Ferrous active site of isopenicillin N synthase: Genetic and sequence analysis of the endogenous ligands

Biochemistry

Volumn 35, Issue 6, 1996, Pages 1981-1987

  Borovok, Ilya ^a   Landman, Orna ^a   Kreisberg Zakarin, Rachel ^a   Aharonowitz, Yair ^a   Cohen, Gerald ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; FERROUS ION; HISTIDINE; ISOPENICILLIN N SYNTHETASE;

AMINO ACID SEQUENCE; ARTICLE; ENZYME ACTIVE SITE; MICHAELIS CONSTANT; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STREPTOMYCES;

AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING SITES; GENE EXPRESSION; GENES, BACTERIAL; IRON; KINETICS; LIGANDS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OLIGODEOXYRIBONUCLEOTIDES; OLIGOPEPTIDES; OXIDOREDUCTASES; SEQUENCE HOMOLOGY, AMINO ACID; STREPTOMYCES;

BACTERIA (MICROORGANISMS); STREPTOMYCES JUMONJINENSIS;

EID: 0030032150     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi951534t     Document Type: Article

References (41)

1. Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) J. Mol. Biol. 215, 403-410.
2. Arciero, D. M., & Lipscomb, J. D. (1986) J. Biol. Chem. 261, 2170-2178.
3. Arnold, F. M., & Zhang, J. (1994) Trends Biotechnol. 12, 189-192.
4. Baldwin, J. E. (1989) in Recent Advances in The Chemistry of β-Lactam Antibiotics (Bentley, P. H., & Southgate, R., Eds.) Chapter 1, Royal Society of Chemistry, London.
5. Baldwin, J. E. & Abraham, E. P. (1988) Nat. Prod. Rep. 5, 129-145.
6. Baldwin, J. E. & Bradley, M. (1990) Chem. Rev. 90, 1079-1088.
7. Bradford, M. M., (1976) Anal. Biochem. 72, 248-254.
8. Britsch, L., Ruhnau-Brich, B., & Forkmann, G. (1992) J. Biol. Chem. 267, 5380-5387.
9. Britsch, L., Dedio, J., Saedler, H., & Forkmann, G. (1993) Eur. J. Biochem. 217, 745-754.
10. Chen, V. J., Orville, A. M., Harpel, M. R., Frolik, C. A., Surerus, K. K., Munck, E., & Lipscomb, J. D. (1989) J. Biol. Chem. 264, 21677-21681.
11. Cohen, G., Shiffman, D., Mevarech, M., & Aharonowitz, Y. (1990) Trends Biotechnol. 8, 105-111.
12. Cooper, R. D. (1993) Bioorg. Med. Chem. 1, 1-17.
13. Devereux, J., Haeberli, P., & Smithies, O. (1984) Nucleic Acids Res. 12, 387-395.
14. Feng, D. F., & Doolittle, R. F. (1987) J. Mol. Evol. 25, 351-360.
15. Fukuda, H., Ogawa, T., Ishihara, K., Fujii, T., Nagahama, K., Omata, T., Inoue, Y., Tanase, S., & Morino, Y. (1992) Biochem. Biophys. Res. Commun. 188, 826-832.
16. Hashimoto, T., & Yamada, Y. (1986) Plant. Physiol. 81, 619-625.
17. Hedden, P., & Graebe, J. E. (1982) J. Plant Growth Regul. 1, 105-116.
18. Ingraham, L. L., & Meyer, D. L. (1985) in Biochemistry of Dioxygen (Frieden. E., Ed.) pp 139-246. Plenum Publishing Co., New York.
19. Jensen, S. E., Westlake, D. W. S., & Wolfe, S. (1982a) J. Antibiot. 35, 1026-1032.
20. Jensen, S. E., Westlake, D. W. S., & Wolfe, S. (1982b) J. Antibiot. 35, 483-490.
21. Jiang, F., Peisach, J., Ming, L. J., Que, L., Jr., & Chen, V. J. (1991) Biochemistry 30, 11437-11445.
22. Kivirikko, K. I., Myllyla, R., & Pihlajaniemi, T. (1989) FASEB J. 3, 1609-1617.
23. Landman, O., Shiffman, D., Av Gay, Y., Aharonowitz, Y., & Cohen, G. (1991) FEMS Microbiol. Lett. 68, 239-244.
24. Matsuda, J., Okabe, S., Hashimoto, T., & Yamada, Y. (1991) J. Biol. Chem. 266, 9460-9464.
25. Ming, L. J., Que, L., Jr., Kriauciunas, A., Frolik, C. A., & Chen, V. J. (1990) Inorg. Chem. 29, 1111-1112.
26. Ming, L. J., Que, L., Jr., Kriauciunas, A., Frolik, C. A., & Chen, V. J. (1991) Biochemistry 30, 11653-11659.
27. Myllyla, R., Gunzler, V., Kivirikko, K. I., & Kaska, D. D. (1992) Biochem. J. 286, 923-927.
28. Orville, A. M., Chen, V. J., Kriauciunas, A., Harpel, M. R., Fox, B. G., Munck, E., & Lipscomb, J. D. (1992) Biochemistry 31, 4602-4612.
29. Perry, D., Abraham, E. P., & Baldwin, J. E. (1988) Biochem. J. 255, 345-351.
30. Que, L., Jr. (1989) in Iron Carriers and Iron Proteins (Loehr, T. M., Ed.) Chapter 6, VCH, New York.
31. Randall, C. R., Zang, Y., True, A. E., Que, L., Jr., Charnock, J. M., Garner, C. D., Fujishima, Y., Schofield, C. J., & Baldwin, J. E. (1993) Biochemistry 32, 6664-6673.
32. Roach, P. L., Clifton, I. T., Fulop, V., Harlos, K., Barton, G. J., Hadjdu, J., Anderson, I., Schofield, C. I., & Baldwin, J. E. (1995) Nature 375, 700-704.
33. Robinson, J. A. (1988) Chem. Soc. Rev. 17, 383-452.
34. Sambrook, J., Fritsch, E. F., & Maniatis, T. (1989) in Molecular Cloning: A Laboratory Manual (Sambrook, J., Fritsch, E. F., & Maniatis, T., Eds.) pp 1.25-1.31, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
35. Sanger, F., Nicklen, S., & Coulson, A. R. (1977) Proc. Natl. Acad. Sci. U.S.A. 74, 5463-5467.
36. Sayer, J. R., & Eckstein, F. (1991) in Directed Mutagenesis: A Practical Approach (McPherson, M. J., Ed.) pp 49-69, IRL Press/Oxford University Press, New York and Tokyo.
37. Scott, R. A., Wang, S., Eidsness, M. K., Kriauciunas, A., Frolik, C. A., & Chen, V. J. (1992) Biochemistry 31, 4596-4601.
38. Stoddard, B. L., Howell, P. L., Ringe, D., & Petsko, G. A. (1990) Biochemistry 29, 8885-8893.
39. Tiow Suan, S., & Tan, D. S. (1994) FEMS Microbiol. Lett. 120, 241-247.
40. White, R. L., John, E. M., Baldwin, J. E., & Abraham, E. P. (1982) Biochem. J. 203, 791-793.
41. Yanisch-Perron, C., Vieira, J., & Messing, J. (1985) Gene 33, 103-119.