메뉴 건너뛰기




Volumn 19, Issue 12, 1999, Pages 2945-2951

Hyperlipidemia of ApoE2(Arg158-Cys) and ApoE3-Leiden transgenic mice is modulated predominantly by LDL receptor expression

Author keywords

Apolipoprotein E; Hypertriglyceridemia; LDL receptor; LDL receptor related protein; VLDL triglyceride lipolysis

Indexed keywords

APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

EID: 0033396449     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.19.12.2945     Document Type: Article
Times cited : (10)

References (35)
  • 1
    • 0024299370 scopus 로고
    • Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology
    • Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. 1988;240:622-630.
    • (1988) Science , vol.240 , pp. 622-630
    • Mahley, R.W.1
  • 2
    • 0001225364 scopus 로고
    • Type III hyperlipoproteinemia (dysbetalipoproteinemia): The role of apolipoprotein e in normal and abnormal lipoprotein metabolism
    • Scriver CR, Beaudet AL, Sly WS, Valle D, eds. New York, NY: McGraw-Hill Inc
    • Mahley RW, Rail SC Jr. Type III hyperlipoproteinemia (dysbetalipoproteinemia): the role of apolipoprotein E in normal and abnormal lipoprotein metabolism. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic Basis of Inherited Disease. 6th ed. New York, NY: McGraw-Hill Inc; 1989:1195-1213.
    • (1989) The Metabolic Basis of Inherited Disease. 6th Ed. , pp. 1195-1213
    • Mahley, R.W.1    Rail S.C., Jr.2
  • 3
    • 0026718601 scopus 로고
    • The role of apolipoprotein E genetic variants in lipoprotein disorders
    • Rail SC Jr, Mahley RW. The role of apolipoprotein E genetic variants in lipoprotein disorders. J Intern Med. 1992;231:653-659.
    • (1992) J Intern Med. , vol.231 , pp. 653-659
    • Rail S.C., Jr.1    Mahley, R.W.2
  • 6
    • 0028268018 scopus 로고
    • The two-receptor model of lipoprotein clearance: Tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins
    • Ishibashi S, Herz J, Maeda N, Goldstein JL, Brown MS. The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins. Proc Natl Acad Sci U S A. 1994;91:4431-4435.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 4431-4435
    • Ishibashi, S.1    Herz, J.2    Maeda, N.3    Goldstein, J.L.4    Brown, M.S.5
  • 7
    • 0028917252 scopus 로고
    • Lipoprotein and receptor interactions in vivo
    • Herz J, Willnow TE. Lipoprotein and receptor interactions in vivo. Curr Opin Lipidol. 1995;6:97-103.
    • (1995) Curr Opin Lipidol. , vol.6 , pp. 97-103
    • Herz, J.1    Willnow, T.E.2
  • 8
    • 0028172032 scopus 로고
    • The role of alpha 2 M receptor/LRP in chylomicron remnant metabolism
    • Beisiegel U, Krapp A, Weber W, Olivecrona G. The role of alpha 2 M receptor/LRP in chylomicron remnant metabolism. Ann N Y Acad Sci. 1994;737:53-69.
    • (1994) Ann N Y Acad Sci. , vol.737 , pp. 53-69
    • Beisiegel, U.1    Krapp, A.2    Weber, W.3    Olivecrona, G.4
  • 9
    • 0025786502 scopus 로고
    • 39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor
    • Herz J, Goldstein JL, Strickland DK, Ho YK, Brown MS. 39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. J Biol Chem. 1991;266: 21232-21238.
    • (1991) J Biol Chem. , vol.266 , pp. 21232-21238
    • Herz, J.1    Goldstein, J.L.2    Strickland, D.K.3    Ho, Y.K.4    Brown, M.S.5
  • 10
    • 0028284556 scopus 로고
    • Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist
    • Willnow TE, Sheng Z, Ishibashi S, Herz J. Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist. Science. 1994;264:1471-1474.
    • (1994) Science , vol.264 , pp. 1471-1474
    • Willnow, T.E.1    Sheng, Z.2    Ishibashi, S.3    Herz, J.4
  • 11
    • 0032004972 scopus 로고    scopus 로고
    • Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants
    • Rohlmann A, Gotthardt M, Hammer RE, Herz J. Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants. J Clin Invest. 1998;101:689-695.
    • (1998) J Clin Invest. , vol.101 , pp. 689-695
    • Rohlmann, A.1    Gotthardt, M.2    Hammer, R.E.3    Herz, J.4
  • 12
    • 0027258140 scopus 로고
    • Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
    • Ishibashi S, Brown MS, Goldstein JL, Gerard RD, Hammer RE, Herz J. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery [see comments]. J Clin Invest. 1993;92:883-893.
    • (1993) J Clin Invest. , vol.92 , pp. 883-893
    • Ishibashi, S.1    Brown, M.S.2    Goldstein, J.L.3    Gerard, R.D.4    Hammer, R.E.5    Herz, J.6
  • 14
    • 13344269692 scopus 로고    scopus 로고
    • Modulation of very low density lipoprotein production and clearance contributes to age- And gender-dependent hyperlipoproteinemia in apolipoprotein E3-Leiden transgenic mice
    • van Vlijmen BJ, van 't Hof HB, Mol MJ, van der Boom H, van der Zee A, Frants RR, Hofker MH, Havekes LM. Modulation of very low density lipoprotein production and clearance contributes to age- and gender-dependent hyperlipoproteinemia in apolipoprotein E3-Leiden transgenic mice. J Clin Invest. 1996;97:1184-1192.
    • (1996) J Clin Invest. , vol.97 , pp. 1184-1192
    • Van Vlijmen, B.J.1    Van 't Hof, H.B.2    Mol, M.J.3    Van Der Boom, H.4    Van Der Zee, A.5    Frants, R.R.6    Hofker, M.H.7    Havekes, L.M.8
  • 17
    • 0014088255 scopus 로고
    • The use of a non-ionic detergent (Triton WR 1339) to determine rates of triglyceride entry into the circulation of the rat under different physiological conditions
    • Otway S, Robinson DS. The use of a non-ionic detergent (Triton WR 1339) to determine rates of triglyceride entry into the circulation of the rat under different physiological conditions. J Physiol Lond. 1967;190: 321-332.
    • (1967) J Physiol Lond. , vol.190 , pp. 321-332
    • Otway, S.1    Robinson, D.S.2
  • 18
    • 0025302165 scopus 로고
    • Opposing effects of apolipoproteins e and C on lipoprotein binding to low density lipoprotein receptor-related protein
    • Kowal RC, Herz J, Weisgraber KH, Mahley RW, Brown MS, Goldstein JL. Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein. J Biol Chem. 1990;265: 10771-10779.
    • (1990) J Biol Chem. , vol.265 , pp. 10771-10779
    • Kowal, R.C.1    Herz, J.2    Weisgraber, K.H.3    Mahley, R.W.4    Brown, M.S.5    Goldstein, J.L.6
  • 19
    • 0025873539 scopus 로고
    • Clearance of chylomicron remnants by the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor
    • Hussain MM, Maxfield FR, Mas Oliva J, Tabas I, Ji ZS, Innerarity TL, Mahley RW. Clearance of chylomicron remnants by the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. J Biol Chem. 1991;266:13936-13940.
    • (1991) J Biol Chem. , vol.266 , pp. 13936-13940
    • Hussain, M.M.1    Maxfield, F.R.2    Mas Oliva, J.3    Tabas, I.4    Ji, Z.S.5    Innerarity, T.L.6    Mahley, R.W.7
  • 21
    • 0027990682 scopus 로고
    • Secretion-capture role for apolipoprotein e in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans
    • Ji ZS, Fazio S, Lee YL, Mahley RW. Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans. J Biol Chem. 1994;269:2764-2772.
    • (1994) J Biol Chem. , vol.269 , pp. 2764-2772
    • Ji, Z.S.1    Fazio, S.2    Lee, Y.L.3    Mahley, R.W.4
  • 24
    • 0027934205 scopus 로고
    • Triglyceride-rich lipoproteins of subjects heterozygous for apolipoprotein E2(Lys146→Gln) are inefficiently converted to cholesterol-rich lipoproteins
    • Mulder M, van der Boom H, de Knijff P, Braam C, van den Maagdenberg A, Leuven JA, Havekes LM. Triglyceride-rich lipoproteins of subjects heterozygous for apolipoprotein E2(Lys146→Gln) are inefficiently converted to cholesterol-rich lipoproteins. Atherosclerosis. 1994;108: 183-192.
    • (1994) Atherosclerosis , vol.108 , pp. 183-192
    • Mulder, M.1    Van Der Boom, H.2    De Knijff, P.3    Braam, C.4    Van Den Maagdenberg, A.5    Leuven, J.A.6    Havekes, L.M.7
  • 26
    • 0032504182 scopus 로고    scopus 로고
    • Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins
    • Huang Y, Liu XQ, Rall SC Jr, Mahley RW. Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins. J Biol Chem. 1998;273:17483-17490.
    • (1998) J Biol Chem. , vol.273 , pp. 17483-17490
    • Huang, Y.1    Liu, X.Q.2    Rall S.C., Jr.3    Mahley, R.W.4
  • 27
    • 0024324398 scopus 로고
    • Inhibition of lipoprotein lipase by the receptor-binding domain of apolipoprotein E
    • McConathy WJ, Wang CS. Inhibition of lipoprotein lipase by the receptor-binding domain of apolipoprotein E. FEBS Lett. 1989;251: 250-252.
    • (1989) FEBS Lett. , vol.251 , pp. 250-252
    • McConathy, W.J.1    Wang, C.S.2
  • 28
    • 0027503301 scopus 로고
    • Different hydrolytic efficiencies of adipose tissue lipoprotein lipase on very-low-density lipoprotein subfractions separated by heparin-Sepharose cnromatography
    • Gomez Coronado D, Saez GT, Lasuncion MA, Herrera E. Different hydrolytic efficiencies of adipose tissue lipoprotein lipase on very-low-density lipoprotein subfractions separated by heparin-Sepharose cnromatography. Biochim Biophys Acta. 1993;1167:70-78.
    • (1993) Biochim Biophys Acta. , vol.1167 , pp. 70-78
    • Gomez Coronado, D.1    Saez, G.T.2    Lasuncion, M.A.3    Herrera, E.4
  • 29
    • 15844414655 scopus 로고    scopus 로고
    • Apolipoprotein e effectively inhibits lipoprotein lipase- Mediated lipolysis of chylomicron-like triglyceride-rich lipid emulsions in vitro and in vivo
    • Rensen PCN, van Berkel TJC. Apolipoprotein E effectively inhibits lipoprotein lipase- mediated lipolysis of chylomicron-like triglyceride-rich lipid emulsions in vitro and in vivo. J Biol Chem. 1996;271: 14791-14799.
    • (1996) J Biol Chem. , vol.271 , pp. 14791-14799
    • Rensen, P.C.N.1    Van Berkel, T.J.C.2
  • 30
    • 0031468464 scopus 로고    scopus 로고
    • Nascent very-low-density lipoprotein triacylglycerol hydrolysis by lipoprotein lipase is inhibited by apolipoprotein e in a dose-dependent manner
    • Jong MC, Dahlmans VE, Hofker MH, Havekes LM. Nascent very-low-density lipoprotein triacylglycerol hydrolysis by lipoprotein lipase is inhibited by apolipoprotein E in a dose-dependent manner. Biochem J. 1997;328:745-750.
    • (1997) Biochem J. , vol.328 , pp. 745-750
    • Jong, M.C.1    Dahlmans, V.E.2    Hofker, M.H.3    Havekes, L.M.4
  • 31
    • 0032523099 scopus 로고    scopus 로고
    • Hepatic apo e expression is required for remnant lipoprotein clearance in the absence of the low density lipoprotein receptor
    • Linton MF, Hasty AH, Babaev VR, Fazio S. Hepatic apo E expression is required for remnant lipoprotein clearance in the absence of the low density lipoprotein receptor. J Clin Invest. 1998;101:1726-1736.
    • (1998) J Clin Invest. , vol.101 , pp. 1726-1736
    • Linton, M.F.1    Hasty, A.H.2    Babaev, V.R.3    Fazio, S.4
  • 32
    • 0029828908 scopus 로고    scopus 로고
    • Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2
    • Huang Y, Schwendner SW, Rail SC Jr, Mahley RW. Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2. J Biol Chem. 1996;271:29146-29151.
    • (1996) J Biol Chem. , vol.271 , pp. 29146-29151
    • Huang, Y.1    Schwendner, S.W.2    Rail S.C., Jr.3    Mahley, R.W.4
  • 33
    • 0031471229 scopus 로고    scopus 로고
    • Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2
    • Huang Y, Rall SC Jr, Mahley RW. Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2. Arterioscler Thromb Vasc Biol. 1997;17: 2817-2824.
    • (1997) Arterioscler Thromb Vasc Biol. , vol.17 , pp. 2817-2824
    • Huang, Y.1    Rall S.C., Jr.2    Mahley, R.W.3
  • 34
    • 0025785658 scopus 로고
    • Type III dyslipoproteinemia in patients heterozygous for familial hypercholesterolemia and apolipoprotein E2: Evidence for a gene-gene interaction
    • Hopkins PN, Wu LL, Schumacher MC, Emi M, Hegele RM, Hunt SC, Lalouel JM, Williams RR. Type III dyslipoproteinemia in patients heterozygous for familial hypercholesterolemia and apolipoprotein E2: evidence for a gene-gene interaction. Arterioscler Thromb. 1991;11: 1137-1146.
    • (1991) Arterioscler Thromb. , vol.11 , pp. 1137-1146
    • Hopkins, P.N.1    Wu, L.L.2    Schumacher, M.C.3    Emi, M.4    Hegele, R.M.5    Hunt, S.C.6    Lalouel, J.M.7    Williams, R.R.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.