Thrombotic risk associated with the use of iodinated contrast media in interventional cardiology: Pathophysiology and clinical aspects

Fundamental and Clinical Pharmacology

Volumn 13, Issue 6, 1999, Pages 613-623

  Idée, Jean Marc ^a   Corot, Claire ^a  

^a Laboratoire Guerbet   (France)

Author keywords

Angiography; Blood platelets; Coagulation; Contrast media; Percutaneous coronary angioplasty; Thrombosis

Indexed keywords

ADIPIODONE MEGLUMINE; DIATRIZOATE; IOBITRIDOL; IODINATED CONTRAST MEDIUM; IODIXANOL; IOHEXOL; IOMEPROL; IONIC CONTRAST MEDIUM; IOPAMIDOL; IOPENTOL; IOPROMIDE; IOTALAMIC ACID; IOTROLAN; IOVERSOL; IOXAGLIC ACID; IOXITALAMIC ACID; IVEPAQUE; MEGLUMINE DIATRIZOATE; MEGLUMINE IOTALAMATE; MEGLUMINE IOXAGLATE PLUS SODIUM IOXAGLATE; MEGLUMINE IOXITALAMATE PLUS SODIUM IOXITALAMATE; NONIONIC CONTRAST MEDIUM; OPTIJECT; UNCLASSIFIED DRUG;

ANGIOGRAPHY; ANTICOAGULATION; BLOOD CLOTTING; CORONARY ARTERY CONSTRICTION; DRUG CLASSIFICATION; HUMAN; ISCHEMIC HEART DISEASE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; THROMBOCYTE ACTIVATION; THROMBOSIS;

EID: 0033450854     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-8206.1999.tb00372.x     Document Type: Review

References (92)

1. [1] Gruentzig A., Senning A., Slegenthaler W.E., Nonoperative dilatation of coronary artery stenosis: percutaneous transluminal angioplasty, N. Engl. J. Med. 301 (1979) 61-68.
2. [2] Sovak M., Contrast media: a journey almost sentimental, Invest. Radiol. 29 (suppl. 1) (1994) S4-S14.
3. [3] Freed M.S., O'Neill W.W., Dissection and acute closure, in: Freed M.S., Grines C.L. (Eds.), Manual of Interventional Cardiology, Physician's Press, Birmingham, 1992, pp. 204-220.
4. [4] Fischell T.A., Coronary artery spasm after percutaneous transluminal coronary angioplasty: pathophysiology and clinical consequences, Cath. Cardiovasc. Diagn. 19 (1990) 1-3.
5. [5] Idée J.M., Effets pharmacologiques des produits de contraste iodés en imagerie cardiaque, in: Gaux J.C. (Ed.), Imagerie du Coeur et des Vaisseaux, Flammarion Médecine Sciences, Paris, 1992. pp. 131-135.
6. [6] Klow E.N., Hevroy O., Mortensen E., Dale K., Mjos O.D., Low osmolality contrast media and metabolic changes in the myocardium during free and reduced coronary flow in the dog, Invest. Radiol. 25 (1990) 127-132.
7. [7] Idée J.M., Beaufils H., Bonnemain B., Iodinated contrast media-induced nephropathy: pathophysiology, clinical aspects and prevention, Fundam. Clin. Pharmacol. 8 (1994) 193-206.
8. [8] Eloy R., Corot C., Belleville J., Contrast media for angiography: physicochemical properties, pharmacokinetics and biocompatibility, Clin. Mat. 7 (1991) 89-197.
9. [9] Doorey A.J., Clinical aspects of contrast media, J. Invas. Cardiol. 3 (suppl. B) (1991) 60B-66B.
10. [10] Corot C., Perrin J.M., Belleville J., Amiel M., Eloy R., Effect of iodinated contrast media on blood clotting, Invest. Radiol. 24 (1989) 390-393.
11. [11] Corot C., Chronos N., Sabattier V., In vitro comparison of the effects of contrast media on coagulation and platelet activation, Blood Coag. Fibrin. 7 (1996) 602-608.
12. [12] Belleville J., Baguet J., Paul J., Eloy R., In vitro study of the inhibition of coagulation induced by different radio contrast molecules, Thromb. Res. 38 (1985) 149-162.
13. [13] Melton L.G., Muga K.M., Gabriel D.A., Effect of contrast media on in vitro bleeding time: assessment by a hollow fibre instrument, Acad. Radiol. 2 (1995) 239-243.
14. [14] Melton L.G., Muga K.M., Gabriel D.A., Effect of iodixanol on in vitro bleeding time, Acad. Radiol. 3 (1996) 407-411.
15. [15] Arora R., Khandelwal M., Gopal A., In vivo effects of non-ionic and ionic contrast media on beta-thromboglobulin and fibrinopeptide levels, J. Am. Coll. Cardiol. 17 (1991) 1533-1536.
16. [16] Biancardi M., Cimminiello C., Toschi V., Schiavina G., Regalia F., Casolo F., Bonfardeci G., TAT, F1 + 2, and D-dimer levels in patients after coronary angiography with non-ionic or ionic contrast media or after cardiac catheterization. Sem. Thromb. Hem. 22 (suppl. 1) (1996) 61-65.
17. [17] Kopko P.M., Smith D.C., Bull B.S., Thrombin generation in non-clottable mixtures of blood and non-ionic contrast agents. Radiology 174 (1990) 459-461.
18. [18] Fay W.P., Parker A.C., Effects of radiographic contrast agents on thrombin formation and activity, Thromb. Haemost. 80 (1998) 266-272.
19. [19] Harker L.A., Hanson S.R., Runge M.S., Thrombin hypothesis of thrombus generation and vascular lesion formation, Am. J. Cardiol. (suppl.) 75 (1995) 12B-17B.
20. [20] Harker L.A., Mann K.G., Thrombosis and fibrinolysis, in: Verstraete M., Fuster V., Topol E.J. (Eds.), Cardiovascular Thrombosis: Thrombocardiology and Thromboneurology, Lippincott Raven, Philadelphia, 1998, pp. 3-22.
21. [21] Gabriel D.A., Jones M.R., Reece N.S., Boothroyd E., Bashore T., Platelet and fibrin modification by radiographic contrast media, Circ. Res. 68 (1991) 881-887.
22. [22] Granger C.B., Gabriel D.A., Reece N.S., Boothroyd E., Harding M.B., Harrison J.K., Kong Y., Bashore T.M., Fibrin modification by ionic and non-ionic contrast media during cardiac catheterization, Am. J. Cardiol. 69 (1992) 821-823.
23. [23] Melton L.G., Dehmer G.J., Gabriel D.A., Alterations in fibrin detected in coronary sinus blood after heparin and coronary angiography with a non-ionic contrast agent (iohexol), Am. J. Cardiol. 82 (1998) 295-298.
24. [24] Ambrose J.A., Almeida O.D., Sharma S.K., Torre S.R., Marmur J.D., Israel D.H. et al., for the TAUSA Investigators, Adjunctive thrombolytic therapy during angioplasty for ischaemic rest angina: results of the TAUSA trial. Circulation 90 (1994) 69-77.
25. [25] Carr M.E., Carr S.L., Merten S.R., Effects of ionic and non-ionic contrast media on clot structure, platelet function and thrombolysis mediated by tissue plasminogen activator in plasma clots, Haemostasis 25 (1995) 172-181.
26. [26] Dehmer G.J., Gresalfi N., Daly D., Oberhardt B., Tate D.A., Impairment of fibrinolysis by streptokinase, urokinase and recombinant tissue-type plasminogen activator in the presence of radiographic contrast agents, J. Am. Coll. Cardiol. 25 (1995) 1069-1075.
27. [27] Pislaru S., Pislaru C., Szilard M., Arnout J., Van De Werf F., In vivo effects of contrast media on thrombolysis, J. Am. Coll. Cardiol. 32 (1998) 1102-1108.
28. [28] Chronos N., Implications of contrast media selection in interventional cardiology, in: Topol E.J., Serruys P.W. (Eds.), Current Review of Interventional Cardiology, Current Medicine, Philadelphia, 1995, pp. 279-293.
29. [29] Van Beck E.J.R., Levi M., Reekers J.A., Hack C.E., Büller H.R., Ten Cate J.W., Increased plasma levels of PAI-1 after administration of non-ionic contrast medium in patients undergoing pulmonary angiography. Radiology 193 (1994) 821-823.
30. [30] Paramo J.A., Colucci M., Collen D., Plasminogen activator inhibitor in blood of patients with coronary artery disease, Br. Med. J. 291 (1985) 573-574.
31. [31] Levi M., Biemond B.J., Sturk A., Hock J., Ten Cate J.W., Variable effects of radiological contrast media on thrombus growth in a rabbit jugular vein thrombosis model, Thromb. Haemost. 66 (1991) 218-221.
32. [32] Grines C.L., Mickelson J.K., Diaz C., DeMaria A.N., Acute thrombosis in a canine model of arterial injury: effect of ionic versus non-ionic contrast media, J. Invas. Cardiol. (suppl.) 3 (1991) 18B-23B.
33. [33] Zir L.M., Carvalho A.C., Harthorne J.W., Colman R.W., Less R.S., Effect of contrast agents on platelet aggregation and 14-C serotonin release, N. Engl. J. Med. 291 (1974) 134-135.
34. [34] Heptinstall S., White A., Edwards N., Pascoe J., Sanderson H.M., Fox S.C., Henderson R.A., Differential effects of three radiographic contrast media on platelet aggregation and degranulation: implications for clinical practice?, Brit. J. Haematol. 103 (1998) 1023-1030.
35. [35] Hay K.L., Bull B.S., An analysis of platelet activation and aggregation produced by three classes of contrast media, Journal of Vascular Interventional Radiology 6 (1995) 211-217.
36. [36] Niewiarowski S., Secreted platelet proteins, in: Bloom A.L., Forbes C.D., Thomas D.P., Tudenham E.G.D. (Eds.), Haemostasis and Thrombosis, Churchill Livingstone, Edinburgh, 1994, pp. 167-181.
37. [37] Badimon L., Badimon J.J., Fuster V., Pathogenesis of thrombosis, in: Verstraete M., Fuster V., Topol E.J. (Eds.), Cardiovascular Thrombosis: Thrombocardiology and Thromboneurology, Lippincott Raven, Philadelphia, 1998. pp. 23-44.
38. [38] Chronos N.A.F., Goodall A.H., Wilson D.J., Sigwart U., Buller N.P., Profound platelet degranulation is an important side effect of some types of contrast media used in interventional cardiology, Circulation (part. 1) 88 (1993) 2035-2044.
39. [39] Hardeman M.R., Konijnenberg A., Sturk A., Reekers J.A., Activation of platelets by low-osmolar contrast media: differential effects of ionic and nonionic agents. Radiology 192 (1994) 563-566.
40. [40] Koza M.J., Shankey V., Walenga J.M., Moncada R., Fareed J., Pifarre R., Flow cytometric evaluation of platelet activation by ionic or non-ionic contrast media and modulation by heparin and recombinant hirudin. Invest. Radiol. 30 (1995) 90-97.
41. [41] Khandelwal M., Garabedian H.D., Gold H.K., Arnout J., Palacios I.F., Intracoronary platelet activation by non-ionic contrast media during angiography: a prospective, double-blind randomized study, Circulation 86 (1992) 2587.
42. [42] Sakariassen K.S., Barstad R.M., Hamers M.J.A.G., Stormorken H., Iohexol, platelet activation and thrombosis. I. Iohexol-induced platelet secretion does not affect thrombus formation in native blood, Acta Radiol. 39 (1998) 349-354.
43. [43] Sakariassen K.S., Buchmann M., Hamers M.J.A.G., Stormorken H., Iohexol, platelet activation and thrombosis. II. Iohexol-induced platelet secretion does not affect collagen-induced or tissue-factor-induced thrombus formation in blood that is anticoagulated with heparin and aspirin, Acta Radiol. 39 (1998) 355-361.
44. [44] Sakariassen K.S., Joss R., Muggli R., Kuhn H., Tschopp T.B., Sage H., Baumgartner H.R., Collagen type III-induced ex vivo thrombogenesis in humans. Role of platelets and leukocytes in deposition of fibrin, Arteriosclerosis 10 (1990) 276-284.
45. [45] Sixma J.J., Interaction of blood platelets with the vessel wall, in: Bloom A.L., Forbes C.D., Thomas D.P., Tuddenham E.G.D. (Eds.), Haemostasis and Thrombosis, Churchill Livingstone, Edinburgh, 1994, pp. 259-285.
46. [46] Grabowski E.F., Rodriguez M., McDonnell S.L., Platelet adhesion/aggregation and endothelial cell function in flowing blood: effects of contrast media, Sem. Hematol. 28 (suppl. 7) (1991) 60-65.
47. [47] Grabowski E.F., Rodriguez M., McDonnell S.L., Platelet adhesion/aggregation in an in vitro model of coronary artery stenosis, Cath. Cardiovasc. Diagn. 28 (1993) 65-71.
48. [48] Ross R., Atherosclerosis: an inflammatory disease, N. Engl. J. Med. 340 (1999) 115-126.
49. [49] Corot C., Stucker O., Duverger J.-P., Pons C., Vicaut E., Effects of iodinated contrast agents on the formation of platelet thrombi in rat arteriole, Invest. Radiol. 29 (suppl. 2) (1994) S203-S205.
50. [50] Li X., Gabriel D.A., Differences between contrast media in the inhibition of platelet activation by specific platelet agonists, Acad. Radiol. 4 (1997) 108-114.
51. [51] Guillin M.-C., Bezeaud A., Bouton M.-C., Jandrot-Perrus M., Thrombin specificity, Thromb. Haemost. 74 (1995) 129-133.
52. [52] Hawkins I.F., Herbert L., Contrast material used as a catheter flushing agent: a method to reduce clot formation during angiography, Radiology 110 (1974) 351-352.
53. [53] Robertson H.J.F., Blood clot formation in angiographic syringes containing non-ionic contrast media, Radiology 163 (1987) 621-622.
54. [54] Grollman J.H., Liu C.K., Astone R.A., Lurie M.D., Thromboembolic complications in coronary angiography associated with the use of non-ionic contrast medium, Cath. Cardiovasc. Diagn. 14 (1988) 159-164.
55. [55] Millet P.J., Sestier F., Thromboembolic complications with non-ionic contrast media, Cath. Cardiovasc. Diagn. 17 (1989) 192.
56. [56] Schräder R., Thrombogenic potential of non-ionic contrast media, fact or fiction?, Eur. J. Radiol. 23 (suppl. 1) (1998) S10-S13.
57. [57] Davidson C.J., Mark D.B., Pieper K.S., Kisslo K.B., Hlatky M.A., Gabriel D.A., Bashore T.M., Thrombotic and cardiovascular complications related to non-ionic contrast media during cardiac catheterization: analysis of 8517 patients. Am. J. Cardiol. 65 (1990) 1481-1484.
58. [58] Sato E., Saito I., Tama Contrast Media Study Group, Risk of clot formation with ionic and non-ionic contrast media in cerebral angiography, Acad. Radiol. 3 (1996) 925-928.
59. [59] Meade T.W., Hypercoagulability and ischaemic heart disease, Blood Reviews 1 (1987) 2-8.
60. [60] Pinton P., Abciximab dans le traitement des syndromes coronariens aigus par angioplastie et stent, Thérapie 53 (1998) 341-347.
61. [61] Windecker S., Meier B., Meyer B.J., Interventional cardiology in Europe: trends from 1992 to 1995, Circulation (suppl.) 96 (1997) 148 (abstract 824).
62. [62] Freed M.S., Grines C.L., Percutaneous revascularization by lesion morphology and location, in: Freed M.S., Grines C.L. (Eds.), Manual of Interventional Cardiology, Physician's Press, Birmingham, Michigan, 1992, pp. 87-90.
63. [63] Au P.K., Non-ionic contrast media and intracatheter clot formation during use of a perfusion catheter, Cath. Cardiovasc. Diagn. 22 (1991) 235-236.
64. [64] Doorey A.J., Stillabower M.E., Gale N., Goldenberg E.M., Catastrophic thrombus development despite systemic heparinization during coronary angioplasty: possible relationship to non-ionic contrast, Clin. Cardiol. 15 (1992) 117-120.
65. [65] Esplugas E., Cequier A., Jara F., Mauri J., Soler T., Sala T., Sabate X., Risk of thrombosis during coronary angioplasty with low osmolality contrast media, Am. J. Cardiol. 68 (1991) 1020-1040.
66. [66] Piessens J.H., Stammen F., Vrolix M.C., Glazier J.J., Benit E., De Geest H., Willems J.L., Effects of an ionic versus a non-ionic low osmolar contrast agent on the thrombotic complications of coronary angioplasty, Cath. Cardiovasc. Diagn. 28 (1993) 99-105.
67. [67] Qureshi N.R., Den Heijer P., Crijns H.J.G.M., Percutaneous coronary angioscopic comparison of thrombus formation during percutaneous coronary angioplasty with ionic and nonionic contrast media in unstable angina, Am. J. Cardiol. 80 (1997) 700-704.
68. [68] Grines C.L., Schreiber T.L., Savas V., Jones D., Zidar F.J., Vellappillil G. et al., A randomised trial of low osmolar ionic versus non-ionic contrast media in patients with myocardial infarction or unstable angina undergoing percutaneous transluminal coronary angioplasty, J. Am. Coll. Cardiol. 27 (1996) 1381-1386.
69. [69] Lembo N.J., King S.B. III, Roubin G.S., Black A.J., Douglas J.S. Jr., Effects of non-ionic versus ionic contrast media on complications of percutaneous transluminal coronary angioplasty, Am. J. Cardiol. 67 (1991) 1046-1050.
70. [70] Malekianpour M., Bonan R., Lespérance J., Gosselin G., Hudon G., Doucet S., Laurier J., Duval D., Comparison of ionic and non-ionic low osmolar contrast media in relation to thrombotic complications of angioplasty in patients with unstable angina, Am. Heart J. 135 (1998) 1067-1075.
71. [71] Schräder R., Esch I., Ensslen R., Fach W.A., Merle H., Scherer D., Sievert H., Spies F., Zeplin H.E., A randomized trial comparing the impact of a non-ionic (iomeprol) versus an ionic (ioxaglate) low osmolar contrast medium on abrupt vessel closure and ischaemic complications after coronary angioplasty, J. Am. Coll. Cardiol. 33 (1999) 395-402.
72. [72] Fleisch M., Mülhauser B., Garachemani A., Eberli F., Hess O., Windecker S., Pedrazzini G., Meier B., Impact of ionic (ioxaglate) and non-ionic (ioversol) contrast media on PTCA-related complications, J. Am. Coll. Cardiol. 33 (suppl. A) (1999) 85A (abstract 1188-92).
73. [73] Bertrand M.E., Esplugas E., Piessens J., Iodixanol and ioxaglate in percutaneous transluminal coronary angioplasty, Circulation (suppl.) 98 (1998) 87 (abstract 443).
74. [74] Davidson C.J., Laskey W.K., Harrison J.K., Hermiller J.B., Matthai W. Jr. Vlietstra R.E. et al., A randomized trial of contrast media utilization in high risk PTCA (the COURT study), J. Am. Coll. Cardiol. 33 (suppl. A) (1999) 85A (abstract 1006 38).
75. [75] Gasperetti C.M., Feldman M.D., Burwell L.R., Angello D.A., Haugh K.H., Owen R.M., Powers E.R., Influence of contrast media on thrombus formation during coronary angioplasty, J. Am. Coll. Cardiol. 18 (1991) 443-450.
76. [76] Lefèvre T., Adjeroud N., Royer T., Glatt B., Morice M.C., Influence of contrast media on the results of percutaneous transluminal coronary angioplasty with provisional stenting: a comparative study, J. Invas. Cardiol. 10 (1998) 380-384.
77. [77] Scheller B., Hennen B., Azmy A., Doerr T., Markwirth T., Schieffer H., Acute and subacute stent occlusion: risk-reduction by combined use of non-ionic and ionic contrast media, J. Am. Coll. Cardiol. 33 (suppl. A) (1999) 85A (abstract 1188-91).
78. [78] Chevalier B., Royer T., Glatt B., Guyon P., Does non-ionic contrast medium still modify angioplasty in the stent era?, J. Am. Coll. Cardiol. 33 (suppl. A) (1999) 85A (abstract 1188-93).
79. [79] Cucherat M., Leizorovicz A., Effects of non-ionic contrast media on abrupt vessel closure and ischaemic complications after angioplasty. A meta-analysis, Am. J. Cardiol. (suppl.) 84 (1999) 98P.
80. [80] Engelhart J.A., Smith D.C., Maloney M.D., Westengard J.C., Bull B.S., A technique for estimating the probability of clots in blood/contrast agent mixture. Invest. Radiol. 23 (1988) 923-927.
81. [81] Corot C, Belleville J., Amiel M., Eloy R., Contrast mediarelated thromboembolic risks: effects of blood mixed with contrast media in contact with angiographic catheters, Sem. Hemat. (suppl.) 28 (1991) 54-59.
82. [82] Raininko R., Rihelä M., Blood clot formation in angiographic catheters. In vitro tests with various contrast media, Acta Radiol. 31 (1990) 217-220.
83. [83] Kurisu Y., Tada S., The anticoagulant effects of ionic and non-ionic low-osmolar contrast media in dogs. Invest. Radiol. 27 (1992) 686-688.
84. [84] Corot C., Cornillac A., Belleville J., Eloy R., the European Clotting Group. Scanning electron microscopic analysis of catheters during routine angiographic procedures: role of the contrast agent, Invest. Radiol. (suppl.) (1991) S96-S100.
85. [85] Casalini E., Role of low-osmolality contrast media in thromboembolic complications: scanning electron microscopy study, Radiology 183 (1992) 741-744.
86. [86] Lefèvre T., Bernard Z., Bertrand M., Lablanche J.M., Cequier A., Esplugas E., Gayet J.L., Gosselin G., Bonan R., Comparaison en microscopie électronique du potentiel antithrombogène de deux produits de contraste iodés de basse osmolalité au cours de l'angioplastie coronaire transluminale percutanée, Arch. Mal. Coeur 87 (1994) 225-233.
87. [87] Ischinger T.A., Antithrombotics in interventional cardiology: optimizing treatment and strategies, Am. J. Cardiol. (suppl.) 82 (1998) 25L-28L.
88. [88] The EPIC Investigators, Use of a monoclonal antibody directed against the platelet glycoprotein IIb, IIIa receptor in high-risk coronary angioplasty, The EPIC investigation, N. Engl. J. Med. 330 (1994) 956-961.
89. [89] Gregorini L., Marco J., Fajadet J., Bernies M., Cassagneau B., Brunei P., Bossi I.M., Mannucci P.M., Ticlopidine and aspirin pre-treatment reduces coagulation and platelet activation during coronary dilation procedures, J. Am. Coll. Cardiol. 29 (1997) 13-20.
90. [90] Serruys P.W., Emanuelsson H., Van der Giessen W., Lunn A.C., Kiemeney F., Macaya C. et al., Heparin-coated Palmaz-Schatz slents in human coronary arteries. Early outcome of the Benestent-II Pilot Study, Circulation 93 (1996) 412-422.
91. [91] Almén T., Contrast media: the relation of chemical structure, animal toxicity and adverse clinical effects, Am. J. Cardiol. (suppl.) 66 (1990) 2F-8F.
92. [92] Dawson P., Chemotoxicity of contrast media and clinical adverse effects: a review, Invest. Radiol. (suppl.) 20 (1985) S84-S91.