An econazole β-cyclodextrin inclusion complex: An unusual dissolution rate, supersaturation, and biological efficacy example

International Journal of Pharmaceutics

Volumn 165, Issue 1, 1998, Pages 57-68

  Pedersen, Morten ^a   Bjerregaard, Simon ^b   Jacobsen, Jette ^b   Rômmelmayer Larsen, Annette ^b   Mehlsen Sørensen, Alex ^b  

^a PEDCY   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Antimycotic; Biological response; Cell culture TR146; Cyclodextrin; Dissolution rate; Erythrocytes; Inclusion complex; Solubility diagram; Supersaturation; Toxicity

Indexed keywords

ANTIFUNGAL AGENT; BETA CYCLODEXTRIN; ECONAZOLE; WATER;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CELL DEATH; CHEEK MUCOSA; COMPLEX FORMATION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG EFFICACY; DRUG RESPONSE; DRUG SOLUBILITY; ELECTRIC RESISTANCE; ERYTHROCYTE; HEMOLYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; NONHUMAN; PH; PRIORITY JOURNAL; TEMPERATURE; WATER CONTENT; X RAY DIFFRACTION;

EID: 0032550318     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)00431-6     Document Type: Article

References (12)

1. Higuchi T., Connors K.A. Phase-solubility techniques. Adv. Anal. Chem. Instrum. 4:1965;117-122.
2. Jacobsen J., van Deurs B., Pedersen M., Rassing M.R. TR146 cells grown on filters as a model for human buccal epithelium: I. Morphology, growth, barrier properties, and permeability. Int. J. Pharm. 125:1995;165-184.
3. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
4. Ohtani Y., Irie T., Uekama K., Fukunaga K., Pitha J. Differential effects of α-, β- and γ-cyclodextrins on human erythrocytes. Eur. J. Biochem. 186:1989;17-22.
5. Pedersen M. Isolation and antimycotic effect of a genuine miconazole β-cyclodextrin complex. Eur. J. Pharm. Biopharm. 40:1994;19-23.
6. Pedersen M. The bioavailability difference between genuine cyclodextrin inclusion complexes and freeze-dried or ground drug cyclodextrin samples may be due to supersaturation differences. Drug Dev. Ind. Pharm. 23:1997;331-335.
7. Pedersen M., Rassing M.R. Miconazole chewing gum as a drug delivery system - application of solid dispersion technique and lecithin. Drug Dev. Ind. Pharm. 16:1990;2015-2030.
8. Pedersen, M., Edelsten, M., Nielsen, V.F., Scarpellini, A., Skytte S., Slot, C., 1993a. Formation and antimycotic effect of cyclodextrin inclusion complexes of econazole and miconazole. Int. J. Pharm. 90, 247-254.
9. Pedersen, M., Pedersen, S., Sørensen, A.M., 1993b. Polymorphism of miconazole during preparation of solid systems of the drug and β-cyclodextrins. Pharm. Acta Helv., 68, 43-47.
10. Rupniak T.H., Rowlatt C., Lane E.B., Steele J.G., Trejdosiewicz L.K., Laskiewicz B., Povey S., Hill B.T. Characteristics of four new human cell lines derived from squamous cell carcinomas of the head and neck. J. Natl. Cancer Inst. 75:1985;621-633.
11. Szejtli, J., 1988. Cyclodextrin Technology, Topics In Inclusion Science, Kluwer, Dordrecht.
12. Van Doorne H., Bosch E.H., Clerk C.F. Formation and antimicrobial activity of complexes of β-cyclodextrin and some antimycotic imidazole derivatives. Pharm. Weekbl. Sci. Ed. 10:1988;80-85.