Immunoglobulin-like domains define the nerve growth factor binding site of the TrkA receptor

Nature Biotechnology

Volumn 15, Issue 7, 1997, Pages 668-672

  Holden, Paul H ^a   Asopa, Vipin ^a   Robertson, Alan G S ^a   Clarke, Anthony R ^b   Tyler, Sue ^a   Bennett, Gavin S ^c   Brain, Susan D ^c   Wilcock, Gordon K ^d   Allen, Shelley J ^a   Smith, Stephanie K F ^a   Dawbarn, David ^a  

^a BRISTOL ROYAL INFIRMARY   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d FRENCHAY HOSPITAL   (United Kingdom)

Author keywords

Drug design; Nerve growth factor; Protein folding; TrkA binding domain

Indexed keywords

CYSTEINE; IMMUNOGLOBULIN; LEUCINE; NERVE GROWTH FACTOR; PROTEIN TYROSINE KINASE; RECEPTOR PROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; CIRCULAR DICHROISM; CONTROLLED STUDY; EXTRAVASATION; FLUORESCENCE SPECTROSCOPY; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; RAT; RECEPTOR BINDING;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; BIOTECHNOLOGY; CIRCULAR DICHROISM; HUMANS; IMMUNOGLOBULINS; MALE; MOLECULAR SEQUENCE DATA; NERVE GROWTH FACTORS; PC12 CELLS; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTO-ONCOGENE PROTEINS; RATS; RATS, WISTAR; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, TRKA; RECEPTORS, NERVE GROWTH FACTOR; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE;

ANIMALIA;

EID: 0030796068     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt0797-668     Document Type: Article

References (37)

1. Hatanaka, H., Tsukui, H., and Nihonmatsu, I. 1988. Developmental change in the nerve growth factor action from induction of choline acetyltransferase to promotion of cell survival in cultured basal forebrain cholinergic neurons from postnatal rats. Dev. Brain Res. 39:85-95.
2. Thoenen, H., Bandtlow, H., and Heumann, R. 1987. The physiological function of nerve growth factor in the central nervous system: comparison with the periphery. Rev. Physiol. Biochem. Pharmacol. 109:145-178.
3. Olsen, L, Nordburg, A., von Hoist, H., Backman, I, Ebendal, T., Alafuzoff, I., et al. 1992. Nerve growth factor affects 11 C-nicotine binding, blood flow, EEG and verbal episodic memory in an Alzheimer patient (case report). J. Neural Transm. Park. Dis. Dement. Sect. 4:79-95.
4. Rodriguez-Tebar, A., Dechant, G., Gotz, R., and Barde, YA. 1992. Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve growth-factor and brain-derived neurotrophic factor. EMBO J. 11:917-922.
5. Martin-Zanca, D., Oskam, R., Mitra, G., Copeland, T., and Barbacid, M. 1989. Molecular and biochemical-characterization of the human trk proto-oncogene. Mol. Cell Biol. 9:24-33.
6. Ip, N.Y., Stitt, T.N., Tapley, P., Klein, R., Glass, D.J., Fandl, J., et al. 1993. Similarities and differences in the way neurotrophins interact with the trk receptors in neuronal and nonneuronal cells. Neuron 10:137-149.
7. Klein, R., Lamballe, E, Bryant, S., and Barbacid, M. 1992. The trkB tyrosine protein-kinase is a receptor for neurotrophin-4. Neuron 8:947-956.
8. Lamballe, F, Klein, R., and Barbacid, M. 1991. TrkC, a new member of the trk family of tyrosine protein-kinases, is a receptor for neurotrophin-3. Cell 66:967-979.
9. Urfer, R., Tsoulfas, P., Soppet, D., Escandon, E., Parada, L.F., and Presta, L.G. 1994. The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin. EMBO J. 13:5896-5909.
10. Schneider, R., and Schweiger, M. 1991. A novel modular mosaic of cell adhesion motifs in the extracellular domains of the neurogenic trk and trkB tyrosine kinase receptors. Oncogene 6:1807-1811.
11. Williams, A.F. and Barclay, A.N. 1988. The immunoglobulin superfamily-domains for cell-surface recognition. Ann. Rev. Immunol. 6:381-405.
12. McDonald, N.Q. and Chao, M.V. 1995. Structural determinants of neurotrophin action. J. Biol. Chem. 270:19669-19672.
13. Pérez, P., Coll, P.M., Hempstead, B.L., Martin-Zanca, D., and Chao, M.V. 1995. NGF binding to the trk tyrosine kinase receptor requires the extracellular immunoglobulin-like domains. Mol. Cell. Neurosci. 6:97-105.
14. Urfer, R., Tsouifas, P., Oconnell, L, Shelton, D.L., Parada, L.F., and Presta, L.G. 1995. An immunoglobulin-like domain determines the specificity of neurotrophin receptors. EMBO J. 14:2795-2805.
15. Windisch, J.M., Marksteiner, R., and Schneider, R. 1995. Nerve growth-factor binding-site on trkA mapped to a single 24-amino acid leucine-rich motif. J. Biol. Chem. 270:28133-28138.
16. Clary, D.O. and Reichardt, L.F. 1994. An alternatively spliced form of the nerve growth-factor receptor trka confers an enhanced response to neurotrophin-3. Proc. Natl. Acad. Sci. USA 91:11133-11137.
17. Allen, S.J., Dawbarn, D., Eckford, S.D., Wilcock, G.K., Ashcroft, M., Colebrook, S.M., et al. 1994. Cloning of a noncatalytic form of human fnVb and distribution of messenger-RNA for trkb in human brain. Neuroscience 60:825-834.
18. Yang, J.T., Wu, C.S.C., and Martinez, H.M. 1986. Calculation of protein conformation from circular-dichroism. Methods Enzymol. 130:208-269.
19. Ikeda, K., Hamaguchi, K., and Migita, S. 1968. Circular dichroism of Bence-Jones proteins and immunoglobulins. J. Biochem. 63:654-660.
20. Vale, R.D. and Shooter, E.M. 1985. Assaying binding of nerve growth-factor to cell-surface receptors. Methods Enzymol. 109:21-39.
21. Loeb, D.M., Maragos, J., Martinzanca, D., Chao, M.V., Parada, L.F., and Greene, LA. 1991. The trk protooncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell-lines. Cell 66:961-966.
22. Kaplan, D.R., Hempstead, B.L, Martinzanca, D., Chao, M.V, and Parada, LF. 1991. The trk protooncogene product—a signal transducing receptor for nerve growth-factor. Science 252:554-558.
23. Fujimori, K. and Fukuzono, S. 1992. Overproduction of biologically-active human nerve growth factor in Escherichia coll. Biosci. Biotech. Biochem. 56:1985-1990.
24. Often, U., Baumann, J.B., and Girard, J. 1984. Nerve growth-factor induces plasma extravasation in rat skin. Eur. J. Pharmacol. 106:199-201.
25. Bennett, G.S. and Brain, S.D. 1996. Nerve growth-factor induces an immediate and also a late-phase of edema formation in rat skin. Br. J. Pharmacol. 119:P55.
26. de Vos, A.M., Ultsch, M., and Kossiakoff, A.A. 1992. Human growth-hormone and extracellular domain of its receptor-crystal-structure of the complex. Science 255:306-312.
27. Yayon, A., Zimmer, Y, Shen, G.H., Avivi, A., Yarden, Y, and Givol, D. 1992. A confined variable region confers ligand specificity on fibroblast growth-factor receptors-implications for the origin of the immunoglobulin fold. EMBO J. 11:1885-1890.
28. Ze, W., Myles, G.M., Brandt, C.S., Lioubin, M.N., and Rohrschneider, L. 1993. Identification of the ligand-binding regions in the macrophage-colony-stimulating factor-receptor extracellular domain. Mol. Cell Biol. 13:5348-5359.
29. Diamond, M.S., Staunton, D.E., Martin, S.D., and Springer, T.A. 1991. Binding of the íntegrin Mac-1 (CD11 b/CD18) to the 3rd immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation. Cell 65:961-971.
30. Heidaran, M.A., Mahadevan, D., and Larochelle, W.J. 1995. Beta-PDGFr-igG chimera demonstrates that human beta-PDGFR ig-like domain-1 to domain-3 are sufficient for high-affinity PDGF-BB binding. FASEB J. 9:140-145.
31. Windisch, J.M., Marksteiner, R., Lang, M.E., Auer, B., and Schneider R. 1995. Brain derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 bind to a single leucine-rich motif of TrkB. Biochemistry 34:11256-11263
32. MacDonald, J.I.S. and Meakin, S.O. 1996. Deletions in the extracellular domain of Rat TrkA lead to an altered differentiative phenotype in neurotrophin responsive cells. Mol. Cell. Neurosci. 7:371-390
33. Lewin, G.R. 1995. Neurotrophic factors and pain. Semin. Neurosci. 7:227-232.
34. Rost, B. and Sander, C. 1993. Prediction of protein secondary structure at better than 70-percent accuracy. J. Mol. Biol. 232:584-599.
35. Sambrook, J., Fritsch, E.F., and Maniatis, T. 1989. Molecular cloning: a laboratory manual. Cold Spring Harbour Laboratory Press, Cold Spring Harbour, NY.
36. Treanor, J.J.S., Dawbarn, D., Allen, S.J., Macgowan, S.H., and Wilcock, G.K. 1991. Low affinity nerve growth-factor receptor-binding in normal and Alzheimer’s-disease basal forebrain. Neuroscience Letters 121:73-76.
37. Brain, S.D. and Williams, T.J. 1985. Inflammatory edema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular-permeability. Br. J. Pharmacol. 86:855-860.