Studying signal transduction in neuronal cells: The Trk/NGF system

Progress in Brain Research

Volumn 117, Issue , 1998, Pages 35-46

  Kaplan, D R ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

NERVE GROWTH FACTOR; NEUROTROPHIN;

ANIMAL CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CONFERENCE PAPER; GENETIC TRANSCRIPTION; NERVE CELL; NERVE FIBER GROWTH; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

EID: 0031772820     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: 10.1016/s0079-6123(08)64005-4     Document Type: Conference Paper

References (70)

1. S.X. Bamji M. Majdan C.D. Pozniak D.J. Belliveau R. Aloyz J. Kohn C.G. Causing F.D. Miller The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally-occuring sympathetic neuron death J. Cell Biol. 1998 in press.
2. D. Bar-Sagi J.R. Feramisco Microinjection of the ras oncogene protein intoPC12 cells induces morphological differentiation Cell. 42 3 1985 841 848
3. D.J. Belliveau I. Krivko J. Kohn C. Lachance C. Pozniak D. Rusakov D. Kaplan F.D. Miller NGF and neurotrophin-3 both activate TrkA on sympathetic neurons but differentially regulate survival and neuritogenesis J. Cell Biol. 136 2 1997 375 388
4. G.D. Borasio A. Markus A. Wittinghofer Y.A. Barde R. Heumann Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neurons J. Cell Biol. 121 3 1993 665 672
5. R.J. Cabelli D.L. Shelton R.A. Segal C.J. Shatz Blockade of endogenous ligands of trkB inhibits formation of ocular dominance columns Neuron 19 1 1997 63 76
6. B.D. Carter U. Zirrgiebel Y.A. Barde Differential regulation of p21 ras activation in neurons by nerve growth factor and brain-derived neurotophic factor J. Biol. Chem. 270 37 1995 21751 21757
7. B.D. Carter G.R. Lewin Neurotrophins live or let die: does p75NTR decide Neuron 18 2 1997 187 190
8. M.V. Chao B.L. Hempstead P75 and Trk: A two-receptor system TINS 18 7 1995 321 326
9. S. Cowley H. Paterson P. Kemp C.J. Marshall Activation of MAP kinase is necessary and sufficient for PC12differentiation and for transformation of NIH 3T3 cells Cell 77 6 1994 841 852
10. M.E. Cunningham R.M. Stephens D.R. Kaplan L.A. Greene Autophosphorylation of activation loop tyrosines regulates signaling by the TRK nerve growth factor receptor J. Biol. Chem. 272 16 1997 10957 10967
11. G. D' Arcangelo S. Halegoua A branched signaling pathway for nerve growth factor is revealed by Src-, Ras-, and Raf-mediated gene inductions Mol. & Cell. Biol. 13 6 1993 3146 3155
12. G. Dechant Y.A. Barde Signalling through the neurotrophin receptor p75NTR Current Opinion in Neuro-biology 7 3 1997 413 418
13. Y. Dobashi T. Kudoh A. Matsumine K. Toyoshima T. Akiyama Constitutive overexpression of CDK2 inhibits neuronal differentiation of rat pheochromocytoma PC12 cells J. Biol. Chem. 270 39 1995 23031 23037
14. R.T. Dobrowsky G.M. Jenkins Y.A. Hannun Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors J. Biol. Chem. 270 38 1995 22135 22142
15. M.D. Ehlers D.R. Kaplan D.L. Price V.E. Koliatsos NGF-stimulated retrograde transport of trkA in the mammalian nervous system J. Cell Biol. 130 1 1995 149 156
16. T.F. Franke D.R. Kaplan L.C. Cantley PI3K: Downstream AKTion blocks apoptosis Cell 88 4 1997 435 437
17. R.H. Fryer D.R. Kaplan S.C. Feinstein M.J. Radeke D.R. Grayson L.F. Kromer Developmental and mature expression of full-length and truncated TrkB receptors in the rat forebrain J. Comp. Neurol. 374 1 1996 21 40
18. M. Fukuda Y. Gotoh T. Tachibana K. Dell S. Hattori Y. Yoneda E. Nishida Induction of neurite outgrowth by MAP kinase in PC12 cells Oncogene 11 2 1995 239 244
19. S.H. Green R.E. Rydel J.L. Connolly L.A. Greene PC12 cell mutants that possess low- but not high-affinity nerve growth factor receptors neither respond to nor internalize nerve growth factor J. Cell Biol. 102 3 1986 830 843
20. L.A. Greene A.S. Tischler Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor Proc. Natl. Acad. Sci. USA 73 7 1976 2424 2428
21. L.A. Greene D.R. Kaplan Early events in neurotrophin signalling via Trk and p75 receptors Current Opinion in Neurobiology 5 5 1995 579 587
22. N. Hagag S. Halegoua M. Viola Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras Nature 319 6055 1986 680 682
23. J. Ham C. Babij J. Whitfield C.M. Pfarr D. Lallemand Yaniv M. L.L. Rubin A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death Neuron 14 5 1995 927 939
24. B.L. Hempstead Rabin S.J. Kaplan L.S. Reid L.F. Parada D.R. Kaplan Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation Neuron 9 5 1992 883 896
25. N. Inagaki H. Thoenen D. Lindholm TrkA tyrosine residues involved in NGF-induced neurite outgrowth of PC12 cells Eur. J. Neurosci. 7 6 1995 1125 1133
26. S. Jing P. Tapley M. Barbacid Nerve growth factor mediates signal transduction through trk homodimer receptors Neuron 9 6 1992 1067 1079
27. D.R. Kaplan B.L. Hempstead D. Martin-Zanca M.V. Chao L.F. Parada The trk protooncogene product: a signal transducing receptor for nerve growth factor Science 252 5005 1991 554 558
28. D.R. Kaplan D. Martin-Zanca L.F. Parada Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF Nature 350 6314 1991 158 160
29. Kaplan D.R. K. Matsumoto E. Lucarelli C.J. Thiele Induction of TrkB by retinoic acid mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells Neuron 11 2 1993 321 331
30. D.R. Kaplan R.M. Stephens Neurotrophin signal transduction by the Trk receptor J. Neurobiol. 25 11 1994 1404 1417
31. D.R. Kaplan F.D. Miller Signal transduction by the neurotrophin receptors Current Opinion in Cell Biology 9 2 1997 213 221
32. K. Kimura S. Hattori Y. Kabuyama Y. Shizawa J. Takayanagi S. Nakamura S. Toki Y. Matsuda K. Onodera Y. Fukui Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase J. Biol. Chem. 69 29 1994 18961 18967
33. R. Klein S.Q. Jing V. Nanduri E. O' Rourke M. Barbacid The trk proto-oncogene encodes a receptor for nerve growth factor Cell 65 1 1991 189 197
34. B. Knusel S.J. Rabin F. Hefti D.R. Kaplan Regulated neurotrophin receptor responsiveness during neuronal migrationand early differentiation J. Neurosci. 14 3 Pt 2 1994 1542 1554
35. N.E. Kremer G. D' Arcangelo S.M. Thomas M. DeMarco J.S. Brugge S. Halegoua Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions J. Cell Biol. 115 3 1991 809 819
36. W.L. Kuo Abe M.J. Rhee E.M. Eves S.A. McCarthy M. Yan D.J. Templeton M. McMahon M.R. Rosner Raf, but not MEK or ERK, is sufficient for differentiation of hippocampal neuronal cells Mol. Cell. Biol. 16 4 1996 1458 1470
37. Y. Li D.M. Holtzman L.F. Kromer D.R. Kaplan J. Chua-Couzens D.O. Clary B. Knusel W.C. Mobley Regulation of TrkA and ChAT expression in developing rat basal forebrain: Evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons J. Neurosci. 15 4 1995 2888 2905
38. H.N. Marsh W.K. Scholz F. Lamballe R. Klein V. Nanduri M. Barbacid H.C. Palfrey Signal transduction events mediated by the BDNF receptor gp 145trkB in primary hippocampal pyramidal cell culture J. Neurosci. 13 10 1993 4281 4292
39. C.J. Marshall Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation Cell 80 2 1995 179 185
40. D. Martin-Zanca S.H. Hughes M. Barbacid A human oncogene formed by the fusion of truncated tropomyosin and protein ttyrosine kinase sequences Nature 319 6056 1986 743 748
41. K. Matsumoto R.K. Wada J.M. Yamashiro D.R. Kaplan C.J. Thiele Expression of brain-derived neurotrophic factor and p145TrkB affects survival, differentiation, and invasiveness of human neuroblastoma cells Cancer Res. 55 8 1995 1798 1806
42. H. Matsushima E. Bogenmann Expression of trkA cDNA in neuroblastomas mediates differentiation in vitro and in vivo Mol. Cell. Biol. 13 12 1993 7447 7456
43. X. Montano P53 associates with trk tyrosine kinase Oncogene 15 3 1997 245 256
44. A. Nakagawara M. Arima-Nakagawara N.J. Scavarda C.G. Azar A.B. Cantor G.M. Brodeur Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma New Engl. J. Med. 328 12 1993 847 854
45. A. Nakagawara C.G. Azar N.J. Scavarda G.M. Brodeur Expression and function of TRK-B and BDNF in human neuroblastomas Mol. Cell. Biol. 14 1 1994 759 767
46. C.D. Nobes A.M. Tolkovsky Neutralizing anti-p21 ras Fabs suppress rat sympathetic neuron survival induced by NGF, LIF, CNTF and cAMP Eur. J. Neurosci. 7 2 1995 344 350
47. M. Noda M. Ko A. Ogura D.G. Liu T. Amano T. Takano Y. Ikawa Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line Nature 318 6041 1985 73 75
48. A. Obermeier R.A. Bradshaw K. Seedorf A. Choidas J. Schlessinger A. Ullrich Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma EMBO Journal. 13 7 1994 1585 1590
49. L. Pang T. Sawada Decker S.J. A.R. Saltiel Inhibition of MAP kinase blocks the differentiation of PC-12 cells induced by nerve growth factor J. Biol. Chem. 270 23 1995 13585 13588
50. T. Pawson Protein modules and signalling networks Nature 373 6515 1995 573 580
51. X. Peng L.A. Greene D.R. Kaplan R.M. Stephens Deletion of a conserved juxta-membrane sequence in Trk abolishes NGF-promoted neuritogenesis Neuron 15 2 1995 395 406
52. G. Rusanescu H. Qi S.M. Thomas J.S. Brugge S. Halegoua Calcium influx induces neurite growth through a Src-Ras signaling cassette Neuron 15 6 1995 1415 1425
53. S. Scala K. Wosikowski P. Giannakakou P. Valle Biedler J.L. B.A. Spengler E. Lucarelli S.E. Bates C.J. Thiele Brain-derived neurotrophic factor protects neuroblastoma cells from vinblastine toxicity Cancer Res. 56 16 1996 3737 3742
54. R.A. Segal L.C. Goumnerova Y.K. Kwon C.D. Stiles S.L. Pomeroy Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma Proc. Natl. Acad. Sci. USA 91 26 1994 12867 12871
55. R.A. Segal A. Bhattacharyya L.A. Rua J.A. Alberta R.M. Stephens D.R. Kaplan C.D. Stiles Differential utilization of Trk autophosphorylation sites J. Biol. Chem. 271 33 1996 20175 20181
56. R.A. Segal M.E. Greenberg Intracellular signaling pathways activated by neurotrophic factors Ann. Rev. Neurosci. 19 1996 463 489
57. R.S. Slack D.J. Belliveau M. Rosenberg J. Atwal H. Lochmuller R. Aloyz A. Haghighi B. Lach P. Seth E. Cooper F.D. Miller Adenovirus-mediated gene transfer of the tumor suppressor, induces apoptosis in postmitotic neurons J. Cell Biol. 135 4 1996 1085 1096
58. R.S. Slack F.D. Miller Viral vectors for modulating gene expression in neurons Current Opinion in Neurobiology. 6 5 1996 576 583
59. W.D. Snider Functions of the neurotrophins during nervous system development: What the knockouts are teaching us Cell 77 5 1994 627 638
60. R.M. Stephens D.M. Loeb T.D. Copeland T. Pawson L.A. Greene D.R. Kaplan Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses Neuron 12 3 1994 691 705
61. S.M. Thomas M. DeMarco G. D' Arcangelo S. Halegoua J.S. Brugge Ras is essential for nerve growth factor-and phorbol ester-induced tyrosine phosphorylation of MAP kinases Cell 68 6 1992 1031 1040
62. S. Traverse N. Gomez H. Paterson C. Marshall P. Cohen Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor Biochem. Journal 288 Pt 2 1992 351 355
63. R.R. Vaillancourt L.E. Heasley J. Zamarripa B. Storey M. Valius A. Kazlauskas G.L. Johnson Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation Mol. Cell. Biol. 15 7 1995 3644 3653
64. V. Vambutas D.R. Kaplan M.A. Sells J. Chernoff Nerve growth factor stimulates tyrosine phosphorylation and activation of Src homology-containing protein-tyrosine phosphatase 1 in PC12 cells J. Biol. Chem. 270 43 1995 25629 25633
65. H.R. Widmer D.R. Kaplan S.J. Rabin K.D. Beck F. Hefti B. Knusel Rapid phosphorylation of phospholipase C gamma 1 by brain-derived neurotrophic factor and neurotrophin-3 in cultures of embryonic rat corticalneurons J. Neurochem. 60 6 1993 2111 2123
66. K.W. Wood C. Sarnecki T.M. Roberts J. Blenis Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK Cell 68 6 1992 1041 1050
67. K.W. Wood H. Qi G. D' Arcangelo R.C. Armstrong T.M. Roberts S. Halegoua The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: A potential role for cellular raf kinases in neuronal growth factor signal transduction Proc. Natl. Acad. Sci. USA 90 11 1993 5016 5020
68. Z. Xia M. Dickens J. Raingeaud R.J. Davis M.E. Greenberg Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis Science 70 5240 1995 1326 1331
69. G.Z. Yan E.B. Ziff NGF regulates the PC12 cell cycle machinery through specific inhibition of the Cdk kinases and induction of cyclin Dl J. Neurosci. 15 9 1995 6200 6212
70. R. Yao G.M. Cooper Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor Science 267 5206 1995 2003 2006