Structural and biochemical evaluation of the interaction of the phosphatidylinositol 3-kinase p85α Src homology 2 domains with phosphoinositides and inositol polyphosphates

Journal of Biological Chemistry

Volumn 274, Issue 22, 1999, Pages 15678-15685

  Lo Surdo, Paola ^a,b   Bottomley, Matthew J ^a,b   Arcaro, Alexandre ^c,d   Siegal, Gregg ^c,e   Panayotou, George ^c,f   Sankar, Andrew ^c   Gaffney, Piers R J ^a,c   Riley, Andrew M ^g   Potter, Barry V L ^g   Waterfield, Michael D ^a,c   Driscoll, Paul C ^a,c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^d LUDWIG INSTITUTE FOR CANCER RESEARCH   (Switzerland)

^e LEIDEN UNIVERSITY   (Netherlands)

^f Institute of Molecular Oncology   (Greece)

^g University of Bath   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INOSITOL POLYPHOSPHATE; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3 KINASE; WORTMANNIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOSENSOR; ENZYME ACTIVITY; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN LIPID INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ANDROSTADIENES; ANIMALS; BINDING SITES; INOSITOL PHOSPHATES; LIGANDS; LIPOSOMES; MICE; MODELS, MOLECULAR; PHOSPHATIDYLINOSITOLS; PHOSPHORYLATION; PHOSPHOTYROSINE; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS;

ANIMALIA;

EID: 0033056853     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.22.15678     Document Type: Article

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