Decrease in cerebral free magnesium concentration following closed head injury and effects of VA-045 in rats

General Pharmacology

Volumn 28, Issue 1, 1997, Pages 119-121

  Suzuki, Masahiko ^a   Nishina, Masami ^a   Endo, Makoto ^a   Matsushita, Kazuhiro ^a   Tetsuka, Mitsue ^a   Shima, Katsuji ^b   Okuyama, Shigeru ^c  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^c TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

31P NMR; closed head injury; free magnesium; rat brain; VA 045

Indexed keywords

APOVINCAMINIC ACID; APOVINCAMINIC ACID DERIVATIVE; EBURNAMENINE 14 CARBOXYLIC ACID (2 NITROXYETHYL) ESTER; MAGNESIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; HEAD INJURY; MALE; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN CHEMISTRY; HEAD INJURIES, CLOSED; HYDROGEN-ION CONCENTRATION; MAGNESIUM; MAGNETIC RESONANCE SPECTROSCOPY; MALE; RATS; RATS, WISTAR;

EID: 0031022410     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(96)00148-6     Document Type: Article

References (15)

1. Dixon C. E., Lyeth B. G., Povlishock J. T., Findling R. L., Hamm R. J., Marmarou A., Young H. F. and Hayes R. L. (1987) A fluid percussion model of experimental brain injury in the rat. J. Neurosurg. 67, 110-119.
2. Ebel H. and Günther T. (1980) Magnesium metabolism: A review. J. Clin. Chem. Clin. Biochem. 18, 257-270.
3. Foda M. A. A. and Marmarou A. (1994) A new model of diffuse brain injury in rats. Part II: Morphological characterization. J. Neurosurg. 80, 301-313.
4. Gupta R. K., Gupta P. and Moore R.D. (1984) NMR studies of intracellular metal ions in intact cells and tissues. Ann. Rev. Biophys. Bioeng. 13, 221-246.
5. Kawashima Y., Ikemoto T., Horiguchi A., Hayashi M., Matsumoto K., Kawarasaki K., Yamazaki R., Okuyama S. and Hatayama K. (1993) Synthesis and pharmacological evaluation of (nitrooxy)alkyl apovincaminates. J. Med. Chem. 36, 815-819.
6. Marmarou A., Foda M. A. A., van den Brink W., Campbell J., Kita H. and Demetriadou K. (1994) A new model of diffuse brain injury in rats. Part I: Pathophysiology and biomechanics. J. Neurosurg. 80, 291-300.
7. McIntosh T. K., Vink R., Noble L., Yamakami I., Fernyak S., Soares H. and Faden A. L. (1989) Traumatic brain injury in the rat: characterization of lateral fluid-percussion model. Neuroscience 28, 233-244.
8. Okuyama S., Imagawa Y., Ogawa S., Araki H., Omoto S., Sakagawa T., Yamada S. and Shima K. (1993) Effect of VA-045 on a closed head injury model in rats. Life Sci. 53, PL 273-278.
9. Prichard J. W. and Shulman R. G. (1986) NMR spectroscopy of brain metabolism in vivo. Ann. Rev. Neurosci. 9, 61-85.
10. 31P-NMR technique. The second dissociation constant of phosphoric acid in a biological system. J. Biochem. (Tokyo) 94, 729-734.
11. Sullivan H. G., Martinez J., Becker D. P., Miller J. D., Grifeith R. and Wist A. O. (1976) Fluid-percussion model of mechanical brain injury in the cat. J. Neurosurg. 45, 520-534.
12. Veloso D., Guynn R. W., Oskarsson M. and Veech R. L. (1973) The concentrations of free and bound magnesium in rat tissues. J. Biol. Chem. 248, 4811-4819.
13. Vink R. (1993) Nuclear magnetic resonance characterization of secondary mechanisms following traumatic brain injury. Mol. Chem. Neuropathol. 18, 279-297.
14. Vink R., McIntosh T. K, Demediuk P. and Faden A. I. (1987) Decrease in total and free magnesium concentration following traumatic brain injury in rats. Biochem. Biophys. Res. Commun. 149, 594-599.
15. 2+ is associated with irreversible tissue injury after brain trauma. J. Biol. Chem. 263, 757-761.