Levels of Ly-49 receptor expression are determined by the frequency of interactions with MHC ligands: Evidence against receptor calibration to a 'useful' level

Journal of Immunology

Volumn 163, Issue 5, 1999, Pages 2628-2633

  Manilay, Jennifer O ^a   Waneck, Gerald L ^a   Sykes, Megan ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR;

ANIMAL CELL; ARTICLE; CHIMERA; HEMATOPOIETIC CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RECEPTOR DOWN REGULATION;

ANIMALS; ANTIGENS, LY; BONE MARROW CELLS; CALIBRATION; CARRIER PROTEINS; H-2 ANTIGENS; HEMATOPOIETIC STEM CELLS; KILLER CELLS, NATURAL; LECTINS, C-TYPE; LIGANDS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; RADIATION CHIMERA; RECEPTORS, IMMUNOLOGIC; TRANSPLANTATION CONDITIONING;

EID: 0033198059     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Takei, F., J. Brennan, and D. L. Mager. 1997. The Ly-49 family: genes, proteins and recognition of class I MHC. Immunol. Rev. 155:67.
2. Stoneman, E. R., M. Bennett, J. An, K. A. Chesnut, E. K. Wakeland, J. B. Scheerer, M. J. Siciliano, V. Kumar, and P. A. Mathew. 1995. Cloning and characterization of 5E6(Ly-49C), a receptor molecule expressed on a subset of murine natural killer cells. J. Exp. Med. 182:305.
3. Smith, H. R. C., F. M. Karlhofer, and W. M. Yokohama. 1994. Ly-49 multigene family expressed by IL-2-activated NK cells. J. Immunol. 153:1068.
4. Mason, L. H., J. R. Ortaldo, H. A. Young, V. Kumar, M. Bennett, and S. K. Anderson. 1995. Cloning and functional characterization of murine large granular lymphocyte-1: a member of the Ly-49 gene family (Ly-49G2). J. Exp. Med. 182:293.
5. Brennan, J., S. Lemieux, J. D. Freeman, D. L. Mager, and F. Takei. 1996. Heterogeneity among Ly-49C natural killer (NK) cells: characterization of highly related receptors with differing functions and expression patterns. J. Exp. Med. 184:2085.
6. Sundback, J., K. Karre, and C. L. Sentman. 1996. Cloning of minimally divergent allelic forms of the natural killer (NK) receptor Ly-49C, differentially controlled by host genes in the MHC and NK gene complexes. J. Immunol. 157:3936.
7. Mason, L. H., S. K. Anderson, W. M. Yokoyama, H. R. C. Smith, R. Winkler-Pickett, and J. R. Ortaldo. 1996. The Ly-49D receptor activates murine natural killer cells. J. Exp. Med. 184:2119.
8. Silver, E. T., J. F. Elliott, and K. P. Kane. 1996. Alternatively spliced Ly-49D and H transcripts are found in IL-2-activated NK cells. Immunogenetics 44:478.
9. Held, W., J. Roland, and D. H. Raulet. 1995. Allelic exclusion of Ly49-family genes encoding class I MHC-specific receptors on NK cells. Nature 376:355.
10. Held, W., and D. H. Raulet. 1997. Expression of the Ly49A gene in murine natural killer cell clones is predominantly but not exclusively mono-allelic. Eur. J. Immunol. 27:2876.
11. Held, W., and B. Kunz. 1998. An allele-specific, stochastic gene expression process controls the expression of multiple Ly49 family genes and generates a diverse, MHC-specific NK cell receptor repertoire. Eur. J. Immunol. 28:2407.
12. Held, W., and D. H. Raulet. 1997. Ly49A transgenic mice provide evidence for a major histocompatibility complex-dependent education process in natural killer cell development. J. Exp. Med. 185:2079.
13. Karlhofer, F. M., R. Hunziker, A. Reichlin, D. H. Margulies, and W. M. Yokoyama. 1994. Host MHC class I molecules modulate in vivo expression of a NK cell receptor. J. Immunol. 153:2407.
14. Mason, L., S. L. Giardina, T. Hecht, J. Ortaldo, and B. J. Mathieson. 1988. LGL-1: a non-polymorphic antigen expressed on a major population of mouse natural killer cells. J. Immunol. 140:4403.
15. Yu, Y. Y. L., T. George, J. R. Dorfman, J. Roland, V. Kumar, and M. Bennett. 1996. The role of Ly49A and 5E6(Ly49C) molecules in hybrid resistance mediated by murine natural killer cells against normal T cell blasts. Immunity 4:67.
16. Gosselin, P., Y. Lusignan, J. Brennan, F. Takei, and S. Lemieux. 1997. The NK2.1 receptor is encoded by Ly-49C and its expression is regulated by MHC class I alleles. Int. Immunol. 9:533.
17. Hoglund, P., J. Sundback, M. Y. Olsson-Alheim, M. Johansson, M. Salcedo, C. Ohlen, H.-G. Ljunggren, C. L. Sentman, and K. Karre. 1997. Host MHC class I gene control of NK-cell specificity in the mouse. Immunol. Rev. 155:11.
18. Sentman, C. L., M. Y. Olsson, and K. Karre. 1995. Missing self recognition by natural killer cells in MHC class I transgenic mice: a "receptor calibration" model for how effector cells adapt to self. Semin. Immunol. 7:109.
19. Sykes, M., M. W. Harty, F. M. Karlhofer, D. A. Pearson, G. L. Szot, and W. Yokoyama. 1993. Hematopoietic cells and radioresistant host elements influence natural killer cell differentiation. J. Exp. Med. 178:223.
20. Johannson, M. H., C. Bieberich, G. Jay, K. Karre, and P. Hoglund. 1997. Natural killer cell tolerance in mice with mosaic expression of major histocompatibility complex class I transgene. J. Exp. Med. 186:353.
21. Sharabi, Y., and D. H. Sachs. 1989. Mixed chimerism and permanent specific transplantation tolerance induced by a non-lethal preparative regimen. J. Exp. Med. 169:493.
22. Olsson, M. Y., K. Karre, and C. L. Sentman. 1995. Altered phenotype and function of natural killer cells expressing the major histocompatibility complex receptor Ly-49 in mice transgenic for its ligand. Proc. Natl. Acad. Sci. USA 92: 1649.
23. Held, W., J. R. Dorfman, M.-F. Wu, and D. H. Raulet. 1996. Major histocompatibility complex class I-dependent skewing of the natural killer cells Ly49 receptor repertoire. Eur. J. Immunol. 26:2286.
24. Kase, A., M. H. Johannson, M. Y. Olsson-Alheim, K. Karre, and P. Hoglund. 1998. External and internal calibration of the MHC class I-specific receptor Ly49A on murine natural killer cells. J. Immunol. 161:6133.
25. Renard, V., A. Cambiaggi, F. Vely, M. Blery, L. Olcese, S. Olivero, M. Bouchet, and E. Vivier. 1997. Transduction of cytotoxic signals in natural killer cells: a general model of fine tuning between activatory and inhibitory pathways in lymphocytes. Immunol. Rev. 155:205.
26. Salcedo, M., A. D. Diehl, M. Y. Olsson-Alheim, J. Sundback, L. V. Kaer, K. Karre, and H.-G. Ljunggren. 1997. Altered expression of Ly-49 inhibitory receptors on natural killer cells from MHC class I-deficient mice. J. Immunol. 158:3174.
27. low NK cells. J. Immunol. 159:3189.
28. Andersson, M., S. Freland, M. H. Johannson, R. Wallin, J. K. Sandberg, B. J. Chambers, B. Christenson, U. Lendahl, S. Lemieux, M. Salcedo, and H.-G. Ljunggren. 1998. MHC class I mosaic mice reveal insights into control of Ly49C inhibitory receptor expression in NK cells. J. Immunol. 161:6475.