A C619Y mutation in the human androgen receptor causes inactivation and mislocalization of the receptor with concomitant sequestration of SRC-1 (steroid receptor coactivator 1)

Molecular Endocrinology

Volumn 13, Issue 12, 1999, Pages 2065-2075

  Nazareth, Lynne V ^a   Stenoien, David L ^a   Bingman III, William E ^a   James, Alaina J ^a   Wu, Carol ^a   Zhang, Yixian ^a   Edwards, Dean P ^b   Mancini, Michael ^a   Marcelli, Marco ^a   Lamb, Dolores J ^a   Weigel, Nancy L ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; METRIBOLONE; STEROID RECEPTOR COACTIVATOR 1;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CASE REPORT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA BINDING; GENE INACTIVATION; GENE MUTATION; HUMAN; HUMAN CELL; MALE; MUSCLE ATROPHY; NONHUMAN; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN AGGREGATION; SOMATIC MUTATION; STEROID BINDING;

EID: 0033323810     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.13.12.0382     Document Type: Article

References (57)

1. Clinical review 37: Endocrine treatment of prostate cancer
2. Stroma-epithelial interactions in adult organs
3. Codon 877 mutation in the androgen receptor gene in advanced prostate cancer: Relation to antiandrogen withdrawal syndrome
4. Androgen receptors in endocrine-therapy-resistant human prostate cancer
5. Growth factor and oncogenes in prostate cancer
6. Transcriptional regulation of prostate kallikrein-like genes by androgen
7. The influence of hormonal therapy on survival of men with advanced prostate cancer
8. Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone
9. Molecular biology of progression of prostate cancer
10. Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor
11. Activation of the human androgen receptor through a protein kinase A signalling pathway
12. Androgen receptor gene mutations in human prostate cancer
13. Androgen receptor status in localized and locally progressive hormone refractory human prostate cancer
14. Androgen receptor alterations in prostatic carcinoma
15. Mutant androgen receptors in prostatic tumors distinguish between amino-acid-sequence requirements for transactivation and ligand binding
16. Mutation of the androgen receptor gene in metastatic androgen-independent prostate cancer
17. Low incidence of androgen receptor gene mutations in human prostatic tumors using single strand conformation polymorphism analysis
18. Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence
19. Androgen receptor mutations in prostate cancer
20. Functional characterization of mutant androgen receptors from androgen-independent prostate cancer
21. Dehydroepiandrosterone activates mutant androgen receptors expressed in the androgen-dependent human prostate cancer xenograft CWR22 and LNCaP cells
22. Identification of two germline point mutations in the 5' UTR of the androgen receptor gene in men with prostate cancer
23. Androgen receptor variants with short glutamine or glycine repeats may identify unique subpopulations of men with prostate cancer
24. Genetic alterations of androgen receptor gene in Japanese human prostate cancer
25. Solution structure of the glucocortoid receptor DNA-binding domain
26. Molecular characterization of the glucocorticoid receptor
27. Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures
28. Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3
29. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
30. Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy
31. Nonneural nuclear inclusions of androgen receptor protein in spinal, bulbar muscular atrophy
32. Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone
33. Cleavage, aggregation and toxicity of the expanded androgen receptor in spinal and bulbar muscular atrophy
34. Cloning of the human androgen receptor cDNA and localization to the X-chromosome
35. The human androgen receptor: Complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate
36. Cloning, structure and expression of a cDNA encoding the human androgen receptor
37. Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors
38. Characterization and expression of a cDNA encoding the human androgen receptor
39. Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity
40. Changes in the abundance of androgen receptor isotypes: Effects of ligand treatment, glutamine-stretch variation, and mutation of putative phosphorylation sites
41. Synthesis and post translational modification of the androgen receptor in LNCaP cells
42. Specificity of ligand-dependent androgen receptor stabilization: Receptor domain interactions influence ligand dissociation and receptor stability
43. The antagonists RU486 and ZK98299 stimulate progesterone receptor binding to deoxyribonucleic acid in vitro and in vivo, but have distinct effects on receptor conformation
44. Interaction of androgen receptors with androgen response element in intact cells
45. Nuclear import of the human androgen receptor
46. Prevalence of androgen receptor gene mutations in latent prostatic carcinomas from Japanese men
47. Growth stimulus-mediated differential translocation of casein kinase 2 to the nuclear matrix. Evidence based on androgen action in the prostate
48. Nuclear association of cyclin D1 in human fibroblasts: Tight binding to nuclear structures and modulation by protein kinase inhibitors
49. A-kinase anchoring protein 100 (AKAP100) is localized in multiple subcellular compartments in the adult rat heart
50. Analysis of chicken progesterone receptor function and phosphorylation using an adenovirus-mediated procedure for high efficiency DNA transfer
51. Modulation by vitamin B6 of glucocorticoid receptor-mediated gene expression requires transcription factors in addition to the glucocorticoid receptor
52. A rapid and sensitive method for quantification of microgram quantities of protein utilizing the principle of protein-dye binding
53. Multiple signaling pathways activate the chicken progesterone receptor
54. Ligands induce conformational changes in the carboxyl-terminus of progesterone receptors which are detected by a site-directed antipeptide monoclonal antibody
55. Assay for estrogen and progesterone receptors of breast cancer cell lines in monolayer culture
56. Molecular interactions of steroid hormone receptor with its enhancer element: Evidence for receptor dimer formation
57. Antibodies to chicken progesterone receptor peptide 523-536 recognize a site exposed in receptor-deoxyribonucleic acid complexes but not in receptor-heat shock protein-90 complexes