Differential effects of three radiographic contrast media on platelet aggregation and degranulation: Implications for clinical practice?

British Journal of Haematology

Volumn 103, Issue 4, 1998, Pages 1023-1030

  Heptinstall, Stan ^a,b   White, A ^a   Edwards, N ^a   Pascoe, J ^a   Sanderson, H M ^a   Fox, S C ^a   Henderson, R A ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

Citrate; Hirudin; Platelet activation; Radiographic contrast media; Whole blood

Indexed keywords

CITRIC ACID; CONTRAST MEDIUM; HIRUDIN; IODIXANOL; IOPAMIDOL; IOXAGLIC ACID; MEGLUMINE IOXAGLATE PLUS SODIUM IOXAGLATE;

ANTICOAGULATION; ARTERIOGRAPHY; ARTICLE; BLOOD CLOTTING; BLOOD SAMPLING; CLINICAL PRACTICE; DEGRANULATION; DRUG EFFECT; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RADIOGRAPHY; THROMBOCYTE AGGREGATION; THROMBOGENESIS;

ADENOSINE DIPHOSPHATE; ANTITHROMBINS; ASPIRIN; CELL DEGRANULATION; CONTRAST MEDIA; HIRUDINS; HUMANS; IOPAMIDOL; IOXAGLIC ACID; P-SELECTIN; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; TRIIODOBENZOIC ACIDS;

EID: 0032441138     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1998.01118.x     Document Type: Article

References (33)

1. Aguejouf, O., Doutremepuich, F., Azougagh Oualane, F. & Doutremepuich, C. (1995) Thrombogenicity of ionic and nonionic contrast media tested in a laser induced rat thrombosis model. Thrombosis Research, 77, 259-269.
2. Aguirre, F.V., Topol, E.J., Donohue, T.J., Kern, M.J., Leimberger, J.D. & Califf, R.M. (1995) Impact of ionic and non-ionic contrast media on post-PCTA ischaemic complications: results from the EPIC trial. Journal of the American College of Cardiology, 25, (Suppl.). 8A.
3. Albanese, J.R., Venditto, J.A., Patel, G.C. & Ambrose, J.A. (1995) Effects of ionic and nonionic contrast media on in vitro and in vivo platelet activation. American Journal of Cardiology, 76, 1059-1063.
4. Bevan, J. & Heptinstall, S. (1985) Serotonin-induced platelet aggregation in whole blood and the effects of ketanserin and mepyramine. Thrombosis Research, 38, 189-194.
5. Carr, M.E., Jr. Carr, S.L. & Merten, S.R. (1995) Effects of ionic and nonionic contrast media on clot structure, platelet function and thrombolysis mediated by tissue plasminogen activator in plasma clots. Haemostasis, 25, 172-181.
6. Casalini, E. (1992) Role of low-osmolality contrast media in thromboembolic complications: scanning electron microscopy study. Radiology, 183, 741-744.
7. Chronos, N.A.F., Goodall, A.H., Wilson, D.J., Sigwart, U. & Buller, N.P. (1993) Profound platelet degranulation is an important side effect of some types of contrast media used in interventional cardiology. Circulation, 88, 2035-2044.
8. Corot, C., Chronos, N. & Sabattier, V. (1996) In vitro comparison of the effects of contrast media on coagulation and platelet activation. Blood Coagulation and Fibrinolysis, 7, 602-608.
9. Dawson, P., Hewitt, P., Mackie, I.J., Machin, S.J., Amin, S. & Bradshaw, A. (1986) Contrast coagulation and fibrinolysis. Investigative Radiology, 21, 248-252.
10. Editorial (1992) Thromboembolism during angiography. Lancet, 339, 1576-1578.
11. Evans, P.A., Glenn, J.R., Madira, W. & Heptinstall, S. (1998) Effects of gelatin-based resuscitation fluids on platelet aggregation. British Journal of Anaesthesia, 81, 198-202.
12. Eloy, R., Corot, C. & Belleville, J. (1991) Contrast media for angiography: physiochemical properties, pharmacokinetics and biocompatibility. Clinical Materials, 7, 89-197.
13. Esplugas, E., Cequier, A., Jara, F., Mauri, J., Soler, T., Sala, J. & Sabate, X. (1991) Risk of thrombosis during coronary angioplasty with low osmolality contrast media. American Journal of Cardiology, 68, 1020-1024.
14. Fox, S.C., Burgess-Wilson, M., Heptinstall, S. & Mitchell, J.R.A. (1982) Platelet aggregation in whole blood determined using the Ultra-Flo 100 Whole Blood Platelet Counter. Thrombosis and Haemostasis, 48, 327-329.
15. Gafter, U., Creter, D., Zevin, D., Catz, R. & Djaldetti, M. (1979) Inhibition of platelet aggregation by contrast media. Radiology, 132, 341-342.
16. Gasperetti, C.M., Feldman, M.D., Burwell, L.R. & Angello, D.A. (1991) Influence of contrast media on thrombus formation during coronary angioplasty. Journal of the American College of Cardiology, 18, 443-450.
17. Grabowski, E.F., Jang, I.K., Gold, H., Palacios, I.F., Boor, S.E., Rodino, L.J. & Michelson, A.D. (1995) Platelet degranulation induced by some contrast media is independent of their nonionic vs ionic nature. Acta Radiologica, 36, (Suppl. 399), 182-184.
18. Grines, C.L., Schreiber, T.L., Savas, V., Jones, D.E., Zidar, F.J., Gangadharan, V., Brodsky, M., Levin, R., Safian, R., Puchrowicz-Ochocki, S., Castellani, M.D. & Oneill, W.W. (1996) A randomized trial of low osmolar ionic verses nonionic contrast media in patients with myocardial infarction or unstable angina undergoing percutaneous transluminal coronary angioplasty. Journal of the American College of Cardiology, 27, 1381-1386.
19. Hardeman, M.R., Konijnenberg, A., Sturk, A. & Reekers, J.A. (1994) Activation of platelets by low-osmolar contrast media: differential effects of ionic and nonionic agents. Radiology, 192, 563-566.
20. Hay, K.L. & Bull, B.S. (1995) An analysis of platelet activation and aggregation produced by three classes of contrast media. Journal of Vascular and Interventional Radiology, 6, 211-217.
21. Heptinstall, S., May, J.A., Glenn, J.R., Sanderson, H.M., Dickinson, J.P. & Wilcox, R.G. (1995) Effects of ticlopidine administered to healthy volunteers on platelet function in whole blood. Thrombosis and Haemostasis, 74, 1310-1315.
22. 2T-purinoceptors. British Journal of Pharmacology, 113, 1057-1063.
23. Hwang, M.H., Piao, Z.E., Murdock, D.K. & Giardina, J.J. (1989) The potential risk of thrombosis during coronary angiography using nonionic contrast media. Catheterization and Cardiovascular Diagnosis, 16, 209-213.
24. Kopko, P.M., Smith, D.C. & Bull, B.S. (1990) Thrombin generation in nonclottable mixtures of blood and nonionic contrast agents. Radiology, 174, 459-461.
25. Koza, M.J., Shankey, T.V., Walenga, J.M., Moncada, R., Fareed, J. & Pifarre, R. (1995) Flow cytometric evaluation of platelet activation by ionic or nonionic contrast media and modulation by heparin and recombinant hirudin. Investigative Radiology, 30, 90-97.
26. Li, X. & Gabriel, D.A. (1997) Differences between contrast media in the inhibition of platelet activation by specific platelet agonists. Academic Radiology, 4, 108-114.
27. May, J.A., Heptinstall, S. & Spangenberg, P. (1996) Changes in the composition of the platelet cytoskeleton in response to ADP: effects of MK-852 and ARL 66096. Blood Coagulation and Fibrinolysis, 7, 221-224.
28. Moliterno, D.J. & Topol, E.J. (1996) Another step towards resolving the contrast controversy. Journal of the American College of Cardiology, 27, 1387-1389.
29. Piessens, J.H., Stammen, F., Vrolix, M.C., Glazier, J.J., Benit, E., De Geest, H. & Willems, J.L. (1993) Effects of an ionic versus a nonionic low osmolar contrast agent on the thrombotic complications of coronary angioplasty. Catheterization and Cardiovascular Diagnosis, 28, 99-105.
30. Schômig, A., Neumann, F.-J., Kastrati, A., Schuelen, H., Blasini, R., Hadamitzky, M., Walter, H., Zitzman-Roth, E.-V., Richardt, G., Alt, E., Schmitt, C. & Ulm, K. (1996) A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents. New England Journal of Medicine, 334, 1084-1089.
31. Tamura, A., Ohata, C., Hirakakiuchi, Y. & Sato, T. (1995) Suppressive effects of iodinated contrast media on human platelet aggregation. Yakugaku Zasshi, 115, 250-255.
32. Taylor, M.A., Angello, D.A., Ayers, C.R. & Gear, A.R.L. (1991) Radiograghic contrast agents and platelet function: a quenched flow study. Catheterization and Cardiovascular Diagnosis, 22, 295-301.
33. Van Beek, E.J.R., Levi, M., Reekers, J.A., Hack, C.E., Buller, H.R. & Ten Cate, J.W. (1994) Increased plasma levels of PAI-1 after administration of nonionic contrast medium in patients undergoing pulmonary angiography. Radiology, 193, 821-823.