Inhibition of iron-dependent and ischemia-induced brain damage by the α-tocopherol analogue MDL 74,722

Experimental Neurology

Volumn 155, Issue 1, 1999, Pages 103-108

  Van Der Worp, H Bernardus ^a   Thomas, Craig E ^b   Kappelle, L Jaap ^a   Hoffman, Wherly P ^b   De Wildt, Dick J ^c   Bär, Peter R ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b ELI LILLY AND COMPANY   (United States)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Cerebral ischemia; Culture; Lipid peroxidation; MDL 74,722; Rat; Tocopherol

Indexed keywords

ALPHA TOCOPHEROL DERIVATIVE; MDL 74722; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; GRANULE CELL; LIPID PEROXIDATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033044337     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1998.6968     Document Type: Article

References (25)

1. Bolkenius F. N., Verne-Mismer J., Wagner J., Grisar J. M. Amphiphilic α-tocopherol analogues as inhibitors of brain lipid peroxidation. Eur. J. Pharmacol. 298:1996;37-43.
2. Brott T. G., Haley E. C., Levy D. E., Barsan W., Broderick J., Sheppard G. L., Spilker J., Kongable G. L., Massey S., Reed R., Marler J. R. Urgent therapy for stroke. Part I. Pilot study of tissue plasminogen activator administered within 90 minutes. Stroke. 23:1992;632-640.
3. Cowley D. J., Lukovic L., Petty M. A. MDL 74,180 reduces cerebral infarction and free radical concentrations in rats subjected to ischaemia and reperfusion. Eur. J. Pharmacol. 298:1996;227-233.
4. Crowell R. M., Olsson Y., Klatzo I., Ommaya A. Temporary occlusion of the middle cerebral artery in the monkey: Clinical and pathological observations. Stroke. 1:1970;439.
5. Dunnett C. W. New tables for multiple comparisons with a control. Biometrics. 20:1964;482-491.
6. Ginsberg M. D., Sternau L. L., Globus M. Y.-T., Dietrich W. D., Busto R. Therapeutic modulation of brain temperature: Relevance to ischemic brain injury. Cerebrovasc. Brain Metab. Rev. 4:1992;189-225.
7. Ginsberg M. D., Busto R. Combating hyperthermia in acute stroke. A significant clinical concern. Stroke. 29:1998;529-534.
8. Grisar J. M., Bolkenius F. N., Petty M. A., Verne J. 2,3-Dihydro-1-benzofuran-5-ols as analogues of α-tocopherol that inhibit in vitro and ex vivo lipid autoxidation and protect mice against central nervous system trauma. J. Med. Chem. 38:1995;453-458.
9. Grotta J. Why do all drugs work in animals but none in stroke patients? 2. Neuroprotective therapy. J. Intern. Med. 237:1995;89-94.
10. Heiss W.-D., Huber M., Fink G. R., Herholz K., Pietrzyk U., Wagner R., Weinhard K. Progressive derangement of periinfarct viable tissue in ischemic stroke. J. Cereb. Blood Flow Metab. 12:1992;193-203.
11. Koizumi J., Yoshida Y., Nakazawa T., Ooneda G. Experimental studies of ischemic brain edema, I: A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn. J. Stroke. 8:1986;1-8.
12. Levi G., Aloisi F., Ciotti M., Thangnipon W., Kingsbury A., Balazs R. Preparation of 98% pure cerebellar granule cell cultures. A Dissection and Tissue Culture Manual of the Nervous System. 1989;A. R. Liss, New York. p. 211-214.
13. Liu T. H., Beckman J. S., Freeman B. A., Hogan E. L., Hsu C. Y. Polyethylene glycol-conjugated superoxide dismutase and catalase reduce ischemic brain injury. Am. J. Physiol. 256:1989;H589-H593.
14. Hall E. D., Pazara K. E., Braughler J. M. 21-aminosteroid lipid peroxidation inhibitor U74006F protects against cerebral ischemia in gerbils. Stroke. 19:1988;997-1002.
15. Kaplan B., Brint J., Tanabe J., Jacewicz M., Wang X.-J., Pulsinelli W. Temporal thresholds for neocortical infarction in rats subjected to reversible focal cerebral ischemia. Stroke. 22:1991;1032-1039.
16. Machlin L. J., Bendich A. Free radical tissue damage: Protective role of antioxidant nutrients. FASEB. J. 1:1987;441-445.
17. Machlin L. J., Gabriel E. Kinetics of tissue α-tocopherol uptake and depletion following administration of high levels of vitamin E. Ann. N.Y. Acad. Sci. 393:1982;48-60.
18. Maher J., Hachinsky V. Hypothermia as a potential treatment for cerebral ischemia. Cerebrovasc. Brain Metab. Rev. 5:1993;277-300.
19. Martz D., Rayos G., Schielke G. P., Betz A. L. Allopurinol and dimethylthiourea reduce brain infarction following middle cerebral artery occlusion in rats. Stroke. 20:1989;488-494.
20. Petty M. A., Poulet P., Haas A., Namer I. J., Wagner J. Reduction of traumatic brain injury-induced cerebral oedema by a free radical scavenger. Eur. J. Pharmacol. 307:1996;149-155.
21. Siesjö B. K., Agardh C.-D., Bengtsson F. Free radicals and brain damage. Cerebrovasc. Brain Metab. Rev. 1:1989;165-211.
22. Thomas C. E., Ohlweiler D. F., Taylor V. L., Schmidt C. J. Radical trapping and inhibition of iron-dependent CNS damage by cyclic nitrone spin traps. J. Neurochem. 68:1997;1173-1182.
23. Traystman R. J., Kirsch J. R., Koehler R. C. Oxygen radical mechanisms of brain injury following ischemia and reperfusion. J. Appl. Physiol. 71:1991;1185-1195.
24. van der Worp H. B., Bär P. R., Kappelle L. J., de Wildt D. J. Dietary vitamin E levels affect outcome of permanent focal cerebral ischemia in rats. Stroke. 29:1998;1002-1006.
25. van der Worp, H. B. L. J. Kappelle, J. van Gijn, 1997, Medical treatment of acute ischemic stroke, Neuroprotection in CNS Diseases, P. R. BärM. F. Beal, 349, 379, Marcel Dekker, New York.