Dynamic Remodeling of the Vascular Bed Precedes Tumor Growth: MLS Ovarian Carcinoma Spheroids Implanted in Nude Mice

Neoplasia

Volumn 1, Issue 3, 1999, Pages 226-230

  Gilead, Assaf ^a   Neeman, Michal ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Angiogenesis; MRI; Multicellular spheroids; Ovarian carcinoma; Vascular maturation

Indexed keywords

ENDOTHELIAL CELL GROWTH FACTOR; LYMPHOKINE; VASCULOTROPIN; VASCULOTROPIN A;

ANIMAL; ARTICLE; CANCER TRANSPLANTATION; CELL CULTURE; CYTOLOGY; FEMALE; HUMAN; MOUSE; MULTICELLULAR SPHEROID; NUDE MOUSE; OVARY TUMOR; PATHOLOGY; PHYSIOLOGY; VASCULAR SMOOTH MUSCLE; VASCULARIZATION; XENOGRAFT;

ANIMALS; ENDOTHELIAL GROWTH FACTORS; FEMALE; HUMANS; LYMPHOKINES; MICE; MICE, NUDE; MUSCLE, SMOOTH, VASCULAR; NEOPLASM TRANSPLANTATION; OVARIAN NEOPLASMS; SPHEROIDS, CELLULAR; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0033170748     PISSN: 15228002     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.neo.7900032     Document Type: Article

References (31)

1. Black WC, and Welch HG (1993). Advances in diagnostic imaging and overestimations of disease prevalence and the benefits of therapy. N Engl J Med 328, 1237-1243..
2. Marches R, Scheuermann RH, and Uhr JW (1998). Cancer dormancy: role of cyclin-dependent kinase inhibitors in induction of cell cycle arrest mediated via membrane IgM. Cancer Res 58, 691-697.
3. Reynolds TY, Rockwell S, and Glazer PM (1996). Genetic instability induced by the tumor microenvironment. Cancer Res 56, 5754-5757.
4. Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW, and Giaccia AJ (1996). Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379, 88-91.
5. Stewart TH (1996). Immune mechanisms and tumor dormancy. Medicina (B Aires) 56 (suppl 1), 74-82.
6. Gimbrone MA, Jr, Leapman SB, Cotran RS, and Folkman J (1972). Tumor dormancy in vivo by prevention of neovascularization. J Exp Med 136, 261-276.
7. Holmgren L, O'Reilly MS, and Folkman J (1995). Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat Med 1, 149-153.
8. Hanahan D, and Folkman J (1996). Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86, 353-364.
9. Abramovitch R, Marikovsky M, Meir G, and Neeman M (1998). Stimulation of tumor angiogenesis by proximal wounds: Spatial and temporal analysis by MRI. Br J Cancer 77, 440-447.
10. Schiffenbauer YS, Abramovitch R, Meir G, Nevo N, Holzinger M, Itin A, Keshet E, and Neeman M (1997). Loss of ovarian function promotes angiogenesis in human ovarian carcinoma. Proc Natl Acad Sci USA 94, 13203-13208.
11. Shweiki D, Itin A, Soffer D, and Keshet E (1992). Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359, 843-845.
12. Shweiki D, Neeman M, Itin A, and Keshet E (1995). Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: Implications for tumor angiogenesis. Proc Natl Acad Sci USA 92, 768-772.
13. Sutherland RM (1988). Cell and environment interactions in tumor microregions: The multicell spheroid model. Science 240, 177-184.
14. Stein I, Neeman M, Shweiki D, Itin A, and Keshet E (1995). Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes. Mol Cell Biol 15, 5363-5368.
15. Waleh NS, Brody MD, Knapp MA, Mendonca HL, Lord EM, Koch CJ, Laderoute KR, and Sutherland RM (1995). Mapping of the vascular endothelial growth factor-producing hypoxic cells in multicellular tumor spheroids using a hypoxia-specific marker. Cancer Res 55, 6222-6226.
16. Ogawa S, Lee TM, Nayak AS, and Glynn P (1990). Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn Reson Med 14, 68-78.
17. Ogawa S, Menon RS, Tank DW, Kim SG, Merkle H, Ellermann JM, and Ugurbil K (1993). Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model. Biophys J 64, 803-812.
18. Abramovitch R, Frenkiel D, and Neeman M (1998). Analysis of subcutaneous angiogenesis by gradient echo magnetic resonance imaging. Magn Reson Med 39, 813-824.
19. Abramovitch R, Dafni H, Smouha E, Benjamin LE, and Neeman M (1999). In Vivo Prediction of Vascular Response to VEGF Withdrawal: Tracking Vascular Maturation by MRI. In Proceedings of the International Society for Magnetic Resonance in Medicine, Philadelphia, PA. p. 142.
20. Abramovitch R, Meir G, and Neeman M (1995). Neovascularization induced growth of implanted C6 glioma multicellular spheroids: Magnetic resonance microimaging. Cancer Res 55, 1956-1962.
21. Carmeliet P, Dor Y, Herbert J-M, Fukumara D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, and Keshet E (1998). Role of HIF-1a in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394, 485-490.
22. Baish JW, Gazit Y, Berk DA, Nozue M, Baxter LT, and Jain RK (1996). Role of tumor vascular architecture in nutrient and drug delivery: An invasion percolation-based network model. Microvasc Res 51, 327-346.
23. Gazit Y, Baish JW, Safabakhsh N, Leunig M, Baxter LT, and Jain RK (1997). Fractal characteristics of tumor vascular architecture during tumor growth and regression. Microcirculation 4, 395-402.
24. Benjamin LE, and Keshet E (1997). Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal. Proc Natl Acad Sci USA 94, 8761-8766.
25. Greeno EW, Bach RR, and Moldow CF (1996). Apoptosis is associated with increased cell surface tissue factor procoagulant activity. Lab Invest 75, 281-289.
26. Yuan F, Chen Y, Dellian M, Safabakhsh N, Ferrara N, and Jain RK (1996). Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc Natl Acad Sci USA 93, 14765-14770.
27. Benjamin LE, Hemo I, and Keshet E (1998). A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. Development 125, 1591-1598.
28. Benjamin LE, Golijanin D, Itin A, Pode D, and Keshet E (1998). Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 103, 159-165.
29. Dunn JF, Zaim-Wadghiri Y, Pogue BW, and Kida I (1998). BOLD MRI vs. NIR spectrophotometry. Will the best technique come forward? Adv Exp Med Biol 454, 103-113.
30. Jacobs RE, Ahrens ET, Meade TJ, and Fraser SE (1999). Looking deeper into vertebrate development. Trends Cell Biol 9, 73-76.
31. Moore A, Basilion JP, Chiocca EA, and Weissleder R (1998). Measuring transferrin receptor gene expression by NMR imaging. Biochim Biophys Acta 1402, 239-249.