Mixed-backbone oligonucleotides containing segments of deoxynucleosides phosphorothioate and 2'-O-methylribonucleosides methylphosphonate: Synthesis and properties

Phosphorus, Sulfur and Silicon and Related Elements

Volumn 144-146, Issue , 1999, Pages 363-366

  Guo, Maojun ^a   Yu, Dong ^a   Agrawal, Sudhir ^a  

^a HYBRIDON INC   (United States)

Author keywords

Antisense; Methylphosphonamidite; Methylphosphonate; Oligonucleotide; Phosphoramidite; Phosphorothioate

Indexed keywords

EID: 0033234618     PISSN: 10426507     EISSN: None     Source Type: Journal    
DOI: 10.1080/10426509908546256     Document Type: Article

References (13)

1. (a) Antisense Therapeutics, S. Agrawal, Ed. Humana Press, Totowa (New Jersey) (1996);
2. (b) S. Agrawal, Trends in Biotechnology, 14, 376 (1996);
3. (c) S. Agrawal, and Q. Zhao, Antisense & Nucleic Acid Drug Dev. 8, 135 (1998);
4. (d) S. Agrawal,; et al Biochem. Pharm. 50, 571 (1995);
5. (e) D. Yu, R. P. Iyer, and S. Agrawal, Bioorg. & Med. Chem, 4, 1685 (1996);
6. (f) S. T. Crooke, et al J. Pharm. Exp. Ther. 277, 923 (1996).
7. S. Agrawal M. P. Civiera, J. Goodchild, T. Ikeuchi, and P. C. Zamecnik, Proc. Natl. Acad. Sci. U. S. A. 85, 7448 (1988).
8. (a) E. R. Kandimalla, J. Temsamani, and S. Agrawal, Nucleosides and Nucleotides, 14, 1031 (1995);
9. (b) J. M. Kean, S. A. Kipp, P. S. Miller, M. Kulka, and L. Aurelian, Biochemistry, 34, 14617 (1995).
10. R. P. Iyer, D. Yu, I. Habus, N. Ho, S. Johnson, T. Devlin, Z. Jiang, W. Zhou, J. Xie, and S. Agrawal, Tetrahedron, 53, 2731 (1997).
11. Y. S. Cho-Chung, M. Nesterova, S. Agrawal, and K. Noguchi, Proc. Am. Assoc. Cancer Res. 351 (1996).
12. R. P. Iyer, D. Yu, J. Xie, W. Zhou, and S. Agrawal, Bioorg & Med. Chem. Lett. 7,1443 (1977).
13. S. Agrawal, Z. Jiang, Q. Zhao, D. Shaw, Q. Cai, A. Roskey, L. Channavajjala, C. Saxinger, and R. Zhang, Proc. Natl. Acad. Sci. U.S.A. 94, 2620 (1997).