Genes that regulate eosinophilic inflammation

American Journal of Human Genetics

Volumn 65, Issue 2, 1999, Pages 302-307

  Broide, David H ^a   Hoffman, Hal ^a   Sriramarao, P ^b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b La Jolla Institute for Experimental Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 5;

ASTHMA; CELL ADHESION; CELL DIFFERENTIATION; CHEMOTAXIS; ENDOTHELIUM CELL; EOSINOPHILIA; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REVIEW;

EID: 0033361948     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302520     Document Type: Article

References (33)

1. Abraham WM, Sielczak MW, Ahmed A, Cortes A, Lauredo IT, Kim J, Pepinsky B, et al (1994) Alpha 4-integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep. J Clin Invest 93:776-787
2. Baranger L, Szapiro N, Gardais J, Hillion J, Derre J, Francois S, Blanchet O, et al (1994) Translocation t(5;12)(q31-q33;p12-p13): a non-random translocation associated with a myeloid disorder with eosinophilia. Br J Haematol 88: 343-347
3. Broide DH, Gleich GJ, Cuomo AJ, Coburn DA, Federman EC, Schwartz LB, Wasserman SI (1991) Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway. J Allergy Clin Immunol 88:637-648
4. Broide DH, Humber D, Sullivan S, Sriramarao P (1998a) Inhibition of eosinophil rolling and recruitment in P-selectin-and intracellular adhesion molecule -1-deficient mice. Blood 91:2847-2856 (erratum: Blood 92:343)
5. Broide DH, Orozco EM, Roman M, Carson DA, Raz E (1997) Intradermal gene vaccination down-regulates both arms of the allergic response. J Allergy Clin Immunol 99:s129
6. Broide DH, Paine MM, Firestein GS (1992) Eosinophils express Interleukin 5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics. J Clin Invest 90:1414-1424
7. Broide D, Schwarze J, Tighe H, Gifford T, Nguyen, Malek S, Van Uden J, et al (1998b) Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice. J Immunol 161:7054-7062
8. Collaborative Study of the Genetics of Asthma (1997) A genome-wide search for asthma susceptibility foci in ethnically diverse populations. Nat Genet 15:389-397
9. Daniels SE, Bhattacharrya S, James A, Leaves NI, Young A, Hill MR, Faux JA, et al (1996) A genome-wide search for asthma genes in an inbred population. Am J Respir Crit Care Med 155:A257
10. Foster P. Hogan SP, Ramsay AJ, Matthaei KI, Young IG (1996) Interleukin-5 deficiency abolishes eosinophilia, airway hyperreactivity and lung damage in a mouse asthma model. J Exp Med 183:195-201
11. Gonzalo JA, Lloyd CM, Wen D, Albar JP, Wells TNC, Proud-foot A, Martinez-A C, et al (1998) The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness. J Exp Med 188: 157-167
12. 2, integrin is expressed on human eosinophils and functions as an alternative ligand for vascular cell adhesion molecule I (VCAM-1). J Exp Med 188:2187-2191
13. Heath H, Qin S, Rao P, Wu L, LaRosa G, Kassam N, Ponath PD, et al (1997) Chemokine receptor usage by human eosinophils: the importance of CCR3 demonstrated using an antagonistic monoclonal antibody. J Clin Invest 99:178-184
14. Henderson WR Jr, Chi EY, Albert RK, Chu SJ, Lamm J, Rochon Y, Jonas M, et al (1997) Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma. J Clin Invest 100:3083-3092
15. Hsu CH, Chua KY, Tao MH, Lai YL, Wu HD, Huang SK, Hsieh KH (1996) Immunoprophylaxis of allergen-induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization. Nat Med 2:540-544
16. Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, et al (1996) Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3. J Biol Chem 271:7725-7730
17. Kitayama J, Mackay CR, Ponath PD, Springer TA (1998) The C-C chemokine receptor CCR3 participates in stimulation of eosinophil arrest on inflammatory endothelium in shear flow. J Clin Invesr 101:2017-2024
18. Kline JN, Waldschmidt TJ, Businga TR, Lemish JE, Weinstock JV, Thorne PS, Krieg AM (1998) Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. J Immunol 160:2555-2559
19. Martinez FD, Solomon S, Holberg CJ, Graves PE, Baldini M, Erickson RP (1998) Linkage of circulating eosinophils to markers on chromosome 5q. Am J Respir Crit Care Med 158:1739-1744
20. Nakajima H, Sano H, Nishimura T, Yoshida S, Iwamoto I (1994) Role of vascular cell adhesion molecule I/very late activation antigen 4 and intercellular adhesion molecule 1/ lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue. J Exp Med 179:1145-1154
21. Ober C, Cox N, Parry R, Kurtz B, Lander ES, Pettersson B, Richardson A, et al (1997) Genome-wide search for asthma genes in an inbred population. Am J Respir Crit Care Med 155:A257
22. Palframan RT, Collins PD, Severs NJ, Rothery S, Williams TJ, Rankin SM (1998) Mechanisms of acute eosinophil mobilization from the bone marrow stimulated by interleukin 5: the role of specific adhesion molecules and phosphatidylinositol 3-kinase. J Exp Med 188:1621-1632
23. Phillips ML, Schwartz BR, Etzioni A, Bayer R, Ochs HD, Paulson JC, Harlan JM (1995) Neutrophil adhesion in leukocyte adhesion deficiency syndrome type 2. J Clin Invest 96: 2898-2906
24. Ponath PD, Qin S, Post TW, Wang J, Wu L, Gerard NP, Newman W, et al (1996) Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. J Exp Med 183:2437-2448
25. Rioux JD, Stone VA, Daly MJ, Cargill M, Green T, Nguyen H, Nutman T, et al (1998) Familial eosinophilia maps to the cytokine gene cluster on human chromosomal region 5q31-q33. Am J Hum Genet 63:1086-1094
26. Rothenberg ME (1998) Eosinophilia. N Engl J Med 338: 1592-1600
27. Rothenberg ME, MacLean JA, Pearlman E, Luster AD, Leder P (1997) Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. J Exp Med 185:785-90
28. Ruuls SR, Sedgwick JD (1999) Unlinking tumor necrosis factor biology from the major histocompatibility complex: lessons from human genetics and animal models. Am J Hum Genet 65:294-301 (in this issue)
29. Sriramarao P, Norton CR, Borgstrom P, DiScipio RG, Wolitzky BA, Broide DH (1996) E-selectin preferentially supports neutrophil but not eosinophil rolling under conditions of flow in vitro and in vivo. J Immunol 157:4672-4680
30. Sriramarao P, Von Andrian UH, Butcher EC, Bourdon MA, Broide DH (1994) Alpha 4 beta 1, integrin and L-selectin mediate eosinophil rolling at physiological shear rates invivo. J Immunol 153:4238-4246
31. Stine OC, Postma DA, Howard T, Koppelman GH, Bergin JS, Zheng S, Meijer GG, et al (1998) Genome screen for asthma and related phenotypes in a restricted Dutch population. Am J Respir Crit Care Med 157:A855
32. Sung KLP, Yang L, Elices M, Jin G, Sriramarao P, Broide DH (1997) GM-CSF regulates the functional adhesive state of VLA-4 expressed by eosinophils. J Immunol 158:919-927
33. Weller PF (1997) Human eosinophils. J Allergy Clin Immunol 100:283-287