Overweight is risking fate

Bailliere's Best Practice in Clinical Endocrinology and Metabolism

Volumn 13, Issue 1, 1999, Pages 47-69

  Björntorp, Per A ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cortisol; Evolution; Hypothalamic arousal; Neuroendocrine; Obesity

Indexed keywords

GLUCOCORTICOID RECEPTOR;

AROUSAL; AUTONOMIC NERVOUS SYSTEM; BODY FAT; ENDOCRINE SYSTEM; EVOLUTION; FEEDBACK SYSTEM; GENE LOCUS; GENETIC POLYMORPHISM; HUMAN; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LIPID STORAGE; NEUROENDOCRINE SYSTEM; OBESITY; REVIEW; RISK FACTOR; SURVIVAL; VISCERA;

EID: 0033117843     PISSN: 1521690X     EISSN: None     Source Type: Journal    
DOI: 10.1053/beem.1999.0006     Document Type: Article

References (71)

1. World Health Organization (1988) Obesity. Preventing and Managing the Global Epidemic. Report of a WHO consultation on obesity. WHO/NUT/NCD/981. Geneva: WHO.
2. Björntorp P (1974) Effects of age, sex and clinical conditions on adipose tissue cellularity in man. Metabolism 23: 1091-1102.
3. Rebuffé-Scrive M, Enk L, Crona N et al (1985) Fat metabolism in different regions in women. Journal of Clinical Investigation 75: 1973-1976.
4. Stubbs RJ, Harbron CG, Murgatroyd PR & Prentice AM, (1995) Covert manipulation of dietary fat and energy density: Effect on substrate flux and food intake in men eating ad libitum. American Journal of Clinical Nutrition. 62: 316-329.
5. Björntorp P & Sjöström L (1978) Carbohydrate storage in man: Speculations and some quantitative considerations. Metabolism 27: 1853-1865.
6. Pond CM & Ramsay MA (1992) Allometry of the distribution of adipose tissue in Carnivora. Canadian Journal of Zoology 70: 342-347.
7. Björntorp P (1992) Abdominal fat distribution: An overview of epidemiological data. Annals of Medicine 24: 15-18.
8. Björntorp P ( 1993) Visceral obesity: A 'civilization syndrome'. Obesity Research 1: 206-222.
9. Després JP, Nadeau A & Tremblay A (1989) Role of deep abdominal fat in the association between regional adipose tissue distribution and glucose tolerance in obese women. Diabetes 38: 304-309.
10. Kissebah AH & Krakower GR (1954) Regional adiposity and morbidity. Physiological Review 4: 761-811.
11. Reaven GH (1988) Role of insulin in human disease. Diabetes 37: 1595-1607.
12. Björntorp P ( 1990) 'Portal' adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. Arteriosclerosis 10: 493-496.
13. Mårin P, Darin N, Amemeiya T et al (1992) Cortisol secretion in relation to body fat distribution in obese premenopausal women. Metabolism 4 1: 882-886.
14. Pasquali R, Cantobelli S, Casimirri F et al (1993) The hypothalamo-pituitary-adrenal axis in obese women with different patterns of body fat distribution. Journal of Clinical Endocrinology and Metabolism 77:341-346.
15. Rosmond R, Dallman MF & Björntorp P (1998) Stress-related cortisol secretion in men: Relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities. Journal of Clinical Endocrinology and Metabolism 83: 1853-1859.
16. Rosmond R, Holm G & Björntorp P (1999) Cortisol secretion and the metabolic syndrome. Obesity Research (in press).
17. Ljung T, Andersson B, Bengtsson B-Å et al (1996) Inhibition of Cortisol secretion by dexamethasone in relation to body fat distribution: A dose-response study. Obesity Research 4: 277-282.
18. Smyth J, Ockenfels MC, Porter L et al (1998) Stressors and mood measured on a momentary basis are associated with salivary cortisol secretion. Psychoneuroendocrinology 23: 353-371.
19. Kvist H, Chowdhury B, Grangård U et al (1988) Total and visceral adipose tissue volumes derived from measurements with computed tomography in adult men and women: Predictive equations. American Journal of Clinical Nutrition 48: 1351-1361.
20. Clemmons DR & Van Wyk JJ (1984) Factors controlling blood concentrations of somatomedin C. Journal of Clinical Endocrinology and Metabolism 13: 113-143.
21. Björntorp P, Holm G & Rosmond R (1999) The pathogenesis of the metabolic syndrome. In Ailhaud G, Ricquier D, Guy-Grand B (eds) Progress in Obesity Research: 8. London: John Libbey (in press).
22. Björntorp P, Holm G & Rosmond R (1999) Non-insulin dependent diabetes mellitus and hypothalamic arousal. Diabetic Medicine (in press).
23. McEwen BS (1998) Protective and damaging effects of stress mediators. New England Journal of Medicine 338: 171-179.
24. Björntorp P (1988) Abdominal obesity and the development of non-insulin dependent diabetes mellitus. Diabetes Metabolism Review 4: 615-622.
25. Chrousos GP & Gold PW (1992) The concepts of stress and stress system disorders. Overview of physical and behavioural homeostasis. Journal of the American Medical Association 267: 1244-1252.
26. Lönn L, Kvist L, Ernest I & Sjöström L (1994) Changes in body composition and adipose tissue distribution after treatment of women with Cushing's syndrome. Metabolism 43: 1517-1522.
27. Friedman TC, Mastorakis G, Newman TD et al (1996) Carbohydrate and lipid metabolism in endogenous hypercortisolism: Shared features with metabolic syndrome X and NIDDM. Endocrinological Journal 46: 645-655.
28. Björntorp P (1996) Review: The regulation of adipose tissue distribution in humans. International Journal of Obesity 20: 291-302.
29. Mårin P, Holmäng S, Gustafsson C et al (1993) Androgen treatment of abdominal obese men. Obesity Research I: 245-251.
30. Johannsson G, Mårin P, Lönn L et al (1997) Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure. Journal of Clinical Endocrinology and Metabolism 82: 727-734.
31. Andersson B, Mattsson L-Å, Hahn L et al (1997) Estrogen replacement therapy decreases hyperandrogenicity and improves glucose homeostasis and plasma lipids in postmenopausal women with non-insulin dependent diabetes mellitus. Journal of Clinical Endocrinology and Metabolism 82: 638-643.
32. Bengtsson B-Å, Edén S, Lönn L et al (1993) Treatment of adults with growth hormone deficiency with recombinant human growth hormone. Journal of Clinical Endocrinology and Metabolism 76: 309-317.
33. Seidell JC, Björntorp P, Sjöström L et al (1990) Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels. Metabolism 39: 897-901.
34. Tibblin G, Adlerberth A, Lindstedt G & Björntorp P (1996) The pituitary-gonadal axis and health in elderly men. A study of men born in 1913. Diabetes 45: 1605-1609.
35. Rosmond R & Björntorp P (1998) The interactions between hypothalamic-pituitary-adrenal axis activity, testosterone, insulin-like growth factor I and abdominal obesity with metabolism and blood pressure in men. International Journal of Obesity 22: 1187-1196.
36. Hall JE, Brands MW, Zappe DH & Alonso Galicia M (1995) Insulin resistance, hyperinsulinemia, and hypertension: Causes, consequences, or merely correlations? Proceedings of the Society of Experimental Biology and Medicine 208: 317-329.
37. Krieger DR & Landsberg L (1988) Mechanisms in obesity-related hypertension: Role of insulin and catecholamines. American Journal of Hypertension 1: 84-90.
38. Rosmond R & Björntorp P (1998) Blood pressure in relation to obesity, insulin and the hypothalamic-pituitary-adrenal axis in Swedish men. Journal of Hypertension 16: 1721-1726.
39. Folkow B (1987) Stress, hypothalamic function and neuroendocrine consequences. Acta Medica Scandinavica 723: 61-69.
40. Considine RV, Sinha MK, Heiman ML et al (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New England Journal of Medicine 334: 292-295.
41. Zharkewska KE, Cusin J, Sainbury A et al (1997) Glucocorticoids are counterregulatory hormones of leptin. Towards an understanding of leptin resistance. Diabetes 46: 717-719.
42. York DA (1992) Genetic models of animal obesity. In Björntorp P & Brodoff BN (eds) Obesity, pp 233-240. Philadelphia: JB Lippincott.
43. Starkman MN, Sebarski SS, Berent S & Schteingardt DE (1992) Hippoocampal volume, memory dys- Function, and cortisol levels in patients with Cushing's syndrome. Biological Psychiatry 32: 756-765.
44. Linkowski P, Van Onderbergen A, Kerkhofs M et al ( 1993) Twin study of the 24-h cortisol profile: Evidence for genetic control of the human circadian clock. American Journal of Physiology 264: 173-181.
45. Weaver JU, Hitman GA & Kopelman PG (1992) An association between a Bcl I restriction fragment length polymorphism of the glucocorticoid receptor locus and hyperinsulinemia in obese women. Journal of Molecular Endocrinology 9: 295-300.
46. BUemann B, Vohl M-C, Chagnon M et al (1997) Abdominal visceral fat is associated with a Bcll restriction fragment length polymorphism at the glucocorticoid receptor gene locus. Obesity Research 5: 186-192.
47. Watt GC, Harrap SB, Foy CJ et al (1992) Abnormalities of glucocorticoid metabolism and the renin angiotensin system: A four-corners approach to the identification of determinants of blood pressure. Journal of Hypertension 10: 473-482.
48. Palmer LA, Hukku B & Harnon JM (1992) Human glucocorticoid receptor gene deletion following exposure to cancer chemotherapeutic drugs and chemical mutagens. Cancer Research 52: 6612-6618.
49. Henry J & Stephens P (1977) Stress, Health, and the Social Environment. A Sociobiological Approach to Medicine, pp New York: Springer-Verlag.
50. Moyer A, Rodin J, Grilo C et al (1994) Stress-induced cortisol response and fat distribution in women. Obesity Research 2: 255-262.
51. Björntorp P (1992) Psychosocial factors and fat distribution. In Ailhaud G, Ricquier D & Guy-Grand B (eds) Obesity in Europe 91, pp. 377-387, London: John Libbey.
52. Rosmond R, Lapidus L, Mårin P & Björntorp P (1996) Mental distress, obesity and body fat distribution in middle-aged men. Obesity Research 4: 245-252.
53. Rosmond R, Lapidus L & Björntorp P (1996) The influence of occupational and social factors on obesity and body fat distribution in middle-aged men. International Journal of Obesity 20: 599-607.
54. Brunner EJ, Marmot MG, Manchahal K et al (1997) Social inequality in coronary risk: Central obesity and the metabolic syndrome. Evidence from the Whitehall II study. Diabetologia 40: 1341-1349.
55. Jayo JM, Shively CA, Kaplan JR & Manuck SB (1993) Effects of exercise and stress on body fat distribution in male Cynomolgus monkeys. International Journal of Obesity 17: 597-604.
56. Law CM, Barker OJP, Osmond C et al (1992) Early growth and abdominal fatness in adult life. Journal of Epidemiology and Community Health 46: 184-186.
57. Reul JMHM, Stec J, Wiegers J et al (1994) Prenatal immune challenge alters the hypothalamic-pituitary-adrenal axis in adult rats. Journal of Clinical Investigation 93: 2600-2607.
58. Nyirenda MJ, Lindsay RS, Kenyon CJ et al (1998) Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring. Journal of Clinical Investigation 101: 2174-2181.
59. Nilsson C, Niklasson M, Eriksson E et al (1998) Imprinting of female offspring with testosterone results in insulin resistance and changes in body fat distribution at adult age in rat. Journal of Clinical Investigation 101:74-78.
60. Bujalska JJ, Kumar S & Stewart PM (1997) Does central obesity reflect 'Cushing's disease of the omentum? Lancet 349: 1210-1213.
61. Ottosson M, Mårin P, Karason K et al (1995) Blockade of the glucocorticoid receptor with RU 486: Effects in vitro and in vivo on human adipose tissue lipoprotein lipase activity. Obesity Research 3: 233-240.
62. Després JP, Tremblay A, Nadeau A & Bouchard C (1988) Physical training and changes in regional fat distribution. Acta Medica Scandinavica 723: 205-212.
63. Björntorp P, deJounge K, Sjöström L & Sullivan L (1970) The effect of physical training on insulin production in obesity. Metabolism 19: 112-117.
64. Bernadet P (1995) Benefits of physical activity in the prevention of cardiovascular disease. Journal of Cardiovascular Pharmacology 25: S3-S8.
65. Kretschmer E (1924/1947) Korperbau und Charakter. Stockholm: Alfa Boktryckeri (in Swedish).
66. Hertz T (1931) Pharmakodynamische untersuchungen an konstitutionstypen. Zeitschrift Neurol Psych, p 134.
67. Hirsch O (1932) Blutzuckerbelastungsproblem zur blutchemischen fundierung der körperbautypen. Zeitschrift Neurol Psych, p 140.
68. Von Rohden-Gründler F (1926) Über körperbau und psychose. Zeitschrift Neural Psych 1926.
69. Vague J (1942) La differenciation sexuelle. Facteur determinant des formes de l'obesité. Press Medicale 55:339-341.
70. Björntorp P (1988) Possible mechanisms relating fat distribution and metabolism. In Bouchard C & Johnston F (eds) Fat Distribution during Growth and Later Health Outcomes, pp 175-191. New York: Alan R Liss.
71. Björntorp P (1991) Metabolic implications of body fat distribution. Diabetes Care 14:1132-1143.