How intestinal bacteria cause disease

Journal of Infectious Diseases

Volumn 179, Issue SUPPL. 2, 1999, Pages

  Guerrant, Richard L ^a,b   Steiner, Ted S ^a,b   Lima, Aldo A M ^a,b   Bobak, David A ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; CYTOTOXIN; EXOTOXIN; PROSTAGLANDIN; THROMBOCYTE ACTIVATING FACTOR;

BACTERIAL COLONIZATION; BACTERIAL VIRULENCE; BACTERIUM ADHERENCE; CONFERENCE PAPER; CYTOKINE RELEASE; DIARRHEA; INFLAMMATORY CELL; INTESTINE FLORA; MALNUTRITION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0033385908     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/513845     Document Type: Conference Paper

References (66)

1. 1. Ernst RK, Guina T, Miller SI. How intracellular bacteria survive: surface modifications that promote resistance to host innate immune responses. J Infect Dis 1999;179(suppl 2):S328-32.
2. 1a. Guerrant RL, Thielman NM. Types of Escherichia coli enteropathogens. In: Blaser MJ, Smith PD, Ravdin JI, Greenberg HB, Guerrant RL, eds. Infections of the gastrointestinal tract. New York: Raven Press, 1995: 687-90.
3. 2. Finlay BB, Cossart P. Exploitation of mammalian host cell functions by bacterial pathogens. Science 1997;276:718-25.
4. 3. Kenny B, DeVinney R, Stein M, Reinscheid DJ, Frey EA, Finlay BB. Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells. Cell 1997;91:511-20.
5. 4. Jarvis KG, Giron JA, Jerse AE, McDaniel TK, Donnenberg MS, Kaper JB. Enteropathogenic Escherichia coli contains a putative type III secretion system necessary for the export of proteins involved in attaching and effacing lesion formation. Proc Natl Acad Sci USA 1995;92:7996-8000.
6. 5. McDaniel TK, Jarvis KG, Donnenberg MS, Kaper JB. A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens. Proc Natl Acad Sci USA 1995;92:1664-8.
7. 6. Abe P, Kenny B, Stein M, Finlay BB. Characterization of two virulence proteins secreted by rabbit enteropathogenic Escherichia coli, ESPA and ESPB, whose maximal expression is sensitive to host body temperature. Infect Immun 1997;65:3547-55.
8. 7. Hughes JM, Murad F, Chang B, Guerrant RL. Role of cyclic GMP in the action of heat-stable enterotoxins of Escherichia coli. Nature 1978;271: 755-6.
9. 8. Field M, Graf LH Jr, Mata LJ. Heat stable enterotoxin of E. coli. In vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine. Proc Natl Acad Sci USA 1978;75: 2800-4.
10. 9. Guerrant RL, Hughes JM, Chang B, Robertson DC, Murad F. Activation of intestinal guanylate cyclase by heat-stable enterotoxin of E. coli: studies of tissue specificity, potential receptors, and intermediates. J Infect Dis 1980;142:220-8.
11. 10. Garbers DL. Guanylate cyclase, a cell surface receptor. J Biol Chem 1989; 264:9103-6.
12. 11. Guerrant RL, Chen LC, Sharp GWG. Intestinal adenyl-cyclase activity in canine cholera: correlation with fluid accumulation. J Infect Dis 1972; 125:377-81.
13. 12. Kimberg DV, Field M, Johnson J, Henderson A, Gershon E. Stimulation of intestinal mucosal adenyl cyclase by cholera enterotoxin and prostaglandins. J Clin Invest 1971;50:1218-30.
14. 13. Zhang JP, Normark S. Induction of gene expression in Escherichia coli after pilus-mediated adherence. Science 1996;273:1234-6.
15. 14. Steiner TS, Lima AM, Nataro JP, Guerrant RL. Enteroaggregative Escherichia coli produce intestinal inflammation and growth impairment and cause interleukin-8 release from intestinal epithelial cells. J Infect Dis 1998;177:88-96.
16. 14a. Waldor MK, Mekalanos JJ. Lysogenic conversion by a filamentous phage encoding cholera toxin. Science 1996;272:1910-4.
17. 15. Guerrant RL, Dickens MD, Wenzel RP, Kapikian AZ. Toxigenic bacterial diarrhea: nursery outbreak involving multiple bacterial strains. J Pediatr 1976;89:885-91.
18. 16. Wachsmuth K, Wells J, Shipley P. Heat-labile enterotoxin production in isolates from a shipboard outbreak of human diarrheal illness. Infect Immun 1979;24:793-7.
19. 17. Ruiz-Palacios GM, Torres J, Torres NI, Escamilla E, Ruiz-Palacios BR, Tamayo J. Cholera-like enterotoxin produced by Campylobacter jejuni: characterization and clinical significance. Lancet 1983;2:250-3.
20. 18. Ball JM, Tian P, Zeng CQ, Morris AP, Estes MK. Age-dependent diarrhea induced by a rotaviral nonstructural glycoprotein. Science 1996;272: 101-4.
21. 19. Peterson JW, Ochoa G. Role of prostaglandins and cAMP in the secretory effects of cholera toxin. Science 1989;245:857-9.
22. 20. Herbert JM, Bernat A, Valette G, et al. Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist. J Pharmacol Exp Ther 1991;259:44-51.
23. 21. Guerrant RL, Fang GD, Thielman NM, Fonteles MC. Role of platelet activating factor (PAF) in the intestinal epithelial secretory and Chinese hamster ovary (CHO) cell cytoskeletal responses to cholera toxin. Proc Natl Acad Sci USA 1994;91:9655-8.
24. 22. Thielman NM, Marcinkiewicz M, Sarosiek J, Fang GD, Guerrant RL. The role of platelet activating factor in Chinese hamster ovary cell responses to cholera toxin. J Clin Invest 1997;99:1999-2004.
25. 23. Madara JL, Patapoff TW, Gillece-Castro B, et al. 5′-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T-84 intestinal epithelial cell monolayers. J Clin Invest 1993;91:2320-5.
26. 24. Mahida YR, Makh S, Hyde S, Gray T, Borriello SP. Effect of Clostridium difficile toxin A on human intestinal epithelial cells: induction of interleukin 8 production and apoptosis after cell detachment. Gut 1996; 38:337-47.
27. 25. Resnick MB, Colgan SP, Patapoff TW, et al. Activated eosinophils evoke chloride secretion in model intestinal epithelia primarily via regulated release of 5′-AMP. J Immunol 1993;151:5716-23.
28. 26. Rocha MFG, Maia MET, Bezerra LRPS, et al. Clostridium difficile toxin A induces the release of neutrophil chemotactic factors from rat peritoneal macrophages - role of interleukin-1-β, tumor necrosis factor alpha, and leukotrienes. Infect Immun 1997;65:2740-6.
29. 27. Bobak D, Gilmer L. Toxin A of Clostridium difficile is a potent activator of interleukin-8 synthesis by human neutrophils [abstract]. Clin Res 1994;42:150A.
30. 28. Bartlett JG. Clostridium difficile infection: pathophysiology and diagnosis. Semin Gastrointest Dis 1997;8:12-21.
31. 29. Fekety R. Guidelines for the diagnosis and management of Clostridium difficile-associated diarrhea and colitis. Am J Gastroenterol 1997;92: 739-50.
32. 30. Mitty RD, LaMont JT. Clostridium difficile colitis: epidemiology, pathophysiology, and treatment. Mt Sinai J Med 1994;61:329-35.
33. 31. Moorman JP, Bobak DA. Clostridial infections. In: Guerrant RL, Walker DH, Weller PF, eds. Tropical infectious diseases: principles, pathogens, and practice. New York: WB Saunders (in press).
34. 32. Bongaerts GP, Lyerly DM. Role of toxins A and B in the pathogenesis of Clostridium difficile disease. Microb Pathog 1994;17:1-12.
35. 33. Moncrief JS, Barroso LA, Wilkins TD. Positive regulation of Clostridium difficile toxins. Infect Immun 1997;65:1105-8.
36. 34. Pothoulakis C. Pathogenesis of Clostridium difficile-associated diarrhoea. Eur J Gastroenterol Hepatol 1996;8:1041-7.
37. 35. Fang GD, Lima AM, Adams R, Lyerly DM, Guerrant RL. Inhibition by quinacrine of the effects of C. difficile toxin A on intestinal secretion, and on T 84 cell tissue resistance and F-actin [abstract]. Clin Res 1991; 39:185A.
38. 36. Fonteles MC, Fang GD, Thielman NM, Yotseff PS, Guerrant RL. Role of platelet activating factor in the inflammatory and secretory effects of Clostridium difficile toxin A. J Lipid Mediators 1995;11:133-43.
39. 37. Aktories K. Bacterial toxins that target RHO proteins. J Clin Invest 1997; 99:827-9.
40. 38. Aktories K. Rho proteins: targets for bacterial toxins. Trends Microbiol 1997;5:282-8.
41. 39. Barroso LA, Moncrief JS, Lyerly DM, Wilkins TD. Mutagenesis of the Clostridium difficile toxin B gene and effect on cytotoxic activity. Microb Pathog 1994;16:297-303.
42. 40. von Eichel-Streiber C, Meyer ZH, Habermann E, Sartingen S. Closing in on the toxic domain through analysis of a variant Clostridium difficile cytotoxin B. Mol Microbiol 1995;17:313-21.
43. 41. von Eichel-Streiber C, Boquet P, Sauerborn M, Thelestam M. Large clostridial cytotoxins - a family of glycosyltransferases modifying small GTP-binding proteins. Trends Microbiol 1996;4:375-82.
44. 42. Just I, Selzer J, Wilm M, von Eichel-Streiber C, Mann M, Aktories K. Glucosylation of Rho proteins by Clostridium difficile toxin B. Nature 1995;375:500-3.
45. 43. Just I, Wilm M, Selzer J, et al. The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins. J Biol Chem 1995;270: 13932-6.
46. 44. Wilkins TD, Lyerly DM. Clostridium difficile toxins attack Rho. Trends Microbiol 1996;4:49-51.
47. 44a. Ciesla W, Bobak D. Clostridium difficile toxins A and B are cation-dependent UDP-glucose hydrolases with differing catalytic activities. J Biol Chem 1998;273:16021-6.
48. 45. Narumiya S, Ishizaki T, Watanabe N. Rho effectors and reorganization of actin cytoskeleton. FEBS Lett 1997;410:68-72.
49. 46. Narumiya S. The small GTPase Rho: cellular functions and signal transduction. J Biochem 1996;120:215-28.
50. 47. Ridley AJ. Rho: theme and variations. Curr Biol 1996;6:1256-64.
51. 48. Symons M. Rho family GTPases: the cytoskeleton and beyond. Trends Biochem Sci 1996;21:178-81.
52. 49. Denhardt DT. Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling. Biochem J 1996;318:729-47.
53. 50. Svanborg C, Agace W, Hedges S, Linder H, Svensson M. Bacterial adherence and epithelial cell cytokine production. Int J Med Microbiol Virol Parasitol Infect Dis 1993;278:359-64.
54. 51. Madara JL, Stafford J. Interferon-γ directly affects barrier function of cultured intestinal epithelial monolayers. J Clin Invest 1989;83:724-7.
55. 52. Checkley W, Gilman RH, Epstein LD, et al. Asymptomatic and symptomatic cryptosporidiosis: their acute effect on weight gain in Peruvian children. Am J Epidemiol 1997;145:156-63.
56. 53. Schorling JB, McAuliffe JF, de Souza MA, Guerrant RL. Malnutrition is associated with increased diarrhoea incidence and duration among children in an urban Brazilian slum. Int J Epidemiol 1990;19:728-35.
57. 54. Guerrant RL, Schorling JB, McAuliffe JF, de Souza MA. Diarrhea as a cause and effect of malnutrition: diarrhea prevents catch-up growth and malnutrition increases diarrhea frequency and duration. Am J Trop Med Hyg 1992;47:28-35.
58. 55. Checkley W, Gilman RH, Epstein LD, et al. The adverse effects of Cryptosporidium parvum infection on the growth of children. In: 5th annual meeting of the NIAID International Centers for Tropical Disease Research (ICTDR), 24-26 April 1996. Bethesda, MD: National Institute of Allergy and Infectious Diseases, 1996.
59. 56. Guerrant RL, Araujo V, Cooper WH, Lee AG. Measurement of fecal lactoferrin as a marker of fecal leukocytes and inflammatory enteritis. J Clin Microbiol 1992;30:1238-42.
60. 57. Miller JR, Barrett LJ, Kotloff K, Guerrant RL. A rapid test for infectious and inflammatory enteritis. Arch Intern Med 1994;154:2660-4.
61. 58. Choi SW, Park CH, Silva TMJ, Zaenker EI, Guerrant RL. To culture or not to culture: fecal lactoferrin screening for inflammatory bacterial diarrhea. J Clin Microbiol 1996;34:928-32.
62. 59. Martins CAP, Fonteles MC, Barrett LJ, Guerrant RL. Correlation of lactoferrin with neutrophilic inflammation in body fluids. Clin Diagn Lab Immunol 1995;2:763-5.
63. 60. Rein MF, Shih LM, Miller JR, Guerrant RL. Use of a lactoferrin assay in the differential diagnosis of female genital tract infections and implications for the pathophysiology of bacterial vaginosis. Sex Transm Dis 1996;23:517-21.
64. 61. Lima AAM, Soares AM, Freire JE Jr, Guerrant RL. Cotransport of sodium with glutamine, alanine, and glucose in the isolated rabbit ileal mucosa. Braz J Med Biol Res 1992;25:637-40.
65. + exchange in experimental porcine cryptosporidiosis. Gastroenterology 1994;106:1418-28.
66. 63. Lima AAM, Barboza MS Jr, Silva TMJ, McAuliffe I, Guerrant RL. Enteroaggregative E. coli associated with persistent diarrhea: pathophysiology and treatment with glutamine-based oral rehydration and nutrition therapy (ORNT). In: 6th annual meeting of the NIAID International Centers for Tropical Disease Research (ICTDR), 5-7 May 1997. Bethesda, MD: National Institute of Allergy and Infectious Diseases, 1997.