Inhibition of HIV-1 transcription and virus replication using soluble Tat peptide analogs

Virology

Volumn 227, Issue 2, 1997, Pages 431-438

  Kashanchi, Fatah ^a   Sadaie, M Reza ^b   Brady, John N ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE; TRANSACTIVATOR PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; VIRUS INHIBITION; VIRUS REPLICATION;

CUCUMBER MOSAIC VIRUS; HTLV; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 17644429769     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1996.8346     Document Type: Article

References (26)

1. Arya, S. K., Guo, C., Josephs, S. F., and Wong-Staal, F. (1985). transactivator gene of human T-lymphotropic virus type III (HTLV-III). Science 229, 69-73.
2. Bohan, C. A., Kashanchi, F., Ensoli, B., Buonaguro, L., Boris-Lawrie, K. A., and Brady, J. N. (1992). Analysis of Tat transactivation of human immunodeficiency virus transcription in vitro. Gene Expression 2, 391-407.
3. Chiang, C.-M., and Roeder, R. G. (1995). Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators. Science 267, 531-536.
4. Chowdhury, M. I., Koyanagi, Y., Horiuchi, S., Hazeki, O., Ui, M., Kitano, K., Golde, D. W., Takada, K., and Yamamoto, N. (1993). cAMP stimulates human immunodeficiency virus (HIV-1) from latently infected cells of monocyte-macrophage lineage: Synergism with TNF-alpha. Virology 194, 345-349.
5. + cell turnover. Nature 375, 194-195.
6. Echetebu, C. O., Rhim, H., Herrmann, C. H., and Rice, A. P. (1994). Construction and characterization of a potent HIV-2 Tat transdominant mutant protein. J. AIDS 7, 655-664.
7. Frankel, A. D., Biancalana, S., and Hudson, D. (1989). Activity of synthetic peptides from the Tat protein of human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 86, 7397-7401.
8. Green, M., Ishino, M., and Lowenstein, P. M. (1989). Mutational analysis of HIV-1 Tat minimal domain peptides: Identification of trans-dominant mutants that suppress HIV-LTR-driven gene expression. Cell 58, 215-223.
9. Herrmann, C., Rice, A. P. (1995). Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor. J. Virol. 69, 1612-1620.
10. Horikoshi, N., Usheva, A., Chen, J., Levine, A. J., Weinmann, R., and Shenk, T. (1995). Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression. Mol. Cell. Biol. 15, 227-234.
11. Huang, L. M., Joshi, A., Wiley, R., Orenstein, J., and Jeang, K. -T. (1994). Human immunideficiency viruses are regulated by alternative transactivators: Genetic evidence for a novel non-transcriptional function of Tat in virion infectivity. EMBO J. 13, 2886-2896.
12. Jeang, K.-T., Chun, R., Lin, N. H., Gatignol, A., Glabe, C. G., and Fan, H. (1993). In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor. J. Virol. 67, 6224-6233.
13. Kashanchi, F., Duvall, J. F., and Brady, J. N. (1992). Electroporation of viral transactivator proteins into lymphocyte suspension cells. Nucleic Acids Res. 20, 4673-4674.
14. Kashanchi, F., Khleif, S. N., Duvall, J. F., Sadaie, M. R., Radonovich, M. F., Cho, M., Martin, M. A., Chen, S. -Y., Weinmann, R., and Brady, J. N. (1996). Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID competes negative factor Dr1 and stabilizes TFIID/TFIIA complex. J. Virol. 70, 5503-5510.
15. Kashanchi, F., Piras, G., Radonovich, M. F., Duvall., J. F., Fattaey, A., Chiang, C.-M., Roeder, R. G., and Brady, J. N. (1994). Direct interaction of human TFIID with the HIV-1 transactivator Tat. Nature 367, 295-299.
16. Livnah, O., Stura, E A., Johnson, D. L., Middleton, S. A., Mulcahy, L. S., Wrighton, N. C., Dower, W. J., Jolliffe, L. K., and Wilson, I. A. (1996). Functional mimicry of a protein hormone by a peptide agonist: The EPO receptor complex at 2.8 Å. Science 273, 464-457.
17. Pearson, L., Garcia, J., Wu, F., Modesti, N., Nelson, J., and Gaynor, R. (1990). A transdominant tat mutant that inhibits tat-induced gene expression from the human immunodeficiency virus long terminal repeat. Proc. Natl. Acad. Sci. USA 87, 5079-5083.
18. Rice, A. P., Wilson, E., and Chan, F. (1993). Limited proteolytic digestions identify common structural features of HIV-1 Tat proteins expressed during infection from alternatively spliced RNAs. J. AIDS 6, 344-352.
19. Sadaie, M. R., Benter, T., and Wong-Staal, F. (1988). Site-directed mutagenesis of two trans- regulatory genes (tat-III, trs) of HIV-1. Science 239, 910-913.
20. Sadaie, M. R., and Hager, G. L. (1994). Induction of developmentally programmed cell death and activation of HIV by sodium butyrate. Virology 202, 513-518.
21. Southgate, C. D., and Green, M. R. (1991). The HIV-1 Tat protein activates transcription from an upstream DNA-binding site: implications for Tat function. Genes Dev. 5, 2496-2507.
22. Veschambre, P., Simard, P., and Jalinot, P. (1995). Evidence for functional interaction between the HIV-1 Tat transactivator and the TATA box binding protein in vivo. J. Mol. Biol. 250, 169-180.
23. Wrighton, N. C., Farrell, F. X., Chang, R., Kashyap, A. K., Barbone, F. P., Mulcahy, L. S., Johnson, D. L., Barrett, R. W., Jolliffe, L. K., and Dower, W. J. (1996). Small peptides as potent mimetics of the protein hormone erythropoietin. Science 273, 458-463.
24. Wu-Baer, F., Sigman, D., and Gaynor, R. B. (1995). Specific binding of RNA polymerase II to the human immunodeficiency virus transactivating region RNA is regulated by cellular cofactors and Tat. Proc. Natl. Acad. Sci. USA 92, 7153-7157.
25. Xhou, Q., and Sharp, P. A. (1995). Novel mechanism and factor for regulation by HIV-1 Tat. EMBO J. 14, 321-328.
26. Yu, L., Loewenstein, P. M., Zhang, Z., and Green, M. (1995). In vitro interaction of the human immunodeficiency virus type 1 Tat transactivator and the general transcription factor TFIIB with the cellular protein TAP. J. Virol. 69, 3017-3023.