Mechanisms of hepatic disposition of polystyrene microspheres in rats: Effects of serum depend on the sizes of microspheres

Journal of Controlled Release

Volumn 61, Issue 3, 1999, Pages 241-250

  Ogawara, Ken ichi ^a   Yoshida, Minoru ^a   Kubo, Jun ichi ^a   Nishikawa, Makiya ^b   Takakura, Yoshinobu ^b   Hashida, Mitsuru ^b   Higaki, Kazutaka ^a   Kimura, Toshikiro ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b Grad Sch Pharmaceutical Sci   (Japan)

Author keywords

Dysopsonin; Hepatic uptake; Liver perfusion; Opsonin; Polystyrene microsphere

Indexed keywords

MICROSPHERE; OPSONIN; POLYSTYRENE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG DISPOSITION; DRUG MECHANISM; LIVER PERFUSION; MALE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; TEMPERATURE;

ANIMALS; BLOOD PROTEINS; COLD; COMPLEMENT C3; LIVER; MALE; MICROSPHERES; PARTICLE SIZE; PERFUSION; PHAGOCYTOSIS; POLYSTYRENES; PROTEIN BINDING; RATS; RATS, WISTAR;

EID: 0032883199     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(99)00121-2     Document Type: Article

References (22)

1. Liu D., Liu F., Song Y.K. Recognition and clearance of liposomes containing phosphatidylserine are mediated by serum opsonin. Biochim. Biophys. Acta. 1235:1995;140-146.
2. Rahman Y.E., Cerny E.A., Patel K.R., Lau E.H., Wright B.J. Differential uptake of liposomes varying in size and lipid composition by parenchymal and Kupffer cells of mouse liver. Life Sci. 31:1982;2061-2071.
3. Luck M., Schroder W., Paulke B.R., Muller R.H. Identification of plasma proteins adsorbed on polystyrene model particles. Proc. Int. Symp. Control. Release Bioact. Mater. 24:1997;849-850.
4. Bachofen V.K. Uptake of silica particles by isolated rat liver macrophages (Kupffer cells) is receptor mediated and can be blocked by competition. J. Clin. Invest. 90:1992;1819-1824.
5. Matsuo H., Funato K., Harashima H., Kiwada H. The complement - but not mannose receptor-mediated phagocytosis is involved in the hepatic uptake of cetylmannoside-modified liposomes in situ. J. Drug Target. 2:1994;141-146.
6. 1. Pharm. Res. 12:1995;1775-1780.
7. Moghimi S.M., Patel H.M. Serum opsonins and phagocytosis of saturated and unsaturated phospholipid liposomes. Biochim. Biophys. Acta. 984:1989;384-387.
8. Nicholas A.R., Jones M.N. The effect of blood on the uptake of liposomal lipid by perfused rat liver. Biochim. Biophys. Acta. 1074:1991;105-111.
9. Ogawara K., Nishikawa M., Takakura Y., Hashida M. Pharmacokinetic analysis of hepatic uptake of galactosylated bovine serum albumin in a perfused rat liver. J. Control. Release. 50:1998;309-317.
10. K. Ogawara, M. Yoshida, K. Higaki, T. Kimura, K. Shiraishi, M. Nishikawa, Y. Takakura, M. Hashida. Hepatic uptake of polystyrene microspheres in rats: Effect of particle size on intrahepatic distribution. J. Control. Release, 1999 (in press).
11. Yamaoka K., Nakagawa T., Uno T. Statistical moments in pharmacokinetics. J. Pharmacokinet. Biopharm. 6:1978;547-558.
12. Yamaoka K., Tanigawara Y., Tanaka H., Uno Y. A pharmacokinetic analysis program (MULTI) for microcomputer. J. Pharmacobio-Dyn. 4:1981;879-885.
13. Alberts B., Bray D., Lewis J., Raff M., Roberts K., Watson J.D. Molecular Biology of the Cell. 3rd ed :1993;599-651 Garland.
14. Nishida K., Tonegawa C., Kakutani T., Hashida M., Sezaki H. Statistical moment analysis of hepatobiliary transport of phenol red in the perfused rat liver. Pharm. Res. 6:1989;140-146.
15. Stahl P. The mannose receptor and other macrophage lectins. Curr. Opin. Immunol. 4:1992;49-52.
16. Savill J., Henson P., Haslett G. Phagocytosis of aged human neutrophils by macrophages is mediated by a novel 'charge-sensitive' recognition mechanism. J. Clin. Invest. 84:1989;1518-1527.
17. Krieger M., Herz J. Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu. Rev. Biochem. 63:1994;601-637.
18. Schnitzer J., Bravo I. High affinity binding, endocytosis, and degradation of conformationally modified albumins. J. Biol. Chem. 268:1993;7562-7570.
19. Kobzik L. Lung macrophage uptake of unopsonized environmental particles. J. Immunol. 155:1995;367-376.
20. Moghimi S.M., Muir I.S., Illum L., Davis S.S., Kolb-Bachofen V. Coating particles with a block co-polymer (poloxamine 908) suppresses opsonization but permits the activity of dysopsonins in serum. Biochim. Biophys. Acta. 1179:1993;157-165.
21. Muller R.H., Ruhl D., Luck M., Paulke B.R. Influence of fluorescent labelling of polystyrene particles on phagocytic uptake, surface hydrophobicity, and plasma protein adsorption. Pharm. Res. 14:1997;18-24.
22. Boxenbaum H. Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance extrapolation of data to benzodiazepines and phenytoin. J. Pharmacokinet. Biopharm. 8:1980;165-176.