Immunological models of type 1 diabetes

Hormone Research

Volumn 52, Issue 1, 1999, Pages 1-10

  Luppi, Patrizia ^a   Trucco, Massimo ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Bystander proliferation; Enteroviruses; Histocompatibility antigens; Molecular mimicry; Superantigens; Tolerance

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; INSULIN;

AUTOIMMUNE DISEASE; AUTOIMMUNITY; ENVIRONMENTAL FACTOR; HUMAN; INFECTION; INSULIN DEPENDENT DIABETES MELLITUS; MOLECULAR MIMICRY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE ACTIVATION;

EID: 0033401020     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000023424     Document Type: Review

References (44)

1. Bach JF: Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr Rev 1994; 15:516-542.
2. Conrad B, Weidmann E, Trucco G, Rudert WA, Ricordi C, Rodriquez-Rilo H, Behboo R, Finegold D, Trucco M: Evidence for superantigen involvement in insulin-dependent diabetes mellitus etiology. Nature 1994;371:351-355.
3. Pietropaolo M, Eisenbarth GS: Molecular targets of the autoimmunity of type I diabetes; in Draznin B, LeRoith D (eds): Molecular Biology of Diabetes. Totowa, Humana Press, 1994, pp 1-33.
4. Lipton RB, Kocova M, LaPorte RE, Dorman JD, Orchard TJ, Riley WJ, Drash AL, Becker DL, Trucco M: Autoimmunity and genetics contribute to the risk of insulin-dependent diabetes mellitus in families: Islet cell antibodies and HLA DQ heterodimers. Am J Epidemiol 1992;136:503-512.
5. Pietropaolo M, Peakman M, Pietropaolo SL, Zanone MM, Foley TP, Becker DJ, Trucco M: Combined analysis of GAD65 and ICA512(IA 2) autoantibodies in organ and non-organ specific autoimmune diseases confers high specificity for insulin-dependent diabetes mellitus. J Autoimmun 1998;11:1-10.
6. Eisenbarth GS: Type I diabetes mellitus. A chronic autoimmune disease. N Engl J Med 1986;314:1360-1368.
7. Delovitch T, Sing B: The non-obese diabetic mouse as a model of autoimmune diabetes: Immune dysregulation gets the NOD. Immunity 1997;7:727-738.
8. Katz J, Wang B, Haskins K, Benoist C, Mathis D: Following a diabetogenic T cell from genesis through pathogenesis. Cell 1993;74:1089-1100.
9. Haskins K, McDuffie M: Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T-cell clone. Science 1990;249:1433-1436.
10. Katz JD, Benoist C, Mathis M: T helper cell subsets in insulin-dependent diabetes mellitus. Science 1995;268:1185-1188.
11. Rapoport MJ, Jaramillo A, Zipris D, Lazarus AH, Serreze DV, Leiter EH, Cyopick P, Danska JS, Delovitch TL: Interleukin-4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J Exp Med 1993;178:87-99.
12. Rabinovich A, Suarez-Pinzon WL, Sorensen O, Bleackey RC, Power RF: IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice. J Immunol 1995; 154:4874-4882.
13. Wang Bo, André I, Gonzales A, Katz JD, Aguet M, Benoist C, Mathis D: Interferon-γ impacts at multiple points during the progression of autoimmune diabetes. Proc Natl Acad Sci USA 1997;94:13844-13849.
14. Hussain MJ, Pcakman M, Gallati H, Lo SS, Hawa M, Viberti GC, Watkins PJ, Leslie RD, Vergani D: Elevated serum of macrophage-derived cytokines precede and accompany the onset of IDDM. Diabetologia 1996;39:60-69.
15. Serreze DV, Chapman HC, Varnum DS, Hanson MS, Reifsnyder PC, Richard SD, Fleming SA, Leiter EH, Shultz LD: B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: Analysis of a new 'speed congenic' stock of NOD.Ig mu null mice. J Exp Med 1996;184:2049-2053.
16. Noorchashm H, Noorchashm N, Kern J, Rostami SY, Barker CF, Naji A: B-cells are required for the initiation of insulitis and sialitis in nonobese diabetic mice. Diabetes 1997;46: 941-946.
17. Dylan D, Wegmann DR: Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc Natl Acad Sci USA 1996; 93:956-960.
18. Tian J, Atkinson MA, Clare-Salzler M, Herschenfeld A, Forsthuber T, Lehmann PV, Kaufman DL: Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J Exp Med 1996;183: 1561-1567.
19. Gianani R, Eisenbarth GS: Predication and prevention of type I diabetes. J Endocrinol Invest. 1994;17:533-543.
20. Todd JA, Fronek Z, Jacobs CO, McDevitt M, Sinha AA, Acha-Orbea H, Bell JI, Chao N, Fronek Z, Jacobs CO, McDermott M, Sinha AA, Timmerman L, Steinman, McDevitt HO: A molecular basis for MHC-associated autoimmunity. Science 1988;240:1003-1009.
21. Gutierrez-Lopez MD, Bertera S, Chantres MT, Vavassori C, Dorman JS, Trucco M, Serrano-Rios M: Susceptibility to type I (insulin-dependent) diabetes mellitus in Spanish patients correlates quantitatively with expression of HLA-DQαArg52 and HLA DQβnon-Asp alleles. Diabetologia 1992;35:583-588.
22. Tisch R, Yang X-D, Singer SM, Liblau RS, Fugger L, McDevitt HO: Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 1993;366:72-75.
23. Pette M, Fujita K, Wilkinson D, Altmann DM, Trowsdale J, Giegerich G, Hinkkanen A, Epplen JT, Kappos L, Wekerle H: Myelin autoreactivity in multiple sclerosis: Recognition of myelin basic prolein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors. Proc Natl Acad Sci USA 1990;87:7968-7972.
24. Webb S, Morris C, Sprent J: Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity. Cell 1990;63:1249-1256.
25. King C, Davies J, Mueller R, Lee M-S, Krahl T, Yeung B, O'Connor E, Sarvetnick N: TGF-β1 alters APC preference, polarizing islet antigen responses toward a Th2 phenotype. Immunity 1998;8:601-613.
26. Oldstone MBA: Molecular mimicry and immune-mediated diseases. FASEB J 1998;12: 1255-1265.
27. Szopa TM, Titchener PA, Portwood ND, Taylor KW: Diabetes mellitus due to viruses -Some recent developments. Diabetologia 1993; 36:687-695.
28. Clements GB, Galbraith DN, Taylor KW: Coxsackie B virus infection and onset of childhood diabetes. Lancet 1995;346:221-223.
29. Yoon JW, Austin M, Onodera T, Notkins AL: Virus-induced diabetes mellitus: Isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N Engl J Med 1979;300:1173-1179.
30. Luppi P, Rudert WA, Zanone MM, Stassi G, Trucco G, Finegold D, Boyle GJ, Del Nido P, McGowan FX, Trucco M: Idiopathic dilated cardiomyopathy: A superantigen-driven autoimmune disease. Circulation 1998;98:777-785.
31. Wucherpfennig KW, Strominger JL: Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein. Cell 1995;80: 695-705.
32. Wucherpfennig KW, Strominger JL: Selective binding of self peptides to disease-associated major histocompatibility complex (MHC) molecules: A mechanism for MHC-linked susceptibility to human autoimmune diseases. J Exp Med 1995;181:1597-1601.
33. Kaufman DL, Erlander MG, Clare-Salzler M, Atkinson MA, Maclaren NK, Tobin AJ: Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus. J Clin Invest 1992;89:283-292.
34. Tian J, Lehmann PV, Kaufman DL: T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele. J Exp Med 1994;180:1979-1984.
35. Honeyman MC, Stone NL, Harrison LC: T-cell epitopes in type I diabetes autoantigen tyrosine phosphatase 1A-2: Potential for mimicry with rotavirus and other environmental agents. Mol Med 1998;4:231-239.
36. Oldstone MBA, Nerenberg M, Southern P, Price J, Lewicki H: Virus infection triggers IDDM in a transgenic model: Role of the antiself (virus) immune response. Cell 1991;65: 319-331.
37. Marrack P, Kappler JW: The staphylococcal enterotoxins and their relatives. Science 1990; 248:705-711.
38. Luppi P, Zanone MM, Rudert WA, Pietropaolo M, Alexander A, Bertera S, Gottlieb P, Becker D, Trucco M: Pedominance of the TCR Vβ7 gene family in pancreatic and in circulating T cells from type I diabetes patients, submitted.
39. Luppi P, Trucco M: Superantigens in insulin dependent diabetes mellitus (review). Springer Semin Immunopathol 1996;17:333-362.
40. Conrad B, Weissmahr RN, Boni J, Arcari R, Schupbach J, Mach B: A human endogenous retroviral superantigen as candidate autoimmune gene in type I diabetes. Cell 1997;90: 303-313.
41. Murphy VJ, Harrison LC, Rudert WA, Luppi P, Trucco M, Fierabracci A, Biro PA, Bottazzo GF: Retroviral superantigens and type I diabetes mellitus. Cell 1998;95:9-11.
42. Tough DF, Borrow P, Sprent J: Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science 1996;272: 1947-1950.
43. Horwitz MS, Bradley LM, Harbertson J, Krahl T, Lee J, Sarvetnick: Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry. Nat Med 1998;4: 781-785.
44. Weekerle H: The viral triggering of autoimmune disease. News & Views. Nat Med 1998;4: 770-771.