Evaluation of 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl) hexanamide (NPC 15437), a protein kinase C inhibitor, as a modulator of P-glycoprotein-mediated resistance in vitro

Investigational New Drugs

Volumn 13, Issue 4, 1995, Pages 285-294

  Sha, Edward C ^a   Sha, Michael C ^a   Kaufmann, Scott H ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

P glycoprotein; protein kinase C

Indexed keywords

2,6 DIAMINO N [[1 (1 OXOTRIDECYL) 2 PIPERIDYL]METHYL]HEXANAMIDE; ANTINEOPLASTIC ANTIBIOTIC; ENZYME INHIBITOR; GLYCOPROTEIN P; PIPERIDINE DERIVATIVE; PROTEIN KINASE C; ANTHRACYCLINE; AZIDOPINE; CAMPTOTHECIN; DAUNORUBICIN; DOXORUBICIN; EPIPODOPHYLLOTOXIN; ETOPOSIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C INHIBITOR; VINBLASTINE; VINCA ALKALOID; VINCRISTINE;

ANIMAL; ARTICLE; BREAST TUMOR; CELL CULTURE; CRICETULUS; DRUG ANTAGONISM; DRUG INTERACTION; DRUG RESISTANCE; HAMSTER; HUMAN; METABOLISM; PHYSIOLOGY; ANIMAL CELL; BREAST CANCER; CANCER CELL; CELL STRAIN MCF 7; CELL SURVIVAL; COLONY FORMING UNIT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; HUMAN CELL; ISOTOPE LABELING; MEMBRANE VESICLE; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BREAST NEOPLASMS; CRICETINAE; CRICETULUS; DRUG INTERACTIONS; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; HUMANS; P-GLYCOPROTEIN; PIPERIDINES; PROTEIN KINASE C; TUMOR CELLS, CULTURED;

EID: 0029682223     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/BF00873134     Document Type: Article

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