Future of interventions in diabetic nephropathy: Antioxidants

Peritoneal Dialysis International

Volumn 19, Issue SUPPL. 2, 1999, Pages

  Ha, Hunjoo ^a   Kim, Kyung H ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

Advanced glycosylation end products; Antioxidants; Diabetic nephropathy; Extracellular matrix; High glucose; Oxidative stress; Protein kinase C; TGF

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; DIHYDROLIPOATE; GLUCOSE; MELATONIN; TAURINE;

BLOOD GLUCOSE MONITORING; CONFERENCE PAPER; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DISEASE COURSE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; KIDNEY FAILURE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; VASCULAR DISEASE;

EID: 0033401420     PISSN: 08968608     EISSN: None     Source Type: Journal    
DOI: 10.1177/089686089901902s38     Document Type: Conference Paper

References (59)

1. Agodoa LY, Egger PW. Renal replacement therapy in the United States: Data from the United States Renal Data System. Am J Kidney Dis. 1995; 25:119-33.
2. The Korean Society of Nephrology. Renal replacement therapy in Korea - Insan Memorial Registry 1996. Korean J Nephrol. 1997; 16(Suppl 2):S1-26.
3. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complication in insulin-dependent diabetes mellitus. N Engl J Med. 1993; 329:977-86.
4. Maxwell SRJ, Lip GYH. Free radicals and antioxidants in cardiovascular disease. Br J Clin Pharmacol. 1997; 43:307-17.
5. Schreck R, Rieber P, Baeuerle PA. Reactive oxygen intermediates as apparently widely used messengers in the activation of NF-KB transcription factor and HIV-1. EMBO J. 1991; 10:2247-58.
6. 2 for platelet-derived growth factor signal transduction. Science. 1995; 270:296-9.
7. Burdon RH. Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radic Biol Med. 1995; 18:775-94.
8. Sen CK, Packer L. Antioxidant and redox regulation of gene transcription. FASEB J. 1996; 10:109-20.
9. Irani K, Xia Y, Zweier JL, Sollott SJ, Der CJ, Feron ER, et al. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblast. Science. 1997; 275:1649-52.
10. Nath KA, Salahudeen AK. Induction of renal growth and injury in the intact rat kidney by dietary deficiency of antioxidants. J Clin Invest. 1990; 86:1179-92.
11. Nath KA, Grande J, Croatt A, Haugen J, Kim Y, Rosenberg ME. Redox regulation of renal DNA synthesis, transforming growth factor-β1 and collagen gene expression. Kidney Int. 1998; 53:367-81.
12. Border WA, Noble NA. Transforming growth factor β in tissue fibrosis. N Engl J Med. 1994; 331:1286-92.
13. Ha H, Kim KH. Role of protein kinase C-mediated oxidative stress in increased TGF-β and fibronectin mRNAs in mesangial cells: Implications for diabetic nephropathy [Abstract]. Nephrology. 1997; 3(Suppl 1):A736.
14. King GL, Ishii H, Koya D. Diabetic vascular dysfunctions: A model of excessive activation of protein kinase C. Kidney Int. 1997; 52(Suppl 60):S77-85.
15. Williamson JE, Chang K, Frangos M, Hasan KS, Ido Y, Kawamura T, et al. Hyperglycemic pseudohypoxia and diabetic complications. Diabetes. 1993; 42:801-13.
16. Derubertis FR, Craven PA. Eicosanoids in the pathogenesis of the functional and structural alterations of the kidney in diabetes. Am J Kidney Dis. 1993; 22: 828-35.
17. Brownlee M, Cerami A, Vlassara H. Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. N Engl J Med. 1988; 318:1315-21.
18. Wolff SP, Jiang ZY, Hunt JV. Protein glycation and oxidative stress in diabetes mellitus and aging. Free Radic Biol Med. 1991; 10:339-52.
19. King GL, Brownlee M. The cellular and molecular mechanisms of diabetic complications. Endocrinol Metab Clin North Am. 1996; 25:255-70.
20. Shah SV. Light emission by isolated rat glomeruli in response to phorbol myristate acetate. J Lab Clin Med. 1981; 98:46-56.
21. Myanoshita A, Takahash T, Endou H. Inhibitory effect of cyclic AMP on phorbol-stimulated production of reactive oxygen metabolites in rat glomeruli. Biochem Biophys Res Commun. 1989; 30:519-25.
22. Ha H, Endou H. Lipid peroxidation in isolated rat nephron segments. Am J Physiol. 1992; 263:F201-7.
23. Ruiz-Munoz LM, Vidal-Vanaclocha F, Lampreabe I. Enalapril inhibits hydrogen peroxide production by murine mesangial cells exposed to high glucose concentrations. Nephrol Dial Transplant. 1997; 12:456-64.
24. Gopalkrishna R, Anderson WB. Reversible oxidative activation and inactivation of protein kinase C by the mitogen/tumor promotor periodate. Arch Biochem Biophys. 1991; 285:382-7.
25. Gschwendt M, Kittstein W, Marks F. Protein kinase C activation by phorbol esters: Do cysteine rich regions and pseudosubstrate motifs play a role? Trends Biochem Sci. 1991; 16:167-9.
26. Studer RK, Craven PA, Derubertis FR. Antioxidant inhibition of protein kinase C-signaled increase in transforming growth factor-beta in mesangial cells. Metabolism. 1997; 46:918-25.
27. Tada H, Ishii H, Isogai S. Protective effect of D-alpha-tocopherol on the function of human mesangial cells exposed to high glucose concentrations. Metabolism: 1997; 46:779-84.
28. Vlassara H. Recent progress in advanced glycation end products and diabetic complications. Diabetes. 1997; 46(Suppl 2):S19-25.
29. Lee HB, Cha MK, Song KI, Kim JH, Lee EY, Kim SI, et al. Pathogenic role of advanced glycosylation end products in diabetic nephropathy. Kidney Int. 1997; 52(Suppl 60):S60-5.
30. Fu M-X, Wells-Knecht KJ, Blackledge JA, Lyons TJ, Thorper SR, Baynes JW. Glycation, glycoxidation, and cross-linking of collagen by glucose. Kinetics, mechanisms, and inhibition of late stage of the Maillard reaction. Diabetes. 1994; 43:676-83.
31. Giardino I, Edelstein D, Brownlee M. BCL-2 expression or antioxidants prevent hyperglycemia-induced formation of intracellular advanced glycation endproducts in bovine endothelial cells. J Clin Invest. 1996; 97:1422-8.
32. Yan SD, Schmidt AM, Anderson GM. Enhanced cellular oxidant stress by the interaction of advanced glycosylation end products with their receptors/binding proteins. J Biol Chem. 1994; 269:9889-97.
33. Wautier JL, Chappeym O, Wautier MP, Hori O, Stern D, Schmidt AM. Receptor-mediated endothelial dysfunction in diabetic vasculopathy: sRAGE blocks hyperpermeability. J Clin Invest. 1996; 97:238-43.
34. Bierhaus A, Chevion S, Chevion M, Hofmann M, Quehenberger P, Illmer T, et al. Advanced glycation end product-induced activation of NF-KB is suppressed by α-lipoic acid in cultured endothelial cells. Diabetes. 1997; 46:1481-90.
35. Salahudeen AK, Kanji V, Reckelhoff JF, Schmidt AM. Pathogenesis of diabetic nephropathy: A radical approach. Nephrol Dial Transplant. 1997; 12:664-8.
36. Ha H, Kamanna VS, Kirschenbaum MA, Kim KH. Role of glycated low density lipoprotein in mesangial extracellular matrix synthesis. Kidney Int. 1997; 52(Suppl 60):S54-9.
37. Ha H, Tojo A, Endou H. Proximal tubular dysfunction as a cause of diabetic microalbuminuria [Abstract]. Physiologist. 1991; 34:249.
38. Ha H, Kim C, Son Y, Chung MH, Kim KH. DNA damage in the kidneys of diabetic rats exhibiting microalbuminuria. Free Radic Biol Med. 1994; 16:271-4.
39. Kakkar R, Mantha SV, Radhi J, Prasad K, Kalra J. Antioxidant defense system in diabetic kidney: A time course study. Life Sci. 1997; 60:667-79.
40. Morgensen CE. Natural history of renal function abnormalities in human diabetes mellitus: From normoalbuminuria to incipient and overt nephropathy. In: Brenner BM, Stein JH, eds. The Kidney in Diabetes Mellitus. New York: Churchill Livingstone; 1989:19-49.
41. Ha H, Yoon SJ, Kim KH. High glucose can induce lipid peroxidation in the isolated rat glomeruli. Kidney Int. 1994; 46:1620-6.
42. Trachtman H, Futterweit S, Bienkowski RS. Taurine prevents glucose-induced lipid peroxidation and increased collagen production in cultured rat mesangial cells. Biochem Biophys Res Commun. 1993; 191:759-65.
43. Trachtman H. Vitamin E prevents glucose-induced lipid peroxidation and increased collagen production in cultured rat mesangial cells. Microvasc Res. 1994; 47:232-9.
44. Ha H, Lee SH, Kim KH. Effects of rebamipide in a model of experimental diabetes on the synthesis of transforming growth factor-β and fibronectin, and lipid peroxidation induced by high glucose in cultured mesangial cells. J Pharmacol Exp Ther. 1997; 281: 1457-62.
45. Steffes MW, Osterby R, Chavers B, Mauer SM. Mesangial expansion as a central mechanism for loss of kidney function in diabetic patients. Diabetes. 1984; 38:1077-81.
46. Ayo SH, Radnik RA, Garoni J, Glass WF II, Kreisberg JI. High glucose causes an increase in extracellular matrix proteins in cultured mesangial cells. Am J Pathol. 1990; 136:1339-48.
47. Ayo SH, Radnik RA, Glass WF II, Garoni J, Rampt ER, Appling ER, et al. Increased extracellular matrix synthesis and mRNA in mesangial cells grown in high glucose medium. Am J Physiol. 1991; 260:F185-91.
48. Ziyadeh F, Han DC. Involvement of transforming growth factor-β and its receptors in the pathogenesis of diabetic nephropathy. Kidney Int. 1997; 52(Suppl 60):S7-11.
49. Maxwell SR, Thomason H, Sandler D, LeGuen C, Baxter MA, Thorpe GH, et al. Poor glycemic control is associated with reduced serum free radical scavenging (antioxidant) activity in non-insulin-dependent diabetes mellitus. Ann Clin Biochem. 1997; 34:638-14.
50. Maxwell SRJ, Thomason H, Sandler D, LeGuen C, Baxter MA, Thorpe GHG, et al. Antioxidant status in patients with uncomplicated insulin-dependent and non-insulin-dependent diabetes mellitus. Eur J Clin Invest. 1997; 27:484-90.
51. Nourooz-Zadeh J, Rahimi A, Tajaddini-Sarmadi J, Tritschler H, Rosen P, Halliwell B, et al. Relationships between plasma measures of oxidative stress and metabolic control in NIDDM. Diabetologia. 1997; 40:647-53.
52. Santini SA, Marra G, Giardina B, Cotroneo P, Mordente A, Martorana GE, et al. Defective plasma antioxidant defenses and enhanced susceptibility to lipid peroxidation in uncomplicated IDDM. Diabetes. 1997; 46:1853-8.
53. Craven PA, DeRubertis FR, Kagan VE, Melhem M, Studer RK. Effects of supplementation with vitamin C or E on albuminuria, glomerular TGF-β, and glomerular size in diabetes. J Am Soc Nephrol. 1997; 8:1405-11.
54. Koya D, Lee I-K, Ishihi H, Kanoh H, King GL. Prevention of glomerular dysfunction in diabetic rats by treatment of d-α-tocopherol. J Am Soc Nephrol. 1997; 8:426-35.
55. Ha H, Kim KH. Role of oxidative stress in the development of diabetic nephropathy. Kidney Int. 1995; 48(Suppl 51):S18-21.
56. Trachtman H, Futterweit S, Maesaka J, Ma C, Valderrama E, Fuchs A, et al. Taurine ameliorates chronic streptozotocin-induced diabetic nephropathy in rats. Am J Physiol. 1995; 269:F429-38.
57. Ha H, Yu MR, Kim KH. Melatonin and taurine reduce early glomerulopathy in diabetic rats. Free Radic Biol Med. 1999; 26: (in press).
58. Packer L, Witt EH, Tritschler HJ. Alpha-lipoic acid as a biological antioxidant. Free Radic Biol Med. 1995; 19:227-50.
59. Gerstein HC, Bosch J, Pogue J, Taylor DW, Zinman B, Yusuf S. Rationale and design of a large study to evaluate the renal and cardiovascular effects of an ACE inhibitor and vitamin E in high-risk patients with diabetes. The MICRO-HOPE study. Diabetes Care. 1996; 19:1225-8.