-
1
-
-
0028905348
-
Novel indolocarbazole compound 6-N-formylamino-12, 13-dihydro-1, 11-dihydroxy-13-(β-D-glucopyranosyl)-5H-indolo [2,3-α] pyrrolo [3,4-c]carbazole-5,7(6H)-dione (NB-506): Its potent antitumor activities in mice
-
Arakawa H, Iguchi T, Morita M, Yoshinari T, Kojiri K, Suda H, Okura A and Nishimura S (1995) Novel indolocarbazole compound 6-N-formylamino-12, 13-dihydro-1, 11-dihydroxy-13-(β-D-glucopyranosyl)-5H-indolo [2,3-α] pyrrolo [3,4-c]carbazole-5,7(6H)-dione (NB-506): Its potent antitumor activities in mice. Cancer Res 55:1316-1320.
-
(1995)
Cancer Res
, vol.55
, pp. 1316-1320
-
-
Arakawa, H.1
Iguchi, T.2
Morita, M.3
Yoshinari, T.4
Kojiri, K.5
Suda, H.6
Okura, A.7
Nishimura, S.8
-
2
-
-
0028090302
-
The Trk family of neurotrophin receptors
-
Barbacid M (1994) The Trk family of neurotrophin receptors. J Neurobiol 25:1386-1403.
-
(1994)
J Neurobiol
, vol.25
, pp. 1386-1403
-
-
Barbacid, M.1
-
4
-
-
0027183950
-
Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness
-
Benedetti M, Levi A and Chao MV (1993) Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness. Proc Natl Acad Sci USA 90:7859-7863.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 7859-7863
-
-
Benedetti, M.1
Levi, A.2
Chao, M.V.3
-
5
-
-
0026512998
-
K-252a inhibits nerve growth factor-induced Trk proto-oncogene tyrosine phosphorylation and kinase activity
-
Berg MM, Sternberg DW, Parada LF and Chao MV (1992) K-252a inhibits nerve growth factor-induced Trk proto-oncogene tyrosine phosphorylation and kinase activity. J Biol Chem 267:13-16.
-
(1992)
J Biol Chem
, vol.267
, pp. 13-16
-
-
Berg, M.M.1
Sternberg, D.W.2
Parada, L.F.3
Chao, M.V.4
-
6
-
-
0032730351
-
A rapid method for semi-quantitative analysis of neunte outgrowth from primary cultures of chick DRG expiants using image analysis
-
in press
-
Bilsland JG, Rigby M, Young L and Harper SJ (1999) A rapid method for semi-quantitative analysis of neunte outgrowth from primary cultures of chick DRG expiants using image analysis. J Neurosci Methods, in press.
-
(1999)
J Neurosci Methods
-
-
Bilsland, J.G.1
Rigby, M.2
Young, L.3
Harper, S.J.4
-
7
-
-
0025190264
-
Differential effects of the protein kinase inhibitor K-252a on the in vitro survival of chick embryonic neurons
-
Borasio GD (1990) Differential effects of the protein kinase inhibitor K-252a on the in vitro survival of chick embryonic neurons. Neurosci Lett 108:207-212.
-
(1990)
Neurosci Lett
, vol.108
, pp. 207-212
-
-
Borasio, G.D.1
-
8
-
-
0000854861
-
Growth of a rat neuroblastoma cell line in serum-free supplemented medium
-
Bottenstein JE and Sato GH (1979) Growth of a rat neuroblastoma cell line in serum-free supplemented medium. Proc Natl Acad Sci USA 76:514-517.
-
(1979)
Proc Natl Acad Sci USA
, vol.76
, pp. 514-517
-
-
Bottenstein, J.E.1
Sato, G.H.2
-
9
-
-
0029021457
-
P75 and Trk: A two-receptor system
-
Chao MV and Hempstead BL (1995) p75 and Trk: A two-receptor system. Trends Neurosci 18:321-326.
-
(1995)
Trends Neurosci
, vol.18
, pp. 321-326
-
-
Chao, M.V.1
Hempstead, B.L.2
-
10
-
-
0032102110
-
The role of neuronal growth factors in neurode-generative disorders of the human brain
-
Connor B and Dragunow M (1998) The role of neuronal growth factors in neurode-generative disorders of the human brain. Brain Res Rev 27:1-39.
-
(1998)
Brain Res Rev
, vol.27
, pp. 1-39
-
-
Connor, B.1
Dragunow, M.2
-
11
-
-
0028228616
-
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
-
Cowley S, Paterson H, Kemp P, Marshall CJ (1984) Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77:841-852.
-
(1984)
Cell
, vol.77
, pp. 841-852
-
-
Cowley, S.1
Paterson, H.2
Kemp, P.3
Marshall, C.J.4
-
12
-
-
0028808732
-
Early events in neurotrophin signalling via Trk and p75 receptors
-
Greene LA and Kaplan DR (1995) Early events in neurotrophin signalling via Trk and p75 receptors. Curr Opin Neurobiol 5:579-587.
-
(1995)
Curr Opin Neurobiol
, vol.5
, pp. 579-587
-
-
Greene, L.A.1
Kaplan, D.R.2
-
13
-
-
0030796068
-
Immunoglobulin-like domains define the nerve growth factor binding site of the TrkA receptor
-
Holden PH, Asopa V, Robertson AGS, Clarke AR, Tyler S, Bennett GS, Brain SD, Wilcock GK, Allen SJ, Smith SKF and Dawbarn D (1997) Immunoglobulin-like domains define the nerve growth factor binding site of the TrkA receptor. Nature Biotechnol 15:668-672.
-
(1997)
Nature Biotechnol
, vol.15
, pp. 668-672
-
-
Holden, P.H.1
Asopa, V.2
Robertson, A.G.S.3
Clarke, A.R.4
Tyler, S.5
Bennett, G.S.6
Brain, S.D.7
Wilcock, G.K.8
Allen, S.J.9
Smith, S.K.F.10
Dawbarn, D.11
-
14
-
-
0027969199
-
EGF induces PC12 cell differentiation in the presence of the protein kinase inhibitor K-252a
-
Isono F, Widmer HR, Hefti F and Knüsel B (1994) EGF induces PC12 cell differentiation in the presence of the protein kinase inhibitor K-252a. J Neurochem 63:1235-1245.
-
(1994)
J Neurochem
, vol.63
, pp. 1235-1245
-
-
Isono, F.1
Widmer, H.R.2
Hefti, F.3
Knüsel, B.4
-
15
-
-
0031772820
-
Studying signal transduction in neuronal cells: The Trk/NGF system
-
Kaplan DR (1998) Studying signal transduction in neuronal cells: The Trk/NGF system. Prog Brain Res 117:35-46.
-
(1998)
Prog Brain Res
, vol.117
, pp. 35-46
-
-
Kaplan, D.R.1
-
16
-
-
0025735392
-
The trk protooncogene product-a signal transducing receptor for nerve growth factor
-
Kaplan DR, Hempstead BL, Martinzanca D, Chao MV and Parada LF (1991) The trk protooncogene product-a signal transducing receptor for nerve growth factor. Science (Wash DC) 252:554-558.
-
(1991)
Science (Wash DC)
, vol.252
, pp. 554-558
-
-
Kaplan, D.R.1
Hempstead, B.L.2
Martinzanca, D.3
Chao, M.V.4
Parada, L.F.5
-
17
-
-
0026595294
-
K-252 compounds: Modulators of neurotrophin signal transduction
-
Knüsel B and Hefti FF (1992) K-252 compounds: Modulators of neurotrophin signal transduction. J Neurochem 59:1987-1996.
-
(1992)
J Neurochem
, vol.59
, pp. 1987-1996
-
-
Knüsel, B.1
Hefti, F.F.2
-
18
-
-
0026710816
-
K-252b selectively potentiates cellular actions and trk tyrosine phosphorylation mediated by NT-3
-
Knüsel B, Kaplan DR, Winslow JW, Rosenthal A, Burton LE, Beck KD, Rabin S, Nikolics K and Hefti F (1992) K-252b selectively potentiates cellular actions and trk tyrosine phosphorylation mediated by NT-3. J Neurochem 59:715-722.
-
(1992)
J Neurochem
, vol.59
, pp. 715-722
-
-
Knüsel, B.1
Kaplan, D.R.2
Winslow, J.W.3
Rosenthal, A.4
Burton, L.E.5
Beck, K.D.6
Rabin, S.7
Nikolics, K.8
Hefti, F.9
-
19
-
-
0023864240
-
K-252a: A specific inhibitor of the action of nerve growth factor on PC12 cells
-
Koizumi S, Contreras ML, Matsuda Y, Hama T, Lazarovici P and Guroff G (1988) K-252a: A specific inhibitor of the action of nerve growth factor on PC12 cells. J Neurosci 8:715-721.
-
(1988)
J Neurosci
, vol.8
, pp. 715-721
-
-
Koizumi, S.1
Contreras, M.L.2
Matsuda, Y.3
Hama, T.4
Lazarovici, P.5
Guroff, G.6
-
20
-
-
0028196552
-
p75 deficient embryonic dorsal root sensory and neunatal sympathetic neurons display a decreased sensitivity to NGF
-
Lee K-F, Davies AM and Jaenisch R (1994) p75 deficient embryonic dorsal root sensory and neunatal sympathetic neurons display a decreased sensitivity to NGF. Development 120:1027-1033.
-
(1994)
Development
, vol.120
, pp. 1027-1033
-
-
Lee, K.-F.1
Davies, A.M.2
Jaenisch, R.3
-
21
-
-
0028870428
-
K-252a induces tyrosine phosphorylation of the focal adhesion kinase and neurite outgrowth in human neuroblastoma SH-SY5Y cells
-
Maroney AC, Lipfert L, Forbes ME, Glicksman MA, Neff NT, Siman R, Dionne CA (1995) K-252a induces tyrosine phosphorylation of the focal adhesion kinase and neurite outgrowth in human neuroblastoma SH-SY5Y cells. J Neurochem 64:540-549.
-
(1995)
J Neurochem
, vol.64
, pp. 540-549
-
-
Maroney, A.C.1
Lipfert, L.2
Forbes, M.E.3
Glicksman, M.A.4
Neff, N.T.5
Siman, R.6
Dionne, C.A.7
-
23
-
-
0023932343
-
Inhibition by K-252a, a new inhibitor of protein kinase, of nerve growth factor-induced neurite outgrowth of chick embryo dorsal root ganglion cells
-
Matsuda Y and Fukuda J (1988) Inhibition by K-252a, a new inhibitor of protein kinase, of nerve growth factor-induced neurite outgrowth of chick embryo dorsal root ganglion cells. Neurosci Lett 87:295-301.
-
(1988)
Neurosci Lett
, vol.87
, pp. 295-301
-
-
Matsuda, Y.1
Fukuda, J.2
-
24
-
-
0028846039
-
Peripheral neuropathies and neurotrophic factors: Animal models and clinical perspectives
-
McMahon SB and Priestly JV (1995) Peripheral neuropathies and neurotrophic factors: Animal models and clinical perspectives. Curr Opin Neurobiol 5:616-624.
-
(1995)
Curr Opin Neurobiol
, vol.5
, pp. 616-624
-
-
McMahon, S.B.1
Priestly, J.V.2
-
25
-
-
0030997428
-
TrkB variants with deletions in the leucine-rich motifs of the extracellular domain
-
Ninkina N, Grashchuck M, Buchman VL and Davies AM (1997) TrkB variants with deletions in the leucine-rich motifs of the extracellular domain. J Biol Chem 272:13019-13025.
-
(1997)
J Biol Chem
, vol.272
, pp. 13019-13025
-
-
Ninkina, N.1
Grashchuck, M.2
Buchman, V.L.3
Davies, A.M.4
-
26
-
-
0027056938
-
K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses
-
Nye SH, Squinto SP, Glass DJ, Stitt TN, Hantzopoulos P, Macchi MJ, Lindsay NS, Ip NY and Yancopoulos GD (1992) K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses. Mol Biol Cell 3:677-686.
-
(1992)
Mol Biol Cell
, vol.3
, pp. 677-686
-
-
Nye, S.H.1
Squinto, S.P.2
Glass, D.J.3
Stitt, T.N.4
Hantzopoulos, P.5
Macchi, M.J.6
Lindsay, N.S.7
Ip, N.Y.8
Yancopoulos, G.D.9
-
27
-
-
0026684676
-
Inhibition of the cellular actions of nerve growth factor by staurosporine and K-252a results from the attenuation of the activity of the Trk tyrosine kinase
-
Ohmichi M and Decker SJ (1992) Inhibition of the cellular actions of nerve growth factor by staurosporine and K-252a results from the attenuation of the activity of the Trk tyrosine kinase. Biochemistry 31:4034-4039.
-
(1992)
Biochemistry
, vol.31
, pp. 4034-4039
-
-
Ohmichi, M.1
Decker, S.J.2
-
28
-
-
0003008910
-
Neurotrophin treatment of peripheral sensory neuropathies
-
(Hefti F ed) Springer, Berlin
-
Rask CA and Escandon E (1998) Neurotrophin treatment of peripheral sensory neuropathies, in Neurotrophic Factors: Handbook of Experimental Pharmacology (Hefti F ed) vol 134, pp 53-72, Springer, Berlin.
-
(1998)
Neurotrophic Factors: Handbook of Experimental Pharmacology
, vol.134
, pp. 53-72
-
-
Rask, C.A.1
Escandon, E.2
-
29
-
-
0001478880
-
Neurotrophic factor mimetics
-
(Hefti F ed) Springer, Berlin
-
Swain C, Harper S, Pollack S, Smith R and Hefti F (1998) Neurotrophic factor mimetics, in Neurotrophic Factors: Handbook of Experimental Pharmacology (Hefti F ed) vol 134, pp 281-300, Springer, Berlin.
-
(1998)
Neurotrophic Factors: Handbook of Experimental Pharmacology
, vol.134
, pp. 281-300
-
-
Swain, C.1
Harper, S.2
Pollack, S.3
Smith, R.4
Hefti, F.5
-
30
-
-
0029055577
-
An immunoglobulin-like domain determines the specificity of neurotrophin receptors
-
Urfer R, Tsoulfas P, O'Connell L, Shelton, DL, Parada, LF and Presta LG (1995) An immunoglobulin-like domain determines the specificity of neurotrophin receptors. EMBO J 14:2795-2805.
-
(1995)
EMBO J
, vol.14
, pp. 2795-2805
-
-
Urfer, R.1
Tsoulfas, P.2
O'Connell, L.3
Shelton, D.L.4
Parada, L.F.5
Presta, L.G.6
-
31
-
-
0032489439
-
High resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptors
-
Urfer R, Tsoulfas P, O'Connell L, Hongo J-A, Zhao W and Presta LG (1998) High resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptors. J Biol Chem 273:5829-5840.
-
(1998)
J Biol Chem
, vol.273
, pp. 5829-5840
-
-
Urfer, R.1
Tsoulfas, P.2
O'Connell, L.3
Hongo, J.-A.4
Zhao, W.5
Presta, L.G.6
-
32
-
-
0028868483
-
Specific neurotrophin binding to leucine-rich motif peptides of TrkA and TrkB
-
Windisch JM, Auer B, Marksteiner R, Lang ME and Schneider R (1995a) Specific neurotrophin binding to leucine-rich motif peptides of TrkA and TrkB. FEBS Lett 374:125-129.
-
(1995)
FEBS Lett
, vol.374
, pp. 125-129
-
-
Windisch, J.M.1
Auer, B.2
Marksteiner, R.3
Lang, M.E.4
Schneider, R.5
-
33
-
-
0028846967
-
Nerve growth factor binding site on TrkA mapped to a single 24-amino acid leucine-rich motif
-
Windisch JM, Marksteiner R and Schneider R (1995b) Nerve growth factor binding site on TrkA mapped to a single 24-amino acid leucine-rich motif. J Biol Chem 1995:28133-28138.
-
(1995)
J Biol Chem
, vol.1995
, pp. 28133-28138
-
-
Windisch, J.M.1
Marksteiner, R.2
Schneider, R.3
-
34
-
-
0027360140
-
K-252a potentiates epidermal growth factor-induced differentiation of PC12 cells
-
Wu C-F and Zhang M (1993) K-252a potentiates epidermal growth factor-induced differentiation of PC12 cells. J Neurosci Res 36:539-550.
-
(1993)
J Neurosci Res
, vol.36
, pp. 539-550
-
-
Wu, C.-F.1
Zhang, M.2
-
35
-
-
0028931509
-
Novel antitumor indolocarbazole compound 6-N-formylamino-12, 13-dihydro-1, 11-dihydroxy-13-(β-D-glucopyranosyl)-5H-indolo[2,3-α]pyrrolo[3,4-c] carbazole-5,7(6H)-dione (NB-506): Induction of toppisomerase I-mediated DNA cleavage and mechanisms of cell line-selective cytotoxicity
-
Yoshinari T, Matsumoto M, Arakawa H, Okada H, Noguchi K, Suda H, Okura A and Nishimura S (1995) Novel antitumor indolocarbazole compound 6-N-formylamino-12, 13-dihydro-1, 11-dihydroxy-13-(β-D-glucopyranosyl)-5H-indolo[2,3-α]pyrrolo[3,4-c] carbazole-5,7(6H)-dione (NB-506): Induction of toppisomerase I-mediated DNA cleavage and mechanisms of cell line-selective cytotoxicity. Cancer Res 55:1310-1315.
-
(1995)
Cancer Res
, vol.55
, pp. 1310-1315
-
-
Yoshinari, T.1
Matsumoto, M.2
Arakawa, H.3
Okada, H.4
Noguchi, K.5
Suda, H.6
Okura, A.7
Nishimura, S.8
|