Endothelial expression of VCAM-1 in experimental crescentic nephritis and effect of antibodies to very late antigen-4 or VCAM-1 on glomerular injury

Journal of Immunology

Volumn 162, Issue 9, 1999, Pages 5519-5527

  Allen, Andrew R ^a   McHale, Julie ^a   Smith, Jennifer ^a   Cook, H Terence ^a   Karkar, Ayman ^a   Haskard, Dorian O ^a   Lobb, Roy R ^b   Pusey, Charles D ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b BIOGEN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; MONOCLONAL ANTIBODY; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN ANTIBODY COMPLEX; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; GLOMERULONEPHRITIS; IMMUNE COMPLEX NEPHRITIS; IMMUNOHISTOCHEMISTRY; LEUKOCYTE MIGRATION; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEINURIA; RAT; RECEPTOR UPREGULATION;

ALBUMINURIA; ANIMALS; ANTIBODIES, MONOCLONAL; APOPTOSIS; CELL MOVEMENT; ENDOTHELIUM, VASCULAR; GLOMERULONEPHRITIS; IMMUNOHISTOCHEMISTRY; INTEGRIN ALPHA4BETA1; INTEGRINS; IODINE RADIOISOTOPES; KIDNEY GLOMERULUS; LEUKOCYTES; MALE; RATS; RATS, INBRED WKY; RECEPTORS, LYMPHOCYTE HOMING; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0033136794     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Wiggins, R. C., L. B. Holzman, and D. J. Legault. 1997. Glomerular inflammation and crescent formation. In Immunologic Renal Diseases. E. G. Neilson, and W. G. Couser, eds. Lippincott-Raven, Philadelphia, p. 669.
2. Wilson, C. B. 1997. Immune models of glomerular injury. In Immunologic Renal Diseases. E. G. Neilson, and W. G. Couser, eds. Lippincott-Raven, Philadelphia, p. 729.
3. von Andrian, U. H., J. D. Chambers, L. M. McEvoy, R. F. Bargatze, K. E. Arfors, and E. C. Butcher. 1991. Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte β2 integrins in vivo. Proc. Natl. Acad. Sci. USA 88:7538.
4. Johnston, B., T. B. Issekutz, and P. Kubes. 1996. The alpha(4)-integrin supports leukocyte rolling and adhesion in chronically inflamed postcapillary venules in vivo. J. Exp. Med. 183:1995.
5. Johnston, B., U. M. Walter, A. C. Issekutz, T. B. Issekutz, D. C. Anderson, and P. Kubes. 1997. Differential roles of selectins and the alpha(4)-integrin in acute, subacute, and chronic leukocyte recruitment in vivo. J. Immunol. 159:4514.
6. Kanwar, S., D. C. Bullard, M. J. Hickey, C. W. Smith, A. L. Beaudet, B. A. Wolitzky, and P. Kubes. 1997. The association between alpha4-integrin, P-selectin, and E-selectin in an allergic model of inflammation. J. Exp. Med. 185:1077.
7. Springer, T. A. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301.
8. Springer, T. A. 1995. Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu. Rev. Physiol. 57:827.
9. Kansas, G. S. 1996. Selectins and their ligands: current concepts and controversies. Blood 88:3259.
10. Mulligan, M. S., K. J. Johnson, R. F. I. Todd, T. B. Issekutz, M. Miyasaka, T. Tamatani, C. W. Smith, D. C. Anderson, and P. A. Ward. 1993. Requirements for leukocyte adhesion molecules in nephrotoxic nephritis. J. Clin. Invest. 91:577.
11. Brady, H. R. 1996. Complex roles for P-selectin in the pathophysiology of glomerulonephritis. Curr. Opin. Nephrol. Hypertens. 5:413.
12. Tipping, P. G., X. R. Huang, M. C. Berndt, and S. R. Holdsworth. 1996. P-selectin directs T lymphocyte-mediated injury in delayed-type hypersensitivity responses: studies in glomerulonephritis and cutaneous delayed-type hypersensitivity. Eur. J. Immunol. 26:454.
13. Zachem, C. R., C. E. Alpers, W. Way, S. J. Shankland, W. G. Couser, and R. J. Johnson. 1997. A role for P-selectin in neutrophil and platelet infiltration in immune complex glomerulonephritis. J. Am. Soc. Nephrol. 8:1838.
14. Lefkowith, J. B. 1997. Leukocyte migration in immune complex glomerulonephritis: role of adhesion receptors. Kidney Int. 51:1469.
15. Hebert, M.-J., and H. R. Brady. 1997. Leukocyte adhesion. In Immunologic Renal Diseases. E. G. Neilson, and W. G. Couser, eds. Lippincott-Raven, Philadelphia, p. 519.
16. Nikolic-Paterson, D. J., H. Y. Lan, and R. C. Atkins. 1997. Macrophages in immune renal injury. In Immunologic Renal Diseases. E. G. Neilson, and W. G. Couser, eds. Lippincott-Raven, Philadelphia, p. 575.
17. Wu, X., J. Pippin, and J. B. Lefkowith. 1993. Attenuation of immune-mediated glomerulonephritis with an anti-CD11b monoclonal antibody. Am. J. Physiol. 264:F715.
18. Kawasaki, K., E. Yaoita, T. Yamamoto, T. Tamatani, M. Miyasaka, and I. Kihara. 1993. Antibodies against intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 prevent glomerular injury in rat experimental crescentic glomerulonephritis. J. Immunol. 150:1074.
19. Kawasaki, K., E. Yaoita, T. Yamamoto, and I. Kihara. 1992. Depletion of CDS positive cells in nephrotoxic serum nephritis of WKY rats. Kidney Int. 41:1517.
20. Kawasaki, K., E. Taoita, T. Yamamoto, T. Watanabe, T. Abo, and I. Kihara. 1994. Characterization of CD8 positive cells in experimental anti-GBM nephritis of WKY rats. J. Am. Soc. Nephrol. 5:754 (Abstr.).
21. Nishikawa, K., Y.-J. Quo, M. Miyasaka, T. Tamatani, A. B. Collins, M.-S. Sy, R. T. McCluskey, and G. Andres. 1993. Antibodies to intercellular adhesion molecule-1 lymphocyte function-associated antigen-1 prevent crescent formation in rat autoimmune glomerulonephritis. J. Exp. Med. 177:667.
22. Elices, M. J., L. Osborn, Y. Takada, C. Crouse, S. Luhowskyj, M. E. Hemler, and R. R. Lobb. 1990. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 60:577.
23. Carlos, T. M., B. R. Schwartz, N. L. Kovach, E. Yee, M. Rosa, L. Osborn, G. Chi Rosso, B. Newman, R. Lobb, M. Rosso, et al. 1990. Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells. Blood 76:965.
24. Komoriya, A., L. J. Green, M. Mervic, S. S. Yamada, K. M. Yamada, and M. J. Humphries. 1991. The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine. J. Biol. Chem. 266:15075.
25. Lobb, R. R., and M. E. Hemler. 1994. The pathophysiologic role of α4 Integrins in vivo. J. Clin. Invest. 94:1722.
26. Issekutz, T. B., M. Miyasaka, and A. C. Issekutz. 1996. Rat blood neutrophils express very late antigen 4 and it mediates migration to arthritic joint and dermal inflammation. J. Exp. Med. 183:2175.
27. Wu, X., A. K. Tiwari, T. B. Issekutz, and J. B. Lefkowith. 1996. Differing roles of CD18 and VLA-4 in leukocyte migration/activation during anti-GBM nephritis. Kidney Int. 50:462.
28. 4 integrin. J. Immunol. 153:2313.
29. 4 integrin and to VCAM-1. J. Am. Soc. Nephrol. 9:1881.
30. Issekutz, T. B., and A. Wyretowicz. 1991. Effect of a new monoclonal antibody, TA-2, that inhibits lymphocyte adherence to cytokine stimulated endothelium in the rat. J. Immunol. 147:109.
31. Issekutz, T. B. 1991. Inhibition of in vivo lymphocyte migration to inflammation and homing to lymphoid tissues by the TA-2 monoclonal antibody: a likely role for VLA-4 in vivo. J. Immunol. 147:4178.
32. May, M. J., G. Entwhistle, M. J. Humphries, and A. Ager. 1993. VCAM-1 is a CS1 peptide-inhibitable adhesion molecule expressed by lymph node high endothelium. J. Cell. Sci. 106:109.
33. Sanz, M.-J., A. Hartnell, P. Chisholm, C. Williams, D. Davies, V. B. Weg, M. Feldmann, M. A. Bolanowski, R. R. Lobb, and S. Nourshargh. 1997. Tumor necrosis factor α-induced eosinophil accumulation in rat skin is dependent on α4 integrin/vascular cell adhesion molecule-1 adhesion pathways. Blood 90:4144.
34. Laurell, C.-B. 1966. Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. Anal. Biochem. 15:45.
35. Cook, H. T., J. Smith, and V. Cattell. 1987. Isolation and characterization of inflammatory leukocytes from glomeruli in an in situ model of glomerulonephritis in the rat. Am. J. Pathol. 126:126.
36. Keelan, E. T., S. T. Licence, A. M. Peters, R. M. Binns, and D. O. Haskard. 1994. Characterization of E-selectin expression in vivo with use of a radiolabeled monoclonal antibody. Am. J. Physiol. 266:H278.
37. Harrison, A. A., C. J. Stocker, P. T. Chapman, Y. T. Tsang, T. Y. Huehns, R. H. Gundel, A. M. Peters, K. A. Davies, A. J. George, M. K. Robinson, et al. 1997. Expression of vascular cell adhesion molecule-1 by vascular endothelial cells in immune and nonimmune inflammatory reactions in the skin. J. Immunol. 159:4546.
38. Henninger, D. D., J. Panes, M. Eppihimer, J. Russell, M. Gerritsen, D. C. Anderson, and D. N. Granger. 1997. Cytokine induced VCAM-1 and ICAM-1 expression in different organs of the mouse. J. Immunol. 158:1825.
39. Erlich, J. H., J. Apostolopoulos, T. C. Wun, K. K. Kretzmer, S. R. Holdsworth, and P. G. Tipping. 1996. Renal expression of tissue factor pathway inhibitor and evidence for a role in crescentic glomerulonephritis in rabbits. J. Clin. Invest. 98:325.
40. Kitching, A. R., S. R. Holdsworth, V. A. Ploplis, E. F. Plow, D. Collen, P. Carmeliet, and P. G. Tipping. 1997. Plasminogen and plasminogen activators protect against renal injury in crescentic glomerulonephritis. J. Exp. Med. 185:963.
41. Lan, H. Y., D. J. Nikolic-Paterson, W. Mu, and R. C. Atkins. 1995. Local macrophage proliferation in the progression of glomerular and tubulointerstitial injury in rat anti-GBM glomerulonephritis. Kidney Int. 48:753.
42. Hughes, J., R. J. Johnson, A. Mooney, C. Hugo, K. Gordon, and J. Savill. 1997. Neutrophil fate in experimental glumerular capillary injury in the rat: emigration exceeds in situ clearance by apoptosis. Am. J. Pathol. 150:223.
43. Hill, P. A., I. W. Main, and R. C. Atkins. 1995. ICAM-1 and VCAM-1 in human renal allograft rejection. Kidney Int. 47:1383.
44. Ogawa, T., N. Yorioka, T. Ito, Y. Taniguchi, J. Kumagai, Y. Awaya, and M. Yamakido. 1996. Ultrastructural localization of vascular cell adhesion molecule 1 in proliferative and crescentic glomerulonephritis. Virchows Arch. Int. J. Pathol. 429:283.
45. Wüthrich, R. P. 1994. Cell adhesion molecules and inflammatory renal diseases. Nephrol. Dial. Transplant. 9:1063.
46. Pall, A. A., A. J. Howie, D. Adu, G. M. Richards, C. D. Inward, D. V. Milford, N. T. Richards, J. Michael, and C. M. Taylor. 1996. Glomerular vascular cell adhesion molecule-1 expression in renal vasculitis. J. Clin. Pathol. 49:238.
47. Binns, R. M., A. Whyte, S. T. Licence, A. A. Harrison, Y. T. M. Tsang, D. O. Haskard, and M. K. Robinson. 1996. The role of E-selectin in lymphocyte and polymorphonuclear cell recruitment into cutaneous delayed hypersensitivity reactions in sensitized pigs. J. Immunol. 157:4094.
48. Hill, P. A., H. Y. Lan, D. J. Nikolic-Paterson, and R. C. Atkins. 1994. The ICAM-1/LFA-1 interaction in glomerular leukocytic accumulation in anti-GBM glomerulonephritis. Kidney Int. 45:700.
49. Fujinaka, H., T. Yamamoto, L. Feng, K. Kawasaki, E. Yaoita, S. Hirose, S. Goto, C. B. Wilson, M. Uchiyama, and I. Kihara. 1997. Crucial role of CD8 positive lymphocytes in glomerular expression of ICAM-1 and cytokines in crescentic glomerulonephritis of WKY rats. J. Immunol. 158:4978.
50. Wada, J., K. Shikata, H. Makino, S. Morioka, K. Hirata, K. Ota, T. Tamatani, M. Miyasaka, T. Horiuchi, S. Noji, et al. 1996. The critical role of intercellular adhesion molecule-1 in Masugi nephritis in rats. Nephron 73:264.
51. Tang, T., A. Rosenkranz, K. J. M. Assmann, M. J. Goodman, J. C. Gutierrez-Ramos, M. C. Carroll, R. S. Cotran, and T. N. Mayadas. 1997. A role for Mac-1 (CD11b/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcγ receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis. J. Exp. Med. 186:1853.
52. Gurtner, G. C., V. Davis, H. Li, M. J. McCoy, A. Sharpe, and M. I. Cybulsky. 1995. Targeted disruption of the murine VCAM-1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation. Genes Dev. 9:1.
53. Kwee, L., H. S. Baldwin, H. M. Shen, C. L. Stewart, C. Buck, C. A. Buck, and M. A. Labow. 1995. Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice. Development 121:489.
54. Enders, U., R. Lobb, R. B. Pepinsky, H. P. Hartung, K. V. Toyka, and R. Gold. 1998. The role of the very late antigen-4 and its counterligand vascular cell adhesion molecule-1 in the pathogenesis of experimental autoimmune neuritis of the Lewis rat. Brain 121:1257.
55. Madri, J. A., F. J. Roll, H. Furtmayr, and J. M. Foidart. 1980. Ultrastructural localization of fibronectin and laminin in the basement membranes of the murine kidney. J. Cell Biol. 77:837.
56. Nickeleit, V., L. Zagachin, K. Nishikawa, J. H. Peters, R. O. Hynes, and R. B. Colvin. 1995. Embryonic fibronectin isoforms are synthesized in crescents in experimental autoimmune glomerulonephritis. Am. J. Pathol. 147:965.
57. Alonso, J., M. Gomezchiarri, A. Ortiz, D. Seron, E. Condom, M. J. Lopezarmada, R. Largo, A. Barat, and J. Egido. 1996. Glomerular up regulation of EIIIA and V120 fibronectin isoforms in proliferative immune complex nephritis. Kidney Int. 50:908.
58. Bergijk, E. C., H. J. Baelde, C. J. Kootstra, E. De Heer, P. D. Killen, and J. A. Bruijn. 1996. Cloning of the mouse fibronectin V-region and variation of its splicing pattern in experimental immune complex glomerulonephritis. J. Pathol. 178:462.
59. Hirji, N. S., T. J. Lin, and A. D. Befus. 1997. A novel CDS molecule expressed by alveolar and peritoneal macrophages stimulates nitric oxide production. J. Immunol. 158:1833.
60. Hirji, N., T. J. Lin, E. Bissonnette, M. Belosevic, and A. D. Befus. 1998. Mechanisms of macrophage stimulation through CD8: macrophage CD8α and CD8β induce nitric oxide production and associated killing of the parasite Leishmania major. J. Immunol. 160:6004.
61. Shnyra, A., R. Brewington, A. Alipio, C. Amura, and D. C. Morrison. 1998. Reprogramming of lipopolysaccharide-primed macrophages is controlled by a counterbalanced production of IL-10 and IL-12. J. Immunol. 160:3729.
62. Tam, F. W. K., J. Smith, D. Morel, A. M. Karkar, E. M. Thompson, H. T. Cook, and C. D. Pusey. 1999. Development of scarring and renal failure in a rat model of crescentic glomerulonephritis. Nephrol. Dial. Transplant. In press.