The role of the very late antigen-4 and its counterligand vascular cell adhesion molecule-1 in the pathogenesis of experimental autoimmune neuritis of the Lewis rat

Brain

Volumn 121, Issue 7, 1998, Pages 1257-1266

  Enders, U ^a   Lobb, R ^b   Pepinsky, R B ^b   Hartung, H P ^a,c   Toyka, K V ^a   Gold, R ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b BIOGEN   (United States)

^c UNIVERSITY OF GRAZ   (Austria)

Author keywords

Adhesion molecules; Guillain Barre syndrome; Neuritis; Therapy; VCAM 1; VLA 4

Indexed keywords

BETA1 INTEGRIN; INTEGRIN; MONOCLONAL ANTIBODY; MYELIN; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CELL TRANSFER; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; GUILLAIN BARRE SYNDROME; HUMAN CELL; IMMUNOHISTOCHEMISTRY; NEURITIS; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE; T LYMPHOCYTE; TIME;

ANIMALS; ANTIBODIES, MONOCLONAL; AUTOIMMUNE DISEASES; CATTLE; FEMALE; INTEGRIN ALPHA4BETA1; INTEGRINS; NEURITIS; RATS; RATS, INBRED LEW; RECEPTORS, LYMPHOCYTE HOMING; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0031866869     PISSN: 00068950     EISSN: None     Source Type: Journal    
DOI: 10.1093/brain/121.7.1257     Document Type: Article

References (39)

1. Archelos JJ, Mäurer M, Jung S, Toyka KV, Hartung H-P. Suppression of experimental allergic neuritis by an antibody to the intercellular adhesion molecule ICAM-1. Brain 1993; 116: 1043-58.
2. Baron JL, Madri JA, Ruddle NH, Hashim G, Janeway CA Jr. Surface expression of α 4 integrin by CD4 T cells is required for their entry into brain parenchyma. J Exp Med 1993; 177: 57-68.
3. Baron JL, Reich E-P, Visintin I, Janeway CA Jr. The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between α 4-integrins and vascular cell adhesion molecule-1. J Clin Invest 1994; 93: 1700-8.
4. Bell EB, Sparshott SM, Ager A. Migration pathways of CD4 T cell subsets in vivo: the CD45RC- subset enters the thymus via alpha 4 integrin-VCAM-1 interaction. Int Immunol 1995; 7: 1861-71.
5. Beyer H. Handbook of tables for probability and statistics. Cleveland: CRC; 1980. p. 401-8.
6. Butcher EC, Picker LJ. Lymphocyte homing and homeostasis. [Review]. Science 1996; 272: 60-6.
7. Chisholm PL, Williams CA, Lobb RR. Monoclonal antibodies to the integrin α 4 subunit inhibit the murine contact hypersensitivity response. Eur J Immunol 1993; 23: 682-8.
8. Chuluyan HE, Osborn L, Lobb R, Issekutz AC. Domains 1 and 4 of vascular cell adhesion molecule-1 (CD 106) both support very late activation antigen-4 (CD49d/CD29)-dependent monocyte transendothelial migration. J Immunol 1995; 155: 3135-44.
9. Diaz-Gonzalez F, Forsyth J, Steiner B, Ginsberg MH. Trans-dominant inhibition of integrin function. Mol Biol Cell 1996; 7: 1939-51.
10. Foster CA. VCAM-1/αt 4-integrin adhesion pathway: therapeutic target for allergic inflammatory disorders. [Review]. J Allergy Clin Immunol 1996; 98: S270-7.
11. Hartung H-P, Schäfer B, Heininger K, Stoll G, Toyka KV. The role of macrophages and eicosanoids in the pathogenesis of experimental allergic neuritis. Brain 1988a; 111: 1039-59.
12. Hartung H-P, Schäfer B, Heininger K, Toyka KV. Suppression of experimental autoimmune neuritis by the oxygen radical scavengers Superoxide dismutase and catalase. Ann Neurol 1988b; 23: 453-60.
13. Hartung H-P, Pollard JD, Harvey GK, Toyka KV. Immunopathogenesis and treatment of the Guillain-Barré syndrome-Part I. [Review]. Muscle Nerve 1995a; 18: 137-53.
14. Hartung H-P, Archelos JJ, Zielasek J, Gold R, Koltzenburg M, Reiners KH, et al. Circulating adhesion molecules and inflammatory mediators in demyelination: a review. [Review]. Neurology 1995b; 45 (6 Suppl 6): 22-32.
15. Heininger K, Schäfer B, Hartung H-P, Fierz W, Linington C, Toyka KV. The role of macrophages in experimental autoimmune neuritis induced by a P2-specific T-cell line. Ann Neurol 1988; 23: 326-31.
16. Hughes RA. Inflammatory neuropathies. [Review]. Baillieres Clin Neurol 1994; 3: 45-72.
17. Issekutz TB. Dual inhibition of VLA-4 and LFA-1 maximally inhibits cutaneous delayed-type hypersensitivity-induced inflammation. Am J Pathol 1993; 143: 1286-93.
18. Jakubowski A, Ehrenfels BN, Pepinskv RB, Burkly LC. Vascular cell adhesion molecule-Ig fusion protein selectively targets activated α 4-integrin receptors in vivo. J Immunol 1995; 155: 938-46.
19. Jones DA, McIntire LV, Smith CW, Picker LJ. A two-step adhesion cascade for T ceel/endothelial cell interactions under flow conditions. J Clin Invest 1994; 94: 2443-50.
20. King RH, Craggs RI, Cross ML, Thomas PK. Effects of glucocorticoids on experimental allergic neuritis. Exp Neurol 1985; 87: 9-19.
21. Kitani A, Nakashima N, Matsuda T, Xu B, Yu S, Nakamura T, et at. T cells bound by vascular cell adhesion molecule-l/CD106 in synovial fluid in rheumatoid arthritis. J Immunol 1996; 156: 2300-8.
22. Linington C, Izumo S, Suzuki M, Uyemura K, Meyermann R, Wekerle H. A permanent rat T cell line that mediates experimental allergic neuritis in the Lewis rat in vivo. J Immunol 1984; 133: 1946-50.
23. Lobb RR, Hemler ME. The pathophysiologic role of α 4 integrins in vivo. [Review]. J Clin Invest 1994; 94: 1722-8.
24. Nakajima H, Sano H, Nishimura T, Yoshida S, Iwamoto I. Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue. J Exp Med 1994; 179: 1145-54.
25. Norton WT, Poduslo SE. Myelination in rat brain: changes in myelin composition during brain maturation. J Neurochem 1973; 21: 759-73.
26. Oppenheimer-Marks N, Lipsky PE. Adhesion molecules as targets for the treatment of autoimmune diseases. [Review]. Clin Immunol Immunopathol 1996; 79: 203-10.
27. Oppenheimer-Marks N, Davis LS, Bogue DT, Ramberg J, Lipsky PE. Differential utilization of ICAM-1 and VCAM-1 during the adhesion and transendothelial migration of human T lymphocytes. J Immunol 1991; 147: 2913-21.
28. Osborn L, Vassallo C, Browning BG, Tizard R, Haskard DO, Benjamin CD, et al. Arrangement of domains, and amino acid residues required for binding of vascular cell adhesion molecule-1 to its counter-receptor VLA-4 (α 4, β 1). J Cell Biol 1994; 124: 601-8.
29. Pall AA, Savage CO. Mechanisms of endothelial cell injury in vasculitis. [Review]. Springer Semin Immunopathol 1994; 16: 23-37.
30. Paul LC, Davidoff CA,. Benediktsson H, Issekutz TB. The efficacy of LFA-1 and VLA-4 antibody treatment in rat vascularized cardiac allograft rejection. Transplantation 1993; 55: 1196-9.
31. Pober JS, Gimbrone MA Jr, Lapierre LA, Mendrick DL, Fiers W, Rothlein R, et al. Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune Interferon. J Immunol 1986; 137: 1893-6.
32. Prineas JW. Pathology of inflammatory demyelinating neuropathies, [Review]. Baillieres Clin Neurol 1994; 3: 1-24.
33. Schmidt B, Toyka KV, Kiefer R, Full' J, Hartung H-P, Pollard J. Inflammatory infiltrates in sural nerve biopsies in Guillain-Barré syndrome and chronic inflammatory demyelinating neuropathy. Muscle Nerve 1996; 19: 474-87.
34. Steffen BJ, Butcher EC, Engelhardt B. Evidence of involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse. Am J Pathol 1994; 145: 189-201.
35. Uyemura K, Tobari C, Hirano S, Tsukada Y. Comparative studies on the myelin proteins of bovine peripheral nerve and spinal cord. J Neurochem 1972; 19: 2607-14.
36. Wang J-H, Pepinsky RB, Stehle T, Liu J-H, Karpusas M, Browning B, et al. The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-l-α 4 integrin interaction. Proc Natl Acad Sci USA 1995; 92: 5714-8.
37. Weishaupt A, Giegerich G, Jung S, Gold R, Enders U, Pette M, et al. T cell antigenic and neuritogenic activity of recombinant human peripheral myelin P2 protein. J Neuroimmunol 1995; 63: 149-56.
38. Yednock TA, Cannon C, Fritz LC, Sanchez-Madrid F, Steinman L, Karin N. Prevention of experimental autoimmune encephalomyelitis by antibodies against α 4, β 1 integrin. Nature 1992; 356: 63-6.
39. Zettl UK, Gold R, Toyka KV, Hartung H-P. In situ demonstration of T cell activation and elimination in the peripheral nervous system during experimental autoimmune neuritis in the Lewis rat. Acta Neuropathol (Berl) 1996; 91: 360-7.