Perilipin: Possible roles in structure and metabolism of intracellular neutral lipids in adipocytes and steroidogenic cells

International Journal of Obesity

Volumn 20, Issue SUPPL. 3, 1996, Pages

  Londos, C ^a,b   Gruia Gray, J ^a   Brasaemle, D L ^a   Rondinone, C M ^a   Takeda, T ^a   Dwyer, N K ^a   Barber, T ^a   Kimmel, A R ^a   Blanchette Mackie, E J ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Adipocyte; Adrenal cortical; Hormone sensitive lipase; Leydig cells; Lipolysis; Neutral lipids; Steroidogenesis

Indexed keywords

CHOLESTEROL ESTERASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FAT DROPLET; ISOPROTEIN; LIPID; PERILIPIN; PHOSPHOPROTEIN; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ADIPOCYTE; CONFERENCE PAPER; ENZYME PHOSPHORYLATION; HORMONAL REGULATION; HYDROLYSIS; LIPID METABOLISM; LIPID STORAGE; PRIORITY JOURNAL; PROTEIN STRUCTURE; STEROIDOGENESIS;

ADIPOCYTES; ANIMALS; CHOLESTEROL ESTERASE; LIPID METABOLISM; LIPIDS; LIPOLYSIS; PHOSPHOPROTEINS; PHOSPHORYLATION; STEROIDS;

EID: 0029920426     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (13)

1. Blanchette-Mackie EJ, Scow RO. Lipolysis and lamellar structures in white adipose tissue of young rats: lipid movement in membranes. Ultrastruct Res 1981; 77: 295-318.
2. Blanchette-Mackie EJ, Scow RO. Continuity of intracellular channels with extracellular space in adipose tissue and liver: demonstration with tannic acid and lanthanum. Anat Rec 1982; 203: 205-219.
3. Stralfors P, Olsson H, Belfrage P. Hormone-sensitive lipase. In: The Enzymes, Academic Press: London, 1987, Vol. 8, pp 147-175.
4. Egan JJ, Greenberg AS, Chang MK, Wek SA, Moos MC, Jr, Londos C. Mechanism of hormone-stimulated lipolysis on adipocytes : translocation of hormone-sensitive lipase to the lipid storage droplet. Proc Natl Acad Sci USA 1992; 89: 8537-8541.
5. Egan JJ, Greenberg AS, Chang MK, Londos C. Control of endogenous phosphorylation of the major cAMP-dependent protein kinase substrate in adipocytes by insulin and beta-adrenergic stimulation. J Biol Chem 1990; 265: 18769-18775.
6. Greenberg AS, Egan JJ, Wek SA, Garty NB, Blanchette-Mackie EJ, Londos C. Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J Biol Chem 1991; 266: 11341-11346.
7. Blanchette-Mackie EJ, Dwyer NK, Barber T, Coxey RA, Rondinone CM, Theodorakis JL, Greenberg AS, Londos C. Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes. J Lipid Res 1995; 36: 1211-1226.
8. Greenberg AS, Egan JJ, Wek SA, Moos MC, Jr, Londos C, Kimmel AR. Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes. Proc Natl Acad Sci USA 1993; 90: 12035-12039.
9. Servetnick DA, Brasaemle DL, Gruia-Gray J, Kimmel AR, Wolff J, Londos C. Perilipins are associated with cholesteryl ester droplets in steroidogenic adrenal cortical and Leydig cells. J Biol Chem 1995; 270: 16970-16973.
10. Jiang H-P, Serrero G. Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein. Proc Natl Acad Sci USA 1992; 89: 7856-7860.
11. Yeaman SJ. Hormone-sensitive lipase: a multipurpose enzyme in lipid metabolism. Biochim Biophys Acta 1990; 1052: 128-123.
12. Yeaman SJ, Smith GM, Jepson CA, Wood SL, Emmison N. The multifunctional role of hormone-sensitive lipase in lipid metabolism. Adv Enzyme Regul 1994; 34: 355-370.
13. Takeda T, Rondinone CM, Theodorakis JL, Barber T, Blanchette-Mackie EJ, Pointer R, Kimmel AR, Greenberg AS, Londos C. Expression of perilipin during differentiation of 3T3-L1 adipocytes: relationship to triacylglycerol deposition. (Submitted).