-
1
-
-
0022637508
-
Phase I Study of Cyclophosphamide and Lysine Salt of Mafosfamide
-
Abele, R., Aapro, M. S., Haefliger, J-M. and Alberto, P., Phase I Study of Cyclophosphamide and Lysine Salt of Mafosfamide. Cancer Chemo. Pharmaco., 16, 182-183 (1986).
-
(1986)
Cancer Chemo. Pharmaco.
, vol.16
, pp. 182-183
-
-
Abele, R.1
Aapro, M.S.2
Haefliger, J.-M.3
Alberto, P.4
-
2
-
-
0343591988
-
Nitrogen mustard N-oxide and its effects on the Yoshida sarcoma
-
Japan
-
Aiko, I., Owari, S and Torigoe, M., Nitrogen mustard N-oxide and its effects on the Yoshida sarcoma. J. Pharm. Soc. (Japan), 72, 1297-1300 (1952).
-
(1952)
J. Pharm. Soc.
, vol.72
, pp. 1297-1300
-
-
Aiko, I.1
Owari, S.2
Torigoe, M.3
-
3
-
-
0021187591
-
Comparative in vitro cytotoxicity of cyclophosphamide, its major active metabolites and the new oxazaphosphorine ASTA Z 7557 (INN mafosfamide)
-
Alberts, D. S., Einspahr, J. G., Struck, R. F., Bignami, G., Young, L., Surwit, E. A. and Salmon, S. E., Comparative in vitro cytotoxicity of cyclophosphamide, its major active metabolites and the new oxazaphosphorine ASTA Z 7557 (INN mafosfamide). Inv. New Drugs, 2, 141-148 (1984).
-
(1984)
Inv. New Drugs
, vol.2
, pp. 141-148
-
-
Alberts, D.S.1
Einspahr, J.G.2
Struck, R.F.3
Bignami, G.4
Young, L.5
Surwit, E.A.6
Salmon, S.E.7
-
4
-
-
0019327316
-
Involvement of thioredoxin in sulfoxide reduction by mammalian tissues
-
Anders, M.W., Ratnayake, J.H., Hanna, P. E. and Fuchs, J. A., Involvement of thioredoxin in sulfoxide reduction by mammalian tissues. Biochem. & Biophys. Res. Comm., 97 (3), 846-851 (1980).
-
(1980)
Biochem. & Biophys. Res. Comm.
, vol.97
, Issue.3
, pp. 846-851
-
-
Anders, M.W.1
Ratnayake, J.H.2
Hanna, P.E.3
Fuchs, J.A.4
-
5
-
-
0009725395
-
Enzymatic reduction of methionine sulfoxide. In vitro experiments with rat liver and kidney
-
Aymard, C., Seyer, L. and Cheftel, J., Enzymatic reduction of methionine sulfoxide. In vitro experiments with rat liver and kidney. Agric. Biol. Chem., 43, 1869-1872 (1979).
-
(1979)
Agric. Biol. Chem.
, vol.43
, pp. 1869-1872
-
-
Aymard, C.1
Seyer, L.2
Cheftel, J.3
-
6
-
-
0025931950
-
Synthesis and Antitumor Properties of Activated Cyclophosphamide Analogues
-
Borch, R. F. and Canute, G. W., Synthesis and Antitumor Properties of Activated Cyclophosphamide Analogues. J. Med. Chem., 34, 3044-3052 (1991).
-
(1991)
J. Med. Chem.
, vol.34
, pp. 3044-3052
-
-
Borch, R.F.1
Canute, G.W.2
-
7
-
-
0025930682
-
Synthesis, activation and cytotoxicity of aldophosphamide analogues
-
Borch, R.F. and Valente R.R., Synthesis, activation and cytotoxicity of aldophosphamide analogues. J. Med. Chem., 34, 3052-3058 (1991).
-
(1991)
J. Med. Chem.
, vol.34
, pp. 3052-3058
-
-
Borch, R.F.1
Valente, R.R.2
-
8
-
-
0018897309
-
Synthesis and Antitumor Activity of Cyclophosphamide Analogues. 3. Preparation, Molecular Structure Determination, and Anticancer Screening of Racemic cis- and trans-4-Phenylcyclophosphamide
-
Boyd, V. L., Zon, G., Himes, V. L., Stalick, J. K., Mighell, A. D. and Secor, H. V., Synthesis and Antitumor Activity of Cyclophosphamide Analogues. 3. Preparation, Molecular Structure Determination, and Anticancer Screening of Racemic cis- and trans-4-Phenylcyclophosphamide. J. Med. Chem., 23, 372-375 (1980).
-
(1980)
J. Med. Chem.
, vol.23
, pp. 372-375
-
-
Boyd, V.L.1
Zon, G.2
Himes, V.L.3
Stalick, J.K.4
Mighell, A.D.5
Secor, H.V.6
-
9
-
-
0017140119
-
Comparative pharmacologic study in vitro and in vivo with cyclophosphamide (NSC-26271), cyclophosphamide metabolites, and plain nitrogen mustard compounds
-
Brock, N., Comparative pharmacologic study in vitro and in vivo with cyclophosphamide (NSC-26271), cyclophosphamide metabolites, and plain nitrogen mustard compounds. Cancer Treat. Rep., 60, 301-307 (1976).
-
(1976)
Cancer Treat. Rep.
, vol.60
, pp. 301-307
-
-
Brock, N.1
-
10
-
-
0017346430
-
The problem of specificity and selectivity of alkylating cytostaticis: Studies on N-2-chloroethylamido-oxazaphosphorines
-
Brock, N. and Hohorst, H. J., The problem of specificity and selectivity of alkylating cytostaticis: Studies on N-2-chloroethylamido-oxazaphosphorines. Zeitschr. Krebsforsch. Klin. Onkol., 88, 185-215 (1977).
-
(1977)
Zeitschr. Krebsforsch. Klin. Onkol.
, vol.88
, pp. 185-215
-
-
Brock, N.1
Hohorst, H.J.2
-
11
-
-
0000349218
-
Tumor hypoxia: Problems and opportunities
-
Bertino, J. R. Ed.; Academic Press: San Diego, Lontoa
-
Brown, J. M., Tumor hypoxia: problems and opportunities. In Encyclopedia of Cancer, Volume III; Bertino, J. R. Ed.; Academic Press: San Diego, Lontoa; pp 1883-1898, 1997.
-
(1997)
Encyclopedia of Cancer
, vol.3
, pp. 1883-1898
-
-
Brown, J.M.1
-
12
-
-
0021805337
-
Phase-l Study of Mafosfamide-Cyclohexylamine (ASTA-Z-7557, NSC 345842) and Limited Phase-l Data on Mafosfamide-Lysine
-
Bruntsch, U., Groos, G., Hiller, T. A., Wandt, H., Tigges, F.-J. and Gallmeier, W. M., Phase-l Study of Mafosfamide-Cyclohexylamine (ASTA-Z-7557, NSC 345842) and Limited Phase-l Data on Mafosfamide-Lysine. Invest. New Drugs, 3, 293-296 (1985).
-
(1985)
Invest. New Drugs
, vol.3
, pp. 293-296
-
-
Bruntsch, U.1
Groos, G.2
Hiller, T.A.3
Wandt, H.4
Tigges, F.-J.5
Gallmeier, W.M.6
-
13
-
-
0343804921
-
-
Wooley, P. V.; Tew, K. D., Eds.; Academic Press: New York
-
Colvin, M. and Hilton, J., In Mechanisms of Drug Resistance in Neoplastic Cells; Wooley, P. V.; Tew, K. D., Eds.; Academic Press: New York,; p 161-171, 1988.
-
(1988)
Mechanisms of Drug Resistance in Neoplastic Cells
, pp. 161-171
-
-
Colvin, M.1
Hilton, J.2
-
14
-
-
0014024073
-
Cure of mice bearing advanced plasma cell tumors with aniline mustard: The relationship between glucurinidase activity and tumor sensitivity
-
Connors, T. A. and Whisson, M.E., Cure of mice bearing advanced plasma cell tumors with aniline mustard: The relationship between glucurinidase activity and tumor sensitivity. Nature, 210, 866-867 (1966).
-
(1966)
Nature
, vol.210
, pp. 866-867
-
-
Connors, T.A.1
Whisson, M.E.2
-
15
-
-
0015813383
-
Metabolism of aniline mustard
-
Connors, T. A., Farmer, P.B., Foster, A.B., Gilsenan, A.M., Jarman, M. and Tisdale, M.J., Metabolism of aniline mustard. Biochem. Pharmacol., 22, 1971-1980 (1973).
-
(1973)
Biochem. Pharmacol.
, vol.22
, pp. 1971-1980
-
-
Connors, T.A.1
Farmer, P.B.2
Foster, A.B.3
Gilsenan, A.M.4
Jarman, M.5
Tisdale, M.J.6
-
16
-
-
0015968586
-
Some studies of the active intermediates formed in the microsomal metabolism of cyclophosphamide and isophosphamide
-
Connors, T. A., Cox, P. J., Farmer, P. B., Foster, A. B.and Jarman, M., Some studies of the active intermediates formed in the microsomal metabolism of cyclophosphamide and isophosphamide. Biochem. Pharmacol., 23, 115-129 (1974).
-
(1974)
Biochem. Pharmacol.
, vol.23
, pp. 115-129
-
-
Connors, T.A.1
Cox, P.J.2
Farmer, P.B.3
Foster, A.B.4
Jarman, M.5
-
17
-
-
21044439834
-
-
Reinhoudt, D. N.; Connors, T. A.; Pinedo, H. M.; van den Poll, K. W., Eds.; The Hague: Martinus Nijhoff
-
Connors, T. A., In "Structure-activity Relationships of Anti-tumour Agents"; Reinhoudt, D. N.; Connors, T. A.; Pinedo, H. M.; van den Poll, K. W., Eds.; The Hague: Martinus Nijhoff,; pp 47-57 (1983).
-
(1983)
Structure-activity Relationships of Anti-tumour Agents
, pp. 47-57
-
-
Connors, T.A.1
-
18
-
-
0026539267
-
Mechanistic studies of enhanced in vitro radiosensitization and hypoxic cell cytotoxicity by targeting radiosensitizers to DNA via intercalation
-
Cowan, D. S. M., Kanagasabapathy, V. M., McClelland, R. A. and Rauth, A. M., Mechanistic studies of enhanced in vitro radiosensitization and hypoxic cell cytotoxicity by targeting radiosensitizers to DNA via intercalation. Int. J. Radiation Oncology Biol. Phys., 22, 541-544 (1992).
-
(1992)
Int. J. Radiation Oncology Biol. Phys.
, vol.22
, pp. 541-544
-
-
Cowan, D.S.M.1
Kanagasabapathy, V.M.2
McClelland, R.A.3
Rauth, A.M.4
-
19
-
-
0018749594
-
Cyclophosphamide cystitis-identification of acrolein as the causative agent
-
Cox, P. J., Cyclophosphamide cystitis-identification of acrolein as the causative agent. Biochem. Pharmacol., 28, 2045-2049 (1979).
-
(1979)
Biochem. Pharmacol.
, vol.28
, pp. 2045-2049
-
-
Cox, P.J.1
-
20
-
-
0022349983
-
Sulindac oxidation/ reduction by microbial cultures; microbial models for mammalian metabolism
-
Davis, P. J. and Guenthner, L. E., Sulindac oxidation/ reduction by microbial cultures; microbial models for mammalian metabolism. Xenobiotica, 15, 845-857 (1985).
-
(1985)
Xenobiotica
, vol.15
, pp. 845-857
-
-
Davis, P.J.1
Guenthner, L.E.2
-
21
-
-
0022535929
-
Considerations for the design of nitrophenyl mustards as agents with selective toxicity for hypoxic tumor cells
-
Denny, W. A. and Wilson, W. R., Considerations for the design of nitrophenyl mustards as agents with selective toxicity for hypoxic tumor cells. J. Med. Chem., 29 (6), 879-887 (1986).
-
(1986)
J. Med. Chem.
, vol.29
, Issue.6
, pp. 879-887
-
-
Denny, W.A.1
Wilson, W.R.2
-
22
-
-
0025274372
-
Hypoxia-selective antitumor agents: 4. Relationships between structure, physicochemical properties, and hypoxia-selective cytotoxicity for nitracrine analogues with varying side chains: the "lminoacridan Hypothesis."
-
Denny, W. A., Atwell, G. J., Anderson, R. F. and Wilson, W. R., Hypoxia-selective antitumor agents: 4. Relationships between structure, physicochemical properties, and hypoxia-selective cytotoxicity for nitracrine analogues with varying side chains: The "lminoacridan Hypothesis." J. Med. Chem., 33, 1288-1295 (1990).
-
(1990)
J. Med. Chem.
, vol.33
, pp. 1288-1295
-
-
Denny, W.A.1
Atwell, G.J.2
Anderson, R.F.3
Wilson, W.R.4
-
23
-
-
0026536057
-
NLA-1: A 2-nitroimidazole radiosensitizer targeted to DNA by intercalation
-
Denny, W. A., Roberts, P. B., Anderson, R. F., Brown, J. M. and Wilson, W. R., NLA-1: A 2-nitroimidazole radiosensitizer targeted to DNA by intercalation. Int. J. Radiation Oncology Biol. Phys., 22, 553-556 (1992).
-
(1992)
Int. J. Radiation Oncology Biol. Phys.
, vol.22
, pp. 553-556
-
-
Denny, W.A.1
Roberts, P.B.2
Anderson, R.F.3
Brown, J.M.4
Wilson, W.R.5
-
24
-
-
0018843531
-
Kinetics of Cyclophosphamide biotransformation in vivo
-
Domeyer, B. E. and Sladek, N. E., Kinetics of Cyclophosphamide biotransformation in vivo. Cancer Res., 40, 174-180 (1980).
-
(1980)
Cancer Res.
, vol.40
, pp. 174-180
-
-
Domeyer, B.E.1
Sladek, N.E.2
-
25
-
-
0017063480
-
Deactivation of cyclophosphamide (NSC-26271) metabolites by sulfhydryl compounds
-
Draeger, U., Peter, G. and Hohorst, H. J., Deactivation of cyclophosphamide (NSC-26271) metabolites by sulfhydryl compounds. Cancer Treat. Rep., 60, 355-359 (1976).
-
(1976)
Cancer Treat. Rep.
, vol.60
, pp. 355-359
-
-
Draeger, U.1
Peter, G.2
Hohorst, H.J.3
-
26
-
-
0018130406
-
Comparative disposition of sulindac and metabolites in five species
-
Duggan, D. E., Hooke, K. F., Noll, R. M., Hucker, H. B. and Van Arman, C. G., Comparative disposition of sulindac and metabolites in five species. Biochem. Pharmacol., 27, 2311-2320 (1978).
-
(1978)
Biochem. Pharmacol.
, vol.27
, pp. 2311-2320
-
-
Duggan, D.E.1
Hooke, K.F.2
Noll, R.M.3
Hucker, H.B.4
Van Arman, C.G.5
-
27
-
-
0020333289
-
31P NMR kinetic studies of the intra- and intermolecular alkylation chemistry of phosphoramide mustard and cognate N-phosphorylated derivatives of N,N-bis(2-chloroethyl) amine
-
31P NMR kinetic studies of the intra- and intermolecular alkylation chemistry of phosphoramide mustard and cognate N-phosphorylated derivatives of N,N-bis(2-chloroethyl) amine. J. Med. Chem., 25, 1347-1357 (1982).
-
(1982)
J. Med. Chem.
, vol.25
, pp. 1347-1357
-
-
Engel, T.W.1
Zon, G.2
Egan, W.3
-
28
-
-
0026520314
-
Assessment of a range of novel nitro-aromatic radiosensitizers and bioreductive drugs
-
Fielden, E. M., Adams, G. E., Cole, S., Naylor, M. A., O'Neill, P., Stephens, M. A. and Stratford, I. J., Assessment of a range of novel nitro-aromatic radiosensitizers and bioreductive drugs. Int. J. Radiation Oncology Biol. Phys., 22, 707-711(1992).
-
(1992)
Int. J. Radiation Oncology Biol. Phys.
, vol.22
, pp. 707-711
-
-
Fielden, E.M.1
Adams, G.E.2
Cole, S.3
Naylor, M.A.4
O'Neill, P.5
Stephens, M.A.6
Stratford, I.J.7
-
29
-
-
0025951037
-
Nitroheterocycle reduction as a paradigm for intramolecular catalysis of drug delivery to hypoxic cells
-
Firestone, A., Mulcahy, R. T. and Borch, R. F., Nitroheterocycle reduction as a paradigm for intramolecular catalysis of drug delivery to hypoxic cells. J. Med. Chem., 34, 2933-2935 (1991).
-
(1991)
J. Med. Chem.
, vol.34
, pp. 2933-2935
-
-
Firestone, A.1
Mulcahy, R.T.2
Borch, R.F.3
-
30
-
-
0017115559
-
Cyclophosphamide (NSC-26271)-related phosphoramide mustards-recent advances and historical perspective
-
Friedman, O. M., Wodinsky, I. and Myles, A., Cyclophosphamide (NSC-26271)-related phosphoramide mustards-recent advances and historical perspective. Cancer Treat. Rep., 60, 337-346 (1976).
-
(1976)
Cancer Treat. Rep.
, vol.60
, pp. 337-346
-
-
Friedman, O.M.1
Wodinsky, I.2
Myles, A.3
-
31
-
-
0345670711
-
Histochemical demonstration of sites of phosphoramidase activity
-
Gomori, G., Histochemical demonstration of sites of phosphoramidase activity. Proc Soc Exp Biol Med, 69, 407-409 (1948).
-
(1948)
Proc Soc Exp Biol Med
, vol.69
, pp. 407-409
-
-
Gomori, G.1
-
32
-
-
0022358539
-
Binding of metabolites of cyclophosphamide to DNA in a rat liver microsomal system and in vivo in mice
-
Hemminki, K., Binding of metabolites of cyclophosphamide to DNA in a rat liver microsomal system and in vivo in mice. Cancer Res., 45, 4237-4243 (1985).
-
(1985)
Cancer Res.
, vol.45
, pp. 4237-4243
-
-
Hemminki, K.1
-
33
-
-
0021722034
-
Role of aldehyde dehydrogenase in cyclophosphamide-resistant L1210 leukemia
-
Hilton, J., Role of aldehyde dehydrogenase in cyclophosphamide-resistant L1210 leukemia. Cancer Res., 44, 5156-5160 (1984).
-
(1984)
Cancer Res.
, vol.44
, pp. 5156-5160
-
-
Hilton, J.1
-
34
-
-
0019442713
-
Role of aldehyde dehydrogenase in the metabolism-dependent biological activity of cyclophosphamide
-
Hipkens, J. H., Struck, R. F. and Gurtoo, H. L., Role of aldehyde dehydrogenase in the metabolism-dependent biological activity of cyclophosphamide. Cancer Res., 41, 3571-3583 (1981).
-
(1981)
Cancer Res.
, vol.41
, pp. 3571-3583
-
-
Hipkens, J.H.1
Struck, R.F.2
Gurtoo, H.L.3
-
35
-
-
0018143999
-
Quantitation by gas chromatography-chemical ionization mass spectrometry of cyclophosphamide, phosphoramide mustard, and nornitrogen mustard in the plasma and urine of patients receiving cyclophosphamide therapy
-
Jardine, I., Fenselau, C., Appler, M., Kan, M. -N., Brundrett, R. B. and Colvin, M., Quantitation by gas chromatography-chemical ionization mass spectrometry of cyclophosphamide, phosphoramide mustard, and nornitrogen mustard in the plasma and urine of patients receiving cyclophosphamide therapy. Cancer Res., 38, 408-415 (1978).
-
(1978)
Cancer Res.
, vol.38
, pp. 408-415
-
-
Jardine, I.1
Fenselau, C.2
Appler, M.3
Kan, M.N.4
Brundrett, R.B.5
Colvin, M.6
-
36
-
-
0018914018
-
The hypoxic tumor cell: A target for selective cancer chemotherapy
-
Kennedy, K. A., Teicher, B. A., Rockwell, S. and Sartorelli, A. C., The hypoxic tumor cell: A target for selective cancer chemotherapy. Biochem. Pharmacol., 29, 1-8 (1980).
-
(1980)
Biochem. Pharmacol.
, vol.29
, pp. 1-8
-
-
Kennedy, K.A.1
Teicher, B.A.2
Rockwell, S.3
Sartorelli, A.C.4
-
37
-
-
0020713095
-
A sulfoxide-reducing enzyme system consisting of aldehyde oxidase and xanthine oxidase - A new electron transfer system
-
Kitamura, S. and Tatsumi, K., A sulfoxide-reducing enzyme system consisting of aldehyde oxidase and xanthine oxidase - a new electron transfer system. Chem. Pharm. Bull. (Japan), 31(2), 760-763 (1983).
-
(1983)
Chem. Pharm. Bull. (Japan)
, vol.31
, Issue.2
, pp. 760-763
-
-
Kitamura, S.1
Tatsumi, K.2
-
38
-
-
0023094045
-
Activation Mechanisms of Mafosfamide and the Role of Thiols in Cyclophosphamide Metabolism
-
won, C.-H., Borch, R. F., Engel, J. and Niemeyer, U., Activation Mechanisms of Mafosfamide and the Role of Thiols in Cyclophosphamide Metabolism. J. Med. Chem., 30, 395-399 (1987).
-
(1987)
J. Med. Chem.
, vol.30
, pp. 395-399
-
-
Won, C.-H.1
Borch, R.F.2
Engel, J.3
Niemeyer, U.4
-
39
-
-
0025981529
-
Chemically stable, lipophilic prodrugs of phosphoramide mustard as potential anticancer agents
-
Kwon, C.-H., Moon, K.-Y., Baturay, N. and Shirota, F. N., Chemically stable, lipophilic prodrugs of phosphoramide mustard as potential anticancer agents. J. Med. Chem., 34, 588-592 (1991).
-
(1991)
J. Med. Chem.
, vol.34
, pp. 588-592
-
-
Kwon, C.-H.1
Moon, K.-Y.2
Baturay, N.3
Shirota, F.N.4
-
40
-
-
0026721021
-
p-(Methyl-sulfinyl)phenyl nitrogen mustard as a novel bioreductive prodrug selective against hypoxic tumors
-
Kwon, C. -H., Blanco, D. R. and Baturay, N., p-(Methyl-sulfinyl)phenyl nitrogen mustard as a novel bioreductive prodrug selective against hypoxic tumors. J. Med. Chem., 35, 2137-2139 (1992).
-
(1992)
J. Med. Chem.
, vol.35
, pp. 2137-2139
-
-
Kwon, C.H.1
Blanco, D.R.2
Baturay, N.3
-
41
-
-
21044439069
-
-
Manuscripts in preparation 1999b
-
Kwon, C. -H. Manuscripts in preparation (1999a and 1999b).
-
(1999)
-
-
Kwon, C.H.1
-
42
-
-
0030018650
-
The effect of tirapazamine (SR-4233) alone or combined with chemotherapeutic agents on xenografted human tumours
-
Lartigau, E. and Guichard, M., The effect of tirapazamine (SR-4233) alone or combined with chemotherapeutic agents on xenografted human tumours. British Journal of Cancer, 73, 1480-1485 (1996).
-
(1996)
British Journal of Cancer
, vol.73
, pp. 1480-1485
-
-
Lartigau, E.1
Guichard, M.2
-
43
-
-
0029049802
-
Sulphoxide reduction by rat and rabbit tissues in vitro
-
Lee, S. C. and Renwick, A. G., Sulphoxide reduction by rat and rabbit tissues in vitro. Biochem. Pharmacol., 49, 1557-1565 (1995).
-
(1995)
Biochem. Pharmacol.
, vol.49
, pp. 1557-1565
-
-
Lee, S.C.1
Renwick, A.G.2
-
44
-
-
0020070463
-
Conversion of 4-hydroperoxycyclophosphamide and 4-hydroxycyclophosphamide to phosphoramide mustard and acrolein mediated by bifunctional catalysts
-
Low, J. E., Borch, R. F. and Sladek, N. E., Conversion of 4-hydroperoxycyclophosphamide and 4-hydroxycyclophosphamide to phosphoramide mustard and acrolein mediated by bifunctional catalysts. Cancer Res., 42, 830-837 (1982).
-
(1982)
Cancer Res.
, vol.42
, pp. 830-837
-
-
Low, J.E.1
Borch, R.F.2
Sladek, N.E.3
-
45
-
-
0022474778
-
Synthesis and Antitumor Activity of Cyclophosphamide Analogues. 4. Preparation, Kinetics Studies, and Anticancer Screening of "Phenylketophosphamide" and Similar Compounds Related to the Cyclophosphamide Metabolite Aldophosphamide
-
Ludeman, S. M., Boyd, V. L., Regan, J. B., Gallo, K. A., Zon, G. and Ishii, K., Synthesis and Antitumor Activity of Cyclophosphamide Analogues. 4. Preparation, Kinetics Studies, and Anticancer Screening of "Phenylketophosphamide" and Similar Compounds Related to the Cyclophosphamide Metabolite Aldophosphamide. J. Med. Chem., 29, 716-727 (1986).
-
(1986)
J. Med. Chem.
, vol.29
, pp. 716-727
-
-
Ludeman, S.M.1
Boyd, V.L.2
Regan, J.B.3
Gallo, K.A.4
Zon, G.5
Ishii, K.6
-
46
-
-
0028356487
-
Glutathione-S-transferase activates novel alkylating agents
-
Lyttle, M. H., Satyam, A., Hocker, M. D., Bauer, K. E., Caldwell, C. G., Hui, H. C., Morgan, A. S., Mergia, A. and Kauvar, L. M., Glutathione-S-transferase activates novel alkylating agents J. Med. Chem., 37, 1501-1507 (1994).
-
(1994)
J. Med. Chem.
, vol.37
, pp. 1501-1507
-
-
Lyttle, M.H.1
Satyam, A.2
Hocker, M.D.3
Bauer, K.E.4
Caldwell, C.G.5
Hui, H.C.6
Morgan, A.S.7
Mergia, A.8
Kauvar, L.M.9
-
47
-
-
21044439217
-
Reduction of sulfoxide by hepatic enzymes
-
Mazel, P., Katzen, J., Skolnick, P. and Shargel, L., Reduction of sulfoxide by hepatic enzymes. Fed Proc. Fed. Am. Soc. Exp. Biol., 28, 546 (1969).
-
(1969)
Fed Proc. Fed. Am. Soc. Exp. Biol.
, vol.28
, pp. 546
-
-
Mazel, P.1
Katzen, J.2
Skolnick, P.3
Shargel, L.4
-
48
-
-
0026572272
-
Second-generation 1,2,4-benzotriazine 1,4-di-N-oxide bioreductive anti-tumor agents: Pharmacology and activity in vitro and in vivo
-
Michinton, A. I., Lemmon, M. J., Tracy, M., Pollart, D. J., Martinez, A. P., Tosto, L. M. and Brown, J. M., Second-generation 1,2,4-benzotriazine 1,4-di-N-oxide bioreductive anti-tumor agents: pharmacology and activity in vitro and in vivo. Int. J. Radiation Oncology Biol. Phys., 22, 701-705 (1992).
-
(1992)
Int. J. Radiation Oncology Biol. Phys.
, vol.22
, pp. 701-705
-
-
Michinton, A.I.1
Lemmon, M.J.2
Tracy, M.3
Pollart, D.J.4
Martinez, A.P.5
Tosto, L.M.6
Brown, J.M.7
-
49
-
-
0028935417
-
Chemically Stable N-Methyl-4-(alkylthio) cyclophosphamide Derivatives as Prodrugs of 4-Hydroxycyclophosphamide
-
Moon, K. -Y., Shirota, F. N., Baturay, N. and Kwon, C. -H., Chemically Stable N-Methyl-4-(alkylthio) cyclophosphamide Derivatives as Prodrugs of 4-Hydroxycyclophosphamide J. Med. Chem., 38, 848-851 (1995).
-
(1995)
J. Med. Chem.
, vol.38
, pp. 848-851
-
-
Moon, K.Y.1
Shirota, F.N.2
Baturay, N.3
Kwon, C.H.4
-
50
-
-
0032493193
-
3-Methyl-Mafosfamide as a Chemically Stable, Alternative Prodrug of Mafosfamide
-
3-Methyl-Mafosfamide as a Chemically Stable, Alternative Prodrug of Mafosfamide. Bioorg Med. Chem. Letters, 8: 1673-1678, (1998).
-
(1998)
Bioorg Med. Chem. Letters
, vol.8
, pp. 1673-1678
-
-
Moon, K.Y.1
Kwon, C.H.2
-
51
-
-
0023104247
-
Mitomycin analogues, I. Indoloquinones as (potential) bisalkylating agents
-
Oostveen, E. A. and Speckamp, W. N., Mitomycin analogues, I. Indoloquinones as (potential) bisalkylating agents. Tetrahedron, 43, 255-262 (1987).
-
(1987)
Tetrahedron
, vol.43
, pp. 255-262
-
-
Oostveen, E.A.1
Speckamp, W.N.2
-
52
-
-
0025606616
-
Nitro analogues of chlorambucil as potential hypoxia-selective anti-tumor drugs
-
Palmer, B. D., Wilson, W. R. and Denny, W. A., Nitro analogues of chlorambucil as potential hypoxia-selective anti-tumor drugs. Anti-cancer Drug Design, 5, 337-349 (1990a).
-
(1990)
Anti-cancer Drug Design
, vol.5
, pp. 337-349
-
-
Palmer, B.D.1
Wilson, W.R.2
Denny, W.A.3
-
53
-
-
0025021102
-
Hypoxia-selective antitumor agents. 3. Relationships between structure and cytotoxicity against cultured tumor cells for substituted N,N-Bis(2-chloroethyl) anilines
-
Palmer, B. D., Wilson, W. R., Pullen, S. M. and Denny, W. A., Hypoxia-selective antitumor agents. 3. Relationships between structure and cytotoxicity against cultured tumor cells for substituted N,N-Bis(2-chloroethyl) anilines. J. Med. Chem., 33, 112-121 (1990b).
-
(1990)
J. Med. Chem.
, vol.33
, pp. 112-121
-
-
Palmer, B.D.1
Wilson, W.R.2
Pullen, S.M.3
Denny, W.A.4
-
54
-
-
0026665360
-
Hypoxia-slective antitumor agents. 5. Synthesis of water-soluble nitroaniline mustards with selective cytotoxicity for hypoxic mammalian cells
-
Palmer, B. D., Wilson, W. R., Cliffe, S. and Denny, W. A., Hypoxia-slective antitumor agents. 5. Synthesis of water-soluble nitroaniline mustards with selective cytotoxicity for hypoxic mammalian cells. J. Med. Chem., 35, 3214-3222 (1992).
-
(1992)
J. Med. Chem.
, vol.35
, pp. 3214-3222
-
-
Palmer, B.D.1
Wilson, W.R.2
Cliffe, S.3
Denny, W.A.4
-
56
-
-
0021227885
-
Experimental Toxicology of ASTA Z 7557 (INN mafosfamide)
-
Pohl, J., Hilgard, P., Jahn, W. and Zechel, H. J., Experimental Toxicology of ASTA Z 7557 (INN mafosfamide). Invest. New Drugs, 2, 201-206 (1984).
-
(1984)
Invest. New Drugs
, vol.2
, pp. 201-206
-
-
Pohl, J.1
Hilgard, P.2
Jahn, W.3
Zechel, H.J.4
-
57
-
-
0022572076
-
Pathogenesis of metastatic disease. Implications for current therapy and for the development of new therapeutic strategies
-
Poste, G., Pathogenesis of metastatic disease. Implications for current therapy and for the development of new therapeutic strategies. Cancer Treat. Rep., 70, 183-199 (1986).
-
(1986)
Cancer Treat. Rep.
, vol.70
, pp. 183-199
-
-
Poste, G.1
-
58
-
-
0020663027
-
Cytotoxic activity relative to 4-hydroxycyclophosphamide and phosphoramide mustard concentrations in the plasma of cyclophosphamide-treated rats
-
Powers, J. F. and Sladek, N. E., Cytotoxic activity relative to 4-hydroxycyclophosphamide and phosphoramide mustard concentrations in the plasma of cyclophosphamide-treated rats. Cancer Res., 43, 1101-1106 (1983).
-
(1983)
Cancer Res.
, vol.43
, pp. 1101-1106
-
-
Powers, J.F.1
Sladek, N.E.2
-
59
-
-
0004997715
-
Sulfoxides and sulfones
-
Damani, L. A., Ed. Ellis Horwood Ltd., London
-
Renwick, A. G., Sulfoxides and sulfones. In Sulfur-containingdrugs and related organic compounds vol.1 Part B; Damani, L. A., Ed. Ellis Horwood Ltd., London,134-154 1989.
-
(1989)
Sulfur-containingdrugs and Related Organic Compounds Vol.1 Part B
, vol.1
, pp. 134-154
-
-
Renwick, A.G.1
-
60
-
-
0023902264
-
Therapeutic attack of hypoxic cells of solid tumors: Presidential Address
-
Sartorelli, A. C., Therapeutic attack of hypoxic cells of solid tumors: Presidential Address. Cancer Res., 48, 775-778 (1988).
-
(1988)
Cancer Res.
, vol.48
, pp. 775-778
-
-
Sartorelli, A.C.1
-
61
-
-
0030066696
-
Comparison of in vivo efficacy of hypoxic cytotoxin tirapazamine and hypoxic cell radiosensitizer KU-2285 in combination with single and fractinated irradiation
-
Shibata, T., Shibamoto, Y, Sasai, K., Oya, N., Murata, R., Takagi, T., Hiraoka, M. and Abe, M., Comparison of in vivo efficacy of hypoxic cytotoxin tirapazamine and hypoxic cell radiosensitizer KU-2285 in combination with single and fractinated irradiation Jpn. J. Cancer Res., 87, 98-104 (1996).
-
(1996)
Jpn. J. Cancer Res.
, vol.87
, pp. 98-104
-
-
Shibata, T.1
Shibamoto, Y.2
Sasai, K.3
Oya, N.4
Murata, R.5
Takagi, T.6
Hiraoka, M.7
Abe, M.8
-
62
-
-
0021864126
-
Restoration of sensitivity to oxazaphosphorines by inhibitors of aldehyde dehydrogenase activity in cultured oxazaphosphorine-resistant L1210 and cross-linking agent-resistant P388 cell lines
-
Sladek, N. E. and Landkamer, G. J., Restoration of sensitivity to oxazaphosphorines by inhibitors of aldehyde dehydrogenase activity in cultured oxazaphosphorine-resistant L1210 and cross-linking agent-resistant P388 cell lines. Cancer Res., 45, 1549-1555 (1985).
-
(1985)
Cancer Res.
, vol.45
, pp. 1549-1555
-
-
Sladek, N.E.1
Landkamer, G.J.2
-
63
-
-
0021922114
-
Collateral sensitivity to cross-linking agents exhibited by cultured L1210 cells resistant to oxazaphosphorines
-
Sladek, N. E., Low, J. E. and Landkamer, G. J., Collateral sensitivity to cross-linking agents exhibited by cultured L1210 cells resistant to oxazaphosphorines. Cancer Res., 45, 625-629 (1985).
-
(1985)
Cancer Res.
, vol.45
, pp. 625-629
-
-
Sladek, N.E.1
Low, J.E.2
Landkamer, G.J.3
-
64
-
-
0023945947
-
Metabolism of oxazaphosphorines
-
Sladek, N. E., Metabolism of oxazaphosphorines. Pharmacol. Ther., 37, 301-355 (1988).
-
(1988)
Pharmacol. Ther.
, vol.37
, pp. 301-355
-
-
Sladek, N.E.1
-
65
-
-
0024452316
-
Xenobiotic oxidation catalyzed by aldehyde dehydrogenases
-
Sladek, N. E., Manthey, C. L., Maki, P. A., Zhang, Z. and Landkamer, G. J., Xenobiotic oxidation catalyzed by aldehyde dehydrogenases. Drug Metab. Rev., 20 (2-4), 697-720 (1989).
-
(1989)
Drug Metab. Rev.
, vol.20
, Issue.2-4
, pp. 697-720
-
-
Sladek, N.E.1
Manthey, C.L.2
Maki, P.A.3
Zhang, Z.4
Landkamer, G.J.5
-
66
-
-
0001358252
-
Oxazaphosphorine-specific acquired cellular resistance
-
Teicher B.A., ed. New York: Marcel Dekker
-
Sladek, N. E., Oxazaphosphorine-specific acquired cellular resistance. In: Teicher B.A., ed. Drug Resistance in Oncology. New York: Marcel Dekker., pp. 375-410, 1993.
-
(1993)
Drug Resistance in Oncology
, pp. 375-410
-
-
Sladek, N.E.1
-
67
-
-
0021205291
-
Mechanisms of DNA strand breakage and interstrand cross-linking by diaziridinylbenzoquinone (diaziquone) in isolated nuclei
-
Smigiero, L. and Kohn, K. W., Mechanisms of DNA strand breakage and interstrand cross-linking by diaziridinylbenzoquinone (diaziquone) in isolated nuclei. Cancer Res., 44, 4453-4457 (1984).
-
(1984)
Cancer Res.
, vol.44
, pp. 4453-4457
-
-
Smigiero, L.1
Kohn, K.W.2
-
68
-
-
21044443164
-
Reduction of methionine sulfoxides by Escherichia coli
-
Sourkes, T. L. and Tano, Y., Reduction of methionine sulfoxides by Escherichia coli. Arch. Biochem. Biophys., 42, 321-326 (1953).
-
(1953)
Arch. Biochem. Biophys.
, vol.42
, pp. 321-326
-
-
Sourkes, T.L.1
Tano, Y.2
-
69
-
-
0000916698
-
Cyclophosphamide and Its Congeners
-
Stec, W. J., Cyclophosphamide and Its Congeners. J. Organophosphorous Chem., 13, 145-174 (1982).
-
(1982)
J. Organophosphorous Chem.
, vol.13
, pp. 145-174
-
-
Stec, W.J.1
-
70
-
-
0022608804
-
RSU 1069. A nitro-imidazole containing an aziridine group
-
Stratford, I. J., O'Neill, P., Sheldon, P. W., Silver, A. R. J., Walling, J. M. and Adams, G. E. RSU 1069. A nitro-imidazole containing an aziridine group. Biochem. Pharm., 35(1), 105-109 (1986).
-
(1986)
Biochem. Pharm.
, vol.35
, Issue.1
, pp. 105-109
-
-
Stratford, I.J.1
O'Neill, P.2
Sheldon, P.W.3
Silver, A.R.J.4
Walling, J.M.5
Adams, G.E.6
-
71
-
-
0016466370
-
Isolation and mass spectral identification of blood metabolites of cyclophosphamide: Evidence for phosphoramide mustard as the biologically active metabolite
-
Struck, R. F., Kirk, M. C., Witt, M. H. and Laster, W. R. Jr., Isolation and mass spectral identification of blood metabolites of cyclophosphamide: Evidence for phosphoramide mustard as the biologically active metabolite. Biomed. Mass Specfrom., 2, 46-52 (1975).
-
(1975)
Biomed. Mass Specfrom.
, vol.2
, pp. 46-52
-
-
Struck, R.F.1
Kirk, M.C.2
Witt, M.H.3
Laster Jr., W.R.4
-
72
-
-
0020675066
-
Isophosphoramide mustard, a metabolite of ifosfamide with activity against murine tumours comparable to cyclophosphamide
-
Struck, R. F., Dykes, D. J., Corbett, T. H., Suling, W. J. and Trader, M. W., Isophosphoramide mustard, a metabolite of ifosfamide with activity against murine tumours comparable to cyclophosphamide. Br. J. Cancer, 47, 15-26 (1983).
-
(1983)
Br. J. Cancer
, vol.47
, pp. 15-26
-
-
Struck, R.F.1
Dykes, D.J.2
Corbett, T.H.3
Suling, W.J.4
Trader, M.W.5
-
74
-
-
0020467177
-
Involvement of liver aldehyde oxidase in sulfoxide reduction
-
Tatsumi, K., Kitamura, S. and Yamada, H., Involvement of liver aldehyde oxidase in sulfoxide reduction. Chem. Pharm. Bull. (Japan), 30(12), 4585-4588 (1982).
-
(1982)
Chem. Pharm. Bull. (Japan)
, vol.30
, Issue.12
, pp. 4585-4588
-
-
Tatsumi, K.1
Kitamura, S.2
Yamada, H.3
-
75
-
-
0003164090
-
Glutathione-S-transferase and anticancer drug resistance
-
Wooley, P. V., Tew, K. D., Eds.; Academic Press: Orlando, FL
-
Tew, K. D. and Clapper, M. L., Glutathione-S-transferase and anticancer drug resistance. In Mechanism of Drug resistance in Neoplastic Cells; Wooley, P. V., Tew, K. D., Eds.; Academic Press: Orlando, FL; pp 141-159, 1987.
-
(1987)
Mechanism of Drug Resistance in Neoplastic Cells
, pp. 141-159
-
-
Tew, K.D.1
Clapper, M.L.2
-
76
-
-
0023123806
-
Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA
-
Tomasz, M., Lipman, R., Chowdary, D., Pawlak, J., Verdine, G. L. and Nakanish, K., Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA. Science, 235, 1204-1208 (1987).
-
(1987)
Science
, vol.235
, pp. 1204-1208
-
-
Tomasz, M.1
Lipman, R.2
Chowdary, D.3
Pawlak, J.4
Verdine, G.L.5
Nakanish, K.6
-
77
-
-
0019769657
-
Identification of three alkylated nucleotide adducts from the reaction of guanosine 5′-monophosphate with phosphoramide mustard
-
Vu, V. T., Fenselau, C. C. and Colvin, M. Identification of three alkylated nucleotide adducts from the reaction of guanosine 5′-monophosphate with phosphoramide mustard. J. Am. Chem. Soc., 103, 7362-7364 (1981).
-
(1981)
J. Am. Chem. Soc.
, vol.103
, pp. 7362-7364
-
-
Vu, V.T.1
Fenselau, C.C.2
Colvin, M.3
-
78
-
-
0024324086
-
Molecular enzymology of the bioactivation of hypoxic cell cytotoxins
-
Walton, M. I., Wolf, C. R. and Workman, P., Molecular enzymology of the bioactivation of hypoxic cell cytotoxins. Int. J. Radiat. Oncol. Biol. Phys., 16, 983-986 (1989).
-
(1989)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.16
, pp. 983-986
-
-
Walton, M.I.1
Wolf, C.R.2
Workman, P.3
-
79
-
-
0025284525
-
Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin
-
Walton, M. I. and Workman, P., Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin. Biochem. Pharmacol., 39, 1735-1742 (1990).
-
(1990)
Biochem. Pharmacol.
, vol.39
, pp. 1735-1742
-
-
Walton, M.I.1
Workman, P.2
-
80
-
-
0026092707
-
Aldophosphamide acetal diacetate and structural analogues: Synthesis and cytotoxicity studies
-
Wang, Y. and Farquhar, D., Aldophosphamide acetal diacetate and structural analogues: synthesis and cytotoxicity studies. J. Med. Chem., 34, 197-203 (1991).
-
(1991)
J. Med. Chem.
, vol.34
, pp. 197-203
-
-
Wang, Y.1
Farquhar, D.2
-
81
-
-
0002217293
-
-
Peterson, H. -I., Ed. CRC Press: Boca Raton, Fl
-
Warren, B. A., In Tumor Blood Circulation. Angiogenesis, vascular morphology and blood flow in experimental and humantumors. Peterson, H. -I., Ed. CRC Press: Boca Raton, Fl, , 1-47, 1978.
-
(1978)
Tumor Blood Circulation. Angiogenesis, Vascular Morphology and Blood Flow in Experimental and Humantumors
, pp. 1-47
-
-
Warren, B.A.1
-
82
-
-
0024427760
-
Reduction of nitromin to nitrogen mustard: Unsceduled DNA synthesis in aerobic or anaerobic rat hepatocytes, JB1, BL8 and Walker carcinoma cell lines
-
White I. N. H., Suzanger, M., Mattocks, A. R., Bailey, E., Farmer, P. B. and Conners, T. A., Reduction of nitromin to nitrogen mustard: unsceduled DNA synthesis in aerobic or anaerobic rat hepatocytes, JB1, BL8 and Walker carcinoma cell lines. Carcinogenesis, 10, 2113 (1989).
-
(1989)
Carcinogenesis
, vol.10
, pp. 2113
-
-
White, I.N.H.1
Suzanger, M.2
Mattocks, A.R.3
Bailey, E.4
Farmer, P.B.5
Conners, T.A.6
-
83
-
-
0024491246
-
Hypoxia-selective antitumor agents. 1. Relationships between structure, redox properties and hypoxia-selective cytotoxicity for 4-substituted derivatives of nitracrine
-
Wilson, W. R., Anderson, R. F. and Denny, W. A., Hypoxia-selective antitumor agents. 1. Relationships between structure, redox properties and hypoxia-selective cytotoxicity for 4-substituted derivatives of nitracrine. J. Med. Chem., 32, 23-30 (1989a).
-
(1989)
J. Med. Chem.
, vol.32
, pp. 23-30
-
-
Wilson, W.R.1
Anderson, R.F.2
Denny, W.A.3
-
84
-
-
0024529829
-
Hypoxia-selective antitumor agents. 2. Electronic effects of 4-substituents on the mechanisms of cytotoxicty and metabolic stability of nitracrine derivatives
-
Wilson, W. R., Thompson, L. H., Anderson, R. F. and Denny, W. A., Hypoxia-selective antitumor agents. 2. Electronic effects of 4-substituents on the mechanisms of cytotoxicty and metabolic stability of nitracrine derivatives. J. Med. Chem., 32, 31-38 (1989b).
-
(1989)
J. Med. Chem.
, vol.32
, pp. 31-38
-
-
Wilson, W.R.1
Thompson, L.H.2
Anderson, R.F.3
Denny, W.A.4
-
85
-
-
0002563124
-
Enzyme-directed bioreductive drug development
-
Adams, G. E.; Breccia, A.; Fielden, E. M.; Wardman, R eds., New York, NY, Plenum
-
Workman, P. and Walton, M. I., Enzyme-directed bioreductive drug development In "Selective activation of drugs by redox process", Adams, G. E.; Breccia, A.; Fielden, E. M.; Wardman, R eds., New York, NY, Plenum; pp. 173-191, 1991.
-
(1991)
Selective Activation of Drugs by Redox Process
, pp. 173-191
-
-
Workman, P.1
Walton, M.I.2
-
87
-
-
0019180231
-
Does acrolein contribute to the cytotoxicity of cyclophosphamide?
-
Wrabetz, E., Peter, G. and Hohorst, H. -J., Does acrolein contribute to the cytotoxicity of cyclophosphamide? Cancer Res. Clin. Oncol., 98, 119-126 (1980).
-
(1980)
Cancer Res. Clin. Oncol.
, vol.98
, pp. 119-126
-
-
Wrabetz, E.1
Peter, G.2
Hohorst, H.J.3
-
88
-
-
0017167325
-
Therapeutic trial of aniline mustard in patients with advanced cancer. Comparison of the therapeutic response with cytochemical assessment of tumor cell β-glucuronidase activity
-
Young, C. W., Yogoda, A., Bitlar, E. S., Smith, S. W., Gradstald, H. and Whitmore, W., Therapeutic trial of aniline mustard in patients with advanced cancer. Comparison of the therapeutic response with cytochemical assessment of tumor cell β-glucuronidase activity Cancer, 38, 1887-1895 (1976).
-
(1976)
Cancer
, vol.38
, pp. 1887-1895
-
-
Young, C.W.1
Yogoda, A.2
Bitlar, E.S.3
Smith, S.W.4
Gradstald, H.5
Whitmore, W.6
-
89
-
-
0022344589
-
Guinea pig liver aldehyde oxidase as a sulfoxide reductase: Its purification and characterization
-
Yoshihara, S. and Tatusumi, K., Guinea pig liver aldehyde oxidase as a sulfoxide reductase: its purification and characterization. Arch. Biochim. Biophys., 242, 213-224 (1985).
-
(1985)
Arch. Biochim. Biophys.
, vol.242
, pp. 213-224
-
-
Yoshihara, S.1
Tatusumi, K.2
-
90
-
-
0020437503
-
Cyclophosphamide Analogues
-
Zon, G., Cyclophosphamide Analogues. Prog. Med. Chem., 19, 205-246 (1982).
-
(1982)
Prog. Med. Chem.
, vol.19
, pp. 205-246
-
-
Zon, G.1
|