메뉴 건너뛰기




Volumn 22, Issue 3, 1996, Pages 341-349

A summary of monoclonal antibody-enzyme/prodrug

Author keywords

anticancer prodrugs; antitumor activities; monoclonal antibodies; pharmacokinetic data

Indexed keywords

ANTIBODIES; CELLS; DISEASES; DRUG THERAPY; ENZYMES; MONOCLONAL ANTIBODIES; OXYGEN; PHARMACOKINETICS;

EID: 0030589728     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(96)00445-0     Document Type: Review
Times cited : (18)

References (57)
  • 1
    • 0022576114 scopus 로고
    • Prodrugs in cancer chemotherapy
    • [1] Wilman, D.E.V. (1986) Prodrugs in cancer chemotherapy. Biochem. Soc. Trans. 14, 375-382.
    • (1986) Biochem. Soc. Trans. , vol.14 , pp. 375-382
    • Wilman, D.E.V.1
  • 2
    • 0023774712 scopus 로고
    • New directions in the design and evaluation of anti-cancer drugs
    • [2] Denny, W.A. (1988) New directions in the design and evaluation of anti-cancer drugs. Drug Des. Deliv. 3, 99-124.
    • (1988) Drug Des. Deliv. , vol.3 , pp. 99-124
    • Denny, W.A.1
  • 3
    • 0023022559 scopus 로고
    • Prodrugs in cancer chemotherapy
    • [3] Conners, T.A. (1986) Prodrugs in cancer chemotherapy. Xenobiotica 16, 975-988.
    • (1986) Xenobiotica , vol.16 , pp. 975-988
    • Conners, T.A.1
  • 5
    • 0345678344 scopus 로고
    • Design of anticancer prodrugs: Substrates for antibody targeted enzymes
    • [5] Jungheim, L.N. and Shepherd, T.A. (1994) Design of anticancer prodrugs: substrates for antibody targeted enzymes. Chem. Rev. 94, 1553-1566.
    • (1994) Chem. Rev. , vol.94 , pp. 1553-1566
    • Jungheim, L.N.1    Shepherd, T.A.2
  • 6
    • 0015860417 scopus 로고
    • Selective cytotoxicity of hapten-substituted cells with an antibody-enzyme conjugate
    • [6] Philpott, G.W., Shearer, W.T., Bower, R.W. and Parker C.W. (1973) Selective cytotoxicity of hapten-substituted cells with an antibody-enzyme conjugate. J. Immunol. 111, 921-929.
    • (1973) J. Immunol. , vol.111 , pp. 921-929
    • Philpott, G.W.1    Shearer, W.T.2    Bower, R.W.3    Parker, C.W.4
  • 7
    • 0024416713 scopus 로고
    • An immunotoxin system intended for bone marrow purging composed of glucose oxidase and lactoperoxidase coupled to monoclonal antibody 097
    • [7] Ito, H., Morizet, J., Coulombel, L., Goavec, M., Rousseau, V., Bernard, A. and Stanislawski, M. (1989) An immunotoxin system intended for bone marrow purging composed of glucose oxidase and lactoperoxidase coupled to monoclonal antibody 097. Bone Marrow Transplant. 4, 519-527.
    • (1989) Bone Marrow Transplant , vol.4 , pp. 519-527
    • Ito, H.1    Morizet, J.2    Coulombel, L.3    Goavec, M.4    Rousseau, V.5    Bernard, A.6    Stanislawski, M.7
  • 8
    • 0025615759 scopus 로고
    • T cell depletion of human bone marrow using an oxidase-peroxidase enzyme immunotoxin
    • [8] Ito, H., Morizet, J., Coulombel, L. and Stanislawski, M. (1990) T cell depletion of human bone marrow using an oxidase-peroxidase enzyme immunotoxin. Bone Marrow Transplant. 6, 395-398.
    • (1990) Bone Marrow Transplant , vol.6 , pp. 395-398
    • Ito, H.1    Morizet, J.2    Coulombel, L.3    Stanislawski, M.4
  • 14
    • 0029019242 scopus 로고
    • In vitro and in vivo activities of a doxorubicin prodrug in combination with monoclonal antibody-β-lactamase conjugates
    • [14] Svensson, H.P., Vrudhula, V.M., Emsweiler, J.E., MacMaster, J.F., Cosand, W.L., Senter, P.D. and Wallace, P.M. (1995) In vitro and in vivo activities of a doxorubicin prodrug in combination with monoclonal antibody-β-lactamase conjugates. Cancer Res. 55, 2357-2365.
    • (1995) Cancer Res. , vol.55 , pp. 2357-2365
    • Svensson, H.P.1    Vrudhula, V.M.2    Emsweiler, J.E.3    MacMaster, J.F.4    Cosand, W.L.5    Senter, P.D.6    Wallace, P.M.7
  • 15
    • 0028154911 scopus 로고
    • Targeting enzymes for cancer therapy: Old enzymes in new roles
    • [15] Deonarain, M.P. and Epenetos, A.A. (1994) Targeting enzymes for cancer therapy: old enzymes in new roles. Br. J. Cancer 70, 786-794.
    • (1994) Br. J. Cancer , vol.70 , pp. 786-794
    • Deonarain, M.P.1    Epenetos, A.A.2
  • 16
    • 0028796170 scopus 로고
    • Antibody-directed enzyme prodrug therapy
    • [16] Knox, R.J. and Conners, T.A. (1995) Antibody-directed enzyme prodrug therapy. Clin. Immunother. 3, 136-153.
    • (1995) Clin. Immunother. , vol.3 , pp. 136-153
    • Knox, R.J.1    Conners, T.A.2
  • 17
    • 0027220125 scopus 로고
    • Site-specific prodrug activation by antibody-β-lactamase conjugates: Regression and long-term growth inhibition of human colon carcinoma xenograft models
    • [17] Meyer, D.L., Jungheim, L.N., Law, K.L., Mikolajczyk, S.D., Shepherd, T.A., Mackensen, D.G., Briggs, S.L. and Starling, J.J. (1993) Site-specific prodrug activation by antibody-β-lactamase conjugates: regression and long-term growth inhibition of human colon carcinoma xenograft models. Cancer Res. 53, 3956-3963.
    • (1993) Cancer Res. , vol.53 , pp. 3956-3963
    • Meyer, D.L.1    Jungheim, L.N.2    Law, K.L.3    Mikolajczyk, S.D.4    Shepherd, T.A.5    Mackensen, D.G.6    Briggs, S.L.7    Starling, J.J.8
  • 18
    • 0029095503 scopus 로고
    • Regressions and cures of melanoma xenografts following treatment with monoclonal antibody β-lactamase conjugates in combination with anticancer prodrugs
    • [18] Kerr, D.E., Schreiber, G.L., Vrudhula, V.M., Svensson, H.P., Hellström, I., Hellström, K.E. and Senter, P.D. (1995) Regressions and cures of melanoma xenografts following treatment with monoclonal antibody β-lactamase conjugates in combination with anticancer prodrugs. Cancer Res. 55, 3558-3563.
    • (1995) Cancer Res. , vol.55 , pp. 3558-3563
    • Kerr, D.E.1    Schreiber, G.L.2    Vrudhula, V.M.3    Svensson, H.P.4    Hellström, I.5    Hellström, K.E.6    Senter, P.D.7
  • 19
    • 0027655158 scopus 로고
    • Antitumor activities of a cephalosporin prodrug in combination with monoclonal antibody-β-lactamase conjugates
    • [19] Vrudhula, V.M., Svensson, H.P., Kennedy, K.A., Senter, P.D. and Wallace, P.M. (1993) Antitumor activities of a cephalosporin prodrug in combination with monoclonal antibody-β-lactamase conjugates. Bioconjugate Chem. 4, 334-340.
    • (1993) Bioconjugate Chem. , vol.4 , pp. 334-340
    • Vrudhula, V.M.1    Svensson, H.P.2    Kennedy, K.A.3    Senter, P.D.4    Wallace, P.M.5
  • 21
    • 0028335819 scopus 로고
    • Intratumoral generation of 5-fluorouracil mediated by an antibody-cytosine deaminase conjugate in combination with 5-fluorocytosine
    • [21] Wallace, P.M., MacMaster, J.F., Smith, V.F., Kerr, D.E., Senter, P.D. and Cosand, W.L. (1994) Intratumoral generation of 5-fluorouracil mediated by an antibody-cytosine deaminase conjugate in combination with 5-fluorocytosine. Cancer Res. 54, 2719-2723.
    • (1994) Cancer Res. , vol.54 , pp. 2719-2723
    • Wallace, P.M.1    MacMaster, J.F.2    Smith, V.F.3    Kerr, D.E.4    Senter, P.D.5    Cosand, W.L.6
  • 22
    • 0028348376 scopus 로고
    • Tumor-selective prodrug activation by fusion protein-mediated catalysis
    • [22] Bosslet, K., Czech, J. and Hoffmann, D. (1994) Tumor-selective prodrug activation by fusion protein-mediated catalysis. Cancer Res. 54, 2151-2159.
    • (1994) Cancer Res. , vol.54 , pp. 2151-2159
    • Bosslet, K.1    Czech, J.2    Hoffmann, D.3
  • 23
    • 0024446208 scopus 로고
    • Enhancement of the in vitro and in vivo antitumor activities of phosphorylated mitomycin c and etoposide derivatives by monoclonal antibody-alkaline phosphatase conjugates
    • [23] Senter, P.D., Schreiber, G.J., Hirschberg, D.L., Ashe, S.A., Hellström, K.E. and Hellström, I. (1989) Enhancement of the in vitro and in vivo antitumor activities of phosphorylated mitomycin c and etoposide derivatives by monoclonal antibody-alkaline phosphatase conjugates. Cancer Res. 49, 5789-5792.
    • (1989) Cancer Res. , vol.49 , pp. 5789-5792
    • Senter, P.D.1    Schreiber, G.J.2    Hirschberg, D.L.3    Ashe, S.A.4    Hellström, K.E.5    Hellström, I.6
  • 24
    • 0026577584 scopus 로고
    • Analysis of a conjugate between anti-carcinoembrionic antigen monoclonal antibody and alkaline phosphatase for specific activation of the prodrug etoposide phosphate
    • [24] Haisma, H.J., Boven, E., van Muijen, M., De Vries, R. and Pinedo, H.M. (1992) Analysis of a conjugate between anti-carcinoembrionic antigen monoclonal antibody and alkaline phosphatase for specific activation of the prodrug etoposide phosphate. Cancer Immunol. Immunother. 34, 343-348.
    • (1992) Cancer Immunol. Immunother. , vol.34 , pp. 343-348
    • Haisma, H.J.1    Boven, E.2    Van Muijen, M.3    De Vries, R.4    Pinedo, H.M.5
  • 25
    • 0025186181 scopus 로고
    • Specific activation of the prodrug mitomycin phosphate by a bispecific anti-CD30/ anti-alkaline phosphatase monoclonal antibody
    • [25] Sahin, U., Hartmann, F., Senter, P., Pohl, C. Engert, A., Diehl, V. and Pfreundschuh, M. (1990) Specific activation of the prodrug mitomycin phosphate by a bispecific anti-CD30/ anti-alkaline phosphatase monoclonal antibody. Cancer Res. 50, 6944-6948.
    • (1990) Cancer Res. , vol.50 , pp. 6944-6948
    • Sahin, U.1    Hartmann, F.2    Senter, P.3    Pohl, C.4    Engert, A.5    Diehl, V.6    Pfreundschuh, M.7
  • 26
    • 0025174052 scopus 로고
    • Activation of prodrugs by antibody-enzyme conjugates: A new approach to cancer therapy
    • [26] Senter, P.D. (1990) Activation of prodrugs by antibody-enzyme conjugates: a new approach to cancer therapy. FASEB J. 4, 188-193.
    • (1990) FASEB J. , vol.4 , pp. 188-193
    • Senter, P.D.1
  • 27
    • 0026212613 scopus 로고
    • In vitro and in vivo activities of monoclonal antibody-alkaline phosphatase conjugates in combination with phenol mustard phosphate
    • [27] Wallace, P.M. and Senter, P.D. (1991) In vitro and in vivo activities of monoclonal antibody-alkaline phosphatase conjugates in combination with phenol mustard phosphate. Bioconjugate Chem. 2, 349-352.
    • (1991) Bioconjugate Chem. , vol.2 , pp. 349-352
    • Wallace, P.M.1    Senter, P.D.2
  • 28
    • 0025936081 scopus 로고
    • Anti-neoplastic glucuronide prodrug treatment of human tumor cells targeted with a monoclonal antibody-enzyme conjugate
    • [28] Roffler, S.R., Wang, S.-M., Chern, J.-W., Yeh, M.-Y. and Tung, E. (1991) Anti-neoplastic glucuronide prodrug treatment of human tumor cells targeted with a monoclonal antibody-enzyme conjugate. Biochem. Pharmacol. 42, 2062-2065.
    • (1991) Biochem. Pharmacol. , vol.42 , pp. 2062-2065
    • Roffler, S.R.1    Wang, S.-M.2    Chern, J.-W.3    Yeh, M.-Y.4    Tung, E.5
  • 29
    • 0026794283 scopus 로고
    • Specific activation of glucuronide prodrugs by antibody-targeted enzyme conjugates for cancer therapy
    • [29] Roffler, S.R., Chern, J.-W., Yeh, M.-Y., Ng, J.C. and Tung, E. (1992) Specific activation of glucuronide prodrugs by antibody-targeted enzyme conjugates for cancer therapy. Cancer Res. 52, 4484-4491.
    • (1992) Cancer Res. , vol.52 , pp. 4484-4491
    • Roffler, S.R.1    Chern, J.-W.2    Yeh, M.-Y.3    Ng, J.C.4    Tung, E.5
  • 30
    • 0026802983 scopus 로고
    • A monoclonal antibody-β-glucuronidase conjugate as activator of the prodrug epirubicin-glucuronide for specific treatment of cancer
    • [30] Haisma, H.J., Boven, E., van Muijen, M., de Jong, J., van der Vijgh, W.J.F. and Pinedo, H.M. (1992) A monoclonal antibody-β-glucuronidase conjugate as activator of the prodrug epirubicin-glucuronide for specific treatment of cancer. Br. J. Cancer 66, 474-478.
    • (1992) Br. J. Cancer , vol.66 , pp. 474-478
    • Haisma, H.J.1    Boven, E.2    Van Muijen, M.3    De Jong, J.4    Van Der Vijgh, W.J.F.5    Pinedo, H.M.6
  • 32
    • 0024583590 scopus 로고
    • Carboxypeptidase-mediated release of methotrexate from methotrexate-α-peptides
    • [32] Kuefner, U., Lohrmann, U., Montejano, Y.D., Vitols, K.S. and Huennekens, P.M. (1989) Carboxypeptidase-mediated release of methotrexate from methotrexate-α-peptides. Biochemistry 28, 2288-2297.
    • (1989) Biochemistry , vol.28 , pp. 2288-2297
    • Kuefner, U.1    Lohrmann, U.2    Montejano, Y.D.3    Vitols, K.S.4    Huennekens, P.M.5
  • 33
    • 0025937458 scopus 로고
    • Construction and chemotherapeutic potential of carboxypeptidase-A/monoclonal antibody conjugate
    • [33] Esswein, A., Hansler, E., Montejano, Y, Vitols, K.S. and Huennekens, F.M. (1991) Construction and chemotherapeutic potential of carboxypeptidase-A/monoclonal antibody conjugate. Adv. Enzyme Regul. 31, 3-12.
    • (1991) Adv. Enzyme Regul. , vol.31 , pp. 3-12
    • Esswein, A.1    Hansler, E.2    Montejano, Y.3    Vitols, K.S.4    Huennekens, F.M.5
  • 34
    • 0028985514 scopus 로고
    • Methotrexate-α-phenylalanine: Optimization of methotrexate prodrug for activation by carboxypeptidase A-monoclonal antibody conjugate
    • [34] Vitols, K.S., Haag-Zeino, B., Baer, T., Montejano, Y.D. and Huennekens, F.M. (1995) Methotrexate-α-phenylalanine: optimization of methotrexate prodrug for activation by carboxypeptidase A-monoclonal antibody conjugate. Cancer Res. 55, 478-481.
    • (1995) Cancer Res. , vol.55 , pp. 478-481
    • Vitols, K.S.1    Haag-Zeino, B.2    Baer, T.3    Montejano, Y.D.4    Huennekens, F.M.5
  • 36
    • 0025189891 scopus 로고
    • Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2
    • [36] Springer, C.J., Antoniw, P., Bagshawe, K.D., Searle, P., Bisset, G.M.F. and Jarman, M. (1990) Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2. J. Med. Chem. 33, 677-681.
    • (1990) J. Med. Chem. , vol.33 , pp. 677-681
    • Springer, C.J.1    Antoniw, P.2    Bagshawe, K.D.3    Searle, P.4    Bisset, G.M.F.5    Jarman, M.6
  • 38
    • 0025373638 scopus 로고
    • Inactivation and clearance of an anti-CEA carboxypeptidase G2 conjugate in blood after localisation in a xenograft model
    • [38] Sharma, S.K., Bagshawe, K.D., Burke, P.J., Boden, R.W. and Rogers, G.T. (1990) Inactivation and clearance of an anti-CEA carboxypeptidase G2 conjugate in blood after localisation in a xenograft model. Br. J. Cancer 61, 659-662.
    • (1990) Br. J. Cancer , vol.61 , pp. 659-662
    • Sharma, S.K.1    Bagshawe, K.D.2    Burke, P.J.3    Boden, R.W.4    Rogers, G.T.5
  • 40
    • 0027942213 scopus 로고
    • Regression of established breast carcinoma xenografts with antibody-directed enzyme prodrug therapy against c-erbB2 p185
    • [40] Eccles, S.A., Court, W.J., Box, G.A., Dean, C.J., Melton, R.G. and Springer, C.J. (1994) Regression of established breast carcinoma xenografts with antibody-directed enzyme prodrug therapy against c-erbB2 p185. Cancer Res. 54, 5171-5177.
    • (1994) Cancer Res. , vol.54 , pp. 5171-5177
    • Eccles, S.A.1    Court, W.J.2    Box, G.A.3    Dean, C.J.4    Melton, R.G.5    Springer, C.J.6
  • 41
    • 0000283906 scopus 로고
    • Antibody-guided enzyme nitrile therapy (Agent): In vitro cytotoxicity and in vivo tumour localisation
    • A.A. Epenetos (Ed.), Chapman and Hall, London
    • [41] Rowlinson-Busza, G., Bamias, A., Krausz, T. and Epenetos, A.A. (1992) Antibody-guided enzyme nitrile therapy (Agent): in vitro cytotoxicity and in vivo tumour localisation. In: A.A. Epenetos (Ed.), Monoclonal Antibodies 2. Applications in Clinical Oncology. Chapman and Hall, London, pp. 111-118.
    • (1992) Monoclonal Antibodies 2. Applications in Clinical Oncology , pp. 111-118
    • Rowlinson-Busza, G.1    Bamias, A.2    Krausz, T.3    Epenetos, A.A.4
  • 43
    • 0025352171 scopus 로고
    • Antibody-penicillin-V-amidase conjugates kill antigen-positive tumor cells when combined with doxorubicin phenoxyacetamide
    • [43] Kerr, D.E., Senter, P.D., Burnett, W.V., Hirschberg, D.L., Hellström, I. and Hellström, K.E. (1990) Antibody-penicillin-V-amidase conjugates kill antigen-positive tumor cells when combined with doxorubicin phenoxyacetamide. Cancer Immunol. Immunother. 31, 202-206.
    • (1990) Cancer Immunol. Immunother. , vol.31 , pp. 202-206
    • Kerr, D.E.1    Senter, P.D.2    Burnett, W.V.3    Hirschberg, D.L.4    Hellström, I.5    Hellström, K.E.6
  • 44
    • 0027537670 scopus 로고
    • Prodrugs of doxorubicin and melphalan and their activation by a monoclonal antibody-penicillin-G amidase conjugate
    • [44] Vrudhula,V.M., Senter, P.D., Fischer, K.J. and Wallace, P.M. (1993) Prodrugs of doxorubicin and melphalan and their activation by a monoclonal antibody-penicillin-G amidase conjugate. J. Med. Chem. 36, 919-923.
    • (1993) J. Med. Chem. , vol.36 , pp. 919-923
    • Senter, P.D.1    Fischer, K.J.2    Wallace, P.M.3
  • 45
    • 0026670255 scopus 로고
    • N-(4′-Hydroxyphenyl)palytoxin: A palytoxin prodrug that can be activated by a monoclonal antibody-penicillin G amidase conjugate
    • [45] Bignami, G.S., Senter, P.D., Grothaus, P.G., Fischer, K.J., Humphreys, T. and Wallace, P.M. (1992) N-(4′-Hydroxyphenyl)palytoxin: A palytoxin prodrug that can be activated by a monoclonal antibody-penicillin G amidase conjugate. Cancer Res. 52, 5759-5764.
    • (1992) Cancer Res. , vol.52 , pp. 5759-5764
    • Bignami, G.S.1    Senter, P.D.2    Grothaus, P.G.3    Fischer, K.J.4    Humphreys, T.5    Wallace, P.M.6
  • 46
    • 0028090161 scopus 로고
    • Self-immolative prodrugs: Candidates for antibody-directed enzyme prodrug therapy in conjunction with a nitroreductase enzyme
    • [46] Mauger, A.B., Burke, P.J., Somani, H.H., Friedlos, F. and Knox, R.J. (1994) Self-immolative prodrugs: candidates for antibody-directed enzyme prodrug therapy in conjunction with a nitroreductase enzyme. J. Med. Chem. 37, 3452-3458.
    • (1994) J. Med. Chem. , vol.37 , pp. 3452-3458
    • Mauger, A.B.1    Burke, P.J.2    Somani, H.H.3    Friedlos, F.4    Knox, R.J.5
  • 47
    • 0025864963 scopus 로고
    • A novel targeted delivery system utilizing a cephalosporin oncolytic prodrug activated by an antibody β-lactamase conjugate for the treatment of cancer
    • [47] Shepherd, T.A., Jungheim, L.N., Meyer, D.L. and Starling. J.J. (1991) A novel targeted delivery system utilizing a cephalosporin oncolytic prodrug activated by an antibody β-lactamase conjugate for the treatment of cancer. Bioorg. Med. Chem. Lett. 1, 21-26.
    • (1991) Bioorg. Med. Chem. Lett. , vol.1 , pp. 21-26
    • Shepherd, T.A.1    Jungheim, L.N.2    Meyer, D.L.3    Starling, J.J.4
  • 48
    • 0026487592 scopus 로고
    • Preparation and characterization of β-lactamase-Fab' conjugates for the site specific activation of oncolytic agents
    • [48] Meyer, D.L., Jungheim, L.N., Mikolajczyk, S.D., Shepherd, T.A., Starling, J.J. and Ahlem, C. (1992) Preparation and characterization of β-lactamase-Fab' conjugates for the site specific activation of oncolytic agents. Bioconjugate Chem. 3, 42-48.
    • (1992) Bioconjugate Chem. , vol.3 , pp. 42-48
    • Meyer, D.L.1    Jungheim, L.N.2    Mikolajczyk, S.D.3    Shepherd, T.A.4    Starling, J.J.5    Ahlem, C.6
  • 49
    • 0026562808 scopus 로고
    • Synthesis of acylhydrazido-substituted cephems. Design of cephalosporin-vinca alkaloid prodrugs: Substrates for an antibody-targeted enzyme
    • [49] Jungheim, L.N., Shepherd, T.A. and Meyer, D.L. (1992) Synthesis of acylhydrazido-substituted cephems. Design of cephalosporin-vinca alkaloid prodrugs: substrates for an antibody-targeted enzyme. J. Org. Chem. 57, 2334-2340.
    • (1992) J. Org. Chem. , vol.57 , pp. 2334-2340
    • Jungheim, L.N.1    Shepherd, T.A.2    Meyer, D.L.3
  • 51
    • 0026826545 scopus 로고
    • Monoclonal antibody-β-lactamase conjugates for the activation of a cephalosporin mustard prodrug
    • [51] Svensson, H.P., Kadow, J.F., Vrudhula, V.M., Wallace, P.M. and Senter, P.D. (1992) Monoclonal antibody-β-lactamase conjugates for the activation of a cephalosporin mustard prodrug. Bioconjugate Chem. 3. 176-181.
    • (1992) Bioconjugate Chem. , vol.3 , pp. 176-181
    • Svensson, H.P.1    Kadow, J.F.2    Vrudhula, V.M.3    Wallace, P.M.4    Senter, P.D.5
  • 52
    • 0028939031 scopus 로고
    • Cephalosporin derivatives of doxorubicin as prodrugs for activation by monoclonal antibody β-lactamase conjugates
    • [52] Vrudhula, V.M., Svensson, H.P. and Senter, P.D, (1995) Cephalosporin derivatives of doxorubicin as prodrugs for activation by monoclonal antibody β-lactamase conjugates. J. Med. Chem. 38, 1380-1385.
    • (1995) J. Med. Chem. , vol.38 , pp. 1380-1385
    • Vrudhula, V.M.1    Svensson, H.P.2    Senter, P.D.3
  • 55
    • 0027235973 scopus 로고
    • Design and synthesis of cephalosporin-carboplatinum prodrug activatable by a β-lactamase
    • [55] Hanessian, S. and Wang, J. (1993) Design and synthesis of cephalosporin-carboplatinum prodrug activatable by a β-lactamase. Can. J. Chem. 71, 896-906.
    • (1993) Can. J. Chem. , vol.71 , pp. 896-906
    • Hanessian, S.1    Wang, J.2
  • 56
    • 0029279040 scopus 로고
    • Synthesis and β-lactamase-mediated activation of a cephalosporin-taxol prodrug
    • [56] Rodrigues, M.L., Carter, P., Wirth, C., Mullins, S., Lee, A. and Blackburn, B.K. (1995) Synthesis and β-lactamase-mediated activation of a cephalosporin-taxol prodrug. Chem. Biol. 2, 223-227.
    • (1995) Chem. Biol. , vol.2 , pp. 223-227
    • Rodrigues, M.L.1    Carter, P.2    Wirth, C.3    Mullins, S.4    Lee, A.5    Blackburn, B.K.6
  • 57
    • 0029061244 scopus 로고
    • Sulfated etoposide and nitrogen mustard prodrugs and their activation by streptomyces arylsulfatase
    • [57] Senter, P.D., Vrudhula, V.M., Wallace, P.M., Sommerville, J.E., Wang, I.-K. and Lowe, D.A. (1995) Sulfated etoposide and nitrogen mustard prodrugs and their activation by streptomyces arylsulfatase. Drug Deliv. 2, 110-116.
    • (1995) Drug Deliv. , vol.2 , pp. 110-116
    • Senter, P.D.1    Vrudhula, V.M.2    Wallace, P.M.3    Sommerville, J.E.4    Wang, I.-K.5    Lowe, D.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.