Autoregulation of glucose production in health and disease

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 2, Issue 2, 1999, Pages 161-164

  Tappy, Luc ^a,b   Chioléro, René ^a   Berger, Mette ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

ANIMAL; BLOOD; DOG; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; METABOLISM; REFERENCE VALUE; REVIEW;

ANIMALS; BLOOD GLUCOSE; DOGS; GLUCONEOGENESIS; HOMEOSTASIS; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIA; REFERENCE VALUES;

EID: 0033090258     PISSN: 13631950     EISSN: None     Source Type: Journal    
DOI: 10.1097/00075197-199903000-00012     Document Type: Article

References (34)

1. Gerich JE. Control of glycaemia. Baillieres Clin Endocrinol Metab 1993; 7:551-586.
2. Stumvoll M, Meyer C, Mitrakou A, Nadkarni V, Gerich JE. Renal glucose production and utilization: new aspects in humans. Diabetologia 1997; 40:749-757.
3. Owen OE, Tappy L, Mozzoli MA, Smalley KJ. Acute starvation. In: The metabolic and molecular basis of acquired disease. Cohen RD, Lewis B, Alberti KGMM, Denman AM (editors). London: Baillière Tindall; 1990. pp. 550-570.
4. Soskin S, Essex HE, Herrick JF, Mann FC. The mechanism of the regulation of blood sugar by the liver. Am J Physiol 1938; 124:558-567.
5. Courtney Moore M, Connolly CC, Cherrington AD. Autoregulation of hepatic glucose production. Eur J Endocrinol 1998; 138:240-248. Excellent review of the concept of autoregulation of glucose production and its mechanisms.
6. Shulman GI, Liljenquist JE, Williams PE, Lacy WW, Cherrington AD. Glucose disposal during insulinopenia in somatostatin-treated dogs: the roles of glucose and glucagon. J Clin Invest 1978; 62:487-491.
7. Chu CA, Sindelar DK, Neal DW, Allen EJ, Donahue EP, Cherrington AD. Comparison of the direct and indirect effects of epinephrine on hepatic glucose production. J Clin Invest 1997; 99:1044-1056.
8. Rossetti L, Giaccari A, Barzilai N, Howard K, Sebel G, Hu M. Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. J Clin Invest 1993; 92:1126-1134.
9. Rossetti L, Giaccari A, Barzilai N, Howard K, Sebel G, Hu M. Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. J Clin Invest 1993; 92:1126-1134.
10. Hellerstein MK, Neese RA, Letscher A, Linfoot P, Turner S. Hepatic glucose-6-phosphatase flux and glucose phosphorylation, cycling, irreversible disposal, and net balance in vivo in rats. Measurement using the secreted glucuronate technique. Metab Clin Exp 1997; 46:1390-1398.
11. Saccá L, Hendler R, Sherwin RS. Hyperglycemia inhibits glucose production in man independent of changes in glucoregulatory hormones. J Clin Endocrinol Metab 1978; 47:1160-1163.
12. Petersen KF, Laurent D, Rothman DL, Cline GW, Shulman GI. Mechanism by which insulin inhibits net hepatic glycogenolysis in man. J Clin Invest 1998; 101:1203-1209.
13. Del Prato S, Matsuda M, Simonson DC, Groop LC, Sheehan P, Leonetti F. Studies on the mass action effect of glucose in NIDDM and IDDM: evidence for glucose resistance. Diabetologia 1997; 40:687-697. In this study, type 2 diabetic patients had a normal suppression of glucose production, but impaired stimulation of glucose utilization in response to hyperglycemia.
14. Mevorach M, Giacca A, Aharon Y, Hawkins M, Shamoon H, Rossetti L. Regulation of endogenous glucose production by glucose per se is impaired in type 2 diabetes mellitus. J Clin Invest 1998; 102:744-753. This study indicates a defect in glucose-induced suppression of glucose production in type 2 diabetes.
15. Tappy L, Schwarz JM, Schneiter P, Cayeux C, Revelly JP, Fagenquist CK, et al. Effects of isoenergetic glucose-based or lipid-based parenteral nutrition on glucose metabolism, de novo lipogenesis, and respiratory gas exchanges in critically ill patients. Crit Care Med 1998; 26:860-867. In this study, endogenous glucose production was higher than under normal conditions in intensive care patients receiving high and low carbohydrate isocaloric parenteral nutrition.
16. •, 17] document a role of glucokinase in the control of fasting and postprandial hepatic glucose metabolism. See [17].
17. Velho G, Petersen KF, Perseghin G, Hwang JH, Rothman DL, Pueyo ME. Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects. J Clin Invest 1996; 98:1755-1761.
18. Saccá L, Cryer PE, Sherwin RS. Blood glucose regulates the effects of insulin and counterregulatory hormones on glucose production in vivo. Diabetes 1979; 28:533-536.
19. Frizzell RT, Hendrick GL, Brown LL, Lacy DB, Donahue EP, Cann RK, et al. Stimulation of glucose production through hormone secretion and other mechanisms during insulin-induced hypoglycemia. Diabetes 1988; 37:1531-1541.
20. Bolli G, De Feo P, Perriello G, De Cosmo S, Ventura M, Campbell P. Role of hepatic autoregulation in defense against hypoglycemia in humans. J Clin Invest 1985; 75:1623-1631.
21. Cersosimo E, Molina PE, Abumrad NN. Renal lactate metabolism and gluconeogenesis during insulin-induced hypoglycemia. Diabetes 1998; 47:1101-1106. In this study, renal glucose production increased in response to hypoglycemia.
22. Felig P, Wahren J, Hendler R. Influence of maturity-onset diabetes on splanchnic glucose balance after oral glucose ingestion. Diabetes 1978; 27:121-126.
23. Zawadski JK, Wolfe RR, Mott DM, Lillioja S, Howard BV, Bogardus C. Increased rate of Cori cycle in obese subjects with NIDDM and effect of weight reduction. Diabetes 1988; 37:154-159.
24. 13C nuclear magnetic resonance study. J Clin Invest 1992; 90:1323-1327.
25. Winkler B, Rathgeb I, Steele R, Altszuler N. Conversion of glycerol to glucose in the normal dog. Am J Physiol 1970; 219:497-502.
26. Jenssen T, Nurjhan N, Consoli A, Gerich JE. Failure of substrate-induced gluconeogenesis to increase overall glucose appearance in normal humans. J Clin Invest 1990; 86:489-497.
27. Tounian P, Schneiter P, Henry S, Jéquier E, Tappy L. Effects of infused fructose on endogenous glucose production, gluconeogenesis and glycogen metabolism in healthy humans. Am J Physiol 1994; 267:E710-E717.
28. Haesler E, Schneiter P, Temler E, Jéquier E, Tappy L. Effects of lactate infusion on hepatic gluconeogenesis and glycogenolysis. Clin Physiol 1995; 15:581-595.
29. Jahoor F, Peters EJ, Wolfe RR. The relationship between gluconeogenic substrate supply and glucose production in humans. Am J Physiol 1990; 258:E288-E296.
30. Magnusson I, Rothman DL, Jucker B, Cline GW, Shulman RG, Shulman GI. Liver glycogen turnover in fed and fasted humans. Am J Physiol 1994; 266:E796-E803.
31. Tappy L, Tounian P, Paquot N. Autoregulation of endogenous glucose production in man. Biochem Soc Trans 1997; 25:11-13.
32. Paquot N, Schneiter P, Jéquier E, Gaillard RC, Lefèbune PD, Scheen A, et al. Effects of ingested fructose and infused glucagon on endogenous glucose production in obese NIDDM patients, obese non-diabetic subjects, and healthy subjects. Diabetologia 1996; 39:580-586.
33. Tappy L, Cayeux M-C, Schneiter P, Schindler C, Teuler E, Jéquier E, et al. Effects of lactate on glucose metabolism in healthy subjects and in severely injured hyperglycemic patients. Am J Physiol 1995; 268:E630-E635.
34. Nuutila P, Koivisto VA, Knuuti J, Ruotsalaimen U, Tenas M, Haapananta M, et al. Glucose-free fatty acid cycle operates in human heart and skeletal muscle in vivo. J Clin Invest 1992; 89:1767-1774.