Genetic evidence for an additional factor required for erythropoietin- induced signal transduction

Blood

Volumn 94, Issue 1, 1999, Pages 74-86

  Gaffen, Sarah L ^b   Lai, Stephen Y ^b   Longmore, Gregory D ^b   Liu, Kathleen D ^b   Goldsmith, Mark A ^a  

^a GLADSTONE INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; STAT5 PROTEIN;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ASSAY; ERYTHROPOIESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

EID: 0033168645     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.1.74.413k36_74_86     Document Type: Article

References (85)

1. D'Andrea AD, Lodish HF, Wong GG: Expression cloning of the murine erythropoietin receptor. Cell 57:277, 1989
2. Lin C-S, Lim S-K, D'Agati V, Costantini F: Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. Gen Dev 10:154, 1996
3. Wu H, Liu X, Jaenisch R, Lodish HF: Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell 83:59, 1995
4. Damen J, Krystal G: Early events in erythropoietin-induced signaling. Exp Hematol 24:1455, 1996
5. Bazan JF: Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA 87:6934, 1990
6. Longmore GD, Lodish HF: An activating mutation in the murine erythropoietin receptor induces erythroleukemia in mice: A cytokine receptor superfamily oncogene. Cell 67:1089, 1991
7. Watowich SS, Yoshimura A, Longmore GD, Hilton DJ, Yoshimura Y, Lodish HF: Homodimerization and constitutive activation of the erythropoietin receptor. Proc Natl Acad Sci USA 89:2140, 1992
8. Yoshimura A, Longmore G, Lodish HF: Point mutation in the exoplasmic domain of the erythropietin receptor resulting in hormone-independent activation and tumorigenicity. Nature 348:647, 1990
9. Watowich SS, Hilton DJ, Lodish HF: Activation and inhibition of erythropoietin receptor function: Role of receptor dimerization. Mol Cell Biol 14:3535, 1994
10. Livnah O, Stura EA, Johnson DL, Middleton SA, Mulcahy LS, Wrighton NC, Dower WJ, Jolliffe LK, Wilson IA: Functional mimicry of a protein hormone by a peptide agonist: The EPO receptor complex at 2.8Å. Science 273:464, 1996
11. Miura O, D'Andrea AD, Kabat D, Ihle JN: Induction of tyrosine phosphorylation by the erythropoietin receptor correlates with mitogenesis. Mol Cell Biol 11:4895, 1991
12. Dusanter-Fort I, Casadevall N, Lacombe C, Muller O, Billat C, Fischer S, Mayeux P: Erythropoietin induces the tyrosine phosphorylation of its own receptor in human erthropoietin-responsive cells. J Biol Chem 267:10670, 1992
13. Yoshimura A, Lodish H: In vitro phosphorylation of the erythropoietin receptor and an associated protein pp130. Mol Cell Biol 12:706, 1992
14. Witthuhn BA, Quelle FW, Silvennoinen O, Yi T, Tang B, Miura O, Ihle JN: JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell 74:227, 1993
15. Gouilleux F, Pallard C, Dusanter-Fourt I, Wakao H, Haldosen L-A, Norstedt G, Levy D, Groner B: Prolactin, growth hormone, erythropoietin and granulocyote-macrophage colony stimulating factor induce MGF-Stat5 DNA bindng activity. EMBO J 14:2005, 1995
16. Liu KD, Gaffen SL, Goldsmith MA: JAK-STAT signaling by cytokine receptors. Curr Opin Immunol 10:271, 1998
17. Yoshimura A, Ichihara M, Kinjyo I, Moriyama M, Copeland NG, Gilbert DJ, Jenkins NA, Hara T, Miyajima A: Mouse oncostatin M: An immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway. EMBO J 15:1055, 1996
18. Matsumoto A, Masuhara M, Mitsui K, Yokouchi M, Ohtsubo M, Misawa H, Miyajima A, Yoshimura A: CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Blood 89:3148, 1997
19. Wang D, Stravopodis D, Teglund S, Kitazawa J, Ihle JN: Naturally occurring dominant negative variants of Stat5. Mol Cell Biol 16:6141, 1996
20. Damen JE, Wakao H, Miyajima A, Krosi J, Humphries RK, Cutler RL, Krystal G: Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation. EMBO J 14:5557, 1995
21. Chrétien S, Varlet P, Verdier F, Gobert S, Cartron J-P, Gisselbrecht S, Mayeux P, Lacombe C: Erythropoietin-induced erythroid differentiation of the human erythroleukemia cell line TF-1 correlates with impaired STAT5 activation. EMBO J 4174, 1996
22. Iwatsuki K, Endo T, Misawa H, Yokouchi M, Matsumoto A, Ohtsuhbo M, Mori KJ, Yoshimura A: STAT5 activation correlates with erythropoietin receptor-mediated erythroid differentiation of an erythro-leukemia cell line. J Biol Chem 272:8149, 1997
23. Liu X, Robinson GW, Wagner K, Garrett L, Wynshaw-Boris A, Hennighausen L: Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev 11:179, 1997
24. Udy GB, Towers RP, Snell RG, Wilkins RJ, Park S-H, Ram PA, Waxman DJ, Davey HW: Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc Natl Acad Sci USA 94:7239, 1997
25. Teglund S, McKay C, Schuetz E, van Deursen JM, Stravopodis D, Wang D, Brown M, Bodner S, Grosveld G, Ihle JN: Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 93:841, 1998
26. Neel BG, Tonks NK: Protein tyrosine phosphatases in signal transduction. CurrOpin Cell Biol 9:193, 1997
27. Gaffen SL, Goldsmith MA, Greene WC: in A. Thomson (ed): The Cytokine Handbook (ed 3). London, UK, Academic, 1998, p 73
28. Goldsmith MA, Lai SY, Xu W, Amaral MC, Kuczek ES, Parent LJ, Mills GB, Tarr KL, Longmore GD, Greene WC: Growth signal transduction by the human IL-2 receptor requires cytoplasmic tyrosines of the β chain and non-tyrosine residues of the γc chain. J Biol Chem 270:21729, 1995
29. Lai SY, Xu W, Gaffen S, Liu KD, Greene WC, Goldsmith MA: The determinants of signal transduction specificity in γc-containing cytokine receptors. Proc Natl Acad Sci USA 93:231, 1996
30. Wang L-M, Myers MG, Sun X-J, Aaronson SA, White M, Pierce JH: IRS-1: Essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells. Science 261:1591, 1993
31. Goldsmith MA, Xu W, Amaral MC, Kuczek ES, Greene WC: The cytoplasmic domain of the IL-2 receptor β chain contains both unique and functionally redundant signal transduction elements. J Biol Chem 269:14698, 1994
32. Ernst J, Yang L, Rosales J, Broaddus V: Preparation and characterization of an endogenously fluorescent annexin for detection of apoptotic cells. Anal Biochem 260:18, 1998
33. Yoshimura A, D'Andrea AD, Lodish HF: Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism. Proc Natl Acad Sci USA 87:4139, 1990
34. Gaffen SL, Lai SY, Ha M, Liu X, Hennighausen L, Greene WC, Goldsmith MA: Distinct tyrosine residues within the interleukin-2 receptor β chain drive signal transduction specificity, redundancy, and diversity. J Biol Chem 271:21381, 1996
35. Latchman DS, in Rickwood D, Hames BD (eds): Transcription Factors: A Practical Approach. New York, NY, IRL, 1993
36. Gaffen SL, Lai SY, Xu W, Gouilleux F, Groner B, Goldsmith MA, Greene WC: Signaling through the IL-2R β chain activates a STAT-5-like DNA binding activity. Proc Natl Acad Sci USA 92:7192, 1995
37. Lamson G, Koshland ME: Changes in J chain and μ chain RNA expression as a function of B cell differentiation. J Exp Med 160:877, 1984
38. Boise LH, Gonzalez-Garcia M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nuñez G, Thompson CB: Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74:597, 1993
39. Goldsmith MA, Dazin PF, Weiss A: At least two non-antigen binding molecules are required for signal transduction by the T cell antigen receptor. Proc Natl Acad Sci USA 85:8613, 1988
40. Koury MJ, Bondurant MC: Maintenance by erythropoietin of viablity and maturation of murine erythroid precursor cells. J Cell Physiol 137:65, 1988
41. Koury MJ, Bondurant MC: Erythropoietin retards DNA breakdown and precents programmed cell death in erythroid progenitor cells. Science 248:378, 1990
42. Bauer J, Liu KD, Lai SY, You Y, Goldsmith MA: Heteromerization of the γ(c) chain with the interleukin-9 receptor α subunit leads to STAT activation and prevention of apoptosis. J Biol Chem 273:9255, 1998
43. Martin JS, Reutelingsperger CPM, McGahon AJ, Rader JA, van Schie DM, LaFace DM, Green DR: Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl. J Exp Med 182:1545, 1995
44. Koopman G, Reutelingsperger CPM, Kuijten GAM, Keehnen RMJ, Pals ST, van Oers MHJ: Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 84:1415, 1994
45. Longmore G, You Y, Molden J, Liu K, Mikami A, Lai SY, Pharr P, Goldsmith MA: Redundant and selective roles for erythropoietin receptor tyrosines in erythropoiesis in vivo. Blood 91:870, 1998
46. Darnell JE, Kerr IM, Stark GR: Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415, 1994
47. Kirito K, Uchida M, Yamada M, Miura Y, Komatsu N: A distinct function of STAT proteins in erythropoietin signal transduction. J Biol Chem 272:16507, 1997
48. Quelle FW, Wang D, Nosaka T, Thierfelder WE, Stravopodis D, Weinstein Y, Ihle JN: Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response. Mol Cell Biol 16:1622, 1996
49. Packham G, White EL, Eischen CM, Yang H, Parganas E, Ihle JN, Grillot DAM, Zambetti GP, Nuñez G, Cleveland JL: Selective regulation of bcl-xL by a Jak kinase-dependent pathway is bypassed in murine hematopoietin malignancies. Genes Dev 12:2475, 1998
50. Silva M, Grillot D, Benito A, Richard C, Nuñez G, Fernández-Luna JL: Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through bcl-xL and bcl-2. Blood 88:1576, 1996
51. Watowich SS, Wu H, Socolovsky M, Klingmuller U, Constantinescu SN, Lodish HF: Cytokine receptor signal transduction and the control of hematopoietic cell development. Annu Rev Cell Dev Biol 12:91, 1996
52. Vaux DL, Cory S, Adam JM: Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335:440, 1988
53. Williams GT, Smith CA, Spooncer E, Dexter TM, Taylor DR: Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature 343:76, 1990
54. Kinoshita T, Yokota T, Arai K-I, Miyajima A: Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors. EMBO J 14:266, 1995
55. Tilbrook P, Bittorf T, Busfield S, Chappell D, Klinken S: Disrupted signaling in a mutant J2E cell line that shows enhanced viability, but does not proliferate or differentiate, with erythropoietin. J Biol Chem 271:3453, 1996
56. Lai SY, Molden J, Goldsmith MA: The shared γc subunit within the human interleukin-7 receptor complex: A molecular basis for the pathogenesis of X-linked severe combined immunodeficiency. J Clin Invest 99:169, 1997
57. Lai SY, Molden J, Liu KD, Puck JM, White MD, Goldsmith MA: Interleukin-4-specific signal transduction events are driven by homotypic interactions of the interleukin-4 receptor a subunit. EMBO J 15:4506, 1996
58. Zamorano J, Wang HY, Wang R, Shi Y, Longmore GD, Keegan AD: Regulation of cell growth by IL-2: Role of STAT5 in protection from apoptosis but not in cell cycle progression. J Immunol 160:3502, 1998
59. Jacobs-Helber SM, Wickrema A, Birrer MJ, Sawyer ST: API regulation of proliferation and initiation of apoptosis in erythropoietin-dependent erythroid cells. Mol Cell Biol 18:3699, 1998
60. Quelle FW, Wang J, Feng J, Wang D, Cleveland JL, Ihle JN, Zambetti GP: Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways. Genes Dev 12:1099, 1998
61. Fairbairn LJ, Cowling GJ, Reipert BM, Dexter TM: Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors. Cell 74:823, 1993
62. Lacronique V, Varlet P, Mayeux P, Porteu A, Gisselbrecht S, Kahn A, Lacombe C: Bcl-2 targeted overexpression into the erythroid lineage of transgenic mice delays but does not prevent the apoptosis of erythropoietin-derprived erythroid progenitors. Blood 90:3050, 1997
63. Hockenberry D, Zutter M, Hickey W, Nahm M, Korsmeyer S: BCL2 protein is topologically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 88:6961, 1991
64. Kondo M, Akashi K, Domen J, Sugamura K, Weissman IL: Bcl-2 rescues T lymphopoiesis but not B or NK cell development, in common γ chain-deficient mice. Immunity 7:155, 1997
65. Akashi K, Kondo M, von Freeden-Jeffry U, Murray R, Weissman IL: Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell 89:1033, 1997
66. -/- mice. Cell 89:1011, 1997
67. Peschon JJ, Morissey PJ, Grabstein KH, Ramsdell FJ, Maraskovsky E, Gliniak BC, Park LS, Ziegler SF, Williams DE, Ware CB, Meyer JD, Davison BL: Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J Exp Med 180:1955, 1994
68. Klingmuller U, Bergelson S, Hsiao JG, Lodish HF: Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STATS. Proc Natl Acad Sci USA 93:8324, 1996
69. Gobert S, Chretien S, Gouilleux F, Muller O, Pallard C, Dusanter-Fourt I, Groner B, Lacombe C, Gisselbrecht S, Mayeux P: Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation. EMBO J 15:2434, 1996
70. Dong YJ, Goldwasser E: Evidence for an accessory component that increases the affinity of the erythropoietin receptor. Exp Hematol 21:483, 1993
71. Krystal G, Humphries K, Damen J: A second erythropoietin receptor subunit. Blood 85:2641, 1995
72. Yoshimura A: Second subunit of the EPO receptor? Nature 372:137, 1994
73. Masuda S, Nagao M, Takahata K, Konishi Y, Gallyas F, Tabira T, Sasaki R: Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells. J Biol Chem 268:11208, 1993
74. Evans G, Goldsmith MA, Johnston JA, Xu W, Weiler SR, Erwin R, Howard OMZ, Abraham RT, O'Shea JJ, Greene WC, Farrar WL: Analysis of interleukin-2-dependent signal transduction through the Shc/Grb2 adapter pathway. J Biol Chem 270:28858, 1995
75. Liu KD, Greene WC, Goldsmith MA: Relationship of IL-2 receptor tyrosines to pathways linked to phosphatidyl-3′-kinase and mitogen-activated protein kinase. (submitted)
76. Barber DL, Corless CN, Xia K, Roberts TM, D'Andrea AA: Erythropoietin activates Raf1 by a Shc-independent pathway in CTLL-EPO-R cells. Blood 89:55, 1997
77. Shultz LD, Schweitzer PA, Rajan TV, Yi T, Ihle J, Matthews RJ, Thomas ML, Beier DR: Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell 73:1445, 1993
78. Tsui HW, Siminovitch KA, deSouza L, Tsui FWL: Motheaten and viable motheaten mice have mutations in the hematopoietic cell phosphatase gene. Nat Genet 4:124, 1993
79. Aman MJ, Leonard WJ: Cytokine signaling: Cytokine-inducible signaling inhibitors. Curr Biol 7:R784, 1997
80. Naka T, Narazaki M, Hirata M, Matsumoto T, Minamoto S, Aono A, Nishimoto N, Kajita T, Taga T, Yoshizaki K, Akira S, Kishimoto T: Structure and function of a new STAT-induced STAT inhibitor. Nature 387:924, 1997
81. Yoshimura A, Ohkubo T, Kiguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Hara T, Miyajima A: A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 2 and erythropoietin receptors. EMBO J 14:2816, 1995
82. Goldsmith MA, Mikami A, You Y, Liu KD, Thomas L, Pharr P, Longmore GD: Absence of cytokine receptor-dependent specificity in red blood cell differentiation in vivo. Proc Natl Acad Sci USA 95:7006, 1998
83. Socolovsky M, Dusanter-Fourt I, Lodish HF: The prolactin receptor and severely truncated erythropoietin receptors support differentiation of erythroid progenitors. J Biol Chem 272:14009, 1997
84. Corcoran AE, Smart FM, Cowling RJ, Crompton T, Owen MJ, Venkitaraman AR: The interleukin-7 receptor α chain transmits direct signals for proliferation and differentiation during B lymphopoiesis. EMBO J 15:1924, 1996
85. Wakao H, Harada N, Kitamura T, Mui AL-F, Miyajima A: Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways. EMBO J 14:2527, 1995