MHC multimerization, antigen expression and the induction of APC amnesia in the developing immune response

Immunology and Cell Biology

Volumn 77, Issue 1, 1999, Pages 99-104

  Lake, Richard A ^a   Robinson, Bruce W S ^a   Hayball, John D ^a  

^a PATHWEST LABORATORY MEDICINE   (Australia)

Author keywords

APC amnesia; Determinant spreading; Immune regulation; Receptor multimerization; T cell activation

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; CYTOTOXIC T LYMPHOCYTE; IMMUNOREGULATION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; REVIEW; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGEN-PRESENTING CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; LIGANDS; MODELS, BIOLOGICAL; PROTEIN CONFORMATION; RECEPTORS, ANTIGEN, T-CELL; SELF TOLERANCE; T-LYMPHOCYTES;

EID: 0033064731     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1711.1999.00794.x     Document Type: Review

References (41)

1. 1 Constant SL, Bottomly K. Induction of Th1 and Th2, CD4+ T cell responses: The alternative approaches. Annu. Rev. Immunol. 1997; 15: 297-322.
2. 2 Steinman RM, Young JW. Signals arising from antigen-presenting cells. Curr. Opin. Immunol. 1991; 3: 361-72.
3. 3 Guerder S, Flavell RA. T-cell activation. Two for T. Curr. Biol. 1995; 5: 866-8.
4. 4 Sprent J. Antigen-presenting cells. Professionals and amateurs. Curr. Biol. 1995; 5: 1095-7.
5. 5 Lanzavecchia A, Immunology. Licence to kill. Nature. 1998; 393: 413-14.
6. 6 Sakihama T, Smolyar A, Reinherz EL. Molecular recognition of antigen involves lattice formation between CD4, MHC class II and TCR molecules. Immunol. Today 1995; 16: 581-7.
7. 7 Smith JA, Tso JY, Clark MR, Cole MS, Bluestone JA. Non-mitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy. J. Exp. Med. 1997; 185: 1413-22.
8. 8 König R, Shen X, Germain RN. Involvement of both major histocompatibility complex class II alpha and beta chains in CD4 function indicates a role for ordered oligomerization in T cell activation. J. Exp. Med. 1995; 182: 779-87.
9. 9 Bachmann MF, Salzmann M, Oxenius A, Ohashi P. Formation of TCR dimers/trimers as a crucial step for T cell activation. Eur. J. Immunol. 1998; 28: 2571-9.
10. 10 Germain RN. T-cell signaling: The importance of receptor clustering. Curr. Biol. 1997; 7: 640-4.
11. 11 Iezzi G, Karjalainen K, Lanzavecchia A. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 1998; 8: 89-95.
12. 12 Schafer PH, Pierce SK, Jardetzky TS. The structure of MHC class II: A role for dimer of dimers. Semin. Immunol. 1995; 7: 389-98.
13. 13 Cherry RJ, Wilson KM, Triantafilou K et al. Detection of dimers of dimers of human leukocyte antigen (HLA)-DR on the surface of living cells by single-particle fluorescence imaging. J. Cell Biol. 1998; 140: 71-9.
14. 14 Hayball JD, Fidler SJ, Palliser D, Rees A, Lamb JR, Lake RA. Tandem peptide epitopes facilitate CD4-dependent activation of T cell clones. Immunol. Cell Biol. 1997; 75: 148-53.
15. 15 Rotzschke O, Falk K, Strominger JL. Superactivation of an immune response triggered by oligomerized T cell epitopes. Proc. Natl Acad. Sci. USA 1997; 94: 14 642-7.
16. 16 Reich Z, Boniface JJ, Lyons DS, Borochov N, Wachtel EJ, Davis MM. Ligand-specific oligomerization of T-cell receptor molecules. Nature 1997; 387: 617-20.
17. 17 Ding YH, Smith KJ, Garboczi DN, Utz U, Biddison WE, Wiley DC. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity 1998; 8: 403-11.
18. 18 Davis MM. T-cell receptors. Serial engagement proposed. Nature 1995; 375: 104.
19. 19 Monks CRF, Frieberg BA, Kupfer H, Sciaky N, Kupfer N. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 1998; 395: 82-6.
20. 20 Kersh GJ, Allen PM. Essential flexibility in the T-cell recognition of antigen. Nature 1996; 380: 495-8.
21. 21 Wulfing C, Rabinowitz JD, Beeson C, Sjaastad MD, McConnell HM, Davis MM. Kinetics and extent of T cell activation as measured with the calcium signal. J. Exp. Med. 1997; 185: 1815-25.
22. 22 Evavold BD, Allen PM. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 1991; 252: 1308-10.
23. 23 De Magistris MT, Alexander J, Coggeshall M et al. Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor. Cell 1992; 68: 625-34.
24. 24 Jameson SC, Carbone FR, Bevan MJ. Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells. J. Exp. Med. 1993; 177: 1541-50.
25. 25 Lyons DS, Lieberman SA, Hampl J et al. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity 1996; 5: 53-61.
26. 26 Hampl J, Chien YH, Davis MM. CD4 augments the response of a T cell to agonist but not to antagonist ligands. Immunity 1997; 7: 379-85.
27. 27 Dietrich J, Hou X, Wegener AM, Geisler C. CD3 gamma contains a phosphoserine-dependent di-leucine motif involved in down-regulation of the T cell receptor. EMBO J. 1994; 13: 2156-66.
28. 28 Viellette A, Bookman MA, Horack EM, Bolen JB. The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. Cell 1988; 55: 301-8.
29. 29 Miyazaki T, Liu ZJ, Kawahara A et al. Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell 1995; 81: 223-31.
30. 30 Lanzavecchia A. Understanding the mechanisms of sustained signaling and T cell activation. J. Exp. Med. 1997; 185: 1717-19.
31. 31 Hayball JD, Jones CM, Lamb JR, Lake RA. A T cell clone with three potential TCR alpha chain rearrangements expresses only one receptor combination at the cell surface. Mol. Immunol. 1996; 33: 1177-81.
32. 32 Tse DB, Pernis B. Spontaneous internalization of Class I major histocompatibility complex molecules in T lymphoid cells. J. Exp. Med. 1984; 159; 193-207.
33. 33 Reid PA, Watts C. Constitutive endocytosis and recycling of major histocompatibility complex class II glycoproteins in human B-lymphoblastoid cells. Immunology 1992; 77: 539-42.
34. 34 Pinet V, Vergelli M, Martin R, Bakke O, Long EO. Antigen presentation mediated by recycling of surface HLA-DR molecules. Nature 1995; 375: 603-6.
35. 35 Lombardi G, Sidu S, Batchelor R, Lechler R. Anergic T cells as supressor cells in vitro. Science 1994; 264: 1587-9.
36. 36 Manca F. Selective functional depletion of HIV gp120 peptides complexed with MHC from antigen-presenting cells engaged with specific T lymphocytes. J. Immunol. 1992; 149: 796-800.
37. 37 Vidovic D, Falcioni F, Bolin DR, Nagy ZA. Down-regulation of class II major histocompatibility complex molecules on antigen presenting cells after interaction with helper T cells. Eur. J. Immunol. 1995; 25: 1326-31.
38. 38 Butz EA, Bevan MJ. Massive expansion of antigen specific CD8+ T cells during an acute virus infection. Immunity 1998; 8: 167-75.
39. 39 Deng H, Apple R, Clare SM et al. Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease. J. Exp. Med. 1993; 178: 1675-80.
40. 40 McMichael AJ, O'Callaghan CA. A new look at T cells. J. Exp. Med. 1998; 187: 1367-71.
41. 41 Kelso A. Th1 and Th2 subsets: paradigms lost. Immunol. Today 1995; 16: 374-9.