Effects of sphingosine stereoisomers on P-glycoprotein phosphorylation and vinblastine accumulation in multidrug-resistant MCF-7 cells

Biochemical Pharmacology

Volumn 52, Issue 4, 1996, Pages 603-612

  Sachs, Clifford W ^a   Balks, Larry M ^b   Mascarella, S Wayne ^c   Safa, Ahmad R ^d   Lewin, Anita H ^c   Loomis, Carson ^b   Carroll, F Ivy ^c   Bell, Robert M ^e   Fine, Robert L ^a,f  

^a DUKE UNIVERSITY   (United States)

^b Sphinx Pharmaceuticals Corporation   (United States)

^c RTI INTERNATIONAL   (United States)

^d SECTION OF HEMATOLOGY ONCOLOGY   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

^f Black Bldg ^*  (United States)

Author keywords

Multidrug resistance; P glycoprotein; Protein kinase C; Sphingosine

Indexed keywords

DOXORUBICIN; FLUOROURACIL; GLYCOPROTEIN P; PROTEIN KINASE C; SPHINGOSINE; VINBLASTINE;

ANIMAL TISSUE; ARTICLE; BRAIN; BREAST CANCER; CELL LINE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; ISOMERISM; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; TISSUE CULTURE;

ANIMALS; BREAST NEOPLASMS; DRUG RESISTANCE, MULTIPLE; FEMALE; HUMANS; P-GLYCOPROTEIN; PHOSPHORYLATION; RATS; SPHINGOSINE; STEREOISOMERISM; TUMOR CELLS, CULTURED; VINBLASTINE;

EID: 0029947698     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00312-7     Document Type: Article

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