Activation of central neuropeptide Y Y1 receptors potently stimulates food intake in male rhesus monkeys

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 10, 1999, Pages 3781-3791

  Larsen, Philip Just ^a,d   Tang Christensen, M ^a   Stidsen, C E ^b   Madsen, K ^b   Smith, M S ^c   Cameron, J L ^c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HYDROCORTISONE; INSULIN; NEUROPEPTIDE Y RECEPTOR AGONIST; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; NEUROPEPTIDE Y1 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HYDROCORTISONE BLOOD LEVEL; INSULIN BLOOD LEVEL; MACACA; MALE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING;

EID: 0033304541     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.84.10.3781     Document Type: Article

References (68)

1. Central effects of neuropeptide Y with emphasis on its role in obesity and diabetes
2. Effects of intracerebro-ventricular injection of neuropeptide Y on energy metabolism
3. Neuropeptide Y: A potent inducer of consummatory behavior in rats
4. Feeding and drinking elicited by central infection of neuropeptide Y: Evidence for a hypothalamic site(s) of action
5. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats
6. Neuropeptide Y: Direct and indirect action on insulin secretion in the rat
7. Neuropeptide Y injected in the paraventricular hypothalamus: A powerful stimulant of feeding behavior
8. Stimulation of feeding in the satiated p g by intracerebroventricular injection of neuropeptide Y
9. The perifornical area: The major focus of (a) patchily distributed hypothalamic neuropeptide Y-sensitive feeding system(s)
10. Induction and reversibility of an obesity syndrome by intracerebroventricular neuropeptide Y administration to normal rats
11. Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity
12. Specific inhibition of endogenous neuropeptide Y synthesis in arcuate nucleus by antisense oligonucleotides supresses feeding behavior and insulin secretion
13. Injection of anti-neuropeptide Y γ-globulin into the hypothalamic paraventricular nculeus decreases food intake in rats
14. Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus
15. Food deprivation and hypothalamic neuropeptide gene expression: Effects of strain background and the diabetes mutation
16. Hypothalamic neuropeptide expression after food restriction in zucker rats: Evidence of persistent neuropeptide Y gene activation
17. Increased neuropeptide Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse
18. The role of neuropeptide Y in the antiobesity action of the obese gene product
19. Attenuation of the obestity syndrome of ob/ob mice by the loss of neuropeptide Y
20. The immunological impairment of arcuate neuropeptide Y neurons by ricin A chain produces persistent decrease of food intake and body weight
21. Components of hypothalamic obesity: Biperidyl-mustard lesions add hyperphagia to monosodium glutamate-induced hyper-insulinemia
22. Neuropeptide Y induced feeding in the rat is mediated by a novel receptor
23. A receptor subtype involved in neuropeptide Y-induced food intake
24. Regional distribution of putative NPY Y1 receptors in forebrain areas of the rat central nervous system
25. Inhibition of food intake by neuropeptide Y Y5 receptor antisense oligodeoxynucleotides
26. Central administration of Y5 receptor antisense decreases spontaneous food intake and attenuates feeding in response to exogenous neuropeptide Y
27. Role of the Y5 neuropeptide Y receptor in feeding and obesity
28. Cardiovascular response, feeding behaviour, and locomotor activity in NPY, Y1 receptor-deficient mice
29. Effect of a novel and orally bio-available NPY Y5 receptor antagonist L-152:804 on feeding behavior in rodents
30. Fasting-induced Fos expression in hypothalamic neuropeptide Y (NPY) neurons of adult male rhesus monkeys: A search for neural systems which may mediate fasting-induced suppression of luteinizing hormone (LH) secretion
31. Intraventricular neuropeptide Y does not stimulate food intake in the baboon
32. Molecular cloning of a novel G protein-coupled receptor that may belong to the neuropeptide receptor family
33. Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY
34. Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype
35. Suppression of pulsatile luteinizing hormone and testosteroine secretion during short term food restriction in the adult male rhesus monkey (Macaca mulatta)
36. 2-noradrenergic receptor mediation
37. 1 receptor antagonist, 1229U91: Blockade of neuropeptide Y-induced and physiological food intake
38. Potent neuropeptide Y receptor anatgonist 1229U91 inhibits NPY-induced and spontaneous food intake by blockade of Y1 receptors but not Y5 receptors
39. Central administration of leptin inhibits food intake and activates the sympathetic nervous system in rhesus macaques
40. Control of food intake and meal patterns in monkeys
41. Intracisternal insulin alters sensitivity to CCK-induced meal suppression in baboons
42. Cerebral subarachnoid sampling of cerebrospinal fluid in the rhesus monkey
43. Intracerebroventricular neuropeptide Y produces hyperinsulinemia in the presence and absence of food
44. Effect of neuropeptide Y on the hypothalamic-pituitary-adrenal axis in the dog
45. Neuropeptide Y increases in the paraventricular nucleus in association with increased appetite for food
46. Colocalization of neuropeptide Y immunoreactivity in brainstem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus
47. An arcuato-paraventricular and dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat
48. Neuropeptide regulation of appetite and weight
49. Neuropeptide Y: A central regulator of energy homeostasis
50. Neuropeptide Y and energy balance: One way ahead for the treatment of obesity?
51. Neuropeptide Y, the hypothalamus, and diabetes: Insights into the central control of metabolism
52. Increased hypothalamic neuropeptide Y expression following food deprivation
53. Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status
54. Altered expression of hypothalamic neuropeptide mRNAs in food- restricted and food-deprived rats
55. Differential effect of fasting on hypothalamic expression of genes encoding neuropeptide Y, galanin, and glutamic acid decarboxylase
56. Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in gentically obese zucker rats and its regulation by food deprivation
57. Increased hypothalamic content of preproneuropeptide-Y messenger ribonucleic acid in streptozocin-diabetic rats
58. Neuropeptide Y distribution in human brain
59. Immunocytochemical localization of neuropeptide Y in the human hypothalamus
60. Neurpeptide Y of the female monkey hypothalamus: Retrograde tracing and immunostaining
61. Multiple receptors and mulitple actions
62. Role of neuropeptide Y receptor in feeding and obesity
63. Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor
64. 1 receptor antagonist
65. Increasing prevalence of overweight among US adults: The national health and nutrition examination surveys, 1960 to 1991
66. Serum immtmoreactive-leptin concentrations in normal weight and obese humans
67. Responses of plasma OB protein concentration to weight cycling in obese woman
68. Feeding inhibiton by neuropeptide Y