Genetic toxicology data in the evaluation of potential human environmental carcinogens

Mutation Research - Reviews in Mutation Research

Volumn 437, Issue 1, 1999, Pages 21-49

  Waters, Michael D ^a   Stack, H Frank ^b   Jackson, Marcus A ^b  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b INTEGRATED LABORATORY SYSTEMS   (United States)

Author keywords

Aneuploidy; Carcinogenic risk; Carcinogenicity; Chemicals; Chromosomal aberrations; Ethylene oxide; Gene mutation; Humans; Mechanisms of carcinogenesis; Mutagenicity; Short term test

Indexed keywords

1,3 BUTADIENE; ACRYLAMIDE; AFLATOXIN B1; AZATHIOPRINE; BENZENE; BENZIDINE; BLEOMYCIN; BUSULFAN; CAPTAFOL; CARCINOGEN; CARMUSTINE; CHLORMETHINE; CHROMIUM DERIVATIVE; CISPLATIN; DOXORUBICIN; ENVIRONMENTAL CHEMICAL; ENVIRONMENTAL MUTAGEN; ESTROGEN; ETHYLENE OXIDE; LEAD; LOMUSTINE; MELPHALAN; PARALDEHYDE; POLYCHLORINATED BIPHENYL; STYRENE; STYRENE OXIDE; TETRACHLOROETHYLENE; THIOTEPA; UNINDEXED DRUG; VINYL ACETATE;

ANEUPLOIDY; CANCER RISK; CARCINOGENICITY; CHROMOSOME ABERRATION; DATA BASE; GENE MUTATION; GENOTOXICITY; HUMAN; MUTAGEN TESTING; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0033166127     PISSN: 13835742     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5742(99)00037-X     Document Type: Article

References (99)

1. Fearon E.R., Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 61:1990;759-767.
2. Vogelstein B., Fearon E.R., Kern S.E., Hamilton S.R., Preisinger A.C., Nakamura Y., White R. Allelotype of colorectal carcinomas. Science. 244:1989;207-211.
3. Fearon E.R., Cho K.R., Nigro J.M., Kern S.E., Simons J.W., Ruppert J.M., Hamilton S.R., Preisinger A.C., Thomas G., Kinzler K.W. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science. 247:1990;49-56.
4. Vogelstein B., Kinzler K.W. The multistep nature of cancer. Trends Genet. 9:1993;138-141.
5. Berenblum I. The carcinogenic action of croton resin. Cancer Res. 1:1941;44-48.
6. Armuth V., Berenblum I. A possible in vivo skin model for tumour promoter assays. Mutat. Res. 15:1982;343-346.
7. Harris C.C. Chemical and physical carcinogenesis: advances and perspective for the 1990s. Cancer Res. 51:1991;5023s-5044s. Suppl.
8. J. Ashby. Use of short-term tests in determining the genotoxicity or nongenotoxicity of chemicals, in: H. Vainio, P.N Magee, D.B. McGregor, A.J. McMichael (Eds.), Mechanisms of Carcinogenesis in Risk Identification (IARC Scientific Publication No. 116), International Agency for Research on Cancer, Lyon, 1992, pp. 135-164.
9. J.C. Barrett. Mechanisms of action of known human carcinogens, in: H. Vainio, P.N. Magee, D.B. McGregor, A.J. McMichael (Eds.), Mechanisms of Carcinogenesis in Risk Identification (IARC Scientific Publication No. 116), International Agency for Research on Cancer, Lyon, 1992, pp. 115-134.
10. Ashby J., Morrod R.S. Detection of human carcinogens. Nature. 352:1991;185-186.
11. Velazquez S.F., Schoeny R., Rice G.E., Cogliano V.J. Cancer risk assessment: historical perspectives, current issues, and future directions. Drug Chem. Toxicol. 19:1996;161-185.
12. Jackson M.A., Stack H.F., Waters M.D. The genetic toxicology of putative nongenotoxic carcinogens. Mutat. Res. 296:1993;241-277.
13. Zeiger E., Tennant R.W. Mutagenesis, clastogenesis, carcinogenesis: expectations, correlations and relations. Prog. Clin. Biol. Res. 209 B:1986;77-84.
14. Tennant R.W., Margolin B.H., Shelby M.D., Zeiger E., Haseman J.K., Spalding J., Caspary W., Resnick M., Stasiewicz S., Anderson B. Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays. Science. 236:1987;933-941.
15. Zeiger E., Haseman J.K., Shelby M.D., Margolin B.H., Tennant R.W. Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: confirmation of earlier results with 41 additional chemicals. Environ. Mol. Mutagen. 16:1990;1-14.
16. International Agency for Research on Cancer. IARC Monographs on the evaluation of carcinogenic risks to humans, Vol. 60, Some industrial chemicals, Lyon, 1994, 560 pp.
17. B.A. Bridges, H.F. Stack, M.D. Waters. The performance of in vitro mutagenicity tests in identifying germ cell mutagens, in: S. Madle, L. Muller, (Eds.), Current Issues In Toxicology, (Bga-schriften; 93, 1), MMV Medizin-Verlag, Munchen, 1993, pp. 17-23.
18. Dearfield K.L., Auletta A.E., Cimino M.C., Moore M.M. Considerations in the US Environmental Protection Agency's testing approach for mutagenicity. Mutat. Res. 258:1991;259-283.
19. Holden H.E. Comparison of somatic and germ cell models for cytogenetic screening. J. Appl. Toxicol. 2:1982;196-200.
20. D. Brusick. Genetic risk estimation, Chapter 5 in: Principles of Genetic Toxicology, 2nd edn., Plenum, New York, 1987, pp. 121-153.
21. Adler I.-D., Ashby J. The present lack of evidence for unique rodent germ-cell mutagens. Mutat. Res. 212:1989;55-66.
22. Ashby J., Waters M.D., Preston J., Adler I.-D., Douglas G.R., Fielder R., Shelby M.D., Anderson D., Sofuni T., Gopalan H.N.B., Becking G., Sonich-Mullin C. IPCS harmonization of methods for the prediction and quantification of human carcinogenic/mutagenic hazard, and for indicating the probable mechanism of action of carcinogens. Mutat. Res. 352:1996;153-157.
23. Kirkland D.J., Galloway S.M., Sofuni T. Report of the international workshop on standardization of genotoxicity test procedures. Summary of major conclusions. Mutat. Res. 312:1994;205-209.
24. Purves D., Harvey C., Tweats D., Lumley C.E. Genotoxicity testing: current practices and strategies used by the pharmaceutical industry. Mutagenesis. 10:1995;297-312.
25. Heddle J.A., Swiger R.R. Risk estimation from somatic mutation assays. Mutat. Res. 365:1996;107-117.
26. H. Vainio, P.N. Magee, D.B. McGregor, A.J. McMichael, (Eds.), International Agency for Research on Cancer. Consensus Report, Mechanisms of Carcinogenesis in Risk Identification (IARC Scientific Publication No. 116), Lyon, International Agency for Research on Cancer, 1992, pp. 9-54.
27. International Agency for Research on Cancer. IARC Monographs on the evaluation of carcinogenic risks to humans, Vol. 53, Occupational exposures in insecticide application, and some pesticides, Lyon, 1991, 612 pp.
28. International Agency for Research on Cancer. IARC Monographs on the evaluation of carcinogenic risks to humans, Vol. 54, Occupational exposures to mists and vapours from strong inorganic acids; and other industrial chemicals, Lyon, 1992, 336 pp.
29. International Agency for Research on Cancer. IARC Monographs on the evaluation of carcinogenic risks to humans, Vol. 56, Some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins, Lyon, 1993, 599 pp.
30. International Agency for Research on Cancer. IARC Monographs on the evaluation of carcinogenic risks to humans, Vol. 57, Occupational exposures of hairdressers and barbers and personal use of hair colourants; some hair dyes, cosmetic colourants, industrial dyestuffs and aromatic amines, Lyon, 1993, 427 pp.
31. International Agency for Research on Cancer. IARC Monographs on the evaluation of carcinogenic risks to humans, Vol. 63, Dry cleaning, some chlorinated solvents and other industrial chemicals, Lyon, 1995, 551 pp.
32. National Toxicology Program. Toxicology and Carcinogenesis Studies of Ethylene Oxide (CAS No. 75-21-8) in B6C3F1 Mice (Inhalation Studies), NTP Technical Report No. 326; NIH Publication No. 88-2582, Research Triangle Park, NC, 1987, 114 pp.
33. Snellings W.M., Weil C.S., Maronpot R.R. A two-year inhalation study of carcinogenic potential of ehtylene oxide in Fischer 344 rats. Toxicol. Appl. Pharmacol. 75:1984;105-117.
34. Garman R.H., Snellings W.M., Maronpot R.R. Brain tumours in F344 rats associated with chronic inhalation exposure to ethylene oxide. Neurotoxicology. 6:1985;117-138.
35. Garman R.H., Snellings W.M., Maronpot R.R. Frequency, size and location of brain tumours in F344 rats chronically exposed to ethylene oxide. Fd. Chem. Toxicol. 24:1986;145-153.
36. Lynch D.W., Lewis T.R., Moorman W.J., Gurg J.R., Groth D.H., Khan A., Ackerman L.J., Cockrell B.Y. Carcinogenic and toxicological effects of inhaled ethylene oxide and propylene oxide. Toxicol. Appl. Pharmacol. 76:1984;69-84.
37. Hogstedt C., Malmqvist N., Wadman B. Leukaemia in workers exposed to ethylene oxide. J. Am. Med. Assoc. 241:1979;1132-1133.
38. Hogstedt C., Rohlen O., Berndsson B.S., Axelson O., Ehrenberg L. A cohort study of mortality and cancer incidence in ethylene oxide production workers. Br. J. Ind. Med. 36:1979;276-280.
39. Hogstedt C., Aringer L., Gustavsson G. Epidemiologic support for ethylene oxide as a cancer-causing agent. J. Am. Med. Assoc. 255:1986;1575-1578.
40. L.C. Hogstedt. Epidemiological studies on ethylene oxide and cancer: an updating, in: H. Bartsch, L. Hemminki, I.K. O'Neill (Eds.), Methods for Detecting DNA Damaging Agents in Humans: Applications in Cancer Epidemiology and Prevention, IARC Scientific Publications No. 89, IARC, Lyon, 1988, pp. 265-270.
41. Steenland K., Stayner L., Greif A., Halperin W., Hayes R., Hornung R., Nowlin S. Mortality among workers exposed to ethylene oxide. New Eng. J. Med. 324:1991;1402-1407.
42. Stayner L., Steenland K., Greife A., Hornung R., Hayes R.B., Nowlin S., Morawetz J., Ringenburg V., Elliot L., Halperin W. Exposure-response analysis of cancer mortality in a cohort of workers exposed to ethylene oxide. Am. J. Epidemiol. 138:1993;787-798.
43. International Agency for Research on Cancer. IARC Monographs on the evaluation of carcinogenic risks to humans, Supplement 6, Genetic and related effects: an updating of selected IARC Monographs from Vols. 1-42, Lyon, 1987, 729 pp.
44. Farmer P.B., Sepai O., Lawrence R., Autrup H., Sabro N.P., Vestergard A.B., Waters R., Leuratti C., Jones N.J., Stone J., Baan R.A., van Delft J.H., Steenwinkle M.J., Kyrtopoulos S.A., Souliotis V.L., Theodorakopoulos N., Bacalis N.C., Natarajan A.T., Tates A.D., Haugen A., Andreassen A., Ovrebo S., Shuker D.E., Amaning K.S., Castelain P.et al. Biomonitoring human exposure to environmental carcinogenic chemicals. Mutagenesis. 11:1996;363-381.
45. Ehrenberg L., Tornqvist M. The research background for risk assessment of ethylene oxide: aspects of dose. Mutat. Res. 330:1995;41-54.
46. Ehrenberg L., Hiesche K.D., Osterman-Golkar S., Wennberg I. Evaluation of genetic risks of alkylation agents: tissue doses in the mouse from air contaminated with ethylene oxide. Mutat. Res. 24:1974;83-103.
47. Osterman-Golkar S., Ehrenberg L., Segerback D., Hallstrom I. Evaluation of genetic risks of alkylating agents. II. Haemoglobin as a dose monitor. Mutat. Res. 34:1976;1-10.
48. Rhomberg L., Dellarco V.L., Siegel-Scott C., Dearfield K.L., Jacobson-Kram D. Quantitative estimation of genetic risk associated with the induction of heritable translocations at low dose exposure. Ethylene oxide as an example. Environ. Mol. Mutagen. 16:1990;104-125.
49. Sobels F.H. Models and assumptions underlying genetic risk assessment. Mutat. Res. 212:1989;77-89.
50. International Agency for Research on Cancer. IARC Monographs on the evaluation of carcinogenic risks to humans, Supplement 7, Overall evaluations of carcinogenesis: an updating of IARC Monographs Vol. 1-42, Lyon, 1987, 440 pp.
51. International Agency for Research on Cancer. IARC Monographs on the evaluation of carcinogenic risks to humans, Vol. 44, Alcohol drinking, Lyon, 1988, 416 pp.
52. International Agency for Research on Cancer. IARC Monographs on the evaluation of carcinogenic risks to humans, Vol. 47, Some organic solvents, resin monomers and related compounds, pigments and occupational exposures in paint manufacture and painting, Lyon, 1989, 535 pp.
53. International Agency for Research on Cancer. IARC Monographs on the evaluation of carcinogenic risks to humans, Vol. 48, Some flame retardants and textile chemicals, and exposures in the textile manufacturing industry, Lyon, 1990, 345 pp.
54. International Agency for Research on Cancer. IARC Monographs on the evaluation of carcinogenic risks to humans, Vol. 49, Chromium, nickle and welding, Lyon, 1990, 677 pp.
55. International Agency for Research on Cancer. IARC Monographs on the evaluation of carcinogenic risks to humans, Vol. 50, Pharmaceutical drugs, Lyon, 1990, 415 pp.
56. International Agency for Research on Cancer. IARC Monographs on the evaluation of carcinogenic risks to humans, Vol. 51, Coffee, tea, mate, methylxanthines and methylglyoxal, Lyon, 1991, 513 pp.
57. International Agency for Research on Cancer. IARC Monographs on the evaluation of carcinogenic risks to humans, Vol. 52, Chlorinated drinking-water; chorination by-products; some other halogenated compounds; cobalt and cobalt compounds, Lyon, 1991, 544 pp.
58. International Agency for Research on Cancer. IARC Monographs on the evaluation of carcinogenic risks to humans, Vol. 58, Beryllium, cadmium, mercury and exposures in the glass manufacturing industry, Lyon, 1994, 444 pp.
59. International Agency for Research on Cancer. IARC Monographs on the evaluation of carcinogenic risks to humans, Vol. 62, Wood dusts and formaldehyde, Lyon, 1995, 405 pp.
60. International Agency for Research on Cancer. IARC Monographs on the evaluation of carcinogenic risks to humans, Vol. 65, Printing processes, printing inks, carbon blacks and some nitro compounds, Lyon, 1996, 578 pp.
61. International Agency for Research on Cancer. IARC Monographs on the evaluation of carcinogenic risks to humans, Vol. 66, Some pharmaceutical drugs, Lyon, 1996, 514 pp.
62. International Agency for Research on Cancer. IARC Monographs on the evaluation of carcinogenic risks to humans, Vol. 68, Silica, some silicates, coal dust and para-aramid fibrils, Lyon, 1997, 506 pp.
63. International Agency for Research on Cancer. IARC Monographs on the evaluation of carcinogenic risks to humans, Vol. 69, Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans, Lyon, 1997, 666 pp.
64. Waters M.D., Stack H.F., Brady A.L., Lohman P.H.M., Vainio H.L. Use of computerized data listings and activity profiles of genetic and related effects in the review of 195 compounds. Mutat. Res. 205:1988;295-312.
65. Waters M.D., Stack H.F., Garrett N.E., Jackson M.A. The genetic activity profile database. Environ. Health Perspect. 96:1991;41-45.
66. Proctor B.L., Gulden M.E., Dowd M.A. Reactivity and fate of benzene and formaldehyde in culture medium with and without fetal calf serum: relevance to in vitro mutagenicity testing. Mutat. Res. 160:1986;259-266.
67. Tsutsui T., Hayashi N., Maizumi H., Huff J., Barrett J.C. Benzene-, catechol-, hydroquinone- and phenol-induced cell transformation, gene mutations, chromosome aberrations, aneuploidy, sister chromatid exchanges and unscheduled DNA synthesis in Syrian hamster embryo cells. Mutat. Res. 373:1997;113-123.
68. Tennant R.W., French J.E., Spalding J.W. Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models. Environ. Health Perspect. 103:1995;942-950.
69. Marchetti F., Lowe X., Morre II D.H., Bishop J., Wyrobek A.J. Paternally inherited chromosomal structural aberrations detected in mouse first-cleavage zygote metaphases by multicolor fluorescence in situ hybridization painting. Chromosome Res. 4:1996;604-613.
70. Wyrobek A.J., Adler I.D. Detection of aneuploidy in human and rodent sperm using FISH and applications of sperm assays of genetic damage in heritable risk evaluation. Mutat. Res. 352:1996;173-179.
71. Tucker J.D., Preston R.J. Chromosome aberrations, micronuclei, aneuploidy, sister chromatid exchanges, and cancer risk assessment. Mutat. Res. 365:1996;147-159.
72. Singh N.P., McCoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175:1988;184-191.
73. Singh N.P., Stephens R.E., Schneider E.L. Modification of alkaline microgel electrophoresis for sensitive detection of DNA damage. Int. J. Radiat. Biol. 66:1994;23-28.
74. R.R. Tice, P.W. Andrews, O. Hirai, N.P. Singh. The single cell gel (SCG) assay: an electrophoretic technique for the detection of DNA damage in individual cells, in: C.R. Witmer, R.R. Snyder, D.J. Jollow, G.F. Kalf, J.J. Kocsis, I.G. Sipes, (Eds.), Biological Reactive Intermediates IV. Molecular and Cellular Effects and Their Impact on Human Health, Plenum, New York, 1991, pp. 157-164.
75. Tice R.R., Strauss G.H. The single cell gel electrophoresis/comet assay: a potential tool for detecting radiation-induced DNA damage in humans. Stem Cell (Dayt). 13:1995;207-214. Suppl. 1.
76. Vaghef H., Wisen A.C., Hellman B. Demonstration of benzo(a)pyrene-induced DNA damage in mice by alkaline single cell gel electrophoresis: evidence for strand breaks in liver but not in lymphocytes and bone marrow. Pharmacol. Toxicol. 78:1996;37-43.
77. Huges C.M., Lewis S.E., McKelvey-Martin V.J., Thompson W. Reproducibility of human sperm DNA measurements using the alkaline single cell gel electrophoresis assay. Mutat. Res. 374:1997;261-268.
78. Sasaki Y.F., Tsuda S., Izumiyama F., Nishidate E. Detection of chemically induced DNA lesions in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow) using the alkaline single cell gel electrophoresis (Comet) assay. Mutat. Res. 388:1997;33-44.
79. Elespuru R.K. Future approaches to genetic toxicology risk assessment. Mutat. Res. 365:1996;191-204.
80. Applegate M.L., Moore M.M., Broder C.B., Burrell A., Juhn G., Kasweck K.L., Lin P.-F., Wadhams A., Hozier J.C. Molecular dissection of mutations at the heterozygous thymidine kinase locus in mouse lymphoma cells. Proc. Natl. Acad. Sci. USA. 87:1990;51-55.
81. Clive D., Glover P., Applegate M., Hozier J. Molecular aspects of chemical mutagenesis in L5178Y tk±mouse lymphoma cells. Mutagenesis. 5:1990;191-197.
82. Fuscoe J.C., Zimmerman L.J., Harrington-Brock K., Moore M. Large deletions are tolerated at the hprt locus of in vivo derived human T-lymphocytes. Mutat. Res. 283:1992;255-262.
83. Isfort R.J., LeBoeuf R.A. Application of in vitro cell transformation assays to predict the carcinogenic potential of chemicals. Mutat. Res. 365:1996;161-173.
84. S.H.H. Swierenga, H. Yamasaki. Performance of tests for cell transformation and gap-junction intercellular communication for detecting nongenotoxic carcinogenic activity, in: H. Vainio, P.N. Magee, D.B. McGregor, A.J. McMichael (Eds.), Mechanisms of Carcinogenesis in Risk Identification (IARC Scientific Publication No. 116), International Agency for Research on Cancer, Lyon, 1992, pp. 165-193.
85. Buzard G.S. Studies of oncogene activation and tumor suppressor gene inactivation in normal and neoplastic rodent tissue. Mutat. Res. 365:1996;43-58.
86. Knudson A.G. Antioncogenes and human cancer. Proc. Natl. Acad. Sci. USA. 90:1993;10914-10921.
87. C.J. Conti, I.B. Gimenez-Conti. Molecular genetic alterations as intermediate end points in chemoprevention studies, in: B.W. Stewart, D. McGregor, P. Kleihues (Eds.), Principles of Chemoprevention (IARC Scientific Publication No. 139), International Agency for Research on Cancer, Lyon, 1996, pp. 249-260.
88. Zambetti G.P., Levine A.J. A comparison of the biological activities of wild-type and mutant p53. FASEB J. 7:1993;855-865.
89. Levine A.J., Perry M.E., Chang A., Silver A., Dittmer D., Wu M. The 1993 Walter Hubert Lecture: the role of the p53 tumor-suppressor gene in tumorigenesis. Br. J. Cancer. 69:1994;409-416.
90. C.C. Harris. Tumor suppressor genes, multistage carcinogenesis and molecular epidemiology, in: H. Vainio, P.N. Magee, D.B. McGregor, A.J. McMichael (Eds.), Mechanisms of Carcinogenesis in Risk Identification (IARC Scientific Publication No. 116), International Agency for Research on Cancer. Lyon, 1992, pp. 67-85.
91. Barnas C., Martel-Planche G., Furukawa Y., Hollstein M., Montesano R., Hainaut P. Inactivation of the p53 protein in cell lines derived from human esophageal cancers. Int. J. Cancer. 71:1997;79-87.
92. Williams J.R., Russell J., Dicello J.F., Mabry M.H. The genotype of the human cancer cell: implications for risk analysis. Mutat. Res. 365:1996;17-42.
93. Bishop J.M. Molecular themes in oncogenesis. Cell. 64:1991;235-248.
94. Cantley L.C., Auger K.R., Carpenter C., Duckworth B., Graziani A., Kapeller R., Soltoff S. Oncogenes and signal transduction. Cell. 64:1991;281-302.
95. Hunter T. Cooperation between oncogenes. Cell. 64:1991;249-270.
96. Barrett J.C. Mechanisms of multistep carcinogenesis and carcinogen risk assessment. Environ. Health Perspect. 100:1993;9-20.
97. J.L. Bos, C.F. van Kreijl. Genes and gene products that regulate proliferation and differentiation: critical targets in carcinogenesis, in: H. Vainio, P.N. Magee, D.B. McGregor, A.J. McMichael (Eds.), Mechanisms of Carcinogenesis in Risk Identification (IARC Scientific Publication No. 116), International Agency for Research on Cancer, Lyon, 1992, pp. 57-65.
98. Scarpelli D.G., Cerny W.L., Mangold K.A. Gene alterations in rodent and human tumors of the exocrine and endocrine pancreas. Prog. Clin. Biol. Res. 376:1992;223-243.
99. Waldman T.A., Korsmeyer S.J., Bakhshi A., Arnold A., Kinch J.R. NIH Conference. Molecular genetic analysis of human lymphoid neoplasma: immunoglobulin genes and the c-myc oncogenes. Ann. Intern. Med. 102:1985;497-510.