Advantages of a two-chamber culture system to test drug nephrotoxicity: The example of cephaloridine?

Kidney and Blood Pressure Research

Volumn 20, Issue 4, 1997, Pages 264-270

  Bolon, Claire ^a   Gauthier, Catherine ^a   Simonnet, Hélène ^a   Baverel, Gabriel ^a  

^a UNIVERSITÉ LYON 1   (France)

Author keywords

Antibiotic; Cephaloridine toxicity; Cultured cells; Kidney proximal tubule; Permeable filter; Two chamber system

Indexed keywords

CEFALORIDINE; CELL PROTEIN; CEPHALOSPORIN DERIVATIVE; COLLAGEN; GLUCOSE; LACTATE DEHYDROGENASE; LUCIFER YELLOW;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIFFUSION; GLUCOSE TRANSPORT; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; MONOLAYER CULTURE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RABBIT;

EID: 0030696765     PISSN: 14204096     EISSN: 14230143     Source Type: Journal    
DOI: 10.1159/000174156     Document Type: Article

References (21)

1. Atkinson RM. Currie JP. Davis B. Pratt DAH. Sharpe HM, Toinich EG: Acute toxicity of ce-phaloridine, an antibiotic derived from cephalosporin C. Toxicol Appl Pharmacol 1966;8: 398-406.
2. Atkinson RM. Caisey JD. Currie JP. Middleton TR, Pratt DAM. Sharpe HM. Tomich EG: Subacute toxicity of cephaloridinc to various species. Toxicol Appl Pharmacol 1966;8:407-428.
3. Rush OF. Ponsler GD: Cephaloridinc-induccd biochemical changes and cytotoxicity in suspensions of rabbit isolated proximal tubules. Toxicol Appl Pharmacol 1991;109:314-326.
4. Blais A. Morvan-Baleynaud J, Friedlander G. Grimcllec C: Primary culture of rabbit proximal tubules as a cellular model to study nephrotoxicity of xenobiotics. Kidney Int 1993;44:13-18.
5. Poujeol P. Vandewalle A: Phosphate uptake by proximal cells isolated from rabbit kidney: Role of dexamethasone. Am J Physiol 1985; 249:F74-F83.
6. Bolon C, Chauvin MF, Simonnet H. Gauthier C, Baverel G: Growth of cultured rabbit renal tubular cells does not require exogenous glutamine. Kidney Int 1995;47:299-305.
7. Stewart WW: Functional connections between cells as revealed by dye-coupling with a highly fluorescent naphthalimidc tracer. Cell 1978:14: 741-759.
8. Bradford MM: A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-254.
9. Lowry OH. Rosebrough NJ, Farr AT, Randall RJ: Protein measurement with the Folin phenol reagent. J BiolChem 1951;193:265-275.
10. Bergmeyer HU. Berndt E, Schmidt F. Stork H: Glucose determination with hexokinase and glucose-6-phosphate dehydrogenase; in Bergmeyer HU, Gawchn K (eds): Methods of Enzymatic Analysis. New York. Academic Press, 1974, vol 3, pp 1196-1201.
11. Gutman I, Wahlefeld AW: Lactate determination with lactate dehydrogenase and NAD; in Bergmeyer HU, Gawehn K (eds): Methods of Enzymatic Analysis. New York, Academic Press, 1974, vol 3. pp 1464-1468.
12. Bergmeyer HU, Gawchn K, Grassl M: Enzymes as biochemical reagents; in Bergmeyer HU. Gawehn K (eds): Methods of Enzymatic Analysis. New York, Academic Press, 1974, vol 3, pp 481-482.
13. Goldstein RS, Smith PF, Tarloff JB. Contardi L. Rush GF. Hook FB: Biochemical mechanisms of cephaloridinc nephrotoxicity. Life Sci 1988; 42:1809-1816.
14. Foord RD: Cephaloridin, cephalothin and the kidney. J Antimicrob Chemother 1975; l(suppl): 119-133.
15. Fine L, Sakhrani LM: Proximal tubular cells in primary culture. Miner Electrolyte Metab 1986: 12:51-57.
16. Tang MJ. Suresh KR, Tannen RL: Carbohydrate metabolism by primary' cultures of rabbit proximal tubules. Am.1 Physiol 1989;256:C532-C539.
17. Chauvin MF. Megnin-Chanet F, Martin G, Lhoste JM, Baverel G: The rabbit kidney utilizes glucose for glutamine synthesis. A,5C NMR study.,.1 Biol Chern 1994;269:26025-26033.
18. Tunc BM. Wu KY. Fravert D, Holtzman D: Effect of cephaloridine on respiration by renal cortical mitochondria. J Pharmacol Exp Ther 1979:210:98-100.
19. Hediger MA. Rhoads DB: Molecular physiology of sodium-glucose transporters. Physiol Rev 1994;74:993-1026.
20. Schwartz JH, Schein P: Fanconi syndrome associated with cephalothin and gcntamycin. Cancer 1978:41:568-577.
21. Tunc BM: Relationship between the transport and toxicity of cephalosporins in the kidney. J Infect Dis 1975:132:189-194.