Mechanisms of macrophage stimulation through CD8: Macrophage CD8α and CD8β induce nitric oxide production and associated killing of the parasite Leishmania major

Journal of Immunology

Volumn 160, Issue 12, 1998, Pages 6004-6011

  Hirji, Nadir ^a   Lin, Tong Jun ^a   Bissonnette, Elyse ^a   Belosevic, Miodrag ^a   Befus, A Dean ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; CROSS LINKING; HOST RESISTANCE; IMMUNOREGULATION; IMMUNOSTIMULATION; INFECTION RESISTANCE; LEISHMANIA MAJOR; LEISHMANIASIS; MACROPHAGE ACTIVATION; MALE; MEDIATOR RELEASE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD8; LEISHMANIA MAJOR; MACROPHAGE ACTIVATION; MACROPHAGES, ALVEOLAR; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, SPRAGUE-DAWLEY; SRC-FAMILY KINASES; UP-REGULATION;

EID: 0032526328     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Barnes, P. J., and F. Y. Liew. 1995. Nitric oxide and asthmatic inflammation. Immunol. Today 16:128.
2. Snyder, S. H., and D. S. Bredt. 1992. Biological roles of nitric oxide. Medicine 266:68.
3. Persoons, J. H. A., K. Schornagel, F. F. H. Tilders, J. de Vente, F. Berkenbosch, and G. Kraal. 1996. Alveolar macrophages autoregulate IL-1 and IL-6 production by endogenous nitric oxide. Am. J. Respir. Cell Mol. Biol. 14:272.
4. Parnes, J. R. 1989. Molecular biology and function of CD4 and CD8. Adv. Immunol. 44:265.
5. O'Rourke, A. M., and M. F. Mescher. 1993. The roles of CD8 in cytotoxic T lymphocyte function. Immunol. Today 14:183.
6. Hirji, N. S., T. J. Lin, and A. D. Befus. 1997. A novel CD8 molecule expressed by alveolar and peritoneal macrophages stimulates nitric oxide production. J. Immunol. 158:1833.
7. + T-cells in CD8β gene-targeted mice. J. Exp. Med. 180:959.
8. lck) that phosphorylates the CD3 complex. Proc. Natl. Acad. Sci. USA 86:3277.
9. Rudd, C. E., O. Janssen, K. V. S. Prasad, M. Raab, A. da Silva, J. C. Telfer, and M. Yammamoto. 1993. src-related protein tyrosine kinases and their surface receptors. Biochim. Biophys. Acta 1155:239.
10. Dong, Z., X. Qi, K. Xie, and I. J. Fidler. 1993. Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in lipopolysaccharide-responsive and lipopolysaccharide-nonresponsive murine macrophages. J. Immunol. 151:2717.
11. Tachado, S. D., P. Gerold, M. J. McConville, T. Balbwin, D. Quilici, R. T. Schwarz, and L. Schofield. 1996. Glycosylphosphatidylinositol toxin of plasmodium induces nitric oxide synthase expression in macrophages and vascular endothelial cells by a protein tyrosine kinase-dependent and protein kinase C-dependent signaling pathway. J. Immunol. 156:1897.
12. Nagai, S., S. Kitani, K. Hirai, T. Takaishi, K. Nakajima, H. Kihara, Y. Nonomura, K. Ito, and Y. Morita. 1995. Pharmacological study of stem-cell-factor-induced mast cell histamine release with kinase inhibitors. Biochem. Biophys. Res. Commun. 208:576.
13. Hanke, J. H., J. P. Gardner, R. L. Dow, P. S. Changelian, W. H. Brissette, E. J. Weringer, B. A. Pollock, and P. A. Connelly. 1996. Discovery of a novel, potent, and SRC family-selective tyrosine kinase inhibitor: study of Lck- and FynT-dependent T-cell activation. J. Biol. Chem. 271:695.
14. Walker, D. L., and P. E. Gold. 1994. Intra-amygdala kinase inhibitors disrupt retention of a learned avoidance response in rats. Neurosci. Lett. 176:255.
15. Eason, S., and W. Martin. 1995. Involvement of tyrosine kinases and protein kinase C in the induction of nitric oxide synthase by lipopolysaccharide and interferon-γ in J774 macrophages. Arch. Int. Pharmacodyn. Ther. 330:225.
16. + T cells. J. Immunol. 158:4699.
17. Marx, J. 1996. Leishmania susceptibility, puzzle gets another twist. Science 271:912.
18. Ramaswamy, K., R. Mathison, L. Carter, D. Kirk, F. Green, J. S. Davison, and D. Befus. 1990. Marked antiinflammatory effects of decentralization of the superior cervical ganglia. J. Exp. Med. 172:1819.
19. 15N] nitrate in biological fluids. Anal. Biochem. 126:131.
20. Chang, K. P., C. A. Nacy, and R. D. Pearson. 1986. Intracellular parasitism of macrophages in leishmaniasis: in vitro systems and their applications. Methods Enzymol. 132:603.
21. Belosevic, M., C. E. Davis, M. S. Meltzer, and C. A. Nacy. 1988. Regulation of activated macrophage antimicrobial activities: identification of lymphokines that cooperate with interferon γ for induction of macrophage resistance to infection. J. Immunol. 141:890.
22. Belosevic, M., D. S. Finbloom, P. H. Van de Meide, M. V. Slayter, and C. A. Nacy. 1989. Administration of monoclonal anti-IFNγ antibodies abrogates natural resistance of C3H/HeN mice to infection with Leishmania major. J. Immunol. 143:266.
23. Belosevic, M., D. S. Finbloom, M. S. Meltzer, and C. A. Nacy. 1990. IL-2: a cofactor for induction of activated macrophage resistance to infection. J. Immunol. 145:831.
24. Green, S. J., R. M. Crawford, J. T. Hockmeyer, M. S. Meltzer, and C. A. Nacy. 1990. Leishmania major amastigotes initiate the L-arginine-dependent killing mechanisms in IFN-γ stimulated macrophages by induction of tumor necrosis factor-α. J. Immunol. 145:4290.
25. Hagemann, L., L. A. A. van Rooijen, J. Traber, and B. H. Schmidt. 1991. Polymixin B is a selective and potent antagonist of calmodulin. Eur. J. Pharmacol. Mol. Pharm. Sect. 207:17.
26. Boulet, I., S. Ralph, E. Stanley, P. Lock, A. R. Dunn, S. P. Green, and W. A. Phillips. 1992. Lipopolysaccharide- and interferon-gamma-induced expression of hck and lyn tyrosine kinases in murine bone marrow-derived macrophages. Oncogens 7:703.
27. Lowell, C. A., P. Soriano, and H. E. Varmus. 1994. Functional overlap in the src gene family: inactivation of hck and fgr impairs immunity. Genes Dev. 8:387.
28. Winkel, K., F. Sotzik, D. Vremec, P. U. Cameron, and K. Shortman. 1994. CD4 and CD8 expression by human and mouse thymic dendritic cells. Immunol. Lett. 40:93.
29. Vremec, D., M. Zorbas, R. Scollay, D. J. Saunders, C. F. Ardavin, L. Wu, and K. Shortman. 1992. The surface phenotype of dendritic cells purified from mouse thymus and spleen. J. Exp. Med. 176:47.
30. Garcia, K. C., C. A. Scott, A. Brunmark, F. R. Carbone, P. A. Peterson, I. A. Wilson, and L. Teyton. 1996. CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes. Science 384:577.
31. Crooks, M. E., and D. R. Littman. 1994. Disruption of T-lymphocyte positive and negative selection in mice lacking the CD8 β chain. Immunity 1:277.
32. Itano, A., D. Cado, F. K. M. Chan, and E. Robey. 1994. A role for the cytoplasmic tail of the β chain of CD8 in thymic selection. Immunity 1:287.
33. Renard, V., J. Delon, I. F. Luescher, B. Malissen, E. Vivier, and A. Trautmann. 1996. The CD8/3 polypeptide is required for the recognition of an altered peptide ligand as an agonist. Eur. J. Immunol. 26:2999.
34. Bolen, J. B. 1991. Signal transduction by the SRC family of kinases in hemopoietic cells. Cell Growth Differ. 2:409.
35. English, B. K., J. N. Ihle, A. Myracle, and T. Yi. 1993. Hck tyrosine kinase activity modulates tumor necrosis factor production by murine macrophages. J. Exp. Med. 178:1017.
36. Irie, Y. H., K. S. Ravichandran, and S. J. Burakoff. 1995. CD8β chain influences CD8α chain-associated lck kinase activity. J. Exp. Med. 181:1267.
37. Paul, A., R. H. Pendreigh, and R. Plevin. 1995. Protein kinase C and tyrosine kinase pathways regulate lipopolysaccharide-induced nitric oxide synthase activity in RAW 264.7 macrophages. Br. J. Pharmacol. 111:482.
38. Raghavan, M., and P. J. Bjorkman. 1996. Fc receptors and their interactions with immunoglobulins. Annu. Rev. Cell. Dev. Biol. 12:181.
39. Bayon, Y., A. Alonso, and M. S. Crespo. 1997. Stimulation of Fcγ receptors in rat peritoneal macrophages induces the expression of nitric oxide synthase and chemokines by mechanisms showing different sensitivities to antioxidants and nitric oxide donors. J. Immunol. 159:887.
40. Wang, A. V. T., P. R. Scholl, and R. S. Geha. 1994. Physical and functional association of the high affinity immunoglobulin G receptor (FcγRI) with the kinases hck and lyn. J. Exp. Med. 180:1165.
41. Lin, C. T., Z. Shen, P. Boros, and J. C. Unkeless. 1994. Fc receptor-mediated signal transduction. J. Clin. Immunol. 14:1.
42. 3 domain of class I MHC. Science 252:1424.
43. lck. J. Exp. Med. 182:1079.