Evaluation of methylated DNA binding protein-1 in mouse liver

Toxicological Sciences

Volumn 49, Issue 2, 1999, Pages 255-262

  Samiec, Paula S ^a,b   Goodman, Jay I ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b BARRY UNIVERSITY   (United States)

Author keywords

DNA methylation; Electrophoretic mobility shift assay (EMSA); MDBP 1; Mouse; Mouse liver; Transcription inhibition

Indexed keywords

DNA BINDING PROTEIN;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; DNA METHYLATION; DNA PROTEIN COMPLEX; GENE EXPRESSION REGULATION; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN DNA INTERACTION; PROTEIN ISOLATION;

ANIMALS; DNA ADDUCTS; DNA-BINDING PROTEINS; ELECTROPHORESIS; LIGANDS; LIVER; MALE; MICE;

ANIMALIA;

EID: 0033063660     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/49.2.255     Document Type: Article

References (40)

1. Asiedu, C. K., Scotto, L., Assoian, R. K., and Ehrlich, M. (1994). Binding of AP-1/CREB proteins and of MDBP to contiguous sites downstream of the human TGF-β1 gene. Biochim. Biaphys. Acta 1219, 55-63.
2. Becker, F. F. (1982). Morphological classification of mouse liver tumors based on biological characteristics. Cancer Res. 42, 3918-3923.
3. INK4a is an early event in lung cancer and a potential biomarker for early diagnosis. Proc. Nail. Acad. Sci. U S A 95, 11891-11896.
4. Bestor, T. H. (1990). DNA methylation: Evolution of a bacterial immune function into a regulator of gene expression and genome structure in higher eukaryotes. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 326, 179-187.
5. Bird, A. (1992). The essentials of DNA methylation. Cell 70, 5-8.
6. Boyes, J., and Bird, A. (1991). DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein. Cell 64, 1123-1134.
7. Boyes, J., and Bird, A. (1992). Repression of genes by DNA methylation depends on CpG density and promoter strength: Evidence for involvement of a methyl-CpG binding protein. EMBO J. 11, 327-333.
8. Cheah, M. S. C., Wallace, C. D., and Hoffman, R. M. (1984). Hypomethylation of DNA in human cancer cells: A site-specific change in the c-myc oncogene. J. Nail. Cancer Inst. 73, 1057-1065.
9. Chen, R. Z., Pettersson, U., Beard, C., Jackson-Grusby, L, and Jaenisch, R. (1998). DNA hypomethylation leads to elevated mutation rates. Nature 395, 89-93.
10. 6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells. J. Biol. Chem. 269, 17228-17237.
11. Counts, J. L., and Goodman, J. I. (1995a). Alterations in DNA methylation may play a variety of roles in carcinogenesis. Cell 83, 13-15.
12. Counts, J. L., and Goodman, J. I. (1995b). Hypomethylation of DNA: A nongenotoxic mechanism involved in tumor promotion. Toxicol. Lett. 82/83, 663-672.
13. Counts, J. L., McClain, R. M., and Goodman, J. I. (1997). Comparison of effect of tumor promoter treatments on DNA methylation status and gene expression in B6C3F1 and C57BL/6 mouse liver and in B6C3F1 mouse liver tumors. Mol. Carcinog. 18, 97-106.
14. Counts, J. L., Sarmiento, J. I., Harbison, M. L., Downing, J. C., McClain, R. M., and Goodman, J. I. (1996). Cell proliferation and global methylation status changes in mouse liver after phenobarbital and/or choline-devoid, methionine-deficient diet administration. Carcinogenesis 17, 1251-1257.
15. Dragan, Y. P., and Pitot, H. C. (1992). The role of the stages of initiation and promotion in phenotypic diversity during hepatocarcinogenesis in the rat. Carcinogenesis 5, 739-750.
16. Fang, J. Y., Zhu, S. S., Xiao, S. D., Jiang, S. J., Shi, Y., Chen, X. Y., Zhou, X. M., and Qian, L. F. (1996). Studies on the hypomethylation of c-myc, c-Ha-ras oncogenes and histopathological changes in human gastric carcinoma. J. Gastroenteral. Hepatol. 11, 1079-1082.
17. Fearon, E. R., and Vogelstein, B. (1990). A genetic model for colorectal tumorigenesis. Cell 61, 759-767.
18. Herman, J. G., Merlo, A., Mao, L., Lapidus, R. G., Issa, J. P., Davidson, N. E., Sidransky, D., and Baylin, S. B. (1995). Inactivation of the CDKN2/p16/ MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res. 55, 4525-4530.
19. Huang, L., Wang, R., Gama-Sosa, M. A., Shenoy, S., and Ehrlich, M. (1984). A protein from human placental nuclei binds preferentially to 5-methylcytosine-rich DNA. Nature 308, 293-295.
20. Jiang, S., and Eberhardt, N. L. (1995). A micro-scale method to isolate DNA-binding proteins suitable for quantitative comparison of expression levels from transfected cells. Nucleic Acids Res. 23, 3607-3608.
21. Jost, J., and Hofsteenge, J. (1992). The represser MDBP-2 is a member of the histone H1 family that binds preferentially in vitro and in vivo to methylated nonspecific DNA sequences. Proc. Natl. Acad. Sci. U S A 89, 9499-9503.
22. Khan, R., Zhang, X.-Y., Supakar, P. C., Ehrlich, K. C., and Ehrlich, M. (1988). Human methylated DNA-binding protein. J. Biol. Chem. 263, 14374-14383.
23. Lee, G., and Drinkwater, N. R. (1995). Hepatocarcinogenesis in BXH recombinant inbred strains of mice: Analysis of diverse phenotypic effects of the hepatocarcinogen sensitivity loci. Mol. Carcinog. 14, 190-197.
24. Lengauer, C., Kinzler, K. W., and Vogelstein, B. (1997). DNA methylation and genetic instability in colorectal cancer cells. Proc. Natl. Acad. Sci. U S A 94, 2545-2550.
25. Lewis, J. D., Meehan, R. R., Henzel, W. J., Maurer-Fogy, I., Jeppesen, P., Klein, F., and Bird, A. (1992). Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell 69, 905-91.
26. Meehan, R. R., Lewis, J. D., and Bird, A. P. (1992). Characterization of MeCP2, a vertebrate DNA-binding protein with affinity for methylated DNA. Nucleic Acids Res. 20, 5085-5092.
27. Meehan, R. R., Lewis, J. D., McKay, S., Kleiner, E. L., and Bird, A. P. (1989). Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs. Cell 58, 499-507.
28. Nan, X., Meehan, R. R., and Bird, A. (1993). Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2. Nucleic Acids Res. 21, 4886-4892.
29. Nan, X., Campoy, F. J., and Bird, A. (1997). MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Cell 88, 471-481.
30. Ray, J. S., Harbison, M. L., McClain, R. M., and Goodman, J. I. (1994). Alterations in the methylation status and expression of the raf oncogene in phenobarbital-induced and spontaneous B6C3F1 mouse liver tumors. Mol. Carcinog. 9, 155-166.
31. Samiec, P. S., Counts, J. L., McClain, R. M., and Goodman, J. I. (1996). Methylation status of the myc oncogene in B6C3F1, C3H/He and C57BL/6 mice. Toxicologist 30, 31.
32. Sharrard, R. M., Royds, J. A., Rogers, S., and Shorthouse, A. J. (1992). Patterns of methylation of the c-myc gene in human colorectal cancer progression. Br. J. Cancer 65, 667-672.
33. Supakar, P. C., Weist, D., Zhang, D., Inamdar, N., Zhang, X.-Y., Khan, R., Ehrlich, K. C., and Ehrlich, M. (1988). Methylated DNA-binding protein is present in various mammalian cell types. Nucleic Acids Res. 16, 8029-8044.
34. Supakar, P. C., Zhang, X.-Y., Githens, S., Khan, R., Ehrlich, K. C., and Ehrlich, M. (1989). How different DNA sequences are recognized by a DNA-binding protein: Effects of partial proteolysis. Nucleic Acids Res. 17, 8611-8629.
35. Xanthopoulos, K. G., Prezioso, V. R., Chen, W. S., Sladek, F. M., Cortese, R., and Darnell, J. E., Jr. (1991). The different tissue transcription patterns of genes for HNF-1, C/EBP, HNF-3, and HNF-4, protein factors that govern liver-specific transcription. Proc. Natl. Acad. Sci. U S A 88, 3807-3811.
36. Zhang, X.-Y., Asiedu, C. K., Supakar, P. C., and Ehrlich, M. (1992). Increasing the activity of affinity-purified DNA-binding proteins by adding high concentrations of nonspecific proteins. Anal. Biochem. 201, 366-374.
37. Zhang, X.-Y., Asiedu, C. K., Supakar, P. C., Khan, R., Ehrlich, K. C., and Ehrlich, M. (1990a). Binding sites in mammalian genes and viral gene regulatory regions recognized by methylated DNA-binding protein. Nucleic Acids Res. 18, 6253-6260.
38. Zhang, X.-Y., Ni, Y., Saifudeen, Z., Asiedu, C. K., Supakar, P. C., and Ehrlich, M. (1995). Increasing binding of a transcription factor immediately downstream of the cap site of a cytomegalovirus gene represses expression. Nucleic Acids Res. 23, 3026-3033.
39. Zhang, X.-Y., Supakar, P. C., Wu, K., Ehrlich, K. C., and Ehrlich, M. (1990b). An MDBP site in the first intron of the human c-myc gene. Cancer Res. 50, 6865-6869.
40. Zhao, C. Q., Young, M. R., Diwan, B. A., Coogan, T. P., and Waalkes, M. P. (1997). Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression. Proc. Natl. Acad. Sci. U S A 94, 10907-10912.