A T cell clone with three potential TCR α chain rearrangements expresses only one receptor combination at the cell surface

Molecular Immunology

Volumn 33, Issue 15, 1996, Pages 1177-1181

  Hayball, John D ^a   Jones, Claerwen M ^b   Lamb, Jonathan R ^c   Lake, Richard A ^d  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b MONASH UNIVERSITY MEDICAL SCHOOL   (Australia)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d PATHWEST LABORATORY MEDICINE   (Australia)

Author keywords

alternative splice variants; T cell receptor

Indexed keywords

ALLERGEN; MESSENGER RNA;

ARTICLE; CELL CLONE; DNA SEQUENCE; GENE REARRANGEMENT; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RNA SPLICING; T LYMPHOCYTE RECEPTOR GENE;

AMINO ACID SEQUENCE; ANIMALS; CLONE CELLS; GENE REARRANGEMENT, ALPHA-CHAIN T-CELL ANTIGEN RECEPTOR; HUMANS; MOLECULAR SEQUENCE DATA; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES;

EID: 0030268478     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(96)00076-4     Document Type: Article

References (29)

1. Anderson S. J., Abraham K. M., Nakayama T., Singer A. and Perlmutter R. M. (1992) Inhibition of T-cell receptor β-chain rearrangement by overexpression of the non-receptor protein tyrosine kinase p56Ick. EMBO J. 11, 4877-4882.
2. Anderson S. J., Levin S. D. and Perlmutter R. M. (1993) Protein tyrosine kinase p561ck controls allelic exclusion of T cell receptor beta-chain genes. Nature 365, 552-554.
3. Balomenos D., Balderas R. S., Mulvany K. P., Kaye J., Kono D. H. and Theofilopoulos A. N. (1995) Incomplete T cell receptor V β allelic exclusion and dual V/β-expressing cells. J. Immun. 155, 3308-3312.
4. Borgulya P., Kishi H., Uematsu Y. and Boelimer H. von (1992) Exclusion and inclusion of α and β T cell receptor alleles. Cell 69, 529-537.
5. Davideau F., Peyrat M. A., Romagne F., Necker A., Hallet M. M., Vie H. and Bonneville M. (1995) Dual T cell receptor β chain expression on human T lymphocytes. J. Exp. Med. 181, 1391-1398.
6. Davis M. M. and Bjorkman P. J. (1988) T-cell antigen receptor genes and T-cell recognition. Nature 334, 395-402.
7. Genevee C., Diti A., Nierat J., Caignard A., Dietrich P. Y., Ferradini L., Roman R. S., Triebel F. and Hercend T. (1992) An experimentally validated panel of subfamily-specific oligonucleotide primers (V alpha 1-w29/V beta 1-w24) for the study of human T cell receptor variable V gene segment usage by polymerase chain reaction. Eur. J. Immun. 22, 1261-1269.
8. Godfrey D. I. and Zlotnik A. (1993) Control points in early T-cell development. Immun. Today 14, 547-553.
9. Green M. R. (1986) Pre-mRNA splicing. Ann. Rev. Genet. 20, 671-708.
10. Groettrup M., Ungewiss K., Azogui O., Palacios R., Owen M. J., Hayday A. C. and Boehmer H. von (1993) A novel disulphide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 Kd MW glycoprotein. Cell 75, 283-294.
11. Hayball J. D., Robinson J. H., O'Hehir R. E., Verhoef A., Lamb J. R. and Lake R. A. (1994) Identification of two binding sites in staphylococcal enterotoxin B that confer specificity for TCR V β gene products. Int. Immun. 6, 199-211.
12. Heath W. R. and Miller J. F. A. P. (1993) Expression of two alpha chains on the surface of T cells in T cell receptor transgenic mice. J. Exp. Med. 178, 1807-1811.
13. Jones C. M., Lake R. A., Lamb J. R. and Faith A. (1994) Degeneracy of T cell receptor recognition of an influenza virus hernagglutinin epitope restricted by HLA-DQ and -DR class II molecules. Eur. J. Immun. 24, 1137-1142.
14. Jorgensen J. L., Esser U., St. Groth B. F. de. Reay P. A. and Davis M. M. (1992) Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics. Nature 355, 224-230.
15. Levelt C. N., Wang B., Ehrfeld A., Terhorst C. and Eichmann K. (1995) Regulation of T cell receptor (TCR)-beta locus allelic exclusion and initiation of TCR-alpha locus rearrangement in immature thymocytes by signaling through the CD3 complex. Eur. J. Immun. 25, 1257-1261.
16. Mahotka C., Hansen H. T. and Bartram C. R. (1995) Alternative splicing of T cell receptor (TCR) alpha chain transcripts containing V alpha 1 or V alpha 14 elements. Leukemia 9, 1700-1703.
17. Malissen M., Trucy J., Jouvin-Marche E., Cazenave P. A., Scollay R. and Malissen B. (1992) Regulation of TCR-α and β gene allelic exclusion during T-cell development. Immun. Today 13, 315-319.
18. Maniatis T., Fritsch E. F. and Sambrook, J. (1989) Molecular Cloning: a Laboratory Manual. Vol. 2, p. 8.11. Cold Spring Harbour Laboratory Press. New York.
19. Marche P. N., Six A., Gahery H., Gris-Liebe C., Cazenave P. A. and Jouvin-Marche E. (1993) T cell receptor V alpha segment with alternate splicing in the junctional region. J. Immun. 151, 5319-5327.
20. Mizushima S. and Nagata S. (1990) pEF-BOS, a powerful mammalian expression vector. Nucl. Acids Res. 18, 5322.
21. Moss P. A. H., Rosenberg W. M. C., Zintzaras E. and Bell J. I. (1993) Characterization of the human T cell receptor alpha chain repertoire and demonstration of a genetic influence on V α usage. Eur. J. Immun 23, 1153-1159.
22. Mount S. M. (1982) A catalogue of splice junction sequences. Nud. Acids Res. 10, 459-472.
23. Ohashi P. S., Mak T. W., Van den Elsen P., Yanagi Y., Yoshikai Y., Calman A. F., Terhorst C., Stobo J. D. and Weiss A. (1985) Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer. Nature 316, 606-608.
24. Padovan E., Giachino C., Cella M., Valitutti S., Acuto O. and Lanzavecchia A. (1995) Normal T lymphocytes can express two different T cell receptor β chains: implications for the mechanism of allelic exclusion. J. Exp. Med. 181, 1587-1591.
25. Petrie H. T., Livak F., Schatz D. G., Strasser A., Crispe I. N. and Shortman K. (1993) Multiple rearrangements in the T cell receptor x chain genes maximise the production of useful thymocytes. J. Exp. Med. 178, 615-622.
26. Saint-Ruf C., Ungewiss M., Groettrup M., Bruno J., Fehling J. and Boehmer H. von (1994) The pre-T cell receptor x chain gene: cloning and expression. Science 266, 1208-1212.
27. Sanger F., Nicklen S. and Coulson A. R. (1977) DNA sequencing with chain-terminating inhibitors. Proc. natn. Acad. Sci. U.S.A. 74, 5463-5467.
28. Uematsu Y., Rysen S., Dembic Z., Borgulya P., Krimpenfort P., Berns A., Boehmer H. von and Steinmetz M. (1988) In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes. Cell 52, 831-841.
29. Verhoef A., Higgins J. A., Thorpe C. J., Marsh S. G., Hayball J. D., Lamb J. R. and O'Hehir R. E. (1993) Clonal analysis of the atopic immune response to the group 2 allergen of Dermatophagoides spp.: identification of HLA-DR and -DQ restricted T cell epitopes. Int. Immun. 5, 1589-1597.