Porphyromonas gingivalis virulence factors and invasion of cells of the cardiovascular system

Journal of Periodontal Research

Volumn 34, Issue 7, 1999, Pages 393-399

  Progulske Fox, Ann ^a   Kozarov, Emil ^a   Dorn, Brian ^a   Dunn Jr , William ^a   Burks, Jacob ^a   Wu, Yi ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

Cardiovascular; P. gingivalis; Secretion; Virulence

Indexed keywords

BACTERIAL PROTEIN; HEMAGGLUTININ; HEMAGGLUTININ A, PORPHYROMONAS GINGIVALIS; LECTIN; PROTEINASE;

ANIMAL; ARTICLE; AUTOPHAGY; CORONARY ARTERY DISEASE; CORONARY BLOOD VESSEL; ELECTRON MICROSCOPY; GENETICS; HUMAN; MICROBIOLOGY; MOLECULAR CLONING; MOUSE; PATHOGENICITY; PERIODONTAL DISEASE; PERIODONTIUM; PHYSIOLOGY; PORPHYROMONAS GINGIVALIS; ROUGH ENDOPLASMIC RETICULUM; SALMONELLA TYPHIMURIUM; SCANNING ELECTRON MICROSCOPY; SEQUENCE HOMOLOGY; VASCULAR ENDOTHELIUM; VIRULENCE;

ANIMALS; AUTOPHAGY; BACTERIAL PROTEINS; CLONING, MOLECULAR; CORONARY DISEASE; CORONARY VESSELS; ENDOPEPTIDASES; ENDOPLASMIC RETICULUM, ROUGH; ENDOTHELIUM, VASCULAR; HEMAGGLUTININS; HUMANS; LECTINS; MICE; MICROSCOPY, ELECTRON; MICROSCOPY, ELECTRON, SCANNING; PERIODONTAL DISEASES; PERIODONTIUM; PORPHYROMONAS GINGIVALIS; SALMONELLA TYPHIMURIUM; SEQUENCE HOMOLOGY; VIRULENCE;

EID: 0033202353     PISSN: 00223484     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0765.1999.tb02272.x     Document Type: Article

References (27)

1. Lepine G, Progulske-Fox A. Duplication and differential expression of hemagglutinin genes in Porphyromonas gingivalis. Oral Microbiol Immunol 1996;11:65-78.
2. Han N, Whitlock J, Progulske-Fox A. The hemagglutinin gene A (hagA) of Porphyromonas gingivaux 381 contains four large, contiguous, direct repeats. Infect Immun 1996;64: 4000-4007.
3. Lee SW, Hillman JD, Progulske-Fox A. The hemagglutinin genes hagB and hagC of Porphyromonas gingivalis are transcribed in vivo as shown by use of a new expression vector. Infect Immun 1996;64:4802-4810.
4. Yogev D, Rosengarten R, Watson-McKown R, Wise KS. Molecular basis of Mycoplasma surface antigenic variation: a novel set of divergent genes undergo spontaneous mutation of periodic coding regions and 5′ regulatory sequences. EMBO J 1991;10:4069-4079.
5. Fischetti VA. Streptococcal M protein. Sci Am 1991;264: 58-65.
6. McNab R, Jenkinson HF, Loach DM, Tannock GW. Cell-surface-associated polypeptides CshA and CshB of high molecular mass are colonization determinants in the oral bacterium Streptococcus gordonii. Mol Microbiol 1994;14: 743-754.
7. Allred DR, McGuire TC, Palmer GH et al. Molecular basis for surface antigen size polymorphisms and conservation of a neutralization-sensitive epitope in Anaplasma marginale. Proc Natl Acad Sci USA 1990;87:3220-3224.
8. Kozarov E, Whitlock J, Dong H, Carrasco E, Progulske-Fox A. The number of direct repeats in hagA is variable among Porphyromonas gingivalis strains. Infect Immun 1998;66:4721-4725.
9. Han N, Lepine G, Whitlock J, Wojciechowski L, Progulske-Fox A. The porphyromonas gingivalis prtP/kgp homologue exists as two open reading frames in strain 381. Oral Dis 1998;4:170-179.
10. Pugsley AP, Francetic O, Possot OM, Sauvonnet N, Hardie KR. Recent progress and future directions in studies of the main terminal branch of the general secretory pathway in Gram-negative bacteria - a review. Gene 1997; 192:13-19.
11. Hoffman CS, Wright A. Fusions of secreted proteins to alkaline phosphatase: an approach for studying protein secretion. Proc Natl Acad Sci USA 1985;82: 5107-5111.
12. Kornacki JA, Oliver DB. Lyme disease-causing Borrelia species encode multiple lipoproteins homologous to peptide-binding proteins of ABC-type transporters. Infect Immun 1998;66:4115-4122.
13. Berthet FX, Lagranderie M, Gounon P et al. Attenuation of virulence by disruption of the Mycobacterium tuberculosis erp gene. Science 1998;282:759-762.
14. Henikoff S, Henikoff JG. Protein family classification based on searching a database of blocks. Genomics 1994;19: 97-107.
15. Fotos PG, Lewis DM, Gerencser VF, Gerencser MA. Cytotoxic and immunostimulatory effects of Bacteroides cell products. J Oral Pathol Med 1990;19:360-366.
16. Johansson A, Bergenholtz A, Holm SE. Strong cytotoxicity to human gingival fibroblasts by Porphyromonas gingivalis ATCC 33277. J Periodont Res 1996;31:477-482.
17. Beck J, Garcia R, Heiss G, Vokonas PS, Offenbacher S. Periodontal disease and cardiovascular disease. J Periodontol 1996;67:1123-1137.
18. Mattila KJ, Nieminen MS, Valtonen VV et al. Association between dental health and acute myocardial infarction (see comments). Br Med J 1989;298:779-781.
19. DeStefano F, Anda RF, Kahn HS, Williamson DF, Russell CM. Dental disease and risk of coronary heart disease and mortality. Br Med J 1993;306:688-691.
20. Silver JG, Martin AW, McBride BC. Experimental transient bacteraemias in human subjects with varying degrees of plaque accumulation and gingival inflammation. J Clin Periodontol 1977;4:92-99.
21. Carroll GC, Sebor RJ. Dental flossing and its relationship to transient bacteremia. J Periodontol 1980;51:691-692.
22. Sconyers JR, Crawford JJ, Moriarty JD. Relationship of bacteremia to toothbrushing in patients with periodontitis. J Am Dent Assoc 1973;87:616-622.
23. Lament RJ, Chan A, Belton CM, Izutsu KT, Vasel D, Weinberg A. Porphyromonas gingivalis invasion of gingival epithelial cells. Infect Immun 1995;63: 3878-3885.
24. Dorn BR, Dunn J, W.A. Progulske-Fox A. Invasion of human coronary artery cells by periodontal pathogens. Infect Immun 1999;11:5792-5798.
25. Dunn WA Jr. Autophagy and related mechanisms of lysosome-mediated protein degradation. Trends Cell Biol 1994;4:139-143.
26. Swanson MS, Isberg RR. Association of Legionella pneumophila with the macrophage endoplasmic reticulum. Infect Immun 1995;63:3609-3620.
27. Pizarro-Cerda J, Meresse S, Parton RG et al. Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes. Infect Immun 1998;66:5711-5724.