnover in human natural killer cells. Role of Ca2+ in Fc gamma R(CD16)-induced transcription and expression of lymphokine genes. J Exp Med 169:549, 1989
47. MEL-14. Proc Natl Acad Sei USA 88:7877, 1991
48. Galandrini R, Albi N, Tripodi G, Zarcone D, Terenzi A, Moretta A, Grossi CE, Velardi A: Antibodies to CD44 trigger effector functions of human T cell clones. J Immunol 150:4225, 1993
49. Pericle F, Sconocchia G, Titus JA, Segal DM: CD44 is a cytotoxic triggering molecule on human polymorphonuclear cells. J Immunol 157:4657, 1996