The glucocorticoid receptor gene as a candidate for gene therapy in asthma

Gene Therapy

Volumn 6, Issue 2, 1999, Pages 245-252

  Mathieu, M ^a,c   Gougat, C ^a   Jaffuel, D ^a   Danielsen, M ^b   Godard, P ^a   Bousquet, J ^a   Demoly, P ^a  

^a MONTPELLIER UNIVERSITY HOSPITAL   (France)

^b GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c INSERM   (France)

Author keywords

AP 1; Asthma; Glucocorticoid receptor; Inflammation; NF B

Indexed keywords

CYTOKINE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; TRANSCRIPTION FACTOR;

ARTICLE; ASTHMA; EPITHELIUM CELL; EXPRESSION VECTOR; GENE THERAPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOASSAY; LUNG ALVEOLUS EPITHELIUM; PRIORITY JOURNAL; RECEPTOR GENE; REPORTER GENE;

ANIMALS; ASTHMA; BETA-GALACTOSIDASE; COS CELLS; DEXAMETHASONE; EPITHELIUM; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENES, REPORTER; GLUCOCORTICOIDS; HUMANS; LUCIFERASES; LUNG; NF-KAPPA B; RANTES; RECEPTORS, GLUCOCORTICOID; TRANSCRIPTION FACTOR AP-1; TUMOR CELLS, CULTURED;

EID: 0033060042     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300814     Document Type: Article

References (48)

1. Cato A, Wade E. Molecular mechanisms of anti-inflammatory action of glucocorticoids. Bioessays 1996; 18: 371-378.
2. Angel P, Karin M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1991; 1072: 129-157.
3. Abate C, Curran T. Encounters with Fos and Jun on the road to AP-1. Semin Cancer Biol 1990; 1: 19-26.
4. Kawakami K, Scheidereit C, Roeder R. Identification and purification of a human immunoglobulin-enhancer-binding protein (NF-kappa B) that activates transcription from a human immunodeficiency virus type 1 promoter in vitro. Proc Natl Acad Sci USA 1988; 85: 4700-4704.
5. Baeuerle P, Baltimore D. A 65-kD subunit of active NF-kB is required for inhibition of NF-kB by I kB. Genes Dev 1989; 3: 1689-1698.
6. Beato M. Gene regulation by steroid hormones. Cell 1989; 56: 335-344.
7. Ming M et al. Beta-adrenoceptors and dexamethasone synergistically stimulate the expression of the angiotensinogen gene in opossum kidney cells. Kidney Int 1996; 50: 94-101.
8. Guo D et al. Identification of a cis-acting glucocorticoid responsive element in the rat angiotensin II type IA promoter. Circ Res 1995; 77: 249-257.
9. Stone E et al. Identification of a gene that causes primary open angle glaucoma. Science 1997; 275: 668-670.
10. Jantzen H et al. Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene. Cell 1987; 49: 29-38.
11. Ogawa H et al. Isolation and nucleotide sequence of the cDNA for rat liver serine dehydratase mRNA and structures of the 5′ and 3′ flanking regions of the serine dehydratase gene. Proc Natl Acad Sci USA 1988; 85: 5809-5813.
12. Imai E et al. Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids. J Biol Chem 1993; 268: 5353-5356.
13. Demoly P et al. Gene therapy strategies for asthma. Gene Therapy 1997; 4: 507-516.
14. Sher ER et al. Steroid-resistant asthma: cellular mechanisms contributing to inadequate response to glucocorticoid therapy. J Clin Invest 1994; 93: 33-39.
15. Adcock IM et al. Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma. J Exp Med 1995; 182: 1951-1958.
16. Wang J et al. Expression of RANTES by human bronchial epithelial cells in vitro and in vivo and the effects of corticosteroids. Am J Respir Cell Mol Biol 1996; 14: 27-35.
17. Curiel D, Pilewski J, Albelda S. Gene therapy approaches for inherited and acquired lung diseases. Am J Respir Cell Mol Biol 1996; 14: 1-18.
18. Martins V et al. Demonstration by confocal microscopy that unliganded overexpressed glucocorticoid receptors are distributed in a nonrandom manner throughout all planes of the nucleus. Mol Endocrinol 1991; 5: 217-225.
19. Htun H et al. Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera. Proc Natl Acad Sci USA 1996; 93: 4845-4850.
20. Nelson P et al. Genomic organization and transcriptional regulation of the RANTES chemokine gene. J Immunol 1993; 151: 2601-2612.
21. Kwon OJ et al. Glucocorticoid inhibition of RANTES expression in human lung epithelial cells. Am J Respir Cell Mol Biol 1995; 12: 488-496.
22. Jonat C et al. Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 1990; 62: 1189-1204.
23. Schüle R et al. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell 1990; 62: 1217-1226.
24. Yang-Yen H-F et al. Transcriptional interference between c-jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 1990; 62: 1205-1215.
25. Ray A, Prefontaine K. Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor. Proc Natl Acad Sci USA 1994; 91: 752-756.
26. Scheinman RI et al. Characterization of mechanisms involved in transrepression of NF-KB by activated glucocorticoid receptors. Mol Cell Biol 1995; 15: 943-953.
27. Caldenhoven E et al. Negative cross-talk between Re1A and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids. Mol Endocrinol 1995; 9: 401-412.
28. Bodine P, Litwack G. The glucocorticoid receptor and its endogenous regulators. Receptor 1990; 1: 83-119.
29. Kamei Y et al. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 1996; 85: 403-414.
30. Auphan N et al. Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science 1995; 270: 286-290.
31. Scheinman R, Cogswell P, Lofquist A, Baldwin AJ. Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids. Science 1995; 270: 283-286.
32. Halazonetis TD, Georgopoulos K, Greenberg ME, Leder P. c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell 1988; 55: 917-924.
33. Nakabeppu Y, Ryder K, Nathans D. DNA binding activities of three murine Jun proteins: stimulation by Fos. Cell 1988; 55: 907-915.
34. Baeuerle P, Baltimore D. I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science 1988; 242: 540-546.
35. Teran L et al. Eosinophil recruitment following allergen challenge is associated with the release of the chemokine RANTES into asthmatic airways. J Immunol 1996; 157: 1806-1812.
36. Stellato C et al. Expression of the chemokine RANTES by a human bronchial epithelial cell line. Modulation by cytokines and glucocorticoids. J Immunol 1995; 155: 410-418.
37. Schall T, Bacon K, Toy K, Goeddel D. Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature 1990; 347: 669-671.
38. Rot A et al. RANTES and macrophage inflammatory protein 1 alpha induce the migration and activation of normal human eosinophil granulocytes. J Exp Med 1992; 176: 1489-1495.
39. Kameyoshi Y et al. Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils. J Exp Med 1992; 176: 587-592.
40. Zhang Y, Lin J, Vilcek J. Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence. Mol Cell Biol 1990; 10: 3818-3823.
41. Danielsen M, Northrop JP, Ringold GM. The mouse glucocorticoid receptor: mapping of functional domains by cloning, sequencing and expression of wild-type and mutant receptor proteins. EMBO J 1986; 5: 2513-2522.
42. Roux P et al. Retrovirus-mediated gene transfer of a human c-fos cDNA into mouse bone marrow stromal cells. Oncogene 1991; 6: 2155-2160.
43. Naumann M, Wulczyn F, Scheidereit C. The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B. EMBO J 1993; 12: 213-222.
44. Curiel D, Agarwal S, Wagner E, Cotten M. Adenovirus enhancement of transferrin-polylysine-mediated gene delivery. Proc Natl Acad Sci USA 1991; 88: 8850-8854.
45. Wagner E, Cotten M, Foisner R, Birnstiel M. Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells. Proc Natl Acad Sci USA 1991; 88: 4255-4259.
46. Gotten M et al. High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs) using the endosome-disruption activity of defective or chemically inactivated adenovirus particles. Proc Natl Acad Sci USA 1992; 89: 6094-6098.
47. Kohout T et al. Novel adenovirus component system that transfects cultured cardiac cells with high efficiency. Circ Res 1996; 78: 971-977.
48. Boussif O et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA 1995; 92: 7297-7301.