Brain free magnesium concentration is predictive of motor outcome following traumatic axonal brain injury in rats

Magnesium Research

Volumn 12, Issue 4, 1999, Pages 269-277

  Heath, Deanne L ^a   Vink, Robert ^a  

^a JAMES COOK UNIVERSITY   (Australia)

Author keywords

Brain trauma; Magnesium; Magnetic resonance; Neurotrauma

Indexed keywords

MAGNESIUM;

ANIMAL; ARTICLE; BRAIN INJURY; BRAIN LEVEL; MALE; METABOLISM; MOTOR ACTIVITY; NEUROLOGIC DISEASE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOPHYSIOLOGY; PH; PROGNOSIS; RAT; SPRAGUE DAWLEY RAT; TIME;

ANIMALS; BRAIN CHEMISTRY; BRAIN INJURIES; HYDROGEN-ION CONCENTRATION; MAGNESIUM; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MOTOR ACTIVITY; NERVOUS SYSTEM DISEASES; PROGNOSIS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 0033250030     PISSN: 09531424     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Fearnside, M.R. & Simpson, D.A. (1997): Epidemiology. In: Head injury: pathophysiology and management of severe closed head injury, eds. P. Reilly & R. Bullock, pp. 3-23. New York: Chapman & Hall Medical.
2. Goldstein, M. (1990): Traumatic brain injury: a silent epidemic. Ann. Neurol. 27, 327.
3. Faden, A.I. (1993): Experimental neurobiology of central nervous system trauma. Crit. Rev. Neurobiol. 7, 175-186.
4. McIntosh, T.K. (1993): Novel pharmacologic therapies in the treatment of experimental traumatic brain injury: a review. J. Neurotrauma 10, 215-261.
5. Vink, R., Heath, D.L. & McIntosh, T.K. (1996): Acute and prolonged alterations in brain free magnesium following fluid percussion induced brain trauma in rats. J. Neurochem. 66, 2477-2483.
6. Headrick, J.P., Bendall, M.R., Faden, A.I. & Vink, R. (1994): Dissociation of adenosine levels from bioenergetic state in experimental brain trauma: potential role in secondary injury. J. Cereb. Blood Flow Metab. 14, 853-861.
7. Heath, D.L. & Vink, R. (1995): Impact acceleration induced severe diffuse axonal injury in rats: characterization of phosphate metabolism and neurologic outcome. J. Neurotrauma 12, 1027-1034.
8. Suzuki, M., Nishina, M., Endo, M., Matsushita, K., Tetsuka, M., Shima, K. & Okuyama, S. (1997): Decrease in cerebral free magnesium concentration following closed head injury and effects of VA-045 in rats. Gen. Pharmacol. 28, 119-121.
9. McIntosh, T.K., Vink, R., Soares, H., Hayes, R.L. & Simon, R.P. (1990): Effect of noncompetitive blockade of N-methyl-D-aspartate receptors on the neurochemical sequelae of experimental brain injury. J. Neurochem. 55, 1170-1179.
10. Shapira, Y., Lam, A.M., Artru, A.A., Eng, C. & Soltow, L. (1993): Ketamine alters calcium and magnesium in brain tissue following experimental head trauma in rats. J. Cereb. Blood Flow Metab. 13, 962-968.
11. Vink, R., McIntosh, T.K., Demediuk, P. & Faden, A.I. (1987): Decrease in total and free magnesium concentration following traumatic brain injury in rats. Biochem. Biophys. Res. Commun. 149, 594-599.
12. Faden, A.I., Demediuk, P., Panter, S.S. & Vink, R. (1989): Excitatory amino acids. N-methyl-D-asparate receptors and traumatic brain injury. Science 244, 798-800.
13. McIntosh, T.K., Vink, R., Yamakami, I. & Faden, A.I. (1989): Magnesium protects against neurological deficit after brain injury. Brain Res. 482, 252-260.
14. Smith, D.H., Okiyama, K., Gennarelli, T.A. & McIntosh, T.K. (1993): Magnesium and ketamine attenuate cognitive dysfunction following experimental brain injury. Neurosci. Lett. 157, 211-214.
15. 2 in closed head injury: a comparative phosphorus NMR study. J. Neurotrauma 15, 183-189.
16. 31P magnetic resonance spectroscopy and behavioural studies. J. Neurotrauma 5, 17-31.
17. Mullins, P.G.M. & Vink, R. (1995): Chronic alcohol exposure decreases brain intracellular free magnesium concentration in rats. NeuroReport 6, 1633-1636.
18. Birch, N.J. (1993): Magnesium and the Cell London: Academic Press.
19. Adams, J.H., Doyle, D. & Ford, I. (1989): Diffuse axonal injury in head injury: definition, diagnosis and grading. Histopaihology. 15, 49-59.
20. Foda, M.A.A. & Marmarou, A. (1994): A new model of diffuse brain injury in rats: Part II: morphological characterization. J. Neurosurg. 80, 301-313.
21. Marmarou, A., Foda, M.A.A., Van den Brink, W., Campbell, J., Kita, H. & Demetriadou, K. (1994): A new model of diffuse brain injury in rats: Part I: pathophysiology and biomechanics. J. Neurosurg. 80, 291-300.
22. Heath, D.L. & Vink, R. (1996): Traumatic brain injury produces sustained decline in intracellular free magnesium concentration. Brain Research 738, 150-153.
23. 31P magnetic resonance spectroscopy study. J. Cereb. Blood Flow Metab. 7, 563-571.
24. Hamm, R.J., Pike, B.R., O'Dell, D.M., Lyeth, B.C. & Jenkins, L.W. (1994): The rotarod test: an evaluation of its effectiveness in assessing motor deficits following traumatic brain injury. J. Neurotrauma 11, 187-196.
25. 31P NMR spectroscopy. Physiol. Chem. Physics Med. NMR 15, 265-280.
26. Vink, R, Golding, E.M. & Headrick, J.P. (1994): Bioenergetic analysis of oxidative metabolism following traumatic brain injury in rats. J. Neurotrauma 11, 265-274.
27. Bock, J.L., Wenz, B. & Gupta, R.K. (1987): Studies on the mechanism of decreased NMR-measured free magnesium in stored erythrocytes. Biochim. Biophys. Acta 928, 8-12.
28. Ishige, M., Pitts, L.H., Hashimoto, T., Nishmura, M.C. & Bartkowski, H.M. (1987): The effect of hypoxia on traumatic brain injury in rats: part 1. Changes in neurological function, electroen-cephalograms, and histopathology. J. Neurosurg. 6, 848-853.
29. Christman, C.W., Grady, M.S., Walker, S.A., Holloway, K.L. & Povlishock, J.T. (1994): Ultrastructural studies of diffuse axonal injury in humans. J. Neurotrauma 11, 173-186.
30. Povlishock, J.T. & Pettus, E.H. (1996): Traumatically induced axonal damage: evidence for enduring changes in axolemmal permeability with associated cytoskeletal change. Acta Neurochir. 66, 81-86.
31. Povlishock, J.T. & Christman, C.W. (1994): The pathobiology of traumatic brain injury. In: The Neurobiology of Central Nervous System Trauma, eds. S.K. Salzman & A.I. Faden, pp. 109-120, New York: Oxford University Press.
32. Povlishock, J.T., Marmarou, A., McIntosh, T.K., Trojanowski, J.Q. & Moroi, J. (1997): Impact acceleration injury in the rat - evidence for focal axolemmal change and related neurofilament sidearm alteration. J. Neuropathol. Exp. Neurol. 56, 347-359.
33. Vink, R. (1993): Nuclear magnetic resonance characterization of secondary mechanisms following traumatic brain injury. Mol. Chem. Neuropathol. 18, 279-297.
34. Ebel, H. & Gunther, T. (1980): Magnesium metabolism: a review. J. Clin. Chem. Clin. Biochem. 18, 257-270.
35. Terasaki, M. & Rubin, H. (1985): Evidence that intracellular magnesium is present in cells at a regulatory concentration for protein synthesis. Proc. Natl. Acad. Sci. USA 82, 7324-7326.
36. Rubin, H. (1976): Magnesium deprivation reproduces the coordinate effects of serum removal or cortisol addition on transport and metabolism in chick embryo fibroblasts. J. Cell Physiol. 89, 613-626.
37. Grubbs, R.D. & Maguire, M.E. (1987): Magnesium as a regulatory cation: criteria and evaluation. Magnesium 6, 113-127.
38. Bara, M. & Guiet-Bara, A. (1984) Potassium, magnesium and membranes. Review of present status and new findings. Magnesium 3, 212-225.
39. Anderson, D. & Hall, E. (1994): Llpid hydrolysis and free radical formation in central nervous system trauma. In: The neurobiology of central nervous system trauma, eds. S. Salzman & A. Faden, pp. New York: Oxford University Press.
40. 2+ of NMDA responses in spinal cord neurons. Nature 309, 261-263.
41. 2+ blockade of NMDA current in mechanically injured neurons. Science 274, 1921-1923.
42. Rothman, S.M. (1983): Synaptic activity mediates death of hypoxic neurons. Science 220, 536-537.