Cutting edge: A short polypeptide domain of HIV-1-Tat protein mediates pathogenesis

Journal of Immunology

Volumn 163, Issue 1, 1999, Pages 15-20

  Boykins, Robert A ^a   Mahieux, Renaud ^b   Shankavaram, Uma T ^c   Gho, Yong Song ^c   Lee, Sherwin F ^a   Hewlett, Indira K ^a   Wahl, Larry M ^c   Kleinman, Hynda K ^c   Brady, John N ^b   Yamada, Kenneth M ^c   Dhawan, Subhash ^a,d  

^a Center for Biologics Evaluation/Res   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^d Center for Biologics Evaluation/Res   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSACTIVATOR PROTEIN;

AMINO ACID SEQUENCE; ANGIOGENESIS; ARTICLE; CELL ACTIVATION; DISEASE COURSE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LONG TERMINAL REPEAT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INDUCTION; VIRUS REPLICATION;

ALLANTOIS; AMINO ACID SEQUENCE; ANIMALS; CHICK EMBRYO; CHORION; CYSTEINE; CYTOPATHOGENIC EFFECT, VIRAL; GENE PRODUCTS, TAT; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; MONOCYTES; MUTAGENESIS, SITE-DIRECTED; NEOVASCULARIZATION, PHYSIOLOGIC; PEPTIDE FRAGMENTS; SARCOMA, KAPOSI; VIRUS ACTIVATION; VIRUS REPLICATION;

EID: 0033168628     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Jeang, K. T. 1998. Tat, Tat-associated kinase, and transcription. J. Biomed. Sci. 5:24.
2. Ensoli, B., L. Buonaguru, G. Barillari, V. Fiorelli, R. Gendelman, R. A. Morgan, P. Wingfield, and R. C. Gallo. 1993. Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation. J. Virol. 67:277.
3. Vaishnav, Y. N., and F. Wong-Staal, F. 1991. The biochemistry of AIDS. Annu. Rev. Biochem. 60:577.
4. Kumar, A., S. K. Manna, S. Dhawan, and B. B. Aggarwal. 1998. HIV-Tat protein activates c-Jun N-terminal kinase and activator protein-1. J. Immunol. 161:776.
5. Lafrenie, R. M., L. M. Wahl, J. S. Epstein, K. M. Yamada, and S. Dhawan. 1997. Activation of monocytes by HIV-Tat treatment is mediated by cytokine expression. J. Immunol. 159:4077.
6. Lafrenie, R. M., L. M. Wahl, J. S. Epstein, I. K. Hewlett, K. M. Yamada, and S. Dhawan. 1996. HIV-1-Tat modulates the function of monocytes and alters their interactions with human microvessel endothelial cells. J. Immunol. 156: 1638.
7. Taylar, J. P., C. Cupp, A. Diaz, M. Choudhury, K. Khalili, S. A. Jimenez, and S. Amini. 1992. Activation of expression of genes for extracellular matrix proteins in Tat-producing glioblastoma cells. Proc. Natl. Acad. Sci. USA 89:9617.
8. Merrifield, R. B. 1963. Solid-phase peptide synthesis: the synthesis of a tetrapeptide. J. Am. Chem. Soc. 85:2149.
9. Wahl, L. M., and P. D. Smith. 1991. Isolation of monocyte/macrophage populations. In Current Protocols in Immunology: J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober, eds. John Wiley & Sons, New York, Vol. 2, p. 7.6.1.
10. Dhawan, S., B. S. Weeks, C. Soderland, H. W. Schnaper, L. A. Toro, S. P. Asthana, I. K. Hewlett, W. G. Stetler-Stevenson, S. S. Yamada, K. M. Yamada, and M. S. Meltzer. 1995. HIV-1 infection alters monocyte interaction with human microvascular endothelial cells. J. Immunol. 154:422.
11. Kashanchi, F., M. R. Sadaie, and J. N. Brady. 1997. Inhibition of HIV-1 transcription and virus replication using soluble Tat peptide analogs. Virology 227: 431.
12. Dhawan, S., S. Singh, and B. B. Aggarwal. 1997. Induction of endothelial cell surface adhesion molecules by tumor necrosis factor is blocked by protein tyrosine phosphatase inhibitors: role of the nuclear factor NF-κB. Eur. J. Immunol. 27:2172.
13. Gho, Y. S., and C.-B. Chae. 1997. Anti-angiogenin activity of the peptides complementary to the receptor-binding site of angiogenin. J. Biol. Chem. 272: 24294.
14. Cujec, T. P., H. Cho, E. Maldonado, J. Meyer, D. Reinberg, and B. M. Peterlin. 1997. The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme. Mol. Cell. Biol. 17:1817.
15. Yankulov, K., and D. Bentley. 1998. Transcriptional control: Tat cofactors and transcriptional elongation. Curr. Biol. 18:R447.
16. Garcia, J. A., D. Harrich, E. Soultanakis, F. Wu, R. Mitsuyasu, and R. B. Gaynor. 1989. Human immunodeficiency virus type 1 LTR TATA and TAR region sequences required for transcriptional regulation. EMBO J. 8:765.
17. Weeks, K. M., C. Ampe, S. C. Schultz, T. A. Steitz, and D. M. Crothers. 1990. Fragments of the HIV-1 Tat protein specifically bind TAR RNA. Science 249: 1281.
18. Cordingley, M. G., R. L. Lafemina, P. L. Callahan, J. H. Condra, V. V. Sardana, D. J. Graham, T. M Nguyen, K. L. LeGrow, L. Gotlib, A. I. Schlabach, and R. J. Colonno. 1990. Sequence-specific interaction of Tat protein and Tat peptides with the transactivation-responsive sequence element of human immunodeficiency virus type 1 in vitro. Proc. Natl. Acad. Sci. USA 87:8985.
19. Feng, S., and E. C. Holland. 1988 HIV-1 tat trans-activation requires the loop sequence within tar. Nature 334:165.
20. Chen, P., M. Mayne, C. Power, and A. Nath. 1997. The Tat protein of HIV-1 induces tumor necrosis factor-α production: implications for HIV-1-associated neurological diseases. J. Biol. Chem. 272:22385.
21. Conant, K., M. Ma, A. Nath, and E. O. Major. 1996. Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-κB binding and protein kinase C activity in primary human astrocytes. J Virol. 70:1384.
22. Ott, M., J. C. Lovett, L. Mueller, and E. Verdin. 1998. Superinduction of IL-8 in T cells by HIV-1 Tat protein is mediated through NF-κB factors. J. Immunol. 160:2872.
23. Mayne, M., A. C. Bratanich, P. Chen, F. Rana, A. Nath, and C. Power. 1998. HIV-1 Tat molecular diversity and induction of TNF-α: implications for HIV-induced neurological disease. Neuroimmunomodulation 5:184.
24. Albini, A., G. Barillari, R. Benelli, R. C Gallo, and B. Ensoli. 1995. Angiogenic properties of human immunodeficiency virus type 1 Tat protein. Proc. Natl. Acad. Sci. USA 92:4838.
25. Albini, A., R. Benelli, M. Presta, M. Rusnati, M. Ziche, A. A. Rubartelli, G. Paglialunga, F. Bussolino, and D. Noonan. 1996. HIV-Tat protein is heparin-binding angiogenic growth factor. Oncogene 12:289.
26. Westendorp, M. O., R. Frank, C. Ochsenbauer, K. Stricker, J. Dhein, H. Walczak, K. M. Debatin, and P. H. Krammer. 1995. Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature 375:497.
27. Re, M. C., G. Furlini, G., M. Vignoli, E. Ramazzotti, G. Zauli, and M. La Placa. 1996. Antibody against human immunodeficiency virus type 1 (HIV-1) Tat protein may have influenced the progression of AIDS in HIV-1-infected hemophiliac patients. Clin. Diagn. Lab. Immunol. 3:230.
28. + T cells from HIV-infected individuals that express intracellular antibodies against HIV-1 gp120 or Tat. Hum. Gene Ther. 9:487.
29. Lafrenie, R. M., L. M. Wahl, J. S. Epstein, I. K. Hewlett, K. M. Yamada, and S. Dhawan. 1996. HIV-Tat protein promotes chemotaxis and invasive behavior by monocytes. J. Immunol. 157:974.
30. Albini, A., R. Benelli, D. Giunciuglio, T. Cai, G. Mariani, S. Ferrini, and D. M. Noonan. 1998. Identification of a novel domain of HIV Tat involved in monocyte chemotaxis. J. Biol. Chem. 273:15895.