-
1
-
-
0026800606
-
Penicillin and cephalosporin biosynthetic genes: Structure, organization, regulation and evolution
-
Aharonowitz Y, Cohen G & Martin JF (1992) Penicillin and cephalosporin biosynthetic genes: structure, organization, regulation and evolution. Annu. Rev. Microbiol. 46: 461-95
-
(1992)
Annu. Rev. Microbiol.
, vol.46
, pp. 461-495
-
-
Aharonowitz, Y.1
Cohen, G.2
Martin, J.F.3
-
2
-
-
0023996141
-
Biosynthesis of penicillins and cephalosporins
-
Baldwin JE & Abraham EP (1988) Biosynthesis of penicillins and cephalosporins. Nat. Prod. Rep. 5: 129-145
-
(1988)
Nat. Prod. Rep.
, vol.5
, pp. 129-145
-
-
Baldwin, J.E.1
Abraham, E.P.2
-
3
-
-
0000502480
-
Isopenicillin N synthase: Mechanistic studies
-
Baldwin JE & Bradley M (1990) Isopenicillin N synthase: mechanistic studies. Chem. Rev. 90: 1079-1088
-
(1990)
Chem. Rev.
, vol.90
, pp. 1079-1088
-
-
Baldwin, J.E.1
Bradley, M.2
-
4
-
-
0029016877
-
A heuristic approach to the analysis of enzymic catalysis: Reaction of δ-L-α-aminoadipoyl-L-cysteinyl-D-α-aminobutyrate and δ-L-α-aminoadipoyl-L-cysteinyl-D-allylglycine catalyzed by isopenicillin N synthase isozymes
-
Blackburn JM, Sutherland JD & Baldwin JE (1995) A heuristic approach to the analysis of enzymic catalysis: reaction of δ-L-α-aminoadipoyl-L-cysteinyl-D-α-aminobutyrate and δ-L-α-aminoadipoyl-L-cysteinyl-D-allylglycine catalyzed by isopenicillin N synthase isozymes. Biochemistry 34: 7548-7562
-
(1995)
Biochemistry
, vol.34
, pp. 7548-7562
-
-
Blackburn, J.M.1
Sutherland, J.D.2
Baldwin, J.E.3
-
5
-
-
0030032150
-
Ferrous active site of isopenicillin N synthase: Genetic and sequence analysis of the endogenous ligands
-
Borovok I, Landman O, Kreisberg-Zakarin R, Aharonowitz Y & Cohen G (1996) Ferrous active site of isopenicillin N synthase: genetic and sequence analysis of the endogenous ligands. Biochemistry 35: 1981-1987
-
(1996)
Biochemistry
, vol.35
, pp. 1981-1987
-
-
Borovok, I.1
Landman, O.2
Kreisberg-Zakarin, R.3
Aharonowitz, Y.4
Cohen, G.5
-
6
-
-
0025420134
-
Microbial isopenicillin N synthetase genes: Structure, function, diversity and evolution
-
Cohen G, Shiffman D, Mevarech M & Aharonowitz Y (1990) Microbial isopenicillin N synthetase genes: structure, function, diversity and evolution. Tr. Biotechnol. 8: 105-111
-
(1990)
Tr. Biotechnol.
, vol.8
, pp. 105-111
-
-
Cohen, G.1
Shiffman, D.2
Mevarech, M.3
Aharonowitz, Y.4
-
7
-
-
0345020330
-
Molecular genetics of antimicrobials: A case study of β-lactam antibiotics
-
Cohen G & Aharonowitz Y (1995) Molecular genetics of antimicrobials: a case study of β-lactam antibiotics. Symp. Soc. Gen. Microbiol., 53: 139-163
-
(1995)
Symp. Soc. Gen. Microbiol.
, vol.53
, pp. 139-163
-
-
Cohen, G.1
Aharonowitz, Y.2
-
8
-
-
0027631543
-
The enzymes involved in biosynthesis of penicillin and cephalosporin; their structure and function
-
Cooper RD (1993) The enzymes involved in biosynthesis of penicillin and cephalosporin; their structure and function. Bioorg. Med. Chem. 1: 1-17
-
(1993)
Bioorg. Med. Chem.
, vol.1
, pp. 1-17
-
-
Cooper, R.D.1
-
9
-
-
0009411657
-
Reactions of non-heme iron (II) centers with dioxygen in biology and chemistry
-
Feig AL & Lippard SJ (1994) Reactions of non-heme iron (II) centers with dioxygen in biology and chemistry. Chem. Rev. 94: 759-805
-
(1994)
Chem. Rev.
, vol.94
, pp. 759-805
-
-
Feig, A.L.1
Lippard, S.J.2
-
10
-
-
0028007358
-
Crystallization and preliminary x-ray diffraction studies on a recombinant isopenicillin N synthase from cephalosporium acremonium
-
Fujishima Y, Nordlund P, Pelosi G, Schofield C, Cole SC, Baldwin J & Hajdu J (1994) Crystallization and preliminary x-ray diffraction studies on a recombinant isopenicillin N synthase from cephalosporium acremonium. J. Mol. Biol. 242: 712-714
-
(1994)
J. Mol. Biol.
, vol.242
, pp. 712-714
-
-
Fujishima, Y.1
Nordlund, P.2
Pelosi, G.3
Schofield, C.4
Cole, S.C.5
Baldwin, J.6
Hajdu, J.7
-
11
-
-
0031574232
-
The 2-his-1-carboxylate facial triad: An emerging structural motif in mononuclear non-heme ironII enzymes
-
Hegg EL & Que L, Jr. (1997) The 2-his-1-carboxylate facial triad: an emerging structural motif in mononuclear non-heme ironII enzymes. Eur. J. Biochem. 240: 625-629
-
(1997)
Eur. J. Biochem.
, vol.240
, pp. 625-629
-
-
Hegg, E.L.1
Que L., Jr.2
-
12
-
-
0345451514
-
-
Ph.D. Thesis, Tel-Aviv University, Israel
-
Kreisberg-Zakarin R (1998) Ph.D. Thesis, Tel-Aviv University, Israel
-
(1998)
-
-
Kreisberg-Zakarin, R.1
-
13
-
-
0345020329
-
-
Jerusalem, Israel
-
Kreisberg-Zakarin R, Yanko M, Borovok I, Landman O, Frolow F, Remington J, Aharonowitz Y & Cohen G (1998) Abstract: 8th International Symposium on The Genetics of Industrial Microorganisms, Jerusalem, Israel
-
(1998)
Abstract: 8th International Symposium on the Genetics of Industrial Microorganisms
-
-
Kreisberg-Zakarin, R.1
Yanko, M.2
Borovok, I.3
Landman, O.4
Frolow, F.5
Remington, J.6
Aharonowitz, Y.7
Cohen, G.8
-
14
-
-
0030964827
-
The glutamine ligand in the ferrrous active site of isopenicillin N synthase of Streptomyces jumonjinensis is not essential for catalysis
-
Landman O, Borovok I, Aharonowitz Y & Cohen G (1997) The glutamine ligand in the ferrrous active site of isopenicillin N synthase of Streptomyces jumonjinensis is not essential for catalysis. FEBS Lett. 405: 172-174
-
(1997)
FEBS Lett.
, vol.405
, pp. 172-174
-
-
Landman, O.1
Borovok, I.2
Aharonowitz, Y.3
Cohen, G.4
-
15
-
-
0031408344
-
Functional analysis of a conserved aspartate D218 in Cephalosporium acremonium isopenicillin N synthase
-
Loke P, Sim J & Sim TS (1997) Functional analysis of a conserved aspartate D218 in Cephalosporium acremonium isopenicillin N synthase. FEMS Microbiol. Lett. 157: 137-140
-
(1997)
FEMS Microbiol. Lett.
, vol.157
, pp. 137-140
-
-
Loke, P.1
Sim, J.2
Sim, T.S.3
-
16
-
-
0031215148
-
Protein templates for the biosynthesis of peptide antibiotics
-
Marahiel MA (1997) Protein templates for the biosynthesis of peptide antibiotics. Chemistry & Biology 4: 561-567
-
(1997)
Chemistry & Biology
, vol.4
, pp. 561-567
-
-
Marahiel, M.A.1
-
17
-
-
0000916977
-
Dioxygenases: Molecular structure and role in metabolism
-
Prescott AG (1996) Dioxygenases: Molecular structure and role in metabolism. Annu. Rev. Plant Physiol. Mol. Biol. 47: 245-271
-
(1996)
Annu. Rev. Plant Physiol. Mol. Biol.
, vol.47
, pp. 245-271
-
-
Prescott, A.G.1
-
18
-
-
0039302669
-
Dioxygen activation by enzymes with mononuclear non-heme iron active sites
-
Que L, Jr & Ho R (1996) Dioxygen activation by enzymes with mononuclear non-heme iron active sites. Chem. Rev. 96: 2607-2624
-
(1996)
Chem. Rev.
, vol.96
, pp. 2607-2624
-
-
Que L., Jr.1
Ho, R.2
-
19
-
-
0029038392
-
Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes
-
Roach PL, Clifton IT, Fulop V, Harlos K, Barton GJ, Hadjdu J, Anderson I, Schofield CI & Baldwin JE (1995) Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes. Nature 375: 700-704
-
(1995)
Nature
, vol.375
, pp. 700-704
-
-
Roach, P.L.1
Clifton, I.T.2
Fulop, V.3
Harlos, K.4
Barton, G.J.5
Hadjdu, J.6
Anderson, I.7
Schofield, C.I.8
Baldwin, J.E.9
-
20
-
-
0030947388
-
Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation
-
Roach PL, Clifton IT, Hensgens cmH, Shabita N, Schofield CI, Hadju J & Baldwin JE (1997) Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation. Nature 387: 827-830
-
(1997)
Nature
, vol.387
, pp. 827-830
-
-
Roach, P.L.1
Clifton, I.T.2
Hensgens, C.M.H.3
Shabita, N.4
Schofield, C.I.5
Hadju, J.6
Baldwin, J.E.7
-
21
-
-
0031004173
-
Glutamine-330 is not essential for activity in isopenicillin N synthase from Aspergillus nidulans
-
Sami M, Brown TJN, Roach PL, Schofield CJ & Baldwin JE (1997) Glutamine-330 is not essential for activity in isopenicillin N synthase from Aspergillus nidulans. FEBS Lett. 405: 191-194
-
(1997)
FEBS Lett.
, vol.405
, pp. 191-194
-
-
Sami, M.1
Brown, T.J.N.2
Roach, P.L.3
Schofield, C.J.4
Baldwin, J.E.5
-
22
-
-
0031469044
-
Proteins of the penicillin biosynthesis pathway
-
Schofield CJ, Baldwin JE, Byford MF, Clifton I, Hadju J, Hensgens C & Roach P (1997) Proteins of the penicillin biosynthesis pathway. Current Opinion in Structural Biology 7: 857-864
-
(1997)
Current Opinion in Structural Biology
, vol.7
, pp. 857-864
-
-
Schofield, C.J.1
Baldwin, J.E.2
Byford, M.F.3
Clifton, I.4
Hadju, J.5
Hensgens, C.6
Roach, P.7
-
23
-
-
0026660914
-
Genetic engineering of β-lactam antibiotic biosynthetic pathways in filamentous fungi
-
Skatrud PL (1992) Genetic engineering of β-lactam antibiotic biosynthetic pathways in filamentous fungi. Tr. Biotechnol. 10: 324-332
-
(1992)
Tr. Biotechnol.
, vol.10
, pp. 324-332
-
-
Skatrud, P.L.1
-
24
-
-
0030025142
-
Functional analysis of conserved histidine residues in Cephalosporium acremonium isopenicillin N synthase by site-directed mutagenesis
-
Tan DSH and Sim T-S (1996) Functional analysis of conserved histidine residues in Cephalosporium acremonium isopenicillin N synthase by site-directed mutagenesis. J. Biol. Chem. 271: 889-894
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 889-894
-
-
Tan, D.S.H.1
Sim, T.-S.2
-
25
-
-
0019941850
-
Stochiometry of oxygen consumption in the biosynthesis of isopenicillin from a tripeptide
-
White RL, John EM, Baldwin JE & Abraham EP (1982) Stochiometry of oxygen consumption in the biosynthesis of isopenicillin from a tripeptide. Biochem. J. 203: 791-793
-
(1982)
Biochem. J.
, vol.203
, pp. 791-793
-
-
White, R.L.1
John, E.M.2
Baldwin, J.E.3
Abraham, E.P.4
|