Structure and organization of the gene encoding human dopamine transporter

Gene

Volumn 195, Issue 1, 1997, Pages 11-18

  Kawarai, Toshitaka ^a   Kawakami, Hideshi ^a   Yamamura, Yasuhiro ^a   Nakamura, Shigenobu ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

5' terminal cap G residue; cDNA cloning; Genomic library; Promoter sequence; Recombinant DNA; Structure comparison

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; CELL DNA; DOPAMINE 1 RECEPTOR; DOPAMINE TRANSPORTER; MESSENGER RNA; TRANSCRIPTION FACTOR SP1;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA FLANKING REGION; EXON; GENE ISOLATION; GENE STRUCTURE; GENETIC ORGANIZATION; HUMAN; INTRON; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR GENE; SEQUENCE HOMOLOGY; TRANSCRIPTION INITIATION;

BASE SEQUENCE; CARRIER PROTEINS; CLONING, MOLECULAR; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; EXONS; GENE LIBRARY; HUMANS; INTRONS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PROMOTER REGIONS (GENETICS); REPETITIVE SEQUENCES, NUCLEIC ACID; RESTRICTION MAPPING; SEQUENCE HOMOLOGY, NUCLEIC ACID; SYMPORTERS;

EID: 0030792168     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(97)00131-5     Document Type: Article

References (29)

1. Bird A.P. CpG-rich islands and the function of DNA methylation. Nature. 321:1986;209-213.
2. Breathnach R., Chambon P. Organization and expression of eukaryotic split genes coding for proteins. Annu. Rev. Biochem. 50:1981;349-383.
3. Cambi F., Fung B., Chikaraishi D. 5′ Flanking DNA sequences direct cell-specific expression of rat tyrosine hydroxylase. J. Neurochem. 53:1989;1656-1659.
4. Chen Z. Simple modifications to increase specificity of 5′ RACE procedure. Trends Genet. 12:1996;87-88.
5. Cook E.H. Jr., Stein M.A., Krasowski M.D., Cox N.J., Olkon D.M., Kieffer J.E., Leventhal B.L. Association of attention-deficit disorder and the dopamine transporter gene. Am. J. Hum. Genet. 56:1996;993-998.
6. Denney R.M., Sharma A., Dave S.K., Waguespack A. A new look at the promoter of the human monoamine oxidase A gene: mapping transcription initiation sites and capacity to drive luciferase expression. J. Neurochem. 63:1994;843-856.
7. Donovan D.M., Vandenbergh D.J., Perry M.P., Bird G.S., Ingersoll R., Nanthakumar E., Uhl G.R. Human and mouse dopamine transporter genes: conservation of 5′-flanking sequence elements and gene structures. Mol. Brain Res. 30:1995;327-335.
8. Gelernter J., Kranzler H.R., Satel S.L., Rao P.A. Genetic association between dopamine transporter protein alleles and cocaine-induced paranoia. Neuropsychopharmacology. 11:1994;195-200.
9. German D.C., Dubach M., Askari S., Speciale S.G., Bowden D.M. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian syndrome in Macaca fascicularis: which midbrain dopaminergic neurons are lost? Neuroscience. 24:1988;161-174.
10. Giros B., el Mestikawy S., Godinot N., Zheng K., Han H., Yang-Feng T., Caron M.G. Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. Mol. Pharmacol. 42:1992;383-390.
11. Giros B., Jaber M., Jones S.R., Wightman R.M., Caron M.G. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature. 379:1996;606-612.
12. Harrington K.A., Augood S.J., Kingsbury A.E., Foster O.J.F., Emson P.C. Dopamine transporter (DAT) and synaptic vesicle amine transporter (VMAT2) gene expression in the substantia nigra of control and Parkinson's disease. Mol. Brain Res. 36:1996;157-162.
13. Hirzmann J., Luo D., Hahnen J., Hobem G. Determination of messenger RNA 5′-ends by reverse transcription of the cap structure. Nucleic Acids Res. 21:1993;3597-3598.
14. Iversen L.L. Role of transmitter uptake mechanisms in synaptic neurotransmission. Br. J. Pharmacol. 41:1971;571-591.
15. Kitayama S., Shimada S., Xu H., Markham L., Donovan D.M., Uhl G.R. Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding. Proc. Natl. Acad. Sci. USA. 89:1992;7782-7785.
16. + transport. Synapse. 15:1993;58-62.
17. Lam D.M.K., Fei J., Zhang X.Y., Tam A.C.W., Zhu L.H., Huang F., King S.C., Guo L.H. Molecular cloning and structure of the human (GABATHG) GABA transporter gene. Mol. Brain Res. 19:1993;227-232.
18. Lesch K.P., Balling U., Gross J., Strauss K., Wolozin B.L., Murphy D.L., Riederer P. Organization of the human serotonin transporter gene. J. Neural Transm. 95:1994;157-162.
19. 1A dopamine receptor gene. Proc. Natl. Acad. Sci. USA. 89:1992;3045-3049.
20. Mironov V.N., Van Montagu M., Inze D. High throughput RNase protection assay. Nucleic Acids Res. 23:1995;3359-3360.
21. Muramatsu T., Higuchi S. Dopamine transporter gene polymorphism and alcoholism. Biochem. Biophys. Res. Commun. 211:1995;28-32.
22. Pearson W.R., Lipman D.J. Improved tools for biological sequence comparison. Proc. Natl. Acad. Sci. USA. 85:1988;2444-2448.
23. Pörzgen P., Bönisch H., Brüss M. Molecular cloning and organization of the coding region of the human norepinephrine transporter gene. Biochem. Biophys. Res. Commun. 215:1995;1145-1150.
24. Sambrook, J., Fritsch, E.F. and Maniatis, T., 1989. Molecular Cloning. A Laboratory Manual. CSHL Press, Cold Spring Harbor, NY.
25. Sanger F., Nicklen S., Coulson A.R. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA. 74:1977;5463-5467.
26. Sano A., Kondoh K., Kakimoto Y., Kondo I. A 40-nucleotide repeat polymorphism in the human dopamine transporter gene. Hum. Genet. 91:1993;405-406.
27. Vandenbergh D.J., Persico A.M., Hawkins A.L., Griffin C.A., Li X., Jabs E.W., Uhl G.R. Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. Genomics. 14:1992;1104-1106.
28. Yoon S.O., Chikaraishi D.M. Tissue-specific transcription of the rat tyrosine hydroxylase gene requires synergy between an AP-1 motif and an overlapping E box-containing dyad. Neuron. 9:1992;55-67.
29. Yoon S.O., Chikaraishi D.M. Isolation of two E-box binding factors that interact with the rat tyrosine hydroxylase enhancer. J. Biol. Chem. 269:1994;18453-18462.