Antiinsulin receptor autoantibodies induce insulin receptors to constitutively associate with insulin receptor substrate-1 and -2 and cause severe cell resistance to both insulin and insulin-like growth factor I

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 9, 1999, Pages 3197-3206

  Auclair, Martine ^a   Vigouroux, Corinne ^a,b   Desbois Mouthon, Christèle ^a   Deibener, Joëlle ^c   Kaminski, Pierre ^c   Lascols, Olivier ^a   Cherqui, Gisèle ^a   Capeau, Jacqueline ^a,b   Caron, Martine ^a  

^a INSERM   (France)

^b HÔPITAL ROTHSCHILD   (France)

^c CHU NANCY BRABOIS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INSULIN ANTIBODY; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; SOMATOMEDIN C;

AGED; ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; BINDING SITE; CASE REPORT; CELL SURFACE; CHO CELL; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; INSULIN BINDING; INSULIN RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALIA;

EID: 0033305302     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.84.9.3197     Document Type: Article

References (53)

1. Insulin and insulin-like growth factor I receptors: Are there functional distinctions?
2. Signalling through the insulin receptor and the insulin-like growth factor-1 receptor
3. The IRS-signalling system: A network of docking proteins that mediate insulin action
4. Effect of intravenous insulin like growth factor 1 in two patients with leprechaunism
5. Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors
6. Severe resistance to insulin and insulin-like growth factor-1 in cells from a patient with leprechaunism as a result of two mutations in the tyrosine kinase domain of the insulin receptor
7. Dissection of the growth vs. metabolic effects of insulin and insuLin-like growth factor-1 in transfected cells expressing kinase-defective human insulin receptors
8. Signal transduction pathways leading to insulin-induced early gene induction
9. The dominant negative effect of a kinase-defective insulin receptor on insulin-like growth factor-1-stimulated signaling in rat-1 fibroblasts
10. Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance
11. Syndromes of severe insulin resistance
12. Antireceptor antibodies as probes of insulinlike growth factor receptor structure
13. Antibodies to insulin-like growth factor 1 receptors in diabetes and other disorders
14. Effects of autoantibodies to the insulin receptor on isolated adipocytes. Studies of insulin binding and insulin action
15. Desensitization of the insulin receptor at an early post-receptor step by prolonged exposure to antireceptor antibody
16. Antibody-induced desensitization of the insulin receptor: Studies of the mechanism of desensitization in 3T3-L1 fatty fibroblasts
17. Autoantibodies against the insulin receptor. Dissociation of the acute effects of the antibodies from the desensitization seen with prolonged exposure
18. Antibody against the insulin receptor causes disappearance of insulin receptors in 3T3-L1 cells: A possible explanation of antibody-induced insulin resistance
19. Anti-receptor antibodies mimic the effect of insulin to down-regulate insulin receptors in cultured human lymphoblastoid (IM-9) cells
20. Effects of anti-insulin receptor antibodies (AIRA) on downregulation and turnover of insulin receptors on cultured hepatocytes
21. Insulin differentially regulates SAPKs/JNKs and ERKs in CHO cells overexpressing human insulin receptors
22. 281 in the α-subunit of the human insulin receptor causes constitutive activation of the receptor and insulin desensitization
23. Insulin/IGF-I hybrid receptors: Implications for the dominant-negative phenotype in syndromes of insulin resistance
24. Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways
25. Insulin receptor structural requirements for the formation of a ternary complex with IRS-1 and PI 3-kinase
26. The IRS-signalling system during insulin and cytokine action
27. Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog
28. Alternative pathway of insulin signalling in mice win targeted disruption of the IRS-1 gene
29. Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1
30. Platelet-derived growth factor receptor signals
31. The signaling pathway coupling epidermal growth factor receptors to activation of p21(ras)
32. Simultaneous insulinlike growth factor I and insulin resistance in obese Zucker rat
33. Physiological concentrations of insulin induce cellular desensitization to the mitogenic effects of insulin-like growth factor 1
34. Investigation of the mechanism of the dominant negative effect of mutations in the tyrosine kinase domain of the insulin receptor
35. Crystal structure of the tyrosine kinase domain of the human insulin receptor
36. Interaction between the insulin receptor and its downstream effectors. Use of individually expressed receptor domains for structure/function analysis
37. Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786
38. Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like growth factor receptor
39. Insulin and insulin-like growth factor-1 signal transduction requires p21(ras)
40. New frontiers in insulin receptor substrate signaling
41. Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains
42. The insulin signalling system and the IRS proteins
43. Interaction between the phosphotyrosine binding domain of Shc and the insulin receptor is required for Shc phosphorylation by insulin in vivo
44. IRS-1 is a common element in insulin and insulin-like growth factor-1 signaling to phosphatidylinositol 3'- kinase
45. Phosphatidylinositol 3-kinase functions upstream of Ras and Raf in mediating insulin stimulation of c-fos transcription
46. The SH2/SH3 domain containing protein GRB2 interacts with tyrosine-phosphorylated IRS-1 and SHC: Implications for insulin control of ras signalling
47. Role of IRS-1-Grb-2 complexes in insulin signaling
48. Evidence for a direct interaction between insulin receptor substrate-1 and Shc
49. Effect of nutritional state on the formation of a complex involving insulin receptor IRS-1, the 52 kDa Src homology/collagen protein (Shc) isoform and phosphatidylinositol 3'-kinase activity
50. Stimulation of MAP kinase and S6 kinase by vanadium and selenium in rat adipocytes
51. Involvement of Shc In insulin- and epidermal growth factor-induced activation of p21(ras)
52. Causes of insulin resistance
53. Identification of enhanced serine kinase activity in insulin resistance