Comparison of effect of tumor promoter treatments on DNA methylation status and gene expression in B6C3F1 and C57BL/6 mouse liver and in B6C3F1 mouse liver tumors

Molecular Carcinogenesis

Volumn 18, Issue 2, 1997, Pages 97-106

  Counts, Jennifer L ^a,c   McClain, R Michael ^b   Goodman, Jay I ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Preclinical Research and Development   (United States)

^c PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

Carcinogenesis; Choline devoid; Ha ras; Methionine deficient diet; Phenobarbital; raf

Indexed keywords

CHOLINE; METHIONINE; PHENOBARBITAL; TUMOR PROMOTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET; DNA METHYLATION; GENE EXPRESSION; LIVER CARCINOGENESIS; MALE; MOUSE; NONHUMAN; ONCOGENE H RAS; PRIORITY JOURNAL; TUMOR PROMOTION;

EID: 0030939434     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199702)18:2<97::AID-MC5>3.0.CO;2-N     Document Type: Article

References (68)

1. Razin A, Kafri T. DNA methylation from embryo to adult. Prog Nucleic Acid Res Mol Biol 48:53-81, 1994.
2. Bird AP. CpG-rich islands and the function of DNA methylation. Nature 321:209-213, 1986.
3. Clark SJ, Harrison J, Frommer M. CpNpG methylation in mammalian cells. Nat Genet 10:20-27, 1995.
4. Gardiner-Garden M, Frommer M. CpG islands in vertebrate genomes. J Mol Biol 196:261-282, 1987.
5. Lewis J, Bird A. DNA methylation and chromatin structure. FEBS Lett 285:155-159, 1991.
6. Jones PA. DNA methylation and cancer. Cancer Res 46:461-466, 1986.
7. Adany R, Iozzo RV. Hypomethylation of the decorin proteoglycan gene in human colon cancer. Biochem J 276:301-306, 1991.
8. Opdecamp K, Riviere M, Molne M, Szpirer J, Szpirer C. Methylation of an α-foetoprotein gene intragenic site modulates gene activity. Nucleic Acids Res 20:171-178, 1992.
9. Komura J-I, Okada T, Ono T. Repression of transient expression by DNA methylation in transcribed regions of reporter genes introduced into cultured human cells. Biochim Biophys Acta 1260:73-78, 1995.
10. Meehan R, Lewis J, Cross S, Nan X, Jeppesen P, Bird A. Transcriptional repression by methylation of CpG. J Cell Sci Suppl 16:9-14, 1992.
11. 6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells. J Biol Chem 269:17228-17237, 1994.
12. Hsieh C-L. Dependence of transcriptional repression on CpG methylation density. Mol Cell Biol 14:5487-5494, 1994.
13. Mikol YB, Hoover KL, Creasia D, Poirier LA. Hepatocarcinogenesis in rats fed methyl-deficient, amino acid-defined diets. Carcinogenesis 4:1619-1629, 1983.
14. Ghoshal AK, Farber E. The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens. Carcinogenesis 5:1367-1370, 1984.
15. Sawada N, Poirier L, Moran S, Xu YH, Pilot HC. The effect of choline and methionine deficiencies on the number and volume percentage of altered hepatic foci in the presence or absence of diethylnitrosamine initiation in rat liver. Carcinogenesis 11:273-281, 1990.
16. Christman JK, Sheikhnejad G, Dizik M, Abileah S, Wainfan E. Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency. Carcinogenesis 14:551-557, 1993.
17. Dragan YP, Sargent L, Xu Y-D, Xu Y-H, Pitot HC. The initiation-promotion-progression model of rat hepatocarcinogenesis. Proc Soc Exp Biol Med 202:16-24, 1993.
18. Wilson MJ, Shovapurkar N, Poirier LA. Hypomethylation of hepatic nuclear DNA in rats fed with a carcinogenic methyl-deficient diet. Biochem J 218:987-990, 1984.
19. Bhave MR, Wilson MJ, Poirier LA. c-Ha-ras and c-Ki-ras gene hypomethylation in the livers and hepatomas of rats fed methyl-deficient, amino acid-defined diets. Carcinogenesis 9:343-348, 1988.
20. Zapisek WF, Cronin GM, Lyn-Cook BD, Poirier LA. The onset of oncogene hypomethylation in the livers of rats fed methyl-deficient, amino acid-defined diets. Carcinogenesis 13:1869-1872, 1992.
21. Wainfan E, Poirier LA. Methyl groups in carcinogenesis: Effects on DNA methylation and gene expression. Cancer Res (Suppl)52:2071s-2077s, 1992.
22. Periano C, Fry RJM, Staffeldt E, Christopher JP. Comparative enhancing effects of phenobarbital, amobarbital, diphenylhydantoin, and dichlorophenyltrichloroethane on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat. Cancer Res 35:2884-2890, 1971.
23. Pilot HC. Altered hepatic foci: Their role in murine hepatocarcinogenesis. Annu Rev Pharmacol Toxicol 30:465-500, 1990.
24. Counts JL, Goodman JI. Hypomethylation of DNA: An epigenetic mechanism that can facilitate the aberrant oncogene expression involved in liver carcinogenesis. In: Jirtle RL (ed), Liver Regeneration and Carcinogenesis: Molecular and Cellular Mechanisms. Academic Press, New York, 1995, pp. 227-255.
25. Mills JJ, Jirtle RL, Boyer IJ. Mechanisms of liver tumor promotion. In: Jirtle RL (ed), Liver Regeneration and Carcinogenesis: Molecular and Cellular Mechanisms. Academic Press, New York, 1995, pp. 199-226.
26. Vorce RL, Goodman JI. Hypomethylation of ras oncogenes in chemically induced and spontaneous B6C3F1 mouse liver tumors. J Toxicol Environ Health 34:367-384, 1991.
27. Ray JS, Harbison ML, McClain RM, Goodman JI. Alterations in the methylation status and expression of the raf oncogene in phenobarbital-induced and spontaneous B6C3F1 mouse liver tumors. Mol Carcinog 9:155-166, 1994.
28. Counts JL, Goodman JI. Hypomethylation of DNA: An epigenetic mechanism involved in tumor promotion. Mol Carcinog 11:185-188, 1994.
29. Finney RE, Bishop JM. Predisposition to neoplastic transformation caused by gene replacement to H-ras1. Science 260:1524-1527, 1993.
30. Mangues R, Kahn JM, Seidman I, Pellicer A. An overexpressed N-ras proto-oncogene cooperates with N-methylnitrosourea in mouse mammary carcinogenesis. Cancer Res 54:6395-6401, 1994.
31. Sakai T, Toguchida J, Ohtani N, Yandell DW, Rapaport JM, Dryja TP. Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene. Am J Hum Genet 48:880-888, 1991.
32. Herman JG, Latif F, Weng Y, et al. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci USA 91:9700-9704, 1994.
33. Counts JL, Goodman JI. Alterations in DNA methylation may play a variety of roles in carcinogenesis. Cell 83:13-15, 1995.
34. Diwan BA, Rice JM, Ohshima M, Ward JM, Dove LF. Comparative tumor-promoting activities of phenobarbital, amobarbital, barbital sodium, and barbituric acid on livers and other organs of male F344/NCr rats following initiation with N-nitrosodiethylamine. J Natl Cancer Inst 74:509-516, 1985.
35. Becker FF. Morphological classification of mouse liver tumors based on biological characteristics. Cancer Res 42:3918-3923, 1982.
36. Newberne PM, deCamargo JLV, Clark AJ. Choline deficiency, partial hepatectomy, and liver tumors in rats and mice. Toxicol Pathol 10:95-106, 1982.
37. Balaghi M, Wagner C. DNA methylation in folate deficiency: Use of CpG methylase. Biochem Biophys Res Commun 193:1184-1190, 1993.
38. Seldon RF. Analysis of DNA sequences by blotting and hybridization. In: Ausubel FM, Brent R, Kinston RE, et al. (eds), Current Protocols in Molecular Biology, Greene Publishing and John Wiley and Sons, New York, 1987, pp. 2.2.1-2.2.3.
39. Koetsier PA, Schorr J, Doerfler W. A rapid optimized protocol for downward alkaline Southern blotting of DNA. Biotechniques 15:260-261, 1993.
40. Vorce RL, Goodman JI. Altered methylation of ras oncogenes in benzidine-induced B6C3F1 mouse liver tumors. Toxicol Appl Pharmacol 100:398-410, 1989.
41. Barbu R, Dautry F. Northern blot normalization with a 28S rRNA oligonucleotide probe. Nucleic Acids Res 17:7115, 1989.
42. Nowell PC. The clonal evolution of tumor cell populations. Science 194:23-28, 1976.
43. Leon J, Guerero I, Pellicer A. Differential expression of the ras gene family in mice. Mol Cell Biol 7:1535-1540, 1987.
44. Webber EM, Godowski PJ, Fausto N. In vivo response of hepatocytes to growth factors requires an initial priming stimulus. Hepatology 14:489-497, 1994.
45. Conover WJ. Practical Nonparametnc Statistics, 2nd ed, John Wiley and Sons, Inc., New York, 1980.
46. Korch C, Hagblom P. In-vivo-modified gonococcal plasmid pJD1. A model system for analysis of restriction enzyme sensitivity to DNA modifications. Eur J Biochem 161:519-524, 1986.
47. Woodcock DM, Crowther PJ, Diver WP. The majority of methylated deoxycytosines in human DNA are not in the CpG dinucleotide. Biochem Biophys Res Commun 145:888-894, 1987.
48. Sinbson KJ, Woodcock D, Orian JM, Brandon MR, Adams TE. Methylation and expression of a metallothionein promoter ovine growth hormone fusion gene (MToGH1) in transgenic mice. Transgenic Res 4:114-122, 1995.
49. Counts JL, Sarmiento JI, Harbison ML, Downing JC, McClain RM, Goodman JI. Cell proliferation and global methylation status changes in mouse liver after phenobarbital and/or choline-devoid, methionine-deficient diet administration. Carcinogenesis 17:1251-1257, 1996.
50. Counts JL, McClain RM, Harbison ML, Downing JC, Goodman JI. Differences in DNA methylation induced by a choline-devoid, methionine-deficient diet or by phenobarbital correlate with liver tumor susceptibility in mice. The Toxicologist 15:56, 1995.
51. Rapp UR. Role of raf-1 serine/threonine protein kinase in growth factor signal transduction. Oncogene 6:495-500, 1991.
52. Ghosh S, Bell RM. Identification of discrete segments of human Raf-1 kinase critical for high affinity binding to Ha-ras. J Biol Chem 269:30785-30788, 1994.
53. Brtva TR, Drugan JK, Ghosh S, et al. Two distinct Raf domains mediate interaction with Ras. J Biol Chem 270:9809-9812, 1995.
54. Davis RJ. The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 268:14553-14556, 1993.
55. Kraupp-Grasl B, Huber W, Putz B, Gerbrache U, Schulte-Hermann R. Tumor promotion by the peroxisome proliferator nafenopin involving a specific subtype of altered foci in rat liver. Cancer Res 50:3701-3708, 1990.
56. Dragan YP, Pitot HP. The role of the stages of initiation and promotion in phenotypic diversity during hepatocarcinogenesis in the rat. Carcinogenesis 13:739-750, 1992.
57. Weinberg RA. E2F and cell proliferation: A world turned upside down. Cell 85:457-459, 1996.
58. Moulds BA, Goodman JI. Spontaneous mutation at codon 61 of the Ha-ras gene in the nascent liver of B6C3F1, C3H/He and C57BL/6 mice. Mutat Res 311:1-7, 1994.
59. Gama-Sosa MA, Slagel VA, Trewyn RW, et al. The 5-methylcytosine content of DNA from human tumors. Nucleic Acids Res 11:6883-6894, 1983.
60. Mayol X, Neal GE, Davies R, Romero A, Domingo J. Etninyl estradiol-induced cell proliferation in rat liver. Involvement of specific populations of hepatocytes. Carcinogenesis 13:2381-2388, 1992.
61. Hanigan MH, Winkler ML, Drinkwater NR. Induction of three histochemically distinct populations of hepatic foci in C57BL/6J mice. Carcinogenesis 14:1035-1040, 1993.
62. Cattley RC, Kato M, Popp JA, Teets VJ, Voss KS. Initiator-specific promotion of hepatocarcinogenesis by WY-14,643 and clofibrate. Carcinogenesis 15:1763-1766, 1994.
63. Fox TR, Schumann AM, Watanabe PG, Yano BL, Maher VM, McCormick JJ. Mutational analysis of the H-ras oncogene in spontaneous C57BL/6 × C3H/He mouse liver tumors and tumors induced with genotoxic and nongenotoxic hepatocarcinogens. Cancer Res 50:4014-4019, 1990.
64. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 61:759-767, 1990.
65. Marx J. Possible new colon cancer gene found. Science 251:1317, 1991.
66. Makos M, Nelkin BD, Lerman MI, Latif F, Zbar B, Baylin SB. Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer. Proc Natl Acad Sci USA 89:1929-1933, 1992.
67. Gonzalez-Zulueta M, Bender CM, Yang AS, et al. Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res 55:4531-4535, 1995.
68. Hendrich S, Campbell HA, Pitot HC. Quantitative stereological evaluation of four histochemical markers of altered foci in multistage hepatocarcinogenesis in the rat. Carcinogenesis 8:1245-1250, 1987.