Marking IL-4-producing cells by knock-in of the IL-4 gene

International Immunology

Volumn 11, Issue 2, 1999, Pages 243-247

  Ho, I Cheng ^a,b   Kaplan, Mark H ^a   Jackson Grusby, Laurie ^c   Glimcher, Laurie H ^a,b   Grusby, Michael J ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Cytokines; T(h)1 T(h)2; Transgenic knockout

Indexed keywords

INTERLEUKIN 4;

ANIMAL CELL; ARTICLE; FLOW CYTOMETRY; GENE LOCUS; GENE TARGETING; HELPER CELL; MAST CELL; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; STEM CELL;

ANIMALS; ANTIBODIES, MONOCLONAL; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL MEMBRANE; FLOW CYTOMETRY; GENE TARGETING; INTERLEUKIN-4; KILLER CELLS, NATURAL; MAST CELLS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; TH2 CELLS;

EID: 0033048242     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/11.2.243     Document Type: Article

References (27)

1. Paul, W. E. and Ohara, J. 1987. B-cell stimulatory factor-1/ interleukin 4. Annu. Rev. Immunol. 5:429.
2. Vitetta, E. S., Ohara, J., Myers, C. D., Layton, J. E., Krammer, P. H. and Paul, W. E. 1985. Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1. J. Exp. Med. 162:1726.
3. Coffman, R. L., Ohara, J., Bond, M. W., Carty, J., Zlotnik, A. and Paul, W. E. 1986. B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J. Immunol. 136:4538.
4. Widmer, M. B. and Grabstein, K. H. 1987. Regulation of cytolytic T-lymphocyte generation by B-cell stimulatory factor. Nature 326:795.
5. + resting murine T lymphocytes. J. Immunol. 140:1101.
6. Le Gros, G., Ben-Sasson, S. Z., Seder, R., Finkelman, F. D. and Paul, W. E. 1990. Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J. Exp. Med. 172:921.
7. h2-like helper effectors. J. Immunol. 145:3796.
8. Howard, M., Farrar, J., Hilfiker, M., Johnson, B., Takatsu, K., Hamaoka, T. and Paul, W. E. 1982. Identification of a T cell-derived B cell growth factor distinct from interleukin 2. J. Exp. Med. 155:914.
9. Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A. and Coffman, R. L. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
10. Brown, M. A., Pierce, J. H., Watson, C. J., Falco, J., Ihle, J. N. and Paul, W. E. 1987. B cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells. Cell 50:809.
11. + T cells can be primed in vitro to produce IL-4. J. Immunol. 148:1652.
12. h2 cytokines. Immunity 2:271.
13. h2-stimulating pathogens by gamma delta T cells in vivo. Nature 373:255.
14. pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179:1285.
15. Sallusto, F., Mackay, C. R. and Lanzavecchia, A. 1997. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science 277:2005.
16. Xu, D., Chan, W. L., Leung, B. P., Huang, F., Wheeler, R., Piedrafita, D., Robinson, J. H. and Liew, F. Y. 1998. Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells. J. Exp. Med. 187:787.
17. Otsuka, T., Villaret, D., Yokota, T., Takebe, Y., Lee, F., Arai, N. and Arai, K. 1987. Structural analysis of the mouse chromosomal gene encoding interleukin 4 which expresses B cell, T cell and mast cell stimulating activities. Nucleic Acids Res. 15:333.
18. Larhammar, D., Hammerling, U., Denaro, M., Lund, T., Flavell, R. A., Rask, L. and Peterson, P. A. 1983. Structure of the murine immune response I-Aβ locus: sequence of the I-Aβ gene and an adjacent β-chain second domain exon. Cell 34:179.
19. h2 cells. Immunity 4:313.
20. He, D., Esquenazi-Behar, S., Soter, N. A. and Lim, H. W. 1990. Mast-cell heterogeneity: functional comparison of purified mouse cutaneous and peritoneal mast cells. J. Invest. Dermatol. 95:178.
21. Plaut, M., Pierce, J. H., Watson, C. J., Hanley-Hyde, J., Nordan, R. P. and Paul, W. E. 1989. Mast cell lines produce lymphokines in response to cross-linkage of FCERI or to calcium ionophores. Nature 339:64.
22. + cells: new clues to their origin, specificity, and function. J. Exp. Med. 182:633.
23. + T cells lose NK1. 1 expression upon in vitro activation. J. Immunol. 158:5112.
24. H2 response and in immunoglobulin E production. Science 270:1845.
25. + T cell development and early IL-4 production in CD1-deficient mice. Immunity 6:459.
26. Mendiratta, S. K., Martin, W. D., Hong, S., Boesteanu, A., Joyce, S. and Van Kaer, L. 1997. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 6:469.
27. Smiley, S. T., Kaplan, M. H. and Grusby, M. J. 1997. Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science 275:977.