N3-methyl-mafosfamide as a chemically stable, alternative prodrug of mafosfamide

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 13, 1998, Pages 1673-1678

  Moon, Ki Young ^a   Kwon, Chul Hoon ^a  

^a ST JOHN'S UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; MAFOSFAMIDE; N METHYLMAFOSFAMIDE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; PRODRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DEMETHYLATION; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; LIVER MICROSOME; STRUCTURE ACTIVITY RELATION; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CELL STRAIN 3T3; CHEMISTRY; LEUKEMIA L 1210; MOUSE; PATHOLOGY; RAT;

3T3 CELLS; ANIMALS; ANTINEOPLASTIC AGENTS; CYCLOPHOSPHAMIDE; LEUKEMIA L1210; MICE; MICE, INBRED BALB C; PRODRUGS; RATS; TUMOR CELLS, CULTURED;

EID: 0032493193     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00287-X     Document Type: Article

References (29)

1. 1. Friedman, O. M.; Myles, A.; Colvin, M. Adv. Cancer Chemother. 1979, 1, 143.
2. 2. Brock, N.; Hohorst, H.-J. Z. Krebsforsch. Klin. Onkol. 1977, 88, 185.
3. 3. Brock, N. Cancer Treat. Rep. 1976, 60, 301.
4. 4. Sladek, N. E. Pharmacol. Ther. 1988, 37, 301.
5. 5. Jardine, I.; Fenselau, C.; Appler, M.; Kan, M.-N.; Brundrett, R. B.; Colvin, M. Cancer Res. 1978, 38, 408.
6. 6. Struck, R. F.; Kirk, M. C.; Witt, M. H.; Laster, W. R. Jr. Biomed. Mass Spectrom. 1975, 2, 46.
7. 7. Alberts, D.S.; Einspahr, J. G.; Struck, R. F.; Bignami, G.; Young, L.; Surwit, E. A.; Salmom, S.E. Invest. New Drugs 1984, 2, 141.
8. 8. Brock, N.; Stekar, J.; Pohl, J.; Niemeyer, U.; Scheffler, G. Arzneim.-Forsch. 1979, 29, 659.
9. 9. Cox, P. J. Biochem. Pharmacol. 1979, 28, 2045.
10. 10. Moon, K-. Y.; Shirota, F. N.; Baturay, N.; Kwon, C-. H. J. Med. Chem. 1995, 38, 848.
11. 11. Berrigan, M. J.; Marinello, A. J.; Pavelic, Z.; Williams, C. J.; Struck, R. F.; Gurtoo, H. C. Cancer Res. 1982, 42, 3688.
12. 12. (a) Brock, N.; Pohl, J.; Stekar, J.; Scheef, W. Eur. J. Cancer Clin. Oncol. 1982, 18, 1377.
13. (b) Schmahl, D.; Habs, M. R. Cancer Treat. Rev. 1983, 10, Suppl. A, 57.
14. (c) Millar, B. C.; Millar, J. L.; Clutterbuck, R.; Jinks, S. Cancer Treat. Rev. 1983, 10, Suppl. A, 63.
15. (d) Wagner, T.; Zink, M.; Schwieder, G. J. Cancer Res. Clin. Oncol. 1987, 113, 160.
16. (e) Bernacki, R. J.; Bansal, S. K.; Gurtoo, H. L. Cancer Res. 1987, 47, 799.
17. 13. Niemeyer, U.; Engel, J.; Scheffler, G.; Molge, K.; Sauerbier, D.; Weigert, W. Invest. New Drugs 1984, 2, 133.
18. 14. Kwon, C.-H.; Borch, R. F.; Engel, J.; Niemeyer, U. J. Med. Chem. 1987, 30, 395.
19. 15. (a) Klein, H. O.; Wickramanayake, P. D.; Christian, E.; Coerper, C. Invest. New Drugs 1984, 2, 191.
20. (b) Berger, M. R.; Bedford, P.; Zeller, W. J.; Kaufmann, M. Invest. New Drugs 1984, 2, 181.
21. (c) Nowrousian, M. R.; Schmidt, C. G. Invest. New Drugs 1984, 2, 207.
22. 16. Atassi, G.; Hilgard, P.; Pohl, J. Invest. New Drugs 1984, 2, 169.
23. 17. Pohl, J.; Hilgard, P.; Jahn, W.; Zechel, H. J. Invest. New Drugs 1984, 2, 201.
24. 18. (a) Bruntsch, U.; Groos, G.; Hiller, T. A.; Wandt, H.; Tigges, F.-J.; Gallmeier, W. M. Invest. New Drugs 1985, 3, 293.
25. (b) Abele, R.; Aapro, M. S.; Haefliger, J-M.; Alberto, P. Cancer Chemo. Pharmaco. 1986, 16, 182.
26. 19. Kwon, C.-H.; Borch, R. F. J. Med. Chem. 1989, 32, 1491.
27. 2O): Calcd, C: 36.78, H: 6.76, N: 7.97; Found, C: 36.76, H: 6.62, N: 7.23.
28. 21. Kwon, C.-H.; Moon, K.-Y.; Baturay, N.; Shirota, F. N. J. Med. Chem. 1991, 34, 588.
29. 22. Baturay, N. Z.; Trombetta, L. D. Arch. Dermatol. Res. 1988, 280, 443.