Protective role of β-chemokines associated with HIV-specific Th responses against perinatal HIV transmission

Journal of Immunology

Volumn 162, Issue 7, 1999, Pages 4355-4364

  Wasik, Thomas J ^a   Bratosiewicz, Jolanta ^a   Wierzbicki, Andrzej ^a   Whiteman, Valerie E ^c   Rutstein, Richard R ^d   Starr, Stuart E ^d   Douglas, Steven D ^d   Kaufman, David ^d   Sison, Antonio V ^a   Polansky, Marcia ^a   Lischner, Harold W ^b   Kozbor, Danuta ^a,e  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b ST CHRISTOPHER'S HOSPITAL FOR CHILDREN   (United States)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^e THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2;

ARTICLE; CELLULAR IMMUNITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; INFANT; MAJOR CLINICAL STUDY; PLACENTAL TRANSFER; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS TRANSMISSION;

ALLELES; CHEMOKINES, CC; DISEASE TRANSMISSION, VERTICAL; FEMALE; FETAL BLOOD; GENE FREQUENCY; GENE PRODUCTS, ENV; HIV INFECTIONS; HIV SERONEGATIVITY; HIV SEROPOSITIVITY; HIV-1; HUMANS; INFANT; INFANT, NEWBORN; LYMPHOCYTE COUNT; MOTHERS; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; RECEPTORS, CCR5; STEM CELLS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0033120077     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Shearer, G. M., and M. Clerici. 1996. Protective immunity against HIV infection: has nature done the experiment for us? Immunol. Today 17:21.
2. Fowler, M. G. 1997. Update: transmission of HIV-1 from mother to child. Curr. Opin. Obstet. Gynecol. 9:343.
3. Frenkel, L. M., J. I. Mullins, G. H. Learn, L. Manns-Arcuino, B. L. Herring, M. L. Kalish, R. W. Steketee, D. M. Thea, J. E. Nichols, S.-L. Liu et al. 1998. Genetic evaluation of suspected cases of transient HIV-1 infection of infants. Science 280:1073.
4. Weiser B., S. Nachman, P. Tropper, K. H. Viscosi, R. Grimson, G. Baxter, G. Fang, C. Reyelt, N. Hutcheon, and H. Burger. 1994. Quantitation of human immunodeficiency virus type 1 during pregnancy: relationship of viral liter to mother-to-child transmission and stability of viral load. Proc. Natl. Acad. Sci. USA 91:8037.
5. Fung, G., H. Burger, R. Grimson, P. Tropper, S. Nachman, D. Mayers, O. Weyslow, R. Moore, C. Reyelt, N. Chutcheon, D. Baker, and B. Weiser. 1995. Maternal plasma human immunodeficiency virus type 1 RNA level: a determinant and projected threshold for mother-to-child transmission. Proc. Natl. Acad. Sci. USA 92:12100.
6. Morrison, J., and N. J. Alp. 1997. Vertical transmission of human immunodeficiency virus. Q. J. Med. 90:5.
7. Koup, R. A., J. T. Safrit, Y. Cao, C. A. Andrews, G. McLeod, W. Borkowsky, C. Farthing, and D. D. Ho. 1994. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68:4650.
8. Wasik, T. J., P. P. Jagodzinski, E. M. Hyjek, J. Wustner, G. Trinchieri, H. W. Lischner, and D. Kozbor. 1997. Diminished HIV-specific CTL activity is associated with lower type 1 and enhanced type 2 responses to HIV-specific peptides during perinatal HIV infection. J. Immunol. 158:6029.
9. McFarland, E. J., P. A. Harding, D. Luckey, B. Conway, R. K. Young, and D. R. Kuritzkes. 1994. High frequency of gag- and env-specific cytotoxic T lymphocyte precursors in children with vertically-acquired human immunodeficiency vims type 1 infection. J. Infect. Dis. 170:766.
10. Cheynier, R., P. Langlade-Demoyen, M. R. Marescot, S. Blanche, G. Blondin, S. Wain-Hobson, C. Griscelli, E. Vilmer, and F. Plata. 1992. Cytotoxic T lymphocyte responses in the peripheral blood of children born to human immunodeficiency virus-1-infected mothers. Eur. J. Immunol. 22:2211.
11. Luzuriaga, K., R. A. Koup, C. A. Pikora, D. B. Brettler, and J. L. Sullivan. 1991. Deficient human immunodeficiency virus type 1-specific cytotoxic T cell responses in vertically infected children. J. Pediatr. 119:230.
12. Luzuriaga, K., D. Holmes, A. Hereema, J. Wong, and D. L. Panicali. 1995. HIV-1-specific cytotoxic T lymphocyte responses in the first year of life. J. Immunol. 154:433.
13. Rowland-Jones, S. L., D. F. Nixon, M. C. Aldhous, F. Gotch, K. Ariyoshi, N. Hallam, J. S. Kroll, K. Froebel, and A. McMichael. 1993. HIV-specific cytotoxic T-cell activity in an HIV-exposed but uninfected infant. Lancet 341:860.
14. Pikora, C. A., J. L. Sullivan, D. Panicali, and K. Luzuriaga. 1997. Early HIV-1 envelope-specific cytotoxic T lymphocyte responses in vertically infected infants. J. Exp. Med. 185:1153.
15. Clerici, M., A. V. Sison, J. A. Berzofsky, T. A. Rakusan, C. D. Brandt, M. Ellaurie, M. Villa, C. Colie, D. J. Venzon, J. L. Sever, and G. M. Shearer. 1993. Cellular immune factors associated with mother-to-infant transmission of HIV. AIDS 7:1427.
16. Walter, E. A., P. D. Greenberg, M. J. Gilbert, R. J. Finch, K. S. Watanabe, E. D. Thomas, and S. R. Riddell. 1995. Reconstitution of cellular immunity against cytomegalovirus in recipients of allogenic bone marrow by transfer of T-cell clones from the donor. N. Engl. J. Med. 333:1038.
17. Thomsen, A. R., J. Johansen, O. Marker, and J. P. Christensen. 1996. Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus infected MHC class II-deficient mice and B cell-deficient mice. J. Immunol. 157:3074.
18. + T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: implications for adoptive immunotherapy of virus carriers. Proc. Natl. Acad. Sci. USA 94:6874.
19. Mosmann, T. R., H. Cherwinski, M. W. Bond, M. A. Giedlin, and R. Coffman. 1986. Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
20. Romagnani, S. 1991. Human Th1 and Th2 subsets: doubt no more. Immunol. Today 12:256.
21. Clerici, M., and G. Shearer. 1994. The Th1-Th2 hypothesis of HIV infection: new insights. Immunol. Today 15:575.
22. H0 cells. Science 265:244.
23. Schrum, S., P. Probst, B. Fleischer, and P. F. Zipfel. 1996. Synthesis of the CC-chemokines MIP-1 α, MIP-1 β, and RANTES is associated with a type 1 immune response. J. Immunol. 157:3598.
24. Deng, H. K., R. Liu, W. Elmeier, S. Choe, D. Unutmaz, M. Burkhart, P. Di Marzio, S. Marmon, R. E. Sutton, C. M. Hill, C. B. Davis, S. C. Peiper, T. J. Schall, D. R. Littman, and N. R. Landau. 1996. Identification of a major co-receptor for primary isolates of HIV-1. Nature 381:661.
25. + cells is mediated by the chemokine receptor CC-CKR-5. Nature 381:667.
26. + T cell responses associated with control of viremia. Science 278:1447.
27. Berzofsky, J. A., C. D. Pendleton, M. Clerici, J. Ahlers, D. R. Lucey, S. D. Putney, and G. M. Shearer. 1991. Construction of peptides encompassing multideterminant clusters of human immunodeficiency virus envelope to induce in vitro T cell responses in mice and humans of multiple MHC types. J. Clin. Invest. 88:876.
28. Hyjek, E., H. W. Lischner, T. Hyslop, J. Bartkowiak, M. Kubin, G. Trinchieri, and D. Kozbor. 1995. Cytokine patterns during progression to AIDS in children with perinatal HIV infection. J. Immunol. 155:4060.
29. Clerici, M., F. T. Hakim, D. J. Venzon, S. Blatt, C. W. Hendrix, T. A. Wynn, and G. M. Shearer. 1993. Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals. J. Clin. Invest. 91:759.
30. Clerici, M., L. De Palma, E. Roilides, R. Baker, and G. M. Shearer. 1993. Analysis of T helper and antigen-presenting cell function in cord blood and peripheral blood leukocytes from healthy children of different ages. J. Clin. Invest. 91:2829.
31. Kozbor, D., E. Hyjek, R. Wiaderkiewicz, Z. Wang, M. Wang, and E. Loh. 1993. Competitor mRNA fragments for quantitation of cytokine specific transcripts in cell lysates. Mol. Immunol. 30:1.
32. Liu, R., W. A. Paxton, S. Choe, D. Ceradini, S. R. Martin, R. Horuk, M. E. MacDonald, H. Stuhlmann, R. A. Koup, and N. R. Landau. 1996. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 86:367.
33. Koup, R. A., C. A. Pikora, K. Luzuriaga, D. B. Brettler, E. S. Day, G. P. Mazzara, and J. L. Sullivan. 1991. Limiting dilution analysis of cytotoxic T lymphocytes to human immunodeficiency virus gag antigens in infected persons: in vitro quantitation of effector cell populations with p17 and p24 specificities. J. Exp. Med. 174:1593.
34. Fazekas de St. Groth, S. 1982. The evaluation of limiting dilution assays. J. Immunol. Methods 49:R11.
35. Lehmann, E. L. 1975. Nonparametrics: Statistical Methods Based on Ranks. E. L. Lehmann, ed. Holden-Day, San Francisco, p. 457.
36. Winer, B. J. 1971. Statistical Principals in Experimental Design, W. Maytham, A. Shapiro, and J. Stern, eds. McGraw Hill, New York, p. 399.
37. Clerici, M., J. V. Giorgi, C. C. Chou, V. K. Gudeman, J. A. Zack, P. Gupta, H. N. Ho, P. G. Nishanian, J. A. Berzofsky, and G. M. Shearer. 1992. Cell-mediated immune response to human immunodeficiency virus (HIV) type 1 in seronegative homosexual men with recent sexual exposure to HIV-1. J. Infect. Dis. 165:1012.
38. Andersson, U., J. Andersson, A. Lindfors, K. Wagner, G. Möller, and C. H. Heusser. 1990. Simultaneous production of interleukin 2, interleukin 4 and interferon-γ by activated human blood lymphocytes. Eur. J. Immunol. 20:1591.
39. Samson, M., F. Libert, B. J. Doranz, J. Rucker, C. Liesnard, C.-M. Farber, S. Saragosti, C. Lapoumeroulie, J. Cognaux, C. Forceille et al. 1996. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382:722.
40. Dean, M., M. Carrington, C. Winkler, G. A. Huttley, M. W. Smith, R. Allikmets, J. J. Goedert, S. P. Buchbinder, E. Vittinghoff, E. Gomperts et al. 1996. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 273:1856.
41. Uittenbogaart, C. H., D. Janisman, B. D. Jamieson, S. Kitchen, I. Schmid, J. A. Zack, and E. F. Hays. 1996. Differential tropism of HIV-1 isolates for distinct thymocyte subsets in vitro. AIDS 10:F9.
42. Calabro, M. L., C. Zanotto, F. Calderazzo, C. Crivellaro, A. Del Mistro, A. De Rossi, and L. Chieco-Bianchi. 1995. HIV-1 infection of the thymus: evidence for a cytopathic and thymotropic viral variant in vivo. AIDS Res. Hum. Retroviruses 11:11.
43. Giovarelli, M., A. Santoni, C. Jemma, T. Musso, A. M. Giuffrida, G. Cavallo, S. Landolfo, and G. Forni. 1988. Obligatory role of IFN-γ in induction of lymphokine-activated and T lymphocyte killer activity, but not in boosting of natural cytotoxity. J. Immunol. 141:2831.
44. Landolfo, S., F. Cofano, M. Giovarelli, M. Prat, G. Cavallo, and G. Forni. 1985. Inhibition of interferon-γ may suppress allograft reactivity by T-lymphocytes in vitro and in vivo. Science 229:176.
45. McMichael, A. J., and R. E. Phillips. 1997. Escape of human immunodeficiency virus from immune control. Annu. Rev. Immunol. 15:271.
46. Korber, B., J. Moore, C. Brander, B. Walker, B. Haynes, and R. Koup, eds. 1997. HIV Molecular Immunology Database. Los Alamos National Laboratory, Los Alamos.
47. Paxton, W. A., S. R. Martin, D. Tse, T. R. O'Brien, J. Skurnik, N. L. VanDevanter, N. Padian, J. F. Braun, D. P. Kotler, S. M. Wolinsky, and R. A. Koup. 1996. Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures. Nat. Med. 2:412.
48. Centers for Disease Control. 1994. Revised classification system for human immunodeficiency virus infection in children less than 13 years of age. Morbid. Mortal. Wkly. Rep. 43:1.